Gene: USF2

7392
FIP|bHLHb12
upstream transcription factor 2, c-fos interacting
protein-coding
19q13.12
Ensembl:ENSG00000105698 MIM:600390 Vega:OTTHUMG00000183182 UniprotKB:Q15853
NG_029241.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.172e-1 (AD)  4.283e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFSF120.941
CTDNEP10.93
ARL6IP40.922
RPS19BP10.918
HIGD2A0.918
COX5B0.917
UCK10.917
COX8A0.914
FBXO20.914
GUK10.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.878
OR4F29-0.873
FER1L6-0.222
SULT1E1-0.212
GSDMA-0.204
IYD-0.203
GADL1-0.203
ZC3H11B-0.202
DPPA4-0.201
KRT73-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of USF2 mRNA]"19467301
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of USF2 mRNA19191707
D000643Ammonium ChlorideAmmonium Chloride affects the expression of USF2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of USF2 mRNA25436934
C006632arsenic trioxidearsenic trioxide results in decreased expression of USF2 protein25436934
C006632arsenic trioxidearsenic trioxide results in increased methylation of USF2 promoter26046465
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USF2 mRNA22228805
C006780bisphenol Abisphenol A results in increased methylation of USF2 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of USF2 mRNA17553608
C584509C646 compoundC646 compound results in decreased expression of USF2 mRNA26191083
D002101Cacodylic AcidCacodylic Acid results in increased expression of USF2 mRNA16122865
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USF2 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of USF2 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of USF2 mRNA17585979
C018021cobaltous chloride[cobaltous chloride results in increased expression of EPAS1 protein] affects the reaction [EPAS1 protein binds to USF2 protein]23958427
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of USF2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of USF2 mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of USF2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of USF2 mRNA]19850644
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of USF2 mRNA"27840820
D004221DisulfiramDisulfiram results in decreased expression of USF2 mRNA20530235
D005485FlutamideFlutamide results in increased expression of USF2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USF2 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of USF2 mRNA19167457
C039281furanfuran results in decreased expression of USF2 mRNA24183702
D005947GlucoseGlucose results in increased activity of USF2 protein15767253
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of USF2 mRNA23086925
C008261lead acetatelead acetate results in increased expression of USF2 mRNA21829687
C045463leflunomideleflunomide results in increased expression of USF2 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USF2 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of USF2 mRNA"20188158
D008790MetoprololMetoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein]19233164
D008790MetoprololMetoprolol results in increased expression of USF2 protein19233164
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of USF2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of USF2 mRNA19167457
D010100Oxygen[Oxygen deficiency results in increased expression of EPAS1 protein] promotes the reaction [EPAS1 protein binds to USF2 protein]23958427
D010634PhenobarbitalPhenobarbital affects the expression of USF2 mRNA23091169
D010936Plant ExtractsPlant Extracts results in decreased expression of USF2 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of USF2 mRNA21278054
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of USF2 mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of USF2 mRNA19244175
D012643SeleniumSelenium results in increased expression of USF2 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USF2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USF2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of USF2 mRNA21215274
D013893ThiramThiram results in decreased expression of USF2 mRNA20530235
D014118Toxins, Biological"Toxins, Biological affects the expression of USF2 mRNA"19682533
C012589trichostatin Atrichostatin A affects the expression of USF2 mRNA28542535
D014635Valproic AcidValproic Acid results in decreased expression of USF2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of USF2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of USF2 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of USF2 mRNA19136453|2142705
D014635Valproic AcidValproic Acid results in increased expression of USF2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of USF2 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of USF2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of USF2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-TAS1589769  8954795  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IMP8576131  
GO:0005515protein binding-IPI17353931  19303849  19505873  25416956  
GO:0042803protein homodimerization activity-IPI8576131  
GO:0043425bHLH transcription factor binding-IPI8576131  
GO:0043565sequence-specific DNA binding-IDA8576131  
GO:0046982protein heterodimerization activity-IPI8576131  
GO ID GO Term Qualifier Evidence PubMed
GO:0000430regulation of transcription from RNA polymerase II promoter by glucose-IC8576131  
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose-IMP7852331  
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose-ISS-  
GO:0006366transcription by RNA polymerase II-IMP8576131  
GO:0007595lactation-IEA-  
GO:0019086late viral transcription-IC8576131  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP8576131  
GO:0055088lipid homeostasis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA8576131  15358760  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16488890Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors. (2006 Apr 21)Chen LJ Biol Chem
25177835A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. (2014 Oct)Faisal MComput Biol Med