| SNP ID | Position | Alleles | Trait | Variation Type |
|---|---|---|---|---|
| rs216318 | chr12:6030095 (GRCh38.p7) | A>C | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs1800385 | chr12:6018725 (GRCh38.p7) | C>A | alcohol dependence | SNV(Single Nucleotide Variation) |
| rs917857 | chr12:5972658 (GRCh38.p7) | G>A | cocaine dependence | SNV(Single Nucleotide Variation) |
| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg23551979 | chr12:6165683 | VWF | 1.600e-11 | Smoking | 27651444 | |
| cg26819609 | chr12:6165816 | VWF | 3.500e-10 | Smoking | 27651444 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| ACVRL1 | 0.873 |
| TGM2 | 0.866 |
| STARD8 | 0.861 |
| THSD4 | 0.854 |
| ELOVL7 | 0.854 |
| ERG | 0.842 |
| CDH5 | 0.839 |
| PRKCH | 0.833 |
| IL13RA1 | 0.829 |
| SLCO2B1 | 0.827 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| CRH | -0.493 |
| CPLX3 | -0.485 |
| WNT7A | -0.45 |
| KCNIP3 | -0.413 |
| SMIM18 | -0.407 |
| SPATA2L | -0.403 |
| KCNG1 | -0.396 |
| MARCH4 | -0.395 |
| NEUROD6 | -0.394 |
| DLX1 | -0.393 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB00025 | Antihemophilic factor, human recombinant | BiotechDrug | 139076-62-3 | Approved|Investigational | Target |
| DB05202 | Egaptivon pegol | BiotechDrug | 934868-74-3 | Investigational | Target |
| DB06081 | Caplacizumab | Small Molecule | 915810-67-2 | Investigational | Target |
| DB09108 | Simoctocog Alfa | BiotechDrug | 1219013-68-9 | Approved | Target |
| DB09329 | Antihemophilic Factor (Recombinant), PEGylated | BiotechDrug | Approved|Investigational | Target | |
| DB11606 | Susoctocog alfa | BiotechDrug | 1339940-90-7 | Approved|Investigational | Target |
| DB11607 | Efmoroctocog alfa | BiotechDrug | 1270012-79-7 | Approved|Investigational | Target |
| DB13998 | Lonoctocog alfa | BiotechDrug | 1388129-63-2 | Approved|Investigational | Target |
| DB13999 | Moroctocog alfa | BiotechDrug | 284036-24-4 | Approved | Target |
| DB09329 | Antihemophilic Factor (Recombinant), PEGylated | BiotechDrug | Approved|Investigational | Carrier |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C026486 | 1,2,5,6-dibenzanthracene | "1,2,5,6-dibenzanthracene results in increased expression of VWF mRNA" | 26377693 |
| C111118 | 2',3,3',4',5-pentachloro-4-hydroxybiphenyl | "2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of VWF mRNA" | 19114083 |
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in decreased expression of VWF mRNA" | 18648102 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA" | 27188386 |
| C119737 | 8-prenylnaringenin | 8-prenylnaringenin results in increased expression of VWF mRNA | 16019205 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of VWF protein | 12654133 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of VWF mRNA | 17562736 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of VWF mRNA | 21641981 |
| D000393 | Air Pollutants | Air Pollutants affects the expression of VWF protein | 17182639 |
| C523074 | allylpyrocatechol | allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VWF protein] | 18431645 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of VWF mRNA | 16483693 |
| D044966 | Anti-Retroviral Agents | Anti-Retroviral Agents results in decreased expression of VWF protein | 19929230 |
| D001151 | Arsenic | Arsenic affects the methylation of VWF gene | 25304211 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of VWF mRNA | 20458559 |
| D000069059 | Atorvastatin Calcium | Atorvastatin Calcium results in increased expression of VWF protein | 19171469 |
| D001554 | Benzene | Benzene results in decreased expression of VWF mRNA | 17905399 |
| C006703 | benzo(b)fluoranthene | benzo(b)fluoranthene results in increased expression of VWF mRNA | 26377693 |
| D019324 | beta-Naphthoflavone | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VWF mRNA | 18164116 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of VWF mRNA | 20064835|2180250 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased mutagenesis of VWF gene | 25435355 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of VWF mRNA | 25566086 |
| D004958 | Estradiol | [Progesterone co-treated with Estradiol] results in increased expression of VWF mRNA | 18692832 |
| C543008 | bis(4-hydroxyphenyl)sulfone | bis(4-hydroxyphenyl)sulfone results in increased expression of VWF mRNA | 27685785 |
| C006780 | bisphenol A | bisphenol A results in increased expression of VWF mRNA | 27685785 |
| C006780 | bisphenol A | bisphenol A affects the expression of VWF mRNA | 25181051 |
| C006780 | bisphenol A | bisphenol A results in increased expression of VWF mRNA | 29097150 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in increased expression of VWF mRNA | 20580663 |
| C055494 | caffeic acid phenethyl ester | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNA | 20360939 |
| D002185 | Cannabidiol | Cannabidiol results in increased expression of VWF mRNA | 21542829 |
| C073718 | cannabidiol hydroxyquinone | cannabidiol hydroxyquinone results in decreased expression of VWF mRNA | 16571653 |
| D002244 | Carbon | Carbon results in increased expression of VWF protein | 20822968 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of VWF protein | 14716496|2852791 |
| D002251 | Carbon Tetrachloride | PLG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein] | 14716496 |
| D002251 | Carbon Tetrachloride | VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] | 28527913 |
| D002251 | Carbon Tetrachloride | VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] | 28527913 |
| D002251 | Carbon Tetrachloride | VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] | 28527913 |
| D002251 | Carbon Tetrachloride | VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] | 28527913 |
| D002251 | Carbon Tetrachloride | VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB2 mRNA] | 28527913 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of VWF mRNA | 23845850 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of VWF protein | 23845850 |
| D002251 | Carbon Tetrachloride | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA] | 23845850 |
| D002251 | Carbon Tetrachloride | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein] | 23845850 |
| D002784 | Cholesterol | [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein | 25833014 |
| D002784 | Cholesterol | resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] | 25833014 |
| D003042 | Cocaine | Cocaine results in increased expression of VWF protein | 10493323|1198821 |
| D003300 | Copper | Copper results in decreased expression of VWF mRNA | 22465980 |
| C015763 | cumene | [cumene co-treated with KRAS gene mutant form] results in decreased expression of VWF mRNA | 18648096 |
| D003471 | Cuprizone | Cuprizone results in increased expression of VWF mRNA | 26577399 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA] | 23845850 |
| D003474 | Curcumin | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein] | 23845850 |
| D003894 | Deamino Arginine Vasopressin | Deamino Arginine Vasopressin results in increased activity of VWF protein | 2738447 |
| D003894 | Deamino Arginine Vasopressin | Deamino Arginine Vasopressin results in increased secretion of VWF protein | 1837767|3259400 |
| C014347 | decitabine | decitabine affects the expression of VWF mRNA | 23300844 |
| D013759 | Dronabinol | Dronabinol results in increased expression of VWF mRNA | 21542829 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of VWF mRNA | 21266533 |
| D002945 | Cisplatin | Cisplatin affects the expression of VWF mRNA | 23300844 |
| D002945 | Cisplatin | Cisplatin results in increased expression of VWF protein | 16301596 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of VWF mRNA | 18042831 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of VWF mRNA | 21852083 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VWF mRNA | 18164116 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNA | 20360939 |
| D002117 | Calcitriol | Calcitriol results in increased expression of VWF mRNA | 26485663 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in increased expression of VWF mRNA" | 19480007 |
| D004656 | Enalapril | Enalapril results in decreased expression of VWF mRNA | 25037058 |
| D004875 | Ergosterol | [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein | 25833014 |
| D004875 | Ergosterol | resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] | 25833014 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein | 12616983 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of VWF mRNA | 18936297 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of VWF protein | 18298783 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of VWF mRNA | 17555576 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of VWF mRNA | 29097150 |
| C442659 | ethinyl estradiol-desogestrel combination | ethinyl estradiol-desogestrel combination results in increased expression of VWF protein | 12616983 |
| D018818 | Fenoldopam | Fenoldopam affects the expression of VWF protein | 11026604 |
| C056507 | gemcitabine | gemcitabine results in decreased expression of VWF protein | 20531411 |
| C033273 | Gestodene | [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein | 12616983 |
| D006854 | Hydrocortisone | Hydrocortisone results in increased expression of VWF mRNA | 25763180 |
| D006854 | Hydrocortisone | Mifepristone inhibits the reaction [Hydrocortisone results in increased expression of VWF mRNA] | 25763180 |
| C016517 | indole-3-carbinol | indole-3-carbinol affects the expression of VWF mRNA | 21396975 |
| D007213 | Indomethacin | allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VWF protein] | 18431645 |
| D007213 | Indomethacin | Indomethacin results in decreased expression of VWF protein | 18431645 |
| D007545 | Isoproterenol | Isoproterenol results in increased expression of VWF mRNA | 20003209 |
| D007840 | Latex | Latex promotes the reaction [Lipopolysaccharides results in increased expression of VWF protein] | 18938192 |
| D008070 | Lipopolysaccharides | Latex promotes the reaction [Lipopolysaccharides results in increased expression of VWF protein] | 18938192 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of VWF protein | 18938192 |
| D058185 | Magnetite Nanoparticles | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of VWF mRNA | 26378955 |
| D008610 | Menthol | [Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of VWF protein | 27818348 |
| C042720 | mercuric bromide | mercuric bromide results in decreased expression of VWF mRNA | 26272509 |
| C042720 | mercuric bromide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA" | 27188386 |
| D008715 | Methionine | Methionine results in increased degradation of VWF protein | 15870546 |
| D008748 | Methylcholanthrene | "[Methylcholanthrene co-treated with Nanotubes, Carbon] affects the expression of VWF mRNA" | 25926378 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in decreased expression of VWF mRNA | 28001369 |
| C004925 | methylmercuric chloride | methylmercuric chloride affects the expression of VWF mRNA | 20864626 |
| D008775 | Methylprednisolone | Methylprednisolone results in decreased expression of VWF protein | 20405515 |
| D008775 | Methylprednisolone | Methylprednisolone results in increased expression of VWF protein | 7491699 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [Hydrocortisone results in increased expression of VWF mRNA] | 25763180 |
| D009151 | Mustard Gas | Mustard Gas results in increased expression of VWF protein | 28962529 |
| D037742 | Nanotubes, Carbon | "[Methylcholanthrene co-treated with Nanotubes, Carbon] affects the expression of VWF mRNA" | 25926378 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in increased expression of VWF mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in increased expression of VWF mRNA" | 25554681 |
| D009538 | Nicotine | Nicotine results in increased expression of VWF mRNA | 11166759 |
| D009538 | Nicotine | Nicotine results in decreased expression of VWF mRNA | 17456735 |
| C010722 | nylestriol | nylestriol results in decreased expression of VWF protein | 12934402 |
| D010126 | Ozone | Ozone results in increased expression of VWF mRNA | 20980218 |
| D000073878 | Palm Oil | Palm Oil results in increased expression of VWF mRNA | 18042831 |
| C084656 | paricalcitol | paricalcitol results in decreased expression of VWF mRNA | 25037058 |
| D052638 | Particulate Matter | Particulate Matter affects the expression of VWF protein | 23231781 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid affects the expression of VWF mRNA | 19429403 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid affects the expression of VWF mRNA | 19429403 |
| D020913 | Perindopril | Perindopril results in decreased expression of VWF protein | 12224817 |
| D010578 | Petroleum | Petroleum affects the expression of VWF mRNA | 25208076 |
| D010662 | Phenylmercuric Acetate | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA" | 27188386 |
| D010662 | Phenylmercuric Acetate | Phenylmercuric Acetate results in decreased expression of VWF mRNA | 26272509 |
| C060974 | phosphatidylinositol 3,4,5-triphosphate | "[VWF protein binds to GP1BA protein binds to GP9 protein binds to GP5 protein] which results in increased abundance of phosphatidylinositol 3,4,5-triphosphate" | 12606772 |
| D048789 | Phytoestrogens | Phytoestrogens results in increased expression of VWF mRNA | 16019205 |
| D011374 | Progesterone | [Progesterone co-treated with Estradiol] results in increased expression of VWF mRNA | 18692832 |
| D011441 | Propylthiouracil | Propylthiouracil results in decreased expression of VWF mRNA | 24780913 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride results in increased expression of VWF protein | 15850603 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] | 25833014 |
| C471074 | rosiglitazone-metformin combination | rosiglitazone-metformin combination results in decreased expression of VWF protein | 16957566 |
| D017632 | Asbestos, Serpentine | "Asbestos, Serpentine results in decreased expression of VWF mRNA" | 21148743 |
| D019821 | Simvastatin | Simvastatin results in increased expression of VWF mRNA | 19109527 |
| D019821 | Simvastatin | Simvastatin results in increased expression of VWF protein | 19109527 |
| C009277 | sodium arsenate | sodium arsenate results in decreased expression of VWF mRNA | 21795629 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of VWF protein | 12703962 |
| D004113 | Succimer | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of VWF mRNA | 26378955 |
| D013629 | Tamoxifen | Tamoxifen results in increased expression of VWF protein | 15850603|9236565 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of VWF mRNA | 22298810 |
| D014028 | Tobacco Smoke Pollution | [APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of VWF protein | 24096154 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of VWF protein] | 24096154 |
| D014028 | Tobacco Smoke Pollution | [Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of VWF protein | 27818348 |
| D014050 | Toluene | Toluene results in increased expression of VWF mRNA | 22967744 |
| D014241 | Trichloroethylene | Trichloroethylene results in decreased expression of VWF mRNA | 17905399 |
| D014302 | Trinitrobenzenesulfonic Acid | NTS protein promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VWF protein] | 25307345 |
| D014302 | Trinitrobenzenesulfonic Acid | Trinitrobenzenesulfonic Acid results in increased expression of VWF protein | 25307345 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of VWF mRNA | 23179753 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in increased expression of VWF mRNA | 20980218 |
| D014747 | Vinblastine | Vinblastine results in increased expression of VWF mRNA | 20624997 |
| D014750 | Vincristine | Vincristine results in increased expression of VWF mRNA | 20624997 |
| D014810 | Vitamin E | Vitamin E results in increased expression of VWF mRNA | 19244175 |
| D014874 | Water Pollutants, Chemical | "Water Pollutants, Chemical affects the expression of VWF mRNA" | 25208076 |
| C104536 | xanthohumol | xanthohumol results in increased expression of VWF mRNA | 16019205 |
| C088658 | zoledronic acid | zoledronic acid results in increased expression of VWF mRNA | 24714768 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0002020 | protease binding | - | IDA | 15824096 |
| GO:0002020 | protease binding | - | IPI | 12775718 |
| GO:0005178 | integrin binding | - | IPI | 9079671 |
| GO:0005515 | protein binding | - | IDA | 16409464 |
| GO:0005515 | protein binding | - | IPI | 2839553 7756647 11943773 12183630 15039442 16221672 16912226 18492805 23414517 25512528 |
| GO:0005518 | collagen binding | - | IDA | 2056120 |
| GO:0019865 | immunoglobulin binding | - | IDA | 3121636 |
| GO:0042802 | identical protein binding | - | IPI | 17895385 18182488 18492805 21857647 |
| GO:0042803 | protein homodimerization activity | - | IDA | 10887119 |
| GO:0047485 | protein N-terminus binding | - | IPI | 7721887 |
| GO:0051087 | chaperone binding | - | IDA | 10887119 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0002576 | platelet degranulation | - | TAS | - |
| GO:0007155 | cell adhesion | - | IDA | 10764791 |
| GO:0007596 | blood coagulation | - | IMP | 16409464 |
| GO:0007596 | blood coagulation | - | TAS | - |
| GO:0007597 | blood coagulation, intrinsic pathway | - | TAS | - |
| GO:0007599 | hemostasis | - | IMP | 10887119 |
| GO:0009611 | response to wounding | - | TAS | 15029268 |
| GO:0030168 | platelet activation | - | IDA | 8565074 |
| GO:0030168 | platelet activation | - | NAS | 12871509 |
| GO:0030168 | platelet activation | - | TAS | - |
| GO:0030198 | extracellular matrix organization | - | TAS | - |
| GO:0031589 | cell-substrate adhesion | - | IDA | 9079671 |
| GO:0051260 | protein homooligomerization | - | IDA | 8874190 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005576 | extracellular region | - | HDA | 27068509 |
| GO:0005576 | extracellular region | - | IDA | 10887119 |
| GO:0005576 | extracellular region | - | NAS | 14718574 |
| GO:0005576 | extracellular region | - | TAS | - |
| GO:0005783 | endoplasmic reticulum | - | IDA | 6754744 |
| GO:0031012 | extracellular matrix | - | IDA | 6754744 |
| GO:0031091 | platelet alpha granule | - | NAS | 9759493 |
| GO:0031093 | platelet alpha granule lumen | - | TAS | - |
| GO:0033093 | Weibel-Palade body | - | IDA | 3082891 3087627 |
| GO:0062023 | collagen-containing extracellular matrix | - | HDA | 23979707 |
| GO:0070062 | extracellular exosome | - | HDA | 19056867 |
| KEGG ID | KEGG Term |
|---|---|
| hsa04510 | Focal adhesion |
| hsa04512 | ECM-receptor interaction |
| hsa04610 | Complement and coagulation cascades |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-109582 | Hemostasis | TAS |
| R-HSA-114608 | Platelet degranulation | TAS |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | TAS |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | TAS |
| R-HSA-1474244 | Extracellular matrix organization | TAS |
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-1643685 | Disease | TAS |
| R-HSA-216083 | Integrin cell surface interactions | TAS |
| R-HSA-354192 | Integrin alphaIIb beta3 signaling | TAS |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | TAS |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | TAS |
| R-HSA-430116 | GP1b-IX-V activation signalling | TAS |
| R-HSA-5663202 | Diseases of signal transduction | TAS |
| R-HSA-5673001 | RAF/MAP kinase cascade | TAS |
| R-HSA-5674135 | MAP2K and MAPK activation | TAS |
| R-HSA-5683057 | MAPK family signaling cascades | TAS |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | TAS |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | TAS |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | TAS |
| R-HSA-6802949 | Signaling by RAS mutants | TAS |
| R-HSA-6802952 | Signaling by BRAF and RAF fusions | TAS |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | TAS |
| R-HSA-6802957 | Oncogenic MAPK signaling | TAS |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | TAS |
| R-HSA-76002 | Platelet activation, signaling and aggregation | TAS |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | TAS |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | TAS |
| R-HSA-9006921 | Integrin signaling | TAS |
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