Gene: KDM6A

7403
KABUK2|UTX|bA386N14.2
lysine demethylase 6A
protein-coding
Xp11.3
Ensembl:ENSG00000147050 MIM:300128 Vega:OTTHUMG00000021402 UniprotKB:O15550
NG_016260.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELF20.825
PCF110.813
MSH60.808
ATM0.805
PBRM10.801
DICER10.801
NIPBL0.8
CNOT20.795
PAXBP10.795
MIER30.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.389
RPS4Y1-0.388
OR4F29-0.372
EIF1AY-0.332
HES5-0.324
TMSB4Y-0.31
DDX3Y-0.294
KDM5D-0.289
ZFY-0.287
USP9Y-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of KDM6A mRNA"20453058
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of KDM6A mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of KDM6A mRNA]28655636
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KDM6A mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of KDM6A mRNA21298039
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of KDM6A mRNA"18687144
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of KDM6A mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KDM6A mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KDM6A mRNA"19150397
D001599BerberineBerberine results in increased expression of KDM6A mRNA27311644
C006780bisphenol Abisphenol A results in increased expression of KDM6A mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of KDM6A mRNA25181051
D002104CadmiumCadmium results in decreased expression of KDM6A mRNA24067728
C018021cobaltous chloridecobaltous chloride results in increased expression of KDM6A mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of KDM6A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of KDM6A mRNA20106945|2556210
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of KDM6A mRNA"23811387
D000431EthanolEthanol affects the expression of KDM6A mRNA29018328
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KDM6A mRNA23649840
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of KDM6A mRNA22213190
D005557FormaldehydeFormaldehyde results in decreased expression of KDM6A mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of KDM6A mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of KDM6A mRNA26705709
C544151jinfukangjinfukang results in decreased expression of KDM6A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KDM6A mRNA22802445
C045463leflunomideleflunomide results in increased expression of KDM6A mRNA28988120
D008694MethamphetamineMethamphetamine results in increased expression of KDM6A mRNA26307267
D008727MethotrexateKDM6A protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KDM6A mRNA26272509|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KDM6A mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KDM6A mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KDM6A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KDM6A mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of KDM6A mRNA23811387
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KDM6A mRNA25729387
D010100OxygenOxygen deficiency promotes the reaction [KDM6A protein binds to DICER1 promoter]25351418
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of KDM6A mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of KDM6A mRNA28655636
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of KDM6A mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of KDM6A mRNA23091169
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KDM6A mRNA26272509
C059514resveratrolresveratrol results in decreased expression of KDM6A mRNA25905778
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of KDM6A mRNA21427059
D012834SilverSilver results in increased expression of KDM6A mRNA26014281
C004648testosterone enanthatetestosterone enanthate affects the expression of KDM6A mRNA17440010
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KDM6A mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KDM6A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KDM6A promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KDM6A mRNA15034205
D013849ThimerosalThimerosal results in decreased expression of KDM6A mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KDM6A mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of KDM6A mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of KDM6A mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of KDM6A mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of KDM6A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KDM6A mRNA21427059
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of KDM6A mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of KDM6A mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KDM6A gene25560391
C111237vorinostatvorinostat results in decreased expression of KDM6A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0003682chromatin binding-IBA21873635  
GO:0031490chromatin DNA binding-IBA21873635  
GO:0031490chromatin DNA binding-IEA-  
GO:0032452histone demethylase activity-TAS-  
GO:0042802identical protein binding-IEA-  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0051213dioxygenase activity-IEA-  
GO:0071558histone demethylase activity (H3-K27 specific)-IBA21873635  
GO:0071558histone demethylase activity (H3-K27 specific)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0003007heart morphogenesis-IEA-  
GO:0003016respiratory system process-IEA-  
GO:0006338chromatin remodeling-ISS-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0032525somite rostral/caudal axis specification-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0048333mesodermal cell differentiation-IEA-  
GO:0048570notochord morphogenesis-IEA-  
GO:0051568histone H3-K4 methylation-ISS17178841  
GO:0055114oxidation-reduction process-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0071557histone H3-K27 demethylation-IEA-  
GO:0072358cardiovascular system development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17500065  
GO:0005654nucleoplasm-TAS-  
GO:0035097histone methyltransferase complex-IDA17500065  
GO:0044666MLL3/4 complex-IBA21873635  
GO:0044666MLL3/4 complex-IDA17500065  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-3214842HDMs demethylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23926199Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. (2013 Aug 7)Poon SLSci Transl Med