Gene info: ID 7415

Gene: VCP

GENE ID: 7415

Synonyms: CDC48|TERA|p97

Description: valosin containing protein

Gene type: protein-coding

Location: 9p13.3

dbXrefs: Ensembl:ENSG00000165280 MIM:601023 Vega:OTTHUMG00000019855 UniprotKB:P55072

RefSeq: NG_007887.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.891e-1 (AD) 6.906e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
XRCC6	0.975
SND1	0.969
PSMD3	0.968
PSMC1	0.966
SRP68	0.966
TMEM248	0.963
GORASP2	0.963
PSMC4	0.963
APMAP	0.962
RTCB	0.962

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.749
OR4F29	-0.708
MTRNR2L6	-0.343
MTRNR2L9	-0.328
MTRNR2L10	-0.295
KLRB1	-0.263
P2RY14	-0.255
TTLL10	-0.243
CTNNA3	-0.239
VNN3	-0.23

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Small Molecule		Experimental	Target
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C492847	1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea	"1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea binds to VCP protein"	21124757
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of VCP mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of VCP mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of VCP protein	16538041
D000255	Adenosine Triphosphate	sodium arsenate promotes the reaction [VCP protein results in increased hydrolysis of Adenosine Triphosphate]	28636814
D000255	Adenosine Triphosphate	VCP protein results in increased hydrolysis of Adenosine Triphosphate	28636814
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [CREBBP protein results in increased expression of VCP mRNA]	18822310
D001280	Atrazine	Atrazine results in decreased expression of VCP mRNA	22378314
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of VCP protein modified form	24464499
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of VCP mRNA	21715664
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of VCP mRNA	22300585
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]	15362974
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of VCP protein	15362974
D004958	Estradiol	Estradiol results in decreased expression of VCP mRNA	23373633
C006780	bisphenol A	bisphenol A affects the expression of VCP mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of VCP mRNA	21932408
C006780	bisphenol A	bisphenol A results in increased expression of VCP protein	28279065
C006780	bisphenol A	bisphenol A results in increased expression of VCP mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of VCP mRNA	20977926
C584509	C646 compound	C646 compound results in increased expression of VCP mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of VCP protein	24874008
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of VCP protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of VCP protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of VCP protein	24419708
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of VCP protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of VCP protein	18261755
D002251	Carbon Tetrachloride	[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of VCP protein	25303780
D002108	Ceruletide	Ceruletide results in decreased expression of VCP protein	18024178
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of VCP mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of VCP protein	21791222
C100187	chloropicrin	chloropicrin results in increased expression of VCP mRNA	26352163
C041167	chromium nitrate	chromium nitrate results in decreased expression of VCP protein	22144121
C018021	cobaltous chloride	cobaltous chloride results in increased expression of VCP mRNA	24612858
D019327	Copper Sulfate	Copper Sulfate results in increased expression of VCP mRNA	19549813
C029892	cupric chloride	cupric chloride results in decreased expression of VCP protein	21641295
D016572	Cyclosporine	Cyclosporine results in decreased methylation of VCP promoter	27989131
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of VCP mRNA]	27941970
D004026	Dieldrin	Dieldrin results in decreased expression of VCP mRNA	28385952
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of VCP mRNA	22467019
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of VCP protein"	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of VCP protein"	22248470
D004147	Dioxins	Dioxins affects the expression of VCP mRNA	20463971
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of VCP mRNA	19118595
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of VCP protein	23301498
D000431	Ethanol	Ethanol results in decreased expression of VCP protein	23702218
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of VCP protein	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of VCP mRNA	17555576\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VCP mRNA	17942748
D018120	Finasteride	Finasteride results in increased expression of VCP mRNA	24136188
D005411	Flame Retardants	Flame Retardants results in decreased expression of VCP protein	18550172
C061365	flusilazole	flusilazole results in decreased expression of VCP mRNA	22382673
C061365	flusilazole	flusilazole results in increased expression of VCP mRNA	22382673
D005485	Flutamide	Flutamide results in increased expression of VCP mRNA	24136188
D017313	Fenretinide	Fenretinide results in increased expression of VCP mRNA	28973697
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of VCP protein]	23178681
C029424	hydrazine	hydrazine results in increased expression of VCP protein	15370871
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of VCP protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of VCP protein	23178681
D002112	Calcifediol	Calcifediol deficiency results in decreased expression of VCP mRNA	17293106
C492448	ICG 001	ICG 001 results in decreased expression of VCP mRNA	26191083
D007213	Indomethacin	Indomethacin results in decreased expression of VCP mRNA	28201806
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of VCP protein"	22248470
D048628	Ketolides	Ketolides analog results in decreased expression of VCP mRNA	24967691
D007657	Ketone Bodies	Ketone Bodies results in increased expression of VCP mRNA	16807920
C067713	lactacystin	lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]	15362974
C067713	lactacystin	lactacystin results in increased expression of VCP protein	15362974
C029891	lead chloride	lead chloride results in decreased expression of VCP protein	24419708
C045463	leflunomide	leflunomide results in decreased expression of VCP mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of VCP mRNA	25613284
D008148	Lovastatin	Lovastatin results in decreased expression of VCP mRNA	20493250
D008148	Lovastatin	Lovastatin results in increased expression of VCP mRNA	20493250
C015329	lycopene	lycopene results in increased expression of VCP mRNA	16886892
C005095	malachite green	malachite green results in increased expression of VCP protein	22446826
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of VCP protein	25809596
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of VCP mRNA	26011545
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of VCP mRNA	29191790
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]	17220478
D015741	Metribolone	Metribolone results in increased expression of VCP protein	17152098
C031721	naphthalene	naphthalene metabolite binds to VCP protein	16206326
C051752	nefazodone	nefazodone results in increased expression of VCP mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of VCP mRNA	17616710
C025589	ochratoxin A	ochratoxin A results in increased expression of VCP protein	19445961
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of VCP mRNA	28939011
D000069463	Olive Oil	[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of VCP protein	25303780
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of VCP mRNA	18636392
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of VCP protein	18550172
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of VCP protein	19954255\|2561625
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of VCP mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of VCP mRNA	20936131
C076994	perfluorooctane sulfonic acid	PPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of VCP mRNA]	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of VCP mRNA	19429403
C058305	phenethyl isothiocyanate	VCP protein binds to phenethyl isothiocyanate	21838287
D010634	Phenobarbital	Phenobarbital results in increased expression of VCP mRNA	19162173
D010894	Piroxicam	Piroxicam results in decreased expression of VCP mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of VCP mRNA	23557933
C027373	potassium chromate(VI)	VCP mRNA affects the susceptibility to potassium chromate(VI)	22144121
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of VCP protein	22144121
C100573	prostaglandin A1	prostaglandin A1 analog results in increased metabolism of VCP protein	19800325
C010313	pseudocumene	pseudocumene results in decreased expression of VCP protein	17337753
C031280	pyrazole	pyrazole results in increased expression of VCP mRNA	17945193
D011791	Quartz	Quartz affects the expression of VCP protein	27917503
D012822	Silicon Dioxide	Silicon Dioxide affects the expression of VCP protein	27917503
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of VCP protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of VCP mRNA	25351596
C009277	sodium arsenate	sodium arsenate results in increased expression of VCP mRNA	23922661
C009277	sodium arsenate	sodium arsenate promotes the reaction [VCP protein results in increased hydrolysis of Adenosine Triphosphate]	28636814
C017947	sodium arsenite	sodium arsenite results in decreased expression of VCP protein	21925251
C017947	sodium arsenite	sodium arsenite results in increased expression of VCP mRNA	20886546
C017947	sodium arsenite	sodium arsenite results in increased expression of VCP protein	15362974
C016104	sodium bichromate	sodium bichromate results in increased expression of VCP mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of VCP mRNA	22561333
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of VCP protein modified form	24464499
C016766	sulforafan	VCP protein binds to sulforafan	21838287
D013467	Sulindac	Sulindac results in decreased expression of VCP mRNA	24136188
C473643	sulphoraphene	sulphoraphene results in increased expression of VCP mRNA	29247643
D013629	Tamoxifen	Tamoxifen affects the expression of VCP mRNA	17555576
D013654	Taurine	Taurine results in decreased expression of VCP mRNA	16579726
C004648	testosterone enanthate	testosterone enanthate affects the expression of VCP mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of VCP mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VCP mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of VCP protein	16548065
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of VCP protein	19201780
D013849	Thimerosal	Thimerosal results in decreased expression of VCP mRNA	27188386
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of VCP mRNA	22363418\|2806579
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased metabolism of VCP protein	23396223
D014241	Trichloroethylene	Trichloroethylene affects the expression of VCP mRNA	21135412
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of VCP mRNA	19042947
C406224	valdecoxib	valdecoxib results in increased expression of VCP mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of VCP mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of VCP gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of VCP gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of VCP mRNA	23034163
C111237	vorinostat	vorinostat results in increased expression of VCP protein	20543569
D014859	Warfarin	Warfarin results in decreased expression of VCP mRNA	20493250
D014859	Warfarin	Warfarin results in increased expression of VCP mRNA	20493250

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22681889
GO:0005515	protein binding	-	IPI	9452483 10364224 10855792 12944474 14743216 15161933 15215856 15743842 16186510 16275660 16407162 16449189 16525503 17314412 17353931 17525332 17681147 17872946 18654987 18656546 18711132 18775313 19275885 19570996 19818707 19822669 20414249 21135095 21343306 21645854 21822278 21900206 21949850 21988832 22120668 22466964 22795130 22902628 22948820 23042605 23042607 23349634 24089527 24726327 25593058 25814554 26389662 26496610 26712280 26842564 27753622
GO:0005524	ATP binding	-	IEA	-
GO:0008289	lipid binding	-	IEA	-
GO:0016887	ATPase activity	-	IBA	21873635
GO:0016887	ATPase activity	-	IMP	23349634 25125609 25878907
GO:0016887	ATPase activity	-	TAS	15215856
GO:0019903	protein phosphatase binding	-	IPI	10364224
GO:0019904	protein domain specific binding	-	IPI	15362974
GO:0031593	polyubiquitin modification-dependent protein binding	-	IBA	21873635
GO:0031593	polyubiquitin modification-dependent protein binding	-	IDA	11483959
GO:0031625	ubiquitin protein ligase binding	-	IPI	22590560
GO:0035800	deubiquitinase activator activity	-	IDA	22970133
GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	-	IEA	-
GO:0042288	MHC class I protein binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	20512113 24055316 26712278 26822609 26849035
GO:0043531	ADP binding	-	IEA	-
GO:0044389	ubiquitin-like protein ligase binding	-	IPI	16186510
GO:1904288	BAT3 complex binding	-	IPI	21636303
GO:1990381	ubiquitin-specific protease binding	-	IPI	22590560 22970133

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006281	DNA repair	-	NAS	16140914
GO:0006302	double-strand break repair	-	IDA	10855792 22120668
GO:0006457	protein folding	-	TAS	-
GO:0006734	NADH metabolic process	-	IMP	23498975
GO:0006888	ER to Golgi vesicle-mediated transport	-	IEA	-
GO:0006914	autophagy	-	IMP	20104022 25125609
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	ISS	-
GO:0006974	cellular response to DNA damage stimulus	-	IDA	16140914 22120668 23042605
GO:0010498	proteasomal protein catabolic process	-	IMP	26565908
GO:0010918	positive regulation of mitochondrial membrane potential	-	IMP	23498975
GO:0016236	macroautophagy	-	IBA	21873635
GO:0016236	macroautophagy	-	IMP	27753622
GO:0016567	protein ubiquitination	-	IDA	22120668
GO:0016567	protein ubiquitination	-	NAS	15215856
GO:0016567	protein ubiquitination	-	TAS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0018279	protein N-linked glycosylation via asparagine	-	IMP	22607976
GO:0019079	viral genome replication	-	IMP	22379090
GO:0019985	translesion synthesis	-	IMP	23042605
GO:0030433	ubiquitin-dependent ERAD pathway	-	IBA	21873635
GO:0030433	ubiquitin-dependent ERAD pathway	-	IDA	17872946
GO:0030433	ubiquitin-dependent ERAD pathway	-	IMP	22607976
GO:0030433	ubiquitin-dependent ERAD pathway	-	TAS	15215856
GO:0030968	endoplasmic reticulum unfolded protein response	-	TAS	15215856
GO:0030970	retrograde protein transport, ER to cytosol	-	IBA	21873635
GO:0030970	retrograde protein transport, ER to cytosol	-	IDA	15215856
GO:0030970	retrograde protein transport, ER to cytosol	-	IMP	25660456
GO:0031334	positive regulation of protein complex assembly	-	IDA	18775313
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	-	IDA	9452483
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	-	IMP	21822278
GO:0034214	protein hexamerization	-	IEA	-
GO:0036503	ERAD pathway	-	IDA	25088257
GO:0036503	ERAD pathway	-	IMP	20104022
GO:0042981	regulation of apoptotic process	-	TAS	16130169
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IMP	20104022
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	NAS	15743842
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045184	establishment of protein localization	-	TAS	15215856
GO:0045732	positive regulation of protein catabolic process	-	IDA	11483959 18775313
GO:0046034	ATP metabolic process	-	IEA	-
GO:0051228	mitotic spindle disassembly	-	IBA	21873635
GO:0051260	protein homooligomerization	-	IEA	-
GO:0055085	transmembrane transport	-	TAS	-
GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control	-	IMP	26565908
GO:0070842	aggresome assembly	-	IEA	-
GO:0070987	error-free translesion synthesis	-	TAS	-
GO:0071712	ER-associated misfolded protein catabolic process	-	IBA	21873635
GO:0071712	ER-associated misfolded protein catabolic process	-	IMP	24089527
GO:0072389	flavin adenine dinucleotide catabolic process	-	IMP	23498975
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IDA	28689657
GO:0097352	autophagosome maturation	-	IBA	21873635
GO:0097352	autophagosome maturation	-	IMP	20104022
GO:1903006	positive regulation of protein K63-linked deubiquitination	-	IDA	22970133
GO:1903007	positive regulation of Lys63-specific deubiquitinase activity	-	IDA	22970133
GO:1903715	regulation of aerobic respiration	-	IMP	23498975
GO:1903862	positive regulation of oxidative phosphorylation	-	IMP	23498975
GO:2000158	positive regulation of ubiquitin-specific protease activity	-	IEA	-
GO:2001171	positive regulation of ATP biosynthetic process	-	IMP	23498975

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000502	proteasome complex	-	IDA	9452483
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	10855792 26842564
GO:0005634	nucleus	-	TAS	16130169
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	27753622
GO:0005783	endoplasmic reticulum	-	IDA	15215856 24089527
GO:0005789	endoplasmic reticulum membrane	-	IDA	17872946
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005811	lipid droplet	-	IDA	23297223
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	10855792 15215856
GO:0005829	cytosol	-	TAS	16186510
GO:0032991	protein-containing complex	-	IDA	21822278 23349634
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	-	IBA	21873635
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	-	ISS	-
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	-	TAS	16186510
GO:0034774	secretory granule lumen	-	TAS	-
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0035861	site of double-strand break	-	IDA	22120668
GO:0036513	Derlin-1 retrotranslocation complex	-	IDA	15215856 17872946
GO:0043209	myelin sheath	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	ISS	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	16275660
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-
GO:1904949	ATPase complex	-	IEA	-
GO:1990730	VCP-NSFL1C complex	-	ISS	-

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum

Reactome ID	Reactome Term	Evidence
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110320	Translesion Synthesis by POLH	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371511	HSF1 activation	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	TAS
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689877	Josephin domain DUBs	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-8852135	Protein ubiquitination	TAS
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	TAS
R-HSA-8876725	Protein methylation	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16461866	Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population. (2006 Feb)	Poling J	Arch Gen Psychiatry
15231524	Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma. (2004 Jul)	Yamamoto S	Ann Surg Oncol
28150141	Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases. (2017 Dec)	Patel N	Mol Cell Pediatr
10465818	Attitudes and experiences of restaurateurs regarding smoking bans in Adelaide, South Australia. (1999 Spring)	Jones K	Tob Control
23797033	Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. (2013 Dec)	D'Amico E	Free Radic Biol Med
27816355	Correlations Between Serum Apolipoprotein A-I and Formation of Vocal Cord Polyp. (2017 May)	Zhang HP	J Voice
27394171	Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment. (2016 Aug)	Bodas M	Free Radic Biol Med
26265139	UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. (2015 Oct 15)	Teng Y	Biochem Pharmacol