Gene: VWF

7450
F8VWF|VWD
von Willebrand factor
protein-coding
12p13.31
Ensembl:ENSG00000110799 MIM:613160 Vega:OTTHUMG00000168265 UniprotKB:P04275
NG_009072.1
PubMed|SNP Mapped
CD|ND|AD
145   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.228e-2 (AD)  9.562e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs216318chr12:6030095 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1800385chr12:6018725 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs917857chr12:5972658 (GRCh38.p7)G>Acocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23551979chr12:6165683VWF1.600e-11Smoking27651444
cg26819609chr12:6165816VWF3.500e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACVRL10.873
TGM20.866
STARD80.861
THSD40.854
ELOVL70.854
ERG0.842
CDH50.839
PRKCH0.833
IL13RA10.829
SLCO2B10.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.493
CPLX3-0.485
WNT7A-0.45
KCNIP3-0.413
SMIM18-0.407
SPATA2L-0.403
KCNG1-0.396
MARCH4-0.395
NEUROD6-0.394
DLX1-0.393

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00025Antihemophilic factor, human recombinantBiotechDrug139076-62-3Approved|InvestigationalTarget
DB05202Egaptivon pegolBiotechDrug934868-74-3InvestigationalTarget
DB06081CaplacizumabSmall Molecule915810-67-2InvestigationalTarget
DB09108Simoctocog AlfaBiotechDrug1219013-68-9ApprovedTarget
DB09329Antihemophilic Factor (Recombinant), PEGylatedBiotechDrugApproved|InvestigationalTarget
DB11606Susoctocog alfaBiotechDrug1339940-90-7Approved|InvestigationalTarget
DB11607Efmoroctocog alfaBiotechDrug1270012-79-7Approved|InvestigationalTarget
DB13998Lonoctocog alfaBiotechDrug1388129-63-2Approved|InvestigationalTarget
DB13999Moroctocog alfaBiotechDrug284036-24-4ApprovedTarget
DB09329Antihemophilic Factor (Recombinant), PEGylatedBiotechDrugApproved|InvestigationalCarrier
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of VWF mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of VWF mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of VWF mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA"27188386
C1197378-prenylnaringenin8-prenylnaringenin results in increased expression of VWF mRNA16019205
D000082AcetaminophenAcetaminophen results in increased expression of VWF protein12654133
D000082AcetaminophenAcetaminophen affects the expression of VWF mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of VWF mRNA21641981
D000393Air PollutantsAir Pollutants affects the expression of VWF protein17182639
C523074allylpyrocatecholallylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VWF protein]18431645
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VWF mRNA16483693
D044966Anti-Retroviral AgentsAnti-Retroviral Agents results in decreased expression of VWF protein19929230
D001151ArsenicArsenic affects the methylation of VWF gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of VWF mRNA20458559
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of VWF protein19171469
D001554BenzeneBenzene results in decreased expression of VWF mRNA17905399
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of VWF mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VWF mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VWF mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of VWF gene25435355
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of VWF mRNA25566086
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of VWF mRNA18692832
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of VWF mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of VWF mRNA27685785
C006780bisphenol Abisphenol A affects the expression of VWF mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of VWF mRNA29097150
D019256Cadmium ChlorideCadmium Chloride results in increased expression of VWF mRNA20580663
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNA20360939
D002185CannabidiolCannabidiol results in increased expression of VWF mRNA21542829
C073718cannabidiol hydroxyquinonecannabidiol hydroxyquinone results in decreased expression of VWF mRNA16571653
D002244CarbonCarbon results in increased expression of VWF protein20822968
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of VWF protein14716496|2852791
D002251Carbon TetrachloridePLG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]14716496
D002251Carbon TetrachlorideVWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]28527913
D002251Carbon TetrachlorideVWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]28527913
D002251Carbon TetrachlorideVWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]28527913
D002251Carbon TetrachlorideVWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]28527913
D002251Carbon TetrachlorideVWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB2 mRNA]28527913
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of VWF mRNA23845850
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of VWF protein23845850
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]23845850
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]23845850
D002784Cholesterol[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein25833014
D002784Cholesterolresveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein]25833014
D003042CocaineCocaine results in increased expression of VWF protein10493323|1198821
D003300CopperCopper results in decreased expression of VWF mRNA22465980
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of VWF mRNA18648096
D003471CuprizoneCuprizone results in increased expression of VWF mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]23845850
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]23845850
D003894Deamino Arginine VasopressinDeamino Arginine Vasopressin results in increased activity of VWF protein2738447
D003894Deamino Arginine VasopressinDeamino Arginine Vasopressin results in increased secretion of VWF protein1837767|3259400
C014347decitabinedecitabine affects the expression of VWF mRNA23300844
D013759DronabinolDronabinol results in increased expression of VWF mRNA21542829
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of VWF mRNA21266533
D002945CisplatinCisplatin affects the expression of VWF mRNA23300844
D002945CisplatinCisplatin results in increased expression of VWF protein16301596
D004041Dietary FatsDietary Fats results in increased expression of VWF mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of VWF mRNA21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VWF mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of VWF mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of VWF mRNA"19480007
D004656EnalaprilEnalapril results in decreased expression of VWF mRNA25037058
D004875Ergosterol[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein25833014
D004875Ergosterolresveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein]25833014
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein12616983
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of VWF mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of VWF protein18298783
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of VWF mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of VWF mRNA29097150
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of VWF protein12616983
D018818FenoldopamFenoldopam affects the expression of VWF protein11026604
C056507gemcitabinegemcitabine results in decreased expression of VWF protein20531411
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein12616983
D006854HydrocortisoneHydrocortisone results in increased expression of VWF mRNA25763180
D006854HydrocortisoneMifepristone inhibits the reaction [Hydrocortisone results in increased expression of VWF mRNA]25763180
C016517indole-3-carbinolindole-3-carbinol affects the expression of VWF mRNA21396975
D007213Indomethacinallylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VWF protein]18431645
D007213IndomethacinIndomethacin results in decreased expression of VWF protein18431645
D007545IsoproterenolIsoproterenol results in increased expression of VWF mRNA20003209
D007840LatexLatex promotes the reaction [Lipopolysaccharides results in increased expression of VWF protein]18938192
D008070LipopolysaccharidesLatex promotes the reaction [Lipopolysaccharides results in increased expression of VWF protein]18938192
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of VWF protein18938192
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of VWF mRNA26378955
D008610Menthol[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of VWF protein27818348
C042720mercuric bromidemercuric bromide results in decreased expression of VWF mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA"27188386
D008715MethionineMethionine results in increased degradation of VWF protein15870546
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] affects the expression of VWF mRNA"25926378
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of VWF mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of VWF mRNA20864626
D008775MethylprednisoloneMethylprednisolone results in decreased expression of VWF protein20405515
D008775MethylprednisoloneMethylprednisolone results in increased expression of VWF protein7491699
D015735MifepristoneMifepristone inhibits the reaction [Hydrocortisone results in increased expression of VWF mRNA]25763180
D009151Mustard GasMustard Gas results in increased expression of VWF protein28962529
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] affects the expression of VWF mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VWF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of VWF mRNA"25554681
D009538NicotineNicotine results in increased expression of VWF mRNA11166759
D009538NicotineNicotine results in decreased expression of VWF mRNA17456735
C010722nylestriolnylestriol results in decreased expression of VWF protein12934402
D010126OzoneOzone results in increased expression of VWF mRNA20980218
D000073878Palm OilPalm Oil results in increased expression of VWF mRNA18042831
C084656paricalcitolparicalcitol results in decreased expression of VWF mRNA25037058
D052638Particulate MatterParticulate Matter affects the expression of VWF protein23231781
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of VWF mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of VWF mRNA19429403
D020913PerindoprilPerindopril results in decreased expression of VWF protein12224817
D010578PetroleumPetroleum affects the expression of VWF mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of VWF mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of VWF mRNA26272509
C060974phosphatidylinositol 3,4,5-triphosphate"[VWF protein binds to GP1BA protein binds to GP9 protein binds to GP5 protein] which results in increased abundance of phosphatidylinositol 3,4,5-triphosphate"12606772
D048789PhytoestrogensPhytoestrogens results in increased expression of VWF mRNA16019205
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of VWF mRNA18692832
D011441PropylthiouracilPropylthiouracil results in decreased expression of VWF mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of VWF protein15850603
C059514resveratrolresveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein]25833014
C471074rosiglitazone-metformin combinationrosiglitazone-metformin combination results in decreased expression of VWF protein16957566
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of VWF mRNA"21148743
D019821SimvastatinSimvastatin results in increased expression of VWF mRNA19109527
D019821SimvastatinSimvastatin results in increased expression of VWF protein19109527
C009277sodium arsenatesodium arsenate results in decreased expression of VWF mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of VWF protein12703962
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of VWF mRNA26378955
D013629TamoxifenTamoxifen results in increased expression of VWF protein15850603|9236565
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VWF mRNA22298810
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of VWF protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of VWF protein]24096154
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of VWF protein27818348
D014050TolueneToluene results in increased expression of VWF mRNA22967744
D014241TrichloroethyleneTrichloroethylene results in decreased expression of VWF mRNA17905399
D014302Trinitrobenzenesulfonic AcidNTS protein promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VWF protein]25307345
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of VWF protein25307345
D014635Valproic AcidValproic Acid results in decreased expression of VWF mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased expression of VWF mRNA20980218
D014747VinblastineVinblastine results in increased expression of VWF mRNA20624997
D014750VincristineVincristine results in increased expression of VWF mRNA20624997
D014810Vitamin EVitamin E results in increased expression of VWF mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of VWF mRNA"25208076
C104536xanthohumolxanthohumol results in increased expression of VWF mRNA16019205
C088658zoledronic acidzoledronic acid results in increased expression of VWF mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IDA15824096  
GO:0002020protease binding-IPI12775718  
GO:0005178integrin binding-IPI9079671  
GO:0005515protein binding-IDA16409464  
GO:0005515protein binding-IPI2839553  7756647  11943773  12183630  15039442  16221672  
16912226  18492805  23414517  25512528  
GO:0005518collagen binding-IDA2056120  
GO:0019865immunoglobulin binding-IDA3121636  
GO:0042802identical protein binding-IPI17895385  18182488  18492805  21857647  
GO:0042803protein homodimerization activity-IDA10887119  
GO:0047485protein N-terminus binding-IPI7721887  
GO:0051087chaperone binding-IDA10887119  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0007155cell adhesion-IDA10764791  
GO:0007596blood coagulation-IMP16409464  
GO:0007596blood coagulation-TAS-  
GO:0007597blood coagulation, intrinsic pathway-TAS-  
GO:0007599hemostasis-IMP10887119  
GO:0009611response to wounding-TAS15029268  
GO:0030168platelet activation-IDA8565074  
GO:0030168platelet activation-NAS12871509  
GO:0030168platelet activation-TAS-  
GO:0030198extracellular matrix organization-TAS-  
GO:0031589cell-substrate adhesion-IDA9079671  
GO:0051260protein homooligomerization-IDA8874190  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-IDA10887119  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005783endoplasmic reticulum-IDA6754744  
GO:0031012extracellular matrix-IDA6754744  
GO:0031091platelet alpha granule-NAS9759493  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0033093Weibel-Palade body-IDA3082891  3087627  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins TAS
R-HSA-372708p130Cas linkage to MAPK signaling for integrinsTAS
R-HSA-430116GP1b-IX-V activation signallingTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-75892Platelet Adhesion to exposed collagenTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-9006921Integrin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8118478von Willebrand factor, the endothelium and obesity. (1993 Dec)Blann ADInt J Obes Relat Metab Disord
11214610Perioperative development of a thrombogenic risk profile in patients with carcinomas of the breast: a cause of increased thrombosis. (2000)Oberhoff CEur J Gynaecol Oncol
11132657Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. (2000 Dec)Lee AJBlood Coagul Fibrinolysis
20003285Predictors of the first cardiovascular event in patients with systemic lupus erythematosus - a prospective cohort study. (2009)Gustafsson JArthritis Res Ther
27684604Genetic analysis of emerging risk factors in coronary artery disease. (2016 Nov)van Iperen EPAtherosclerosis
15618045Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study. (2005 Feb)Yarnell JEur Heart J
29669506Mutations and Common Polymorphisms in ADAMTS13 and vWF Genes Responsible for Increasing Risk of Thrombosis. (2018 Apr 18)Haybar HCardiovasc Hematol Disord Drug Targets
22593709Endothelial cell markers in patients with pseudoexfoliation syndrome. (2012)Stafiej JScientificWorldJournal
21042046Insulin resistance explains the relationship between novel cardiovascular risk factors and hypertension. The Telde Study. (2011 Dec)Wagner AMJ Endocrinol Invest
19390122The difference between mean plasma levels of von Willebrand factor and platelet aggregation in type 2 diabetes mellitus with and without peripheral vascular disease at Sardjito General Hospital, Yogyakarta. (2009 Apr)Renaldi OActa Med Indones
9531345Haemostatic factors and prediction of ischaemic heart disease and stroke in claudicants. (1998 Mar)Smith FBBr J Haematol
10093968Platelet spontaneous aggregation in platelet-rich plasma is increased in habitual smokers. (1999 Mar 15)Fusegawa YThromb Res
21198559Circulating endothelial-coagulative activation markers after smoking cessation: a 12-month observational study. (2011 Jun)Caponnetto PEur J Clin Invest
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