Gene: VIPR2

7434
C16DUPq36.3|DUP7q36.3|PACAP-R-3|PACAP-R3|VIP-R-2|VPAC2|VPAC2R|VPCAP2R
vasoactive intestinal peptide receptor 2
protein-coding
7q36.3
Ensembl:ENSG00000106018 MIM:601970 Vega:OTTHUMG00000151446 UniprotKB:P41587
NC_000007.14
PubMed
0   ANCO-SNPs
CD|OD|ND
2   
9.334e-1 (AD)  NA (ND)   (Frontal_Cortex)
9.185e-1 (AD)  7.094e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23058037chr7:158824108VIPR28.040e-10Maternal smoking in pregnancy27040690
cg23058037chr7:158824108VIPR22.810e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL5A20.662
SLX40.653
VWA70.649
SUSD50.647
OSBPL30.641
PAX70.636
ATP2B20.635
DAGLA0.634
MAP3K120.634
MROH10.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF4EBP1-0.44
RAB13-0.422
ROM1-0.419
RARRES3-0.386
NUPR1-0.382
PXDC1-0.381
TMEM176A-0.371
HEBP2-0.369
AGTRAP-0.367
TMEM176B-0.365

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of VIPR2 mRNA25088246
D000082AcetaminophenAcetaminophen results in decreased expression of VIPR2 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of VIPR2 mRNA28959563
D000242Cyclic AMP[ADCYAP1 protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP7733904
D000242Cyclic AMP[VIP protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP7733904
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of VIPR2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VIPR2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VIPR2 mRNA21839799
C006780bisphenol Abisphenol A results in increased expression of VIPR2 mRNA20678512
C006780bisphenol Abisphenol A results in decreased expression of VIPR2 mRNA25181051
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of VIPR2 mRNA18636392
D003471CuprizoneCuprizone results in decreased expression of VIPR2 mRNA26577399
D003520CyclophosphamideCyclophosphamide affects the expression of VIPR2 mRNA18563302
D004026DieldrinDieldrin results in increased expression of VIPR2 mRNA20682304
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VIPR2 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of VIPR2 mRNA18035473
C039281furanfuran results in increased expression of VIPR2 mRNA27387713
C039281furanfuran results in increased methylation of VIPR2 gene22079235
D006220HaloperidolHaloperidol results in decreased expression of VIPR2 mRNA27900577
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of VIPR2 mRNA12057914
D015122MercaptopurineMercaptopurine results in decreased expression of VIPR2 mRNA23358152
C030589methylmercury cysteinemethylmercury cysteine results in increased expression of VIPR2 mRNA19465457
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of VIPR2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of VIPR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of VIPR2 mRNA"25554681
C076029olanzapineolanzapine affects the expression of VIPR2 mRNA27900577
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of VIPR2 mRNA18636392
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of VIPR2 mRNA23602845
D011374ProgesteroneProgesterone results in increased expression of VIPR2 mRNA22238285
D053260SootSoot results in decreased expression of VIPR2 mRNA26551751
C012052sultopridesultopride results in decreased expression of VIPR2 mRNA27900577
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of VIPR2 mRNA25172293
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VIPR2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VIPR2 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VIPR2 mRNA16979875
D019284ThapsigarginThapsigargin results in increased expression of VIPR2 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of VIPR2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of VIPR2 gene26756918
D014415TunicamycinTunicamycin results in increased expression of VIPR2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of VIPR2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of VIPR2 gene29154799
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VIPR2 mRNA16979875
D015032ZincZinc affects the expression of VIPR2 mRNA16413754
D019287Zinc SulfateZinc Sulfate results in increased expression of VIPR2 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS7811244  
GO:0004999vasoactive intestinal polypeptide receptor activity-IBA21873635  
GO:0004999vasoactive intestinal polypeptide receptor activity-IEA-  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0017046peptide hormone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS7811244  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007190activation of adenylate cyclase activity-IEA-  
GO:0007267cell-cell signaling-TAS8757618  
GO:0048662negative regulation of smooth muscle cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7811244  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21849985A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. (2011 Nov)Yang BZNeuropsychopharmacology
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One