Gene: VASP

7408
-
vasodilator stimulated phosphoprotein
protein-coding
19q13.32
Ensembl:ENSG00000125753 MIM:601703 Vega:OTTHUMG00000182124 UniprotKB:P50552
NC_000019.10
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.375e-1 (AD)  2.751e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC10.924
TGFB10.894
LTBR0.889
TAGLN20.889
S100A110.886
ARPC1B0.881
PPP1R180.879
TUBB60.878
TNFRSF10B0.875
DRAM10.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.51
MARCH4-0.493
SLC7A4-0.479
NEUROD6-0.476
KCNB2-0.47
XKR4-0.467
ABCC12-0.463
CALHM1-0.454
SVOP-0.443
GRIN3A-0.443

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]"17868048
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased phosphorylation of VASP protein]"17868048
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one results in increased phosphorylation of VASP protein"26525565
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of VASP mRNA"25380136
C0716445,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate"5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased phosphorylation of VASP protein"11799084
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride results in increased phosphorylation of VASP protein15475462|1616632
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased phosphorylation of VASP protein"16166323
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in decreased phosphorylation of VASP protein"11799084
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased phosphorylation of VASP protein"11799084
D000079AcetaldehydeAcetaldehyde affects the expression of VASP mRNA22634333
D000082AcetaminophenAcetaminophen affects the expression of VASP mRNA17562736
D000393Air PollutantsAir Pollutants results in decreased expression of VASP mRNA25056781
D013196Dihydrotestosterone[Dihydrotestosterone results in increased activity of AR protein mutant form] which results in increased phosphorylation of VASP protein18819937
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of VASP mRNA24449571
D001280AtrazineAtrazine results in increased expression of VASP mRNA22378314
D001542BenomylBenomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]15331769
D001542BenomylBenomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein]15331769
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VASP mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VASP mRNA19770486
D004958EstradiolEstradiol deficiency results in decreased phosphorylation of VASP protein18787021
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VASP mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of VASP mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VASP mRNA28628672
C006780bisphenol Abisphenol A affects the expression of VASP mRNA21786754
C006780bisphenol Abisphenol A affects the expression of VASP mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of VASP mRNA20977926
C013418bromfenacoumbromfenacoum results in decreased expression of VASP protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of VASP mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of VASP mRNA26191083
D002104CadmiumCadmium results in increased expression of VASP mRNA22562489
D002220CarbamazepineCarbamazepine affects the expression of VASP mRNA22634333
D002248Carbon MonoxideCarbon Monoxide results in decreased phosphorylation of VASP protein26582457
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of VASP mRNA27339419
D002706ChlordanChlordan results in decreased expression of VASP mRNA23153324
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VASP gene20938992
D002857ChromiumChromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein]17215582
C055162clopidogrelCYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]16772608
C018021cobaltous chloridecobaltous chloride results in decreased expression of VASP mRNA19320972
D005576ColforsinColforsin results in increased phosphorylation of VASP protein18182247
D019327Copper SulfateCopper Sulfate results in increased expression of VASP mRNA19549813
C402665CP 31398CP 31398 results in increased expression of VASP mRNA15155752
D003471CuprizoneCuprizone results in increased expression of VASP mRNA26577399
D003474CurcuminCurcumin results in increased expression of VASP mRNA17198877
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of and affects the localization of VASP protein23929704
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of VASP protein24677693|2735282
C057862cyanoginosin LRSB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein]24677693
C057862cyanoginosin LRU 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein]24677693
D003513CycloheximideVASP mutant form promotes the reaction [[TNF co-treated with Cycloheximide] results in increased cleavage of SPTAN1 protein]18182247
D016572CyclosporineCyclosporine results in decreased expression of VASP mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of VASP mRNA25562108
C093628cyproconazolecyproconazole results in decreased expression of VASP mRNA22045034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VASP mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VASP mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of VASP mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of VASP mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of VASP mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of VASP mRNA21266533
D003633Dichlorodiphenyl Dichloroethylene[Dichlorodiphenyl Dichloroethylene results in increased activity of AR protein mutant form] which results in increased phosphorylation of VASP protein18819937
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of VASP mRNA24535843
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of VASP mRNA25380136
D004837EpinephrineEpinephrine results in increased phosphorylation of VASP protein22144680
D004837EpinephrineSimvastatin inhibits the reaction [Epinephrine results in increased phosphorylation of VASP protein]22144680
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VASP mRNA17942748
D005472FluorouracilFluorouracil promotes the reaction [resveratrol results in decreased expression of VASP protein]25936796
D005472FluorouracilFluorouracil results in decreased expression of VASP protein25936796
D005472Fluorouracilresveratrol promotes the reaction [Fluorouracil results in decreased expression of VASP protein]25936796
C061365flusilazoleflusilazole affects the expression of VASP mRNA22634333
D005485FlutamideFlutamide results in increased expression of VASP mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VASP gene20938992
D019833GenisteinGenistein results in decreased expression of VASP mRNA22228119
D005839GentamicinsGentamicins results in increased expression of VASP mRNA22061828
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of VASP protein]19332549
C102521GGTI 298GGTI 298 results in decreased phosphorylation of VASP protein19332549
D006427HeminHemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]17541025
D017313FenretinideFenretinide results in increased expression of VASP mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of VASP mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VASP mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VASP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VASP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VASP mRNA28628672
C008261lead acetatelead acetate results in decreased expression of VASP mRNA21829687
D008628MercuryMercury analog results in decreased expression of VASP mRNA25056781
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VASP gene20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of VASP mRNA21613230
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [N(6)-benzoyl-cyclic AMP results in increased phosphorylation of VASP protein]22363678
C050086N(6)-benzoyl-cyclic AMPN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [N(6)-benzoyl-cyclic AMP results in increased phosphorylation of VASP protein]22363678
C050086N(6)-benzoyl-cyclic AMPN(6)-benzoyl-cyclic AMP results in increased phosphorylation of VASP protein22363678
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VASP mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of VASP mRNA25380136
D000068577NebivololNebivolol results in increased phosphorylation of VASP protein12692005
D000068577NebivololNebivolol inhibits the reaction [AGT protein results in decreased expression of VASP protein]16940222
D000068577NebivololNebivolol inhibits the reaction [Phorbol Esters results in decreased phosphorylation of VASP protein]16940222
D009532NickelNickel results in increased expression of VASP mRNA24768652
D005996Nitroglycerin"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]"17868048
D005996NitroglycerinNitroglycerin results in increased phosphorylation of VASP protein17868048|2012949
D005996NitroglycerinNitroglycerin results in decreased phosphorylation of VASP protein11331261
D005996NitroglycerinBenomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]15331769
D005996NitroglycerinHemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]17541025
D005996NitroglycerinNitroglycerin results in decreased phosphorylation of VASP protein11331261|1754102
D005996NitroglycerinNitroglycerin results in increased phosphorylation of VASP protein14551241|1533176
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of VASP protein11799084
D010098OxycodoneOxycodone results in decreased expression of VASP mRNA23439660
D010100OxygenOxygen deficiency affects the localization of VASP protein20164382
D010269ParaquatParaquat results in decreased expression of VASP mRNA12595580
D010416PentachlorophenolPentachlorophenol results in increased expression of VASP mRNA23892564
D010417Pentaerythritol TetranitrateBenomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein]15331769
D010417Pentaerythritol TetranitratePentaerythritol Tetranitrate results in increased phosphorylation of VASP protein15331769|1754102
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of VASP mRNA28973697
D015232DinoprostoneDinoprostone results in increased phosphorylation of VASP protein18182247
D010703Phorbol EstersNebivolol inhibits the reaction [Phorbol Esters results in decreased phosphorylation of VASP protein]16940222
D010703Phorbol EstersPhorbol Esters results in decreased phosphorylation of VASP protein16940222
D010936Plant ExtractsPlant Extracts results in decreased expression of VASP mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of VASP mRNA18497975
D000527AlprostadilAlprostadil results in increased phosphorylation of VASP protein20129490
C059514resveratrol"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased phosphorylation of VASP protein]"17868048
C059514resveratrolresveratrol results in decreased expression of VASP protein18089832
C059514resveratrolresveratrol results in decreased expression of VASP protein modified form25550561
C059514resveratrolresveratrol results in increased phosphorylation of VASP protein17868048|1871615
C059514resveratrolFluorouracil promotes the reaction [resveratrol results in decreased expression of VASP protein]25936796
C059514resveratrolresveratrol promotes the reaction [Fluorouracil results in decreased expression of VASP protein]25936796
C059514resveratrolresveratrol results in decreased expression of VASP protein25936796
C059514resveratrol[resveratrol results in increased activity of GSK3B protein] which results in increased phosphorylation of VASP protein19135050
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of VASP mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein]24677693
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of VASP protein]19332549
D019821SimvastatinSimvastatin inhibits the reaction [Epinephrine results in increased phosphorylation of VASP protein]22144680
D019821SimvastatinSimvastatin results in decreased phosphorylation of VASP protein19332549
D019821SimvastatinSimvastatin results in decreased phosphorylation of VASP protein19332549
D012999SomanSoman results in increased expression of VASP mRNA19281266
D019311StaurosporineVASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]18182247
D013395SucroseChromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein]17215582
D013395SucroseSucrose results in decreased phosphorylation of VASP protein17215582
C025463sulindac sulfonesulindac sulfone results in increased phosphorylation of VASP protein16166323
C061133tamibarotenetamibarotene results in increased expression of VASP mRNA15498508
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of VASP mRNA]20032058
C004648testosterone enanthatetestosterone enanthate affects the expression of VASP mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VASP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VASP mRNA17942748
D013849ThimerosalThimerosal results in decreased expression of VASP mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of VASP mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of VASP mRNA28111298
D014212TretinoinTretinoin results in increased expression of VASP mRNA15498508
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of VASP mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein]24677693
D014635Valproic AcidValproic Acid affects the expression of VASP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of VASP mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of VASP mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of VASP mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of VASP mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of VASP mRNA21427059
D014640VancomycinVancomycin results in decreased expression of VASP mRNA18930951
C025643vinclozolinvinclozolin affects the expression of VASP mRNA19015723
D014750VincristineVincristine results in increased expression of VASP mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of VASP mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI8836115  16189514  16631741  16940418  17599063  20195357  
21423205  23153535  24076653  25416956  
GO:0005522profilin binding-IPI17914456  
GO:0017124SH3 domain binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-IEA-  
GO:0007411axon guidance-TAS-  
GO:0008154actin polymerization or depolymerization-IEA-  
GO:0030838positive regulation of actin filament polymerization-IDA23153535  
GO:0034329cell junction assembly-TAS-  
GO:0051289protein homotetramerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005923bicellular tight junction-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA-  
GO:0015629actin cytoskeleton-TAS7828592  
GO:0031258lamellipodium membrane-IEA-  
GO:0031527filopodium membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  20458337  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-168256Immune SystemIEA
R-HSA-202403TCR signalingIEA
R-HSA-202433Generation of second messenger moleculesIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21621250The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent. (2011 Oct)Gremmel TThromb Res
28877606Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On-Clopidogrel Platelet Reactivity After ST-Segment Elevation Myocardial Infarction. (2018 Jan)Sun JClin Appl Thromb Hemost
24202700Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome. (2014 Jul)Zhang YYJ Thromb Thrombolysis
20170822Slow response to clopidogrel predicts low response. (2010 Feb 23)Bellemain-Appaix AJ Am Coll Cardiol
20822337Decreased VASP phosphorylation in platelets of male and female smokers of young age. (2010)Assinger APlatelets
25916518Genetic determined low response to thienopyridines is associated with higher systemic inflammation in smokers. (2015)Shahabi PPharmacogenomics
23498169Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity. (2013 Jun)Shi RThromb Res
23602770The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study. (2013 Aug 6)Gurbel PAJ Am Coll Cardiol