Gene: VIPR1

7433
HVR1|II|PACAP-R-2|PACAP-R2|RDC1|V1RG|VAPC1|VIP-R-1|VIPR|VIRG|VPAC1|VPAC1R|VPCAP1R
vasoactive intestinal peptide receptor 1
protein-coding
3p22.1
Ensembl:ENSG00000114812 MIM:192321 Vega:OTTHUMG00000131792 UniprotKB:P32241
NG_030371.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.310e-1 (AD)  8.753e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYT70.939
RAB40C0.93
CPNE50.928
EPHB60.924
NGEF0.924
CACNB10.923
RAP1GAP0.921
CHRM10.917
CACNG80.916
RAPGEFL10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.545
ZNF114-0.51
MBNL3-0.51
LRAT-0.508
NXT2-0.506
MYL3-0.504
WWTR1-0.504
REST-0.503
FAM89A-0.503
PHEX-0.502

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of VIPR1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of VIPR1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of VIPR1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of VIPR1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of VIPR1 mRNA"25510870
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of VIPR1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of VIPR1 mRNA]28655636
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of VIPR1 mRNA"25380136
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of VIPR1 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of VIPR1 mRNA23626723
C0293704-toluidine4-toluidine results in decreased expression of VIPR1 mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of VIPR1 mRNA17562736
C016601afimoxifeneafimoxifene results in increased expression of VIPR1 mRNA19901195
C103303alitretinoinalitretinoin inhibits the reaction [GW 4064 results in increased expression of VIPR1]16037943
C015001arsenitearsenite results in increased methylation of VIPR1 promoter23974009
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of VIPR1 mRNA26377693
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of VIPR1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of VIPR1 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of VIPR1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of VIPR1 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of VIPR1 mRNA25596134
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of VIPR1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of VIPR1 mRNA16644059
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of VIPR1 mRNA16037943
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of VIPR1 protein16037943
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of VIPR1 mRNA18636392
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of VIPR1 mRNA25596134
D004390ChlorpyrifosChlorpyrifos results in increased expression of VIPR1 mRNA20682304
C059262cidofovircidofovir results in increased expression of VIPR1 mRNA25596134
D019327Copper SulfateCopper Sulfate results in increased expression of VIPR1 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of VIPR1 mRNA18563302
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of VIPR1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of VIPR1 mRNA19041683|1963824
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of VIPR1 mRNA25380136
D005485FlutamideFlutamide results in decreased expression of VIPR1 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of VIPR1 mRNA24136188
C004312glycidolglycidol results in increased expression of VIPR1 mRNA24915197
C412815GW 4064alitretinoin inhibits the reaction [GW 4064 results in increased expression of VIPR1]16037943
C412815GW 4064GW 4064 results in increased expression of VIPR116037943
D008727MethotrexateMethotrexate affects the expression of VIPR1 mRNA18502557
D008731MethoxychlorMethoxychlor results in decreased expression of VIPR1 mRNA21782745
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to VIPR1 promoter]20348232
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VIPR1 mRNA"19285098
C500085muraglitazarmuraglitazar results in decreased expression of VIPR1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of VIPR1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of VIPR1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of VIPR1 mRNA25380136
D000068577NebivololNebivolol results in increased expression of VIPR1 mRNA17467819
D009532NickelNickel results in decreased expression of VIPR1 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of VIPR1 mRNA24136188
D009966OrphenadrineOrphenadrine affects the expression of VIPR1 mRNA23665939
D010100OxygenOxygen deficiency results in decreased expression of VIPR1 mRNA25596134
D010126OzoneOzone results in increased expression of VIPR1 mRNA15127121|1514460
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of VIPR1 mRNA18636392
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of VIPR1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of VIPR1 mRNA22178795|2865563
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of VIPR1 mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VIPR1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of VIPR1 mRNA20813756
C005556propionaldehydepropionaldehyde results in increased expression of VIPR1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of VIPR1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of VIPR1 mRNA15309432
C089730rosiglitazonerosiglitazone results in decreased expression of VIPR1 mRNA21515302
D012643SeleniumSelenium results in increased expression of VIPR1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of VIPR1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of VIPR1 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of VIPR1 mRNA23221170
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of VIPR1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VIPR1 mRNA12377990|1961957
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of VIPR1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of VIPR1 mRNA23830798
C057693troglitazonetroglitazone results in decreased expression of VIPR1 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of VIPR1 mRNA17127020
D014635Valproic AcidValproic Acid results in increased methylation of VIPR1 gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of VIPR1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of VIPR1 mRNA28655636
C025643vinclozolinvinclozolin affects the expression of VIPR1 mRNA19015723
C088658zoledronic acidzoledronic acid results in increased expression of VIPR1 mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004999vasoactive intestinal polypeptide receptor activity-IBA21873635  
GO:0004999vasoactive intestinal polypeptide receptor activity-IDA8390245  
GO:0005515protein binding-IPI23597562  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0017046peptide hormone binding-IBA21873635  
GO:0017046peptide hormone binding-IPI8390245  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IDA8390245  
GO:0008284positive regulation of cell proliferation-TAS8389448  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8179610  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26672247[The expression and significance of VIP and its receptor in the cochlea of different degrees of chronic alcoholism rats]. (2015 Jul)Feng JLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi