Gene: BEST1

7439
ARB|BEST|BMD|RP50|TU15B|VMD2
bestrophin 1
protein-coding
11q12.3
Ensembl:ENSG00000167995 MIM:607854 Vega:OTTHUMG00000167469 UniprotKB:O76090
NG_009033.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.759e-1 (AD)  7.557e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VWA10.84
TTYH20.84
CDC42EP10.836
RTKN0.828
TFEB0.826
CYP27A10.821
ELOVL10.819
NPC10.818
SEMA3B0.816
RHOG0.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FREM3-0.407
PTHLH-0.406
BEAN1-0.406
CUX2-0.401
VIP-0.399
IGF1-0.397
CNTN5-0.392
GPR26-0.389
HS6ST3-0.38
CHRNA2-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0581765-nitro-2-(3-phenylpropylamino)benzoic acid5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of BEST1 protein19828819
D000082AcetaminophenAcetaminophen affects the expression of BEST1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of BEST1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BEST1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of BEST1 mRNA24449571
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BEST1 mRNA28628672
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of BEST1 mRNA"20162321
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BEST1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of BEST1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BEST1 gene28505145
D001965BromidesBEST1 protein results in increased transport of Bromides19828819
D001965BromidesPAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Bromides]19828819
D002118CalciumCalcium results in increased activity of BEST1 protein19828819
D002118Calcium[PAR-1-activating peptide results in increased abundance of Calcium] which results in increased activity of BEST1 protein19828819
D002712ChloridesBEST1 protein results in increased transport of Chlorides19828819
D002712ChloridesPAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Chlorides]19828819
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEST1 mRNA20938992
D003300CopperCopper deficiency results in increased expression of BEST1 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of BEST1 mRNA27523638
C014347decitabinedecitabine affects the expression of BEST1 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BEST1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BEST1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of BEST1 mRNA22733784
D002945CisplatinCisplatin affects the expression of BEST1 mRNA23300844
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BEST1 mRNA26924002
D004026DieldrinDieldrin results in increased expression of BEST1 mRNA23041725
D019422Dietary SucroseDietary Sucrose results in increased expression of BEST1 mRNA26033743
D005439Flufenamic AcidFlufenamic Acid results in decreased activity of BEST1 protein19828819
D005459FluoridesBEST1 protein results in increased transport of Fluorides19828819
D005459FluoridesPAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Fluorides]19828819
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEST1 mRNA20938992
C492448ICG 001ICG 001 results in increased expression of BEST1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BEST1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BEST1 mRNA28628672
D007454IodidesBEST1 protein results in increased transport of Iodides19828819
D007454IodidesPAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Iodides]19828819
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BEST1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BEST1 mRNA28628672
C031895lead chromatelead chromate results in increased expression of BEST1 mRNA23584427
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEST1 mRNA20938992
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BEST1 mRNA26924002
D009544Niflumic AcidNiflumic Acid results in decreased activity of BEST1 protein19828819
C462999PAR-1-activating peptidePAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Bromides]19828819
C462999PAR-1-activating peptidePAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Chlorides]19828819
C462999PAR-1-activating peptidePAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Fluorides]19828819
C462999PAR-1-activating peptidePAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Iodides]19828819
C462999PAR-1-activating peptide[PAR-1-activating peptide results in increased abundance of Calcium] which results in increased activity of BEST1 protein19828819
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BEST1 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of BEST1 mRNA17685462
D019284ThapsigarginThapsigargin results in increased expression of BEST1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of BEST1 mRNA22378314

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005229intracellular calcium activated chloride channel activity-TAS-  
GO:0005254chloride channel activity-IBA21873635  
GO:0005254chloride channel activity-IDA17003041  
GO:0005254chloride channel activitycontributes_toIDA17003041  
GO:0015106bicarbonate transmembrane transporter activity-TAS-  
GO:0042802identical protein binding-IPI19372599  
GO ID GO Term Qualifier Evidence PubMed
GO:0006821chloride transport-IDA17003041  
GO:0007601visual perception-TAS9662395  
GO:0015701bicarbonate transport-IEA-  
GO:0030321transepithelial chloride transport-IDA17003041  
GO:0034220ion transmembrane transport-TAS-  
GO:0050908detection of light stimulus involved in visual perception-IEA-  
GO:0051924regulation of calcium ion transport-IEA-  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS17003041  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS10737974  
GO:0016021integral component of membrane-TAS10737974  
GO:0016323basolateral plasma membrane-IDA11050159  19853238  
GO:0034707chloride channel complex-IBA21873635  
GO:0034707chloride channel complex-IDA17003041  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301346Best Vitelliform Macular Dystrophy (1993)MacDonald IM-