Gene: VEGFB

7423
VEGFL|VRF
vascular endothelial growth factor B
protein-coding
11q13.1
Ensembl:ENSG00000173511 MIM:601398 Vega:OTTHUMG00000167813 UniprotKB:P49765
NG_029823.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.237e-1 (AD)  4.901e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MT30.917
DCXR0.896
USF20.882
CST30.879
ENHO0.877
METRN0.877
ECI10.876
TNFSF120.872
ZNF385A0.871
SERF20.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.74
OR4F29-0.739
PP2D1-0.3
TXK-0.287
SLCO4C1-0.281
ACTA2-AS1-0.278
GCNT4-0.273
CCDC158-0.264
PROX2-0.264
POLQ-0.264

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08885AfliberceptBiotechDrug862111-32-8ApprovedTarget
ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased expression of VEGFB mRNA"15313899
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of VEGFB mRNA26821219
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of VEGFB mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of VEGFB mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of VEGFB mRNA25596134
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA22129741
D000537Aluminum OxideAluminum Oxide results in increased expression of VEGFB mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VEGFB mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of VEGFB mRNA24449571
D001151ArsenicArsenic affects the expression of VEGFB mRNA18414638
D001151ArsenicArsenic affects the expression of VEGFB protein24675094
D001151ArsenicArsenic results in increased expression of VEGFB mRNA11134558
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VEGFB mRNA19770486|2222880
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of VEGFB mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of VEGFB mRNA29275510
C006780bisphenol Abisphenol A affects the expression of VEGFB mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of VEGFB mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of VEGFB gene28505145
D000069286BortezomibBortezomib results in decreased expression of VEGFB mRNA17659339
D000069286BortezomibBortezomib results in increased expression of VEGFB mRNA17895889
C584509C646 compoundC646 compound results in increased expression of VEGFB mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of VEGFB mRNA25596134
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of VEGFB mRNA12734012
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of VEGFB mRNA25596134
D002746ChlorpromazineChlorpromazine results in increased expression of VEGFB mRNA25596134
C059262cidofovircidofovir results in increased expression of VEGFB mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of VEGFB mRNA25596134
D002994ClofibrateClofibrate results in increased expression of VEGFB mRNA21318169
C018021cobaltous chloridecobaltous chloride results in decreased expression of VEGFB mRNA22941251
D045424Complex Mixtures[Complex Mixtures co-treated with Sulfadimethoxine] results in increased expression of VEGFB mRNA22687987
D019327Copper SulfateCopper Sulfate results in decreased expression of VEGFB mRNA19549813
D016572CyclosporineCyclosporine affects the expression of VEGFB mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of VEGFB mRNA25596134
D003976DiazinonDiazinon affects the expression of VEGFB mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of VEGFB mRNA27392435
D004026DieldrinDieldrin affects the expression of VEGFB mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of VEGFB mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of VEGFB mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of VEGFB mRNA18597072
D004052Diethylnitrosamine[troglitazone co-treated with Diethylnitrosamine] results in increased expression of VEGFB mRNA18597072
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA22129741
D004052Diethylnitrosamine[Mastic Resin co-treated with Diethylnitrosamine] results in decreased expression of VEGFB mRNA18977376
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of VEGFB mRNA"22485181
D000431EthanolEthanol results in decreased expression of VEGFB mRNA22198099
D011345FenofibrateFenofibrate results in increased expression of VEGFB mRNA17264098|2559613
C069837fullerene C60fullerene C60 results in increased expression of VEGFB mRNA19167457
C039281furanfuran results in increased methylation of VEGFB gene22079235
D017313FenretinideFenretinide results in decreased expression of VEGFB mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of VEGFB mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of VEGFB mRNA20044591
C492448ICG 001ICG 001 results in increased expression of VEGFB mRNA26191083
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA22129741
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of VEGFB mRNA27392435
C544151jinfukangjinfukang results in increased expression of VEGFB mRNA27392435
C045463leflunomideleflunomide results in increased expression of VEGFB mRNA24136188
D000069997Mastic Resin[Mastic Resin co-treated with Diethylnitrosamine] results in decreased expression of VEGFB mRNA18977376
D008687MetforminMetformin results in increased expression of VEGFB mRNA25596134
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of VEGFB mRNA"20188158
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of VEGFB mRNA]16173061
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of VEGFB mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of VEGFB mRNA"25620056
C022838nickel chloridenickel chloride affects the expression of VEGFB mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of VEGFB mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of VEGFB mRNA17914565|2559613
D010100OxygenOxygen deficiency results in increased expression of VEGFB mRNA24205000
D010672PhenytoinPhenytoin results in decreased expression of VEGFB mRNA14741686
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of VEGFB mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of VEGFB mRNA17950772|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of VEGFB mRNA]17950772|2005976
C059514resveratrolresveratrol results in increased expression of VEGFB mRNA24604347
C059514resveratrolresveratrol results in increased expression of VEGFB protein24604347
C089730rosiglitazonerosiglitazone results in increased expression of VEGFB mRNA25596134
D000068677Sildenafil CitrateSildenafil Citrate results in increased expression of VEGFB mRNA20583517
D013412Sulfadimethoxine[Complex Mixtures co-treated with Sulfadimethoxine] results in increased expression of VEGFB mRNA22687987
D013749Tetrachlorodibenzodioxin[AHR gene mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of VEGFB mRNA24035824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VEGFB mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of VEGFB mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VEGFB mRNA12167310|1918226
D013849ThimerosalThimerosal results in decreased expression of VEGFB mRNA27188386
D014118Toxins, Biological"Toxins, Biological affects the expression of VEGFB mRNA"19682533
D014303TrinitrotolueneTrinitrotoluene affects the expression of VEGFB mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of VEGFB mRNA"26179874
C057693troglitazone[troglitazone co-treated with Diethylnitrosamine] results in increased expression of VEGFB mRNA18597072
D014520UrethaneUrethane results in decreased expression of VEGFB mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of VEGFB mRNA24136188
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of VEGFB mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of VEGFB gene29154799
D014635Valproic AcidValproic Acid affects the expression of VEGFB mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of VEGFB mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of VEGFB gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of VEGFB mRNA25423262

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19483306  
GO:0008083growth factor activity-IBA21873635  
GO:0008201heparin binding-IEA-  
GO:0042056chemoattractant activity-IBA21873635  
GO:0042803protein homodimerization activity-IEA-  
GO:0043183vascular endothelial growth factor receptor 1 binding-IBA21873635  
GO:0043184vascular endothelial growth factor receptor 2 binding-IBA21873635  
GO:0043185vascular endothelial growth factor receptor 3 binding-IBA21873635  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IBA21873635  
GO:0001666response to hypoxia-IBA21873635  
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0001938positive regulation of endothelial cell proliferation-IBA21873635  
GO:0002040sprouting angiogenesis-IBA21873635  
GO:0002576platelet degranulation-TAS-  
GO:0006493protein O-linked glycosylation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0038084vascular endothelial growth factor signaling pathway-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0045766positive regulation of angiogenesis-IBA21873635  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IBA21873635  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0050930induction of positive chemotaxis-IBA21873635  
GO:0051781positive regulation of cell division-IEA-  
GO:0060048cardiac muscle contraction-IEA-  
GO:0060754positive regulation of mast cell chemotaxis-IBA21873635  
GO:0060976coronary vasculature development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0016020membrane-IEA-  
GO:0031093platelet alpha granule lumen-TAS-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04150mTOR signaling pathway
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05219Bladder cancer
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-162582Signal TransductionTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194313VEGF ligand-receptor interactionsTAS
R-HSA-195399VEGF binds to VEGFR leading to receptor dimerizationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22464775Low levels of vascular endothelial growth factor B predict left ventricular remodeling after acute myocardial infarction. (2012 Apr)Devaux YJ Card Fail