Gene: USF1

7391
FCHL|FCHL1|HYPLIP1|MLTF|MLTFI|UEF|bHLHb11
upstream transcription factor 1
protein-coding
1q23.3
Ensembl:ENSG00000158773 MIM:191523 Vega:OTTHUMG00000031472 UniprotKB:P22415
NG_011612.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.538e-1 (AD)  3.674e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRCC0.952
THYN10.952
AKR1B10.948
CAPNS10.943
PSMB30.942
RRAGA0.94
EIF60.94
APMAP0.939
CDC1230.939
PEF10.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.777
OR4F29-0.737
MTRNR2L6-0.298
MTRNR2L9-0.292
MTRNR2L10-0.264
KLRB1-0.238
ZBTB20-0.233
P2RY14-0.222
TTLL10-0.214
TRPV5-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of USF1 mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of USF1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of USF1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of USF1 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of USF1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of USF1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased methylation of USF1 promoter26046465
D001280AtrazineAtrazine results in decreased expression of USF1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USF1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USF1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of USF1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of USF1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of USF1 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of USF1 mRNA26191083
D002104CadmiumUSF1 affects the reaction [Cadmium results in increased expression of MT1 mRNA]10605938
C033394CGP 12177USF1 gene polymorphism promotes the reaction [CGP 12177 results in increased metabolism of Lipids]15985485
C033394CGP 12177USF1 protein affects the reaction [CGP 12177 results in increased metabolism of Lipids]15985485
D060729Coal AshCoal Ash results in increased activity of USF1 protein19000753
D005576ColforsinUSF1 gene polymorphism promotes the reaction [Colforsin results in increased metabolism of Lipids]15985485
D005576ColforsinUSF1 protein affects the reaction [Colforsin results in increased metabolism of Lipids]15985485
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of USF1 mRNA21266533
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of USF1 mRNA"22485181
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of USF1 mRNA"27840820
D004280DobutamineUSF1 gene polymorphism promotes the reaction [Dobutamine results in increased metabolism of Lipids]15985485
D004280DobutamineUSF1 protein affects the reaction [Dobutamine results in increased metabolism of Lipids]15985485
D000431EthanolEthanol results in decreased expression of USF1 mRNA15353170
D019833GenisteinGenistein results in increased expression of USF1 mRNA22553218
D005897GlafenineGlafenine results in decreased expression of USF1 mRNA24136188
C008261lead acetatelead acetate results in decreased expression of USF1 mRNA21829687
D008055LipidsUSF1 gene polymorphism promotes the reaction [CGP 12177 results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 gene polymorphism promotes the reaction [Colforsin results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 gene polymorphism promotes the reaction [Dobutamine results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 gene polymorphism promotes the reaction [Norepinephrine results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 gene polymorphism promotes the reaction [Terbutaline results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 protein affects the reaction [CGP 12177 results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 protein affects the reaction [Colforsin results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 protein affects the reaction [Dobutamine results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 protein affects the reaction [Norepinephrine results in increased metabolism of Lipids]15985485
D008055LipidsUSF1 protein affects the reaction [Terbutaline results in increased metabolism of Lipids]15985485
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of USF1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of USF1 mRNA"20188158
D009638NorepinephrineUSF1 gene polymorphism promotes the reaction [Norepinephrine results in increased metabolism of Lipids]15985485
D009638NorepinephrineUSF1 protein affects the reaction [Norepinephrine results in increased metabolism of Lipids]15985485
D010416PentachlorophenolPentachlorophenol results in increased expression of USF1 mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of USF1 mRNA16221962
D010936Plant ExtractsPlant Extracts results in increased expression of USF1 mRNA23557933
D012834SilverSilver results in decreased expression of USF1 mRNA27131904
D013726TerbutalineUSF1 gene polymorphism promotes the reaction [Terbutaline results in increased metabolism of Lipids]15985485
D013726TerbutalineUSF1 protein affects the reaction [Terbutaline results in increased metabolism of Lipids]15985485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USF1 mRNA24058054
D014635Valproic AcidValproic Acid results in increased methylation of USF1 gene29154799
D014639VanadiumVanadium results in increased activity of USF1 protein19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003690double-stranded DNA binding-IEA-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IDA2249772  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IMP8576131  18234320  
GO:0005515protein binding-IPI17353931  19303849  25416956  27141965  
GO:0019899enzyme binding-IPI19303849  
GO:0019901protein kinase binding-IPI19303849  
GO:0042802identical protein binding-IPI25416956  
GO:0042803protein homodimerization activity-IPI8576131  
GO:0042803protein homodimerization activity-TAS2249772  
GO:0042826histone deacetylase binding-IPI19303849  
GO:0043425bHLH transcription factor binding-IPI8576131  
GO:0043565sequence-specific DNA binding-IDA2249772  8576131  
GO:0046982protein heterodimerization activity-IPI8576131  
GO ID GO Term Qualifier Evidence PubMed
GO:0000430regulation of transcription from RNA polymerase II promoter by glucose-IC8576131  
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose-IMP7852331  
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose-ISS-  
GO:0001666response to hypoxia-IMP12917334  
GO:0006006glucose metabolic process-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS2249772  
GO:0006366transcription by RNA polymerase II-IDA2249772  
GO:0009411response to UV-ISS-  
GO:0019086late viral transcription-IDA2249772  
GO:0032869cellular response to insulin stimulus-IDA19303849  
GO:0042593glucose homeostasis-TAS15054483  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP8576131  18234320  
GO:0045990carbon catabolite regulation of transcription-TAS19303849  
GO:0051918negative regulation of fibrinolysis-IC18234320  
GO:0055088lipid homeostasis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA27141965  
GO:0005634nucleus-IDA2249772  8576131  15358760  18234320  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA19303849  
GO:0016589NURF complexcolocalizes_withIDA27141965  
GO:0048188Set1C/COMPASS complexcolocalizes_withIDA27141965  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26068452The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking. (2015 Jun 10)Niemiec PInt J Mol Sci
18577828Allelic variants of upstream transcription factor 1 associate with carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns study. (2008 Jul)Collings ACirc J
23271305Association analysis of USF1 gene polymorphisms and total unstable carotid plaque area in atherosclerotic stroke patients. (2013 Oct)Wang RMJ Thromb Thrombolysis
16488890Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors. (2006 Apr 21)Chen LJ Biol Chem