Gene: UTRN

7402
DMDL|DRP|DRP1
utrophin
protein-coding
6q24.2
Ensembl:ENSG00000152818 MIM:128240 Vega:OTTHUMG00000015746 UniprotKB:P46939
NG_042293.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.776e-1 (AD)  2.080e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7762384chr6:144719159 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12664298chr6:144362485 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEG10.711
ZEB10.699
ENTPD10.684
KLF30.68
DLC10.678
SYNE20.676
VANGL10.663
PTPRG0.661
PAWR0.659
STAG10.658

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.447
OR4F29-0.438
DMRT3-0.264
MUC12-0.241
LRRC26-0.235
TNFRSF18-0.23
CCDC166-0.228
TGFBR3L-0.226
FOXD4L6-0.211
GSG1-0.21

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of UTRN mRNA"26377693
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of UTRN mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of UTRN mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of UTRN mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UTRN mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UTRN mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of UTRN mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of UTRN mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UTRN mRNA16483693
D047310ApigeninApigenin results in increased expression of UTRN mRNA22028826
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of UTRN mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UTRN mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UTRN mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of UTRN mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UTRN mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UTRN mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of UTRN gene25435355
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UTRN mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UTRN mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UTRN mRNA"19150397|2038263
D004958EstradiolEGF protein promotes the reaction [Estradiol results in decreased expression of UTRN mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of UTRN mRNA24758408
C006780bisphenol Abisphenol A results in increased expression of UTRN mRNA26063408
C006780bisphenol Abisphenol A affects the expression of UTRN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of UTRN gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of UTRN mRNA26079696
D002104CadmiumCadmium results in decreased expression of UTRN mRNA23369406
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of UTRN mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UTRN mRNA27858113
C043561chrysinchrysin results in increased expression of UTRN mRNA22028826
D002994ClofibrateClofibrate results in increased expression of UTRN mRNA17585979
D003010ClorgylineClorgyline results in increased expression of UTRN mRNA22028826
D003033Coal TarCoal Tar results in decreased expression of UTRN mRNA27858113
C030973cupric oxidecupric oxide results in decreased expression of UTRN mRNA22077320
D003471CuprizoneCuprizone results in increased expression of UTRN mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of UTRN mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of UTRN mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of UTRN mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UTRN mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of UTRN mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of UTRN mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UTRN mRNA]17942915
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UTRN mRNA18164116
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of UTRN mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of UTRN mRNA22079256
D004857EquilinEquilin results in increased expression of UTRN mRNA22028826
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of UTRN mRNA23649840
C540355fenamidonefenamidone results in increased expression of UTRN mRNA27029645
C039281furanfuran results in decreased expression of UTRN mRNA25539665
C013015hesperetinhesperetin results in increased expression of UTRN mRNA22028826
D017313FenretinideFenretinide results in decreased expression of UTRN mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UTRN mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of UTRN mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UTRN mRNA23430699
C006552kaempferolkaempferol results in increased expression of UTRN mRNA22028826
C011889kavainkavain results in increased expression of UTRN mRNA22028826
C045463leflunomideleflunomide results in increased expression of UTRN mRNA22028826
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of UTRN mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of UTRN mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UTRN mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of UTRN mRNA18548127
D008942MitoxantroneUTRN protein affects the susceptibility to Mitoxantrone16217747
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of UTRN mRNA"29244179
C035605nabumetonenabumetone results in increased expression of UTRN mRNA22028826
C035605nabumetonenabumetone results in increased expression of UTRN protein22028826
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of UTRN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UTRN mRNA"25554681
C046012pentanalpentanal results in decreased expression of UTRN mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of UTRN mRNA26794494
D010621PhenazopyridinePhenazopyridine results in increased expression of UTRN mRNA22028826
D010634PhenobarbitalPhenobarbital results in increased expression of UTRN mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of UTRN mRNA26272509
C008922piperinepiperine results in increased expression of UTRN mRNA22028826
C006253pirinixic acidpirinixic acid results in increased expression of UTRN mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of UTRN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of UTRN mRNA22079256|2271453
D015125OxyquinolineOxyquinoline results in increased expression of UTRN mRNA21632981
C059514resveratrolresveratrol results in increased expression of UTRN mRNA22028826
C059514resveratrolresveratrol results in increased expression of UTRN mRNA22795790
D019782RiluzoleRiluzole results in increased expression of UTRN mRNA22028826
C016104sodium bichromatesodium bichromate affects the expression of UTRN mRNA22110744
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of UTRN mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UTRN mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UTRN mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of UTRN mRNA25613284
D013827ThiabendazoleThiabendazole results in increased expression of UTRN mRNA22028826
C009495titanium dioxidetitanium dioxide results in decreased expression of UTRN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of UTRN mRNA28065790
D014212TretinoinTretinoin results in decreased expression of UTRN mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of UTRN mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of UTRN mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTRN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of UTRN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UTRN mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UTRN gene25560391
C111237vorinostatvorinostat results in increased expression of UTRN mRNA27188386
C016837zinc chloridezinc chloride binds to UTRN protein17009962

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IDA16803572  
GO:0005178integrin binding-IPI16803572  
GO:0005515protein binding-IPI10767429  16777071  18838687  19786618  
GO:0008270zinc ion binding-IEA-  
GO:0017166vinculin binding-IPI16803572  
GO:0019901protein kinase binding-IPI16803572  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001954positive regulation of cell-matrix adhesion-IMP19786618  
GO:0006936muscle contraction-TAS9288751  
GO:0007517muscle organ development-TAS9288751  
GO:0007528neuromuscular junction development-IEA-  
GO:0014894response to denervation involved in regulation of muscle adaptation-IEA-  
GO:2000649regulation of sodium ion transmembrane transporter activity-ISS21677768  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA19786618  
GO:0005856cytoskeleton-TAS8977119  
GO:0005886plasma membrane-IDA-  
GO:0016010dystrophin-associated glycoprotein complex-IEA-  
GO:0016020membrane-TAS1426262  
GO:0030054cell junction-IEA-  
GO:0030175filopodium-IDA16803572  
GO:0030426growth cone-IEA-  
GO:0030864cortical actin cytoskeleton-IEA-  
GO:0031527filopodium membrane-IDA16803572  
GO:0031594neuromuscular junction-IEA-  
GO:0032991protein-containing complex-IDA18468998  
GO:0042383sarcolemma-IEA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0070938contractile ringcolocalizes_withIDA16803572  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal