Gene: EZR

7430
CVIL|CVL|HEL-S-105|VIL2
ezrin
protein-coding
6q25.3
Ensembl:ENSG00000092820 MIM:123900 Vega:OTTHUMG00000015917 UniprotKB:P15311
NG_052952.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.663e-1 (AD)  5.159e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06585203chr6:159238500EZRGene body2.515e-4Alcohol use disorders26763658
cg22871253chr6:159238744EZR1.300e-15Smoking27651444
cg17390562chr6:159238463EZR8.800e-14Smoking27651444
cg06585203chr6:159238500EZR5.700e-9Smoking27651444
cg17390562chr6:159238463EZR1.590e-9Alcohol consumption der day27843151
cg22871253chr6:159238744EZR1.270e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC42EP40.939
SELENBP10.915
TP53BP20.908
EMX20.908
STOX10.905
NR2E10.905
SLC1A30.904
ATP1A20.904
MLC10.904
PON20.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
OR4F29-0.507
TYRP1-0.418
NRG1-0.414
PAQR9-0.41
COL19A1-0.396
IL12RB2-0.395
ZNF860-0.391
PROKR2-0.391
GABRG3-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of EZR protein"21673325
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EZR mRNA"19167446
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EZR mRNA"12376462
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of EZR protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EZR mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of EZR mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C5605976,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide"[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of EZR protein"25236891
D000082AcetaminophenAcetaminophen affects the expression of EZR mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of EZR mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of EZR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EZR mRNA23630614
D0150812-Naphthylamine2-Naphthylamine results in increased expression of EZR mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EZR mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of EZR protein16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of EZR mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in increased expression of EZR mRNA]12205029
C023650anilineaniline results in increased nitrosation of EZR protein21708182
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EZR mRNA24449571
D001151ArsenicArsenic affects the methylation of EZR gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of EZR mRNA22521957
C006632arsenic trioxidearsenic trioxide results in increased expression of EZR protein25419056
D001241AspirinAspirin results in decreased expression of EZR mRNA14976132
D001285AtropineAtropine inhibits the reaction [Parathion results in increased expression of EZR protein]17390078
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EZR mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EZR mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EZR promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EZR mRNA"19150397
D004958EstradiolEstradiol results in increased expression of EZR mRNA19167446
D004958EstradiolEstradiol results in increased expression of EZR protein15737688
D004958EstradiolEstradiol results in increased expression of EZR mRNA15289156
C053541bicalutamidebicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]16873375
C053541bicalutamidebicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]16873375
C006780bisphenol Abisphenol A affects the expression of EZR mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of EZR mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of EZR promoter27334623
C006780bisphenol Abisphenol A affects the expression of EZR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of EZR mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of EZR mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of EZR gene28505145
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of EZR protein26930160
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of EZR protein22174045
D001761BleomycinBleomycin results in decreased expression of EZR protein25933445
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EZR mRNA12419474
D002104CadmiumCadmium results in increased expression of EZR mRNA24376830
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]"20230807
D000074262Canola OilCanola Oil metabolite results in decreased expression of EZR mRNA27363782
D000074262Canola OilStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of EZR mRNA]27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of EZR mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EZR mRNA27339419
C100187chloropicrinchloropicrin results in decreased expression of EZR mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EZR mRNA20938992
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EZR mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of EZR mRNA17553155|1937684
D003042CocaineCocaine results in decreased expression of EZR mRNA20948987
D019327Copper SulfateCopper Sulfate results in increased expression of EZR mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EZR mRNA"19167446
C030973cupric oxidecupric oxide results in decreased expression of EZR protein25470785
D003471CuprizoneCuprizone results in increased expression of EZR mRNA26577399
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of EZR protein24677693|2735282
C057862cyanoginosin LRSB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EZR protein]24677693
C057862cyanoginosin LRU 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EZR protein]24677693
C057862cyanoginosin LRcyanoginosin LR results in increased expression of EZR mRNA23342045
D016572CyclosporineCyclosporine results in increased expression of EZR mRNA25562108
D003561CytarabineCytarabine results in decreased expression of EZR mRNA21198554
D003993Dibutyl PhthalateDibutyl Phthalate affects the expression of EZR mRNA21745491
D002945CisplatinCisplatin results in increased expression of EZR mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of EZR mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EZR mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EZR mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of EZR mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of EZR mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZR mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of EZR mRNA21658437
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of EZR protein"22248470
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of EZR mRNA"12376462
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of EZR protein"22248470
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of EZR mRNA25380136
D004237DiuronDiuron results in increased expression of EZR mRNA21551480
C013525ENNG[ENNG co-treated with Isoflavones] results in increased expression of EZR protein22248470
C013525ENNGENNG results in increased expression of EZR protein22248470
C118739entinostatentinostat results in increased expression of EZR mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EZR protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EZR mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EZR mRNA29097150
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EZR mRNA17108234|1755790
D005411Flame RetardantsFlame Retardants results in decreased expression of EZR protein18550172
D005419FlavonoidsFlavonoids results in decreased expression of EZR mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EZR mRNA20938992
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of EZR protein26930160
C039281furanfuran results in increased expression of EZR mRNA25539665|2619464
D019833GenisteinGenistein results in increased expression of EZR mRNA15289156
D005839GentamicinsGentamicins results in increased expression of EZR mRNA22061828
D005839GentamicinsGentamicins results in increased expression of EZR protein22061828
D017313FenretinideFenretinide results in increased expression of EZR mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EZR protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EZR mRNA20044591
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EZR protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of EZR protein23178681
C492448ICG 001ICG 001 results in decreased expression of EZR mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EZR mRNA25613284
D007529Isoflavones"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of EZR protein"22248470
D007529Isoflavones[ENNG co-treated with Isoflavones] results in increased expression of EZR protein22248470
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of EZR protein10768784
D007854LeadLead results in decreased expression of EZR mRNA19921347
C017461lead nitratelead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]11891201
C045463leflunomideleflunomide results in decreased expression of EZR mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of EZR mRNA27339419
D008094LithiumLithium results in increased expression of EZR mRNA15687245
D008094LithiumLithium results in increased expression of EZR protein15687245|1829663
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EZR mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of EZR mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EZR mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EZR mRNA26272509
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of EZR protein26558463
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of EZR mRNA17412507
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EZR protein26558463
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]"20230807
D015741Metribolonebicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]16873375
D015741Metribolonebicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]16873375
D015741MetriboloneMetribolone promotes the reaction [EZR protein binds to PRKCA protein]16873375
D015741MetriboloneMetribolone results in increased expression of EZR mRNA16873375
D015741MetriboloneMetribolone results in increased phosphorylation of EZR protein16873375
D015741MetribolonePRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein]16873375
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of EZR protein"22001959
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of EZR protein19438287
C031721naphthalenenaphthalene results in decreased expression of EZR protein19438287
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of EZR mRNA25380136
D009538NicotineNicotine results in increased expression of EZR mRNA18247414
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]"20230807
D009569Nitric OxideNitric Oxide deficiency results in increased phosphorylation of EZR protein14732730
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of EZR mRNA19716841
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of ATF3 mRNA]27137931
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of ATF4 mRNA]27137931
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of DDIT3 mRNA]27137931
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of DDIT4 mRNA]27137931
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of PTGS2 mRNA]27137931
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of TRIB3 mRNA]27137931
C025589ochratoxin Aochratoxin A metabolite results in increased expression of EZR mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of EZR mRNA26314263
C025589ochratoxin Aochratoxin A results in increased phosphorylation of EZR protein28286205
C507134ON 01910ON 01910 results in increased expression of EZR mRNA22351695
D000073878Palm OilPalm Oil results in increased expression of EZR mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EZR mRNA26272509
D010278ParathionAtropine inhibits the reaction [Parathion results in increased expression of EZR protein]17390078
D010278ParathionParathion results in increased expression of EZR protein17390078
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of EZR protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of EZR protein19954255
D010416PentachlorophenolPentachlorophenol results in increased expression of EZR mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EZR mRNA26794494
D010634PhenobarbitalPhenobarbital affects the expression of EZR mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EZR mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of EZR mRNA15728792
D010862PilocarpinePilocarpine results in increased expression of EZR protein17366478
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of EZR mRNA21334430
C015586propiverinepropiverine binds to EZR protein29273565
D011441PropylthiouracilPropylthiouracil affects the expression of EZR mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of EZR protein19264907
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EZR mRNA27029645
C093642SB 203580SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EZR protein]24677693
C410733scriptaidscriptaid affects the expression of EZR mRNA18813790
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of EZR mRNA19244175
D012643SeleniumSelenium results in decreased expression of EZR mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of EZR protein25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EZR mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of EZR protein21925251
C017947sodium arsenitesodium arsenite results in increased expression of EZR protein19072884
C016104sodium bichromatesodium bichromate results in increased expression of EZR mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of EZR protein27548804
D012999SomanSoman results in increased expression of EZR mRNA19281266
D013213StarchStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of EZR mRNA]27363782
D013605T-2 ToxinT-2 Toxin affects the expression of EZR protein26141394
C004648testosterone enanthatetestosterone enanthate affects the expression of EZR mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EZR mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EZR mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of EZR mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of EZR mRNA23411599
D014212TretinoinTretinoin results in decreased expression of EZR mRNA23724009
D014212TretinoinTretinoin results in increased expression of EZR mRNA16236135|1660451
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EZR mRNA24935251|2627250
C113580U 0126U 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EZR protein]24677693
D014520UrethaneUrethane results in increased expression of EZR mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EZR mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EZR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EZR mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of EZR gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of EZR gene25560391
C025643vinclozolinvinclozolin affects the expression of EZR mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of EZR mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of EZR mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of EZR mRNA20044591
C009684withaferin A"[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of EZR protein"25236891
C108830Y 27632Y 27632 deficiency results in increased phosphorylation of EZR protein14732730
C088658zoledronic acidzoledronic acid results in increased expression of EZR mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003779actin binding-IDA17825285  
GO:0005515protein binding-IPI7844168  10793131  10806479  11285285  11598191  12651155  
15020681  15498789  17046996  17242191  17353931  17911601  
18046454  19555689  20195357  20442317  20551903  22570591  
22805611  23414517  24555568  25554515  25591774  26496610  
29568061  
GO:0008017microtubule binding-IMP23857773  
GO:0008022protein C-terminus binding-IEA-  
GO:0019904protein domain specific binding-IPI25554515  
GO:0034236protein kinase A catalytic subunit binding-IPI17911601  
GO:0034237protein kinase A regulatory subunit binding-IPI17911601  
GO:0042802identical protein binding-IPI11285285  21988832  29568061  
GO:0044548S100 protein binding-IPI25554515  
GO:0045296cadherin binding-HDA25468996  
GO:0050839cell adhesion molecule binding-IPI12082081  15498789  
GO:0051015actin filament binding-IDA10793131  
GO:0051018protein kinase A binding-IPI25097019  
GO:0051117ATPase binding-IPI17825285  
GO:0097718disordered domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP20551903  
GO:0001951intestinal D-glucose absorption-IEA-  
GO:0003376sphingosine-1-phosphate signaling pathway-IMP23106337  
GO:0007016cytoskeletal anchoring at plasma membrane-NAS10793131  
GO:0007159leukocyte cell-cell adhesion-IEP12082081  
GO:0007411axon guidance-TAS-  
GO:0008360regulation of cell shape-IMP20551903  
GO:0008361regulation of cell sizeNOTIMP22467863  
GO:0010628positive regulation of gene expression-IGI23264465  
GO:0010737protein kinase A signaling-IMP17911601  
GO:0022612gland morphogenesisNOTIMP24862762  
GO:0022614membrane to membrane docking-IEP12082081  
GO:0030033microvillus assembly-IMP22797597  
GO:0030953astral microtubule organization-IMP20551903  
GO:0031532actin cytoskeleton reorganization-IMP23106337  
GO:0031623receptor internalization-IEA-  
GO:0032532regulation of microvillus length-IEA-  
GO:0032956regulation of actin cytoskeleton organizationNOTIMP20551903  
GO:0034629cellular protein-containing complex localization-IMP20551903  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0043622cortical microtubule organization-IMP20551903  
GO:0045198establishment of epithelial cell apical/basal polarityNOTIMP22797597  24862762  
GO:0046847filopodium assembly-IMP23106337  
GO:0048015phosphatidylinositol-mediated signaling-IDA25591774  
GO:0050714positive regulation of protein secretion-IMP25591774  
GO:0050860negative regulation of T cell receptor signaling pathway-IMP20551903  
GO:0051017actin filament bundle assembly-IDA10793131  
GO:0051660establishment of centrosome localization-IMP20551903  
GO:0061028establishment of endothelial barrier-IGI23264465  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IMP20551903  
GO:0071320cellular response to cAMP-IMP17911601  
GO:0072659protein localization to plasma membrane-IMP17825285  17911601  
GO:0072697protein localization to cell cortex-IMP25554515  
GO:1900041negative regulation of interleukin-2 secretion-IMP17911601  
GO:1901222regulation of NIK/NF-kappaB signalingNOTIMP20551903  
GO:1902115regulation of organelle assembly-IGI21148287  
GO:1902115regulation of organelle assembly-IMP21148287  
GO:1902896terminal web assembly-IEA-  
GO:1902966positive regulation of protein localization to early endosome-IGI21148287  
GO:1903078positive regulation of protein localization to plasma membrane-IEA-  
GO:1903364positive regulation of cellular protein catabolic process-IGI21148287  
GO:1903753negative regulation of p38MAPK cascade-IMP20551903  
GO:2000643positive regulation of early endosome to late endosome transport-IGI21148287  
GO:2000643positive regulation of early endosome to late endosome transport-IMP21148287  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0001726ruffle-IDA9852149  25554515  
GO:0001772immunological synapse-IDA20551903  
GO:0001772immunological synapsecolocalizes_withIDA17911601  
GO:0001931uropod-IEA-  
GO:0005615extracellular space-HDA16502470  
GO:0005737cytoplasm-IDA23106337  25554515  25591774  
GO:0005768endosome-IDA21148287  
GO:0005829cytosol-IDA9852149  
GO:0005829cytosol-TAS-  
GO:0005884actin filament-IDA11598191  
GO:0005886plasma membrane-IDA23106337  
GO:0005902microvillus-IDA12082081  
GO:0005903brush border-ISS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesioncolocalizes_withIDA21282464  
GO:0015629actin cytoskeleton-IDA10793131  
GO:0016020membrane-HDA19946888  
GO:0016323basolateral plasma membrane-ISS-  
GO:0016324apical plasma membrane-IDA17825285  22797597  24862762  
GO:0019898extrinsic component of membrane-IDA7844168  
GO:0030175filopodium-IDA12082081  23106337  
GO:0030315T-tubule-IEA-  
GO:0030863cortical cytoskeleton-TAS11598191  
GO:0031528microvillus membrane-IEA-  
GO:0031982vesicle-HDA19190083  
GO:0032587ruffle membrane-IEA-  
GO:0032991protein-containing complex-IDA25097019  
GO:0036064ciliary basal body-IEA-  
GO:0036398TCR signalosomeNOT colocalizes_withIDA20551903  
GO:0042995cell projection-IDA25889165  
GO:0043209myelin sheath-IEA-  
GO:0044297cell body-IEA-  
GO:0044393microspike-IEA-  
GO:0044853plasma membrane raft-IDA17911601  
GO:0045177apical part of cell-IDA12082081  
GO:0048471perinuclear region of cytoplasm-IDA24862762  
GO:0051286cell tip-IEA-  
GO:0070062extracellular exosome-HDA20458337  23533145  
GO:0071437invadopodium-IDA25486435  
GO:0071944cell periphery-IDA22291017  
GO:0097449astrocyte projection-IEA-  
GO:0097454Schwann cell microvillus-IEA-  
GO:0098592cytoplasmic side of apical plasma membrane-IDA25591774  
KEGG ID KEGG Term
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04971Gastric acid secretion
hsa05130Pathogenic Escherichia coli infection
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1TAS
R-HSA-437239Recycling pathway of L1IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23877438CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (2013 Oct)Matsuura SOncol Rep