Gene: VHL

7428
HRCA1|RCA1|VHL1|pVHL
von Hippel-Lindau tumor suppressor
protein-coding
3p25.3
Ensembl:ENSG00000134086 MIM:608537 Vega:OTTHUMG00000128668 UniprotKB:P40337
NG_008212.3
PubMed
0   ANCO-SNPs
ND
22   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.079e-1 (AD)  6.617e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASH1L0.903
MTPN0.898
DDX60.893
SPIRE10.886
GLYR10.885
XIAP0.884
FBXO110.873
HIPK10.873
ZNF2360.872
PHF200.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.553
OR4F29-0.523
NANOGNB-0.286
CSAG1-0.285
S100A1-0.262
S100A14-0.253
MTRNR2L10-0.247
KLRK1-0.238
APOA1-0.237
KLRC3-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of VHL mRNA"19162173
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"VHL protein results in increased susceptibility to 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"24403227
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of VHL mRNA"21346803
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"VHL protein promotes the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of HIF1A protein]"18682687
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of VHL mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of VHL mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of VHL mRNA19770486
C029743alpha-ketoglutaric acid[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]19263519
C029743alpha-ketoglutaric acidmanganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]19263519
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VHL mRNA16483693
D001151ArsenicArsenic affects the methylation of VHL gene25304211
D001205Ascorbic Acid[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]19263519
D001205Ascorbic Acidmanganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]19263519
D001280AtrazineAtrazine results in decreased expression of VHL mRNA22378314
D001507BeclomethasoneBeclomethasone results in increased expression of VHL mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to VHL promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VHL mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]19263519
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]17973296
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VHL protein binds to HIF1A protein]19263519
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydemanganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]19263519
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeQuercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]]17973296
C044887beta-methylcholinebeta-methylcholine affects the expression of VHL mRNA21179406
D0150822,2'-Dipyridyl"[2,2'-Dipyridyl inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]"12606543
C006780bisphenol Abisphenol A affects the expression of VHL mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of VHL mRNA25181051
C584509C646 compoundC646 compound results in increased expression of VHL mRNA26191083
D002104CadmiumCadmium results in decreased expression of VHL mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of VHL mRNA23741332
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of VHL mRNA18636392
D003035Cobalt[Cobalt binds to EPAS1 protein] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
D003035CobaltCobalt inhibits the reaction [EPAS1 protein modified form binds to VHL protein]12606543
D003035Cobalt[Cobalt inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
D003035CobaltCobalt inhibits the reaction [HIF1A protein modified form binds to VHL protein]12606543
D003474CurcuminVHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]18682687
C014347decitabinedecitabine affects the expression of VHL mRNA16954373
C014347decitabinedecitabine inhibits the reaction [VHL mutant form results in decreased expression of ATP1B1 mRNA]24452105
C014347decitabinedecitabine inhibits the reaction [VHL mutant form results in increased methylation of ATP1B1 promoter]24452105
C014347decitabineVHL protein promotes the reaction [decitabine results in increased expression of ABCG2 mRNA]16954373
C014347decitabineVHL protein promotes the reaction [decitabine results in increased expression of ABCG2 protein]16954373
D003676DeferoxamineVHL protein mutant form affects the reaction [Deferoxamine results in decreased susceptibility to Hydrogen Peroxide]18515279
D003676Deferoxamine[Deferoxamine inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
D003976DiazinonDiazinon results in increased methylation of VHL gene22964155
D003976DiazinonDiazinon affects the expression of VHL mRNA22546817
D004026DieldrinDieldrin affects the expression of VHL mRNA22546817
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of VHL protein27070252
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of VHL protein27070252
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of VHL mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VHL mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of VHL mRNA17557909
C029451ferrous chloride[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]19263519
C029451ferrous chloridemanganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]19263519
C029451ferrous chloride"[2,2'-Dipyridyl inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]"12606543
C029451ferrous chloride[Cobalt inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
C029451ferrous chloride[Deferoxamine inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
C029451ferrous chloride[ferrous chloride results in increased hydroxylation of EPAS1 protein] promotes the reaction [EPAS1 protein binds to VHL protein]12606543
C029451ferrous chloride[ferrous chloride results in increased hydroxylation of EPAS1 protein] promotes the reaction [HIF1A protein binds to VHL protein]12606543
D005419FlavonoidsFlavonoids results in increased expression of VHL mRNA18035473
D005485FlutamideFlutamide results in increased expression of VHL mRNA24136188
D005492Folic AcidFolic Acid results in increased expression of VHL protein14633603
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of VHL mRNA22634610
D017313FenretinideFenretinide results in decreased expression of VHL mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of VHL mRNA21179406
D006861Hydrogen PeroxideVHL protein mutant form affects the reaction [Deferoxamine results in decreased susceptibility to Hydrogen Peroxide]18515279
D006861Hydrogen PeroxideVHL protein mutant form affects the susceptibility to Hydrogen Peroxide18515279
C492448ICG 001ICG 001 results in increased expression of VHL mRNA26191083
C025340manganese chloridemanganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]19263519
C025340manganese chlorideVHL protein affects the reaction [manganese chloride results in increased expression of HIF1A protein]19263519
D008727MethotrexateMethotrexate results in decreased expression of VHL mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VHL mRNA"20188158
C043243methyl tert-butyl ethermethyl tert-butyl ether inhibits the reaction [VHL mutant form results in increased expression of HIF1AA mRNA]24128854
C043243methyl tert-butyl etherVHL mutant form inhibits the reaction [methyl tert-butyl ether results in decreased expression of KDRL mRNA]24128854
C043243methyl tert-butyl etherVHL mutant form inhibits the reaction [methyl tert-butyl ether results in decreased expression of VEGFAA mRNA]24128854
C043243methyl tert-butyl etherVHL mutant form inhibits the reaction [methyl tert-butyl ether results in decreased expression of VEGFC mRNA]24128854
D008911MinocyclineMinocycline promotes the reaction [HIF1A protein binds to VHL protein]24292262
D008911Minocycline[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]24292262
D008911Minocycline[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein24292262
C437683motexafin gadoliniummotexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of VHL mRNA16357179
C022838nickel chloride[nickel chloride co-treated with VHL protein] results in increased expression of NDRG1 mRNA12767066
C022838nickel chloridenickel chloride inhibits the reaction [VHL protein binds to HIF1A protein]16649251
C022838nickel chloridenickel chloride affects the expression of VHL mRNA22546817
D010100Oxygen[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]24292262
D010100Oxygen[Oxygen deficiency co-treated with VHL protein] results in increased expression of NDRG1 mRNA12767066
D010100OxygenOxygen deficiency results in decreased expression of VHL protein22279137
D010100Oxygen[Polyphenols co-treated with Oxygen deficiency] promotes the reaction [VHL protein results in increased degradation of HIF1A protein]22279137
D010100OxygenPolyphenols inhibits the reaction [Oxygen deficiency results in decreased expression of VHL protein]22279137
D010100Oxygen[Propolis co-treated with Oxygen deficiency] promotes the reaction [VHL protein results in increased degradation of HIF1A protein]22279137
D010100OxygenPropolis inhibits the reaction [Oxygen deficiency results in decreased expression of VHL protein]22279137
D010100OxygenVHL protein results in increased susceptibility to Oxygen deficiency24403227
D010100Oxygen[Oxygen results in increased hydroxylation of HIF1A protein] promotes the reaction [HIF1A protein modified form binds to VHL protein]15741220
D010100Oxygen[[Oxygen results in increased hydroxylation of HIF1A protein] promotes the reaction [HIF1A protein modified form binds to VHL protein]] which results in increased degradation of HIF1A15741220
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of VHL mRNA18636392
D010433PentylenetetrazolePentylenetetrazole affects the expression of VHL mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of VHL mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of VHL mRNA23557933
D059808Polyphenols[Polyphenols co-treated with Oxygen deficiency] promotes the reaction [VHL protein results in increased degradation of HIF1A protein]22279137
D059808PolyphenolsPolyphenols inhibits the reaction [Oxygen deficiency results in decreased expression of VHL protein]22279137
D059808Polyphenols[Polyphenols results in decreased expression of CDC42 protein] which results in increased expression of VHL protein22279137
D059808Polyphenols[[Polyphenols results in decreased expression of CDC42 protein] which results in increased expression of VHL protein] which results in increased degradation of HIF1A protein22279137
D011429Propolis[Propolis co-treated with Oxygen deficiency] promotes the reaction [VHL protein results in increased degradation of HIF1A protein]22279137
D011429PropolisPropolis inhibits the reaction [Oxygen deficiency results in decreased expression of VHL protein]22279137
D011429Propolis[Propolis results in decreased expression of CDC42 protein] which results in increased expression of VHL protein22279137
D011429Propolis[[Propolis results in decreased expression of CDC42 protein] which results in increased expression of VHL protein] which results in increased degradation of HIF1A protein22279137
D011794QuercetinQuercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]]17973296
D011794QuercetinQuercetin inhibits the reaction [HIF1A protein binds to VHL protein]17973296
D011794QuercetinQuercetin results in increased expression of VHL mRNA14715546
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of VHL mRNA23806026
C017947sodium arseniteMALAT1 mRNA affects the reaction [sodium arsenite inhibits the reaction [HIF1A protein binds to VHL protein]]27287256
C017947sodium arsenitesodium arsenite inhibits the reaction [HIF1A protein binds to VHL protein]27287256
C017947sodium arsenitesodium arsenite results in decreased expression of VHL mRNA16014739
D012965Sodium ChlorideSodium Chloride results in increased expression of VHL mRNA23634900
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VHL mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VHL mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VHL mRNA19770486
D013853ThioacetamideThioacetamide results in increased expression of VHL mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased mutagenesis of VHL gene15177666|9137812
D014635Valproic AcidValproic Acid results in decreased expression of VHL mRNA23527032
C025643vinclozolinvinclozolin results in increased expression of VHL mRNA23034163
D019345Zinc Acetatemotexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of VHL mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI10205047  11292862  11641274  11739384  12004076  12032852  
12050673  12169691  15601820  15721254  16234850  16511565  
17350623  17353276  17353931  18323857  19208626  19584355  
20802534  20871634  21602890  21625219  22286099  23455924  
23976881  24899725  25416956  25438054  25661653  
GO:0008134transcription factor binding-IPI11641274  
GO:0019899enzyme binding-IPI11641274  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IDA24899725  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS7660122  
GO:0000902cell morphogenesis-NAS12169691  
GO:0006355regulation of transcription, DNA-templated-IMP15824735  
GO:0006508proteolysis-TAS10353251  
GO:0008285negative regulation of cell proliferation-IMP23338840  
GO:0010629negative regulation of gene expression-IMP23338840  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IDA24899725  
GO:0016567protein ubiquitination-IEA-  
GO:0016567protein ubiquitination-IMP12169691  
GO:0043066negative regulation of apoptotic process-NAS12169691  
GO:0043687post-translational protein modification-TAS-  
GO:0045597positive regulation of cell differentiation-NAS12169691  
GO:0045893positive regulation of transcription, DNA-templated-IMP17973242  
GO:0046426negative regulation of JAK-STAT cascade-IMP23338840  
GO:0050821protein stabilization-NAS12169691  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0061428negative regulation of transcription from RNA polymerase II promoter in response to hypoxia-IDA11641274  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS7604013  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005739mitochondrion-NAS12169691  
GO:0005783endoplasmic reticulum-NAS12169691  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
GO:0030891VCB complex-IBA21873635  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenIEA
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262749Cellular response to hypoxiaIEA
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26500709Molecular and immunologic markers of kidney cancer-potential applications in predictive, preventive and personalized medicine. (2015)Mickley AEPMA J
11107547[Prevention of renal carcinoma: the nutri-genetic approach]. (2000)Junien CJ Soc Biol
16892044Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma. (2006 Aug 7)van Dijk BABr J Cancer
8946619Renal cell carcinoma: basic biology and clinical behavior. (1996 Nov)Franklin JRSemin Urol Oncol
259576602'-Hydroxyflavanone: A promising molecule for kidney cancer prevention. (2015 Aug 1)Singhal SSBiochem Pharmacol
16458203Lipid peroxidation and renal cell carcinoma: further supportive evidence and new mechanistic insights. (2006 Feb 15)Gago-Dominguez MFree Radic Biol Med
9502393Molecular genetics of renal carcinogenesis. (1998 Jan-Feb)Walker CToxicol Pathol
19097356Pathology of renal tumors in adults. Molecular biology, histopathological diagnosis and prognosis. (2008)Okon KPol J Pathol
16364563Perturbations in hypoxia detection: a shared link between hereditary and sporadic tumor formation? (2006)Sharifi NMed Hypotheses
12518864Loss of heterozygosity at loci of candidate tumor suppressor genes in microdissected primary non-small cell lung cancer. (2002)Ho WLCancer Detect Prev
18722600Reduced expression of von Hippel-Lindau gene in subjects exposed to polychlorinated biphenyls and dibenzofurans. (2008 Oct)Tsai PCEnviron Res
16208141Hypertension, antihypertensives and mutations in the Von Hippel-Lindau gene in renal cell carcinoma: results from the Netherlands Cohort Study. (2005 Nov)Schouten LJJ Hypertens
22022277Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors. (2011 Oct)Moore LEPLoS Genet
21621909Familial renal cell carcinoma from the Swedish Family-Cancer Database. (2011 Nov)Liu HEur Urol
11144893Precancerous lesions in the kidney. (2000)Van Poppel HScand J Urol Nephrol Suppl
22199344Clinical significance of hypermethylation status in NSCLC: evaluation of a 30-gene panel in patients with advanced disease. (2011 Dec)Pesek MAnticancer Res
17992578Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma. (2008 Mar)van Dijk BACancer Causes Control
24482100Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)Jang JHAnn Hematol
21078381Frequent gene hypermethylation in laryngeal cancer cell lines and the resistance to demethylation induction by plant polyphenols. (2011 Feb)Paluszczak JToxicol In Vitro
23552698Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation. (2012 Jun 25)Moore LEOncogenesis
9827526von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors. (1998 Nov 18)Shiao YHJ Natl Cancer Inst
22906772Longitudinal analysis of retinal hemangioblastomatosis and visual function in ocular von Hippel-Lindau disease. (2012 Dec)Toy BCOphthalmology