Gene: VAV1

7409
VAV
vav guanine nucleotide exchange factor 1
protein-coding
19p13.3
Ensembl:ENSG00000141968 MIM:164875 Vega:OTTHUMG00000181965 UniprotKB:P15498
NC_000019.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.313e-1 (AD)  8.947e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4807101chr19:6815937 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCKAP1L0.88
RUNX10.861
IL10RA0.861
DOCK20.861
LAIR10.861
ARHGAP300.858
SLA0.857
CYTH40.857
TLR10.856
BTK0.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.377
HES5-0.344
HES6-0.333
CPLX3-0.307
PYGM-0.306
ASPDH-0.303
ZNF98-0.296
HHATL-0.296
ATP2C2-0.294
GLIPR1L2-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of VAV1 mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of VAV1 mRNA"23195993
D000447AldehydesAldehydes results in increased expression of VAV1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VAV1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of VAV1 mRNA24449571
D001151ArsenicArsenic results in increased methylation of VAV1 gene24525453
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of VAV1 mRNA15894607
D001241AspirinAspirin results in decreased expression of VAV1 mRNA15928584
D001280AtrazineAtrazine results in increased expression of VAV1 mRNA22378314
D001379AzathioprineAzathioprine results in increased expression of VAV1 protein12697733
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VAV1 mRNA21569818
C006780bisphenol Abisphenol A affects the methylation of VAV1 promoter27334623
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of VAV1 mRNA18958704
C018475butyraldehydebutyraldehyde results in increased expression of VAV1 mRNA26079696
D000074262Canola OilCanola Oil metabolite results in decreased expression of VAV1 mRNA27363782
D002737ChloropreneChloroprene results in decreased expression of VAV1 mRNA23125180
D003471CuprizoneCuprizone results in increased expression of VAV1 mRNA27523638
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of VAV1 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of VAV1 mRNA]27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of VAV1 mRNA20360939
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of VAV1 mRNA25380136
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of VAV1 mRNA19118595
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of VAV1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VAV1 mRNA17942748
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of VAV1 protein25980585
C546771gardiquimodgardiquimod results in increased expression of VAV1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of VAV1 mRNA]28003376
D019833GenisteinGenistein inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of VAV1 protein]20561557
D007295Inositol Phosphates[VAV1 protein mutant form binds to and results in increased activity of PLCG2 protein mutant form] which results in increased chemical synthesis of Inositol Phosphates27542411
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of VAV1 mRNA25613284
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of VAV1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of VAV1 mRNA]27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of VAV1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of VAV1 mRNA12057914
D008070LipopolysaccharidesVAV1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]12848851
D008070LipopolysaccharidesVAV1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]12848851
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of VAV1 mRNA25613284
D015122MercaptopurineMercaptopurine results in increased expression of VAV1 protein12697733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VAV1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of VAV1 mRNA"25554681
D009532NickelNickel results in decreased expression of VAV1 mRNA23195993
D009532NickelNickel results in increased expression of VAV1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of VAV1 mRNA19167457
C046012pentanalpentanal results in increased expression of VAV1 mRNA26079696
C006253pirinixic acidpirinixic acid results in decreased expression of VAV1 mRNA19162173
C005556propionaldehydepropionaldehyde results in increased expression of VAV1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of VAV1 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of VAV1 mRNA]28003376
C059514resveratrolresveratrol inhibits the reaction [COL1A1 protein promotes the reaction [PTPN11 protein binds to VAV1 protein]]26482867
C059514resveratrolresveratrol inhibits the reaction [COL1A1 protein results in increased phosphorylation of VAV1 protein]26482867
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of VAV1 mRNA25895662
C061133tamibarotenetamibarotene results in increased expression of VAV1 mRNA17229644
D013749TetrachlorodibenzodioxinGenistein inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of VAV1 protein]20561557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [VAV1 protein binds to PRKCQ protein]20561557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VAV1 protein20561557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of VAV1 protein20561557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VAV1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VAV1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VAV1 mRNA15328365
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of VAV1 mRNA25613284
C402769tipifarnibtipifarnib results in increased expression of VAV1 mRNA16403772
C009495titanium dioxidetitanium dioxide results in increased expression of VAV1 mRNA27760801
D014118Toxins, Biological"Toxins, Biological affects the expression of VAV1 mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of VAV1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of VAV1 mRNA15894607
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of VAV1 mRNA]15363585
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of VAV1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0003700DNA-binding transcription factor activity-TAS2477241  
GO:0005085guanyl-nucleotide exchange factor activity-EXP8990121  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI8673706  9047237  10347175  10394361  11390470  12186560  
15345594  15558030  16467851  17306257  17855053  18511940  
18692475  19234221  20598684  21725281  24728074  
GO:0030676Rac guanyl-nucleotide exchange factor activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006955immune response-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0008361regulation of cell size-IGI22467863  
GO:0008361regulation of cell sizeNOTIGI22467863  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030168platelet activation-TAS-  
GO:0030217T cell differentiation-IEA-  
GO:0030593neutrophil chemotaxis-IEA-  
GO:0031295T cell costimulation-TAS-  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043087regulation of GTPase activity-IGI22467863  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0072593reactive oxygen species metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IEA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-109582HemostasisTAS
R-HSA-114604GPVI-mediated activation cascadeIEA
R-HSA-114604GPVI-mediated activation cascadeTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194138Signaling by VEGFIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationIEA
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389359CD28 dependent Vav1 pathwayTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5218920VEGFR2 mediated vascular permeabilityTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-912631Regulation of signaling by CBLTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20525804Cigarette smoke inhibits engulfment of apoptotic cells by macrophages through inhibition of actin rearrangement. (2011 Apr)Minematsu NAm J Respir Cell Mol Biol
17409975Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (2006 Nov)Lam DCJ Thorac Oncol