Gene: WARS

7453
GAMMA-2|HMN9|IFI53|IFP53
tryptophanyl-tRNA synthetase
protein-coding
14q32.2
Ensembl:ENSG00000140105 MIM:191050 Vega:OTTHUMG00000171572 UniprotKB:P23381
NG_029914.1
PubMed
0   ANCO-SNPs
OD|ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.770e-2 (AD)  2.149e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC590.849
OGFOD10.839
TAP20.83
CKAP40.83
LGMN0.825
RNF19B0.817
TBL20.815
STAT10.813
SRXN10.812
IFNGR20.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.45
OR4F29-0.411
DIAPH3-0.401
SNX22-0.334
KCNJ16-0.326
P2RY14-0.311
PDE11A-0.307
PON1-0.304
MYOM1-0.295
GPR17-0.292

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00150L-TryptophanSmall Molecule73-22-3Approved|Nutraceutical|WithdrawnEnzyme
DB09395Sodium acetateSmall Molecule127-09-3ApprovedEnzyme
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
DB11127Selenious acidSmall Molecule7783-00-8Approved|InvestigationalEnzyme
DB11135SeleniumSmall Molecule7782-49-2Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of WARS mRNA25596134
C0326681-nitropyrene1-nitropyrene results in increased expression of WARS mRNA19041380
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of WARS mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of WARS mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of WARS mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of WARS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of WARS mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of WARS protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WARS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WARS mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of WARS mRNA"19561079
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of WARS mRNA"21346803
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of WARS mRNA26975756
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WARS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WARS mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of WARS mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of WARS mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of WARS mRNA28959563
C103505AM 251AM 251 results in increased expression of WARS mRNA16500647
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of WARS mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of WARS protein19364129
C015001arsenitearsenite affects the expression of WARS mRNA22959463
D001205Ascorbic AcidAscorbic Acid results in decreased expression of WARS mRNA19197388
D001241AspirinAspirin results in decreased expression of WARS mRNA11906190|1592858
D001280AtrazineAtrazine results in decreased expression of WARS mRNA22378314
D004958EstradiolEstradiol affects the expression of WARS mRNA23557687
D004958EstradiolEstradiol results in increased expression of WARS mRNA15159206|1575766
D004958EstradiolEstradiol results in increased expression of WARS mRNA17823450
C053541bicalutamidebicalutamide results in increased expression of WARS mRNA15638997
C006780bisphenol Abisphenol A results in decreased expression of WARS mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of WARS mRNA29275510
C006780bisphenol Abisphenol A affects the expression of WARS mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of WARS protein28903499
C515564bromovaninbromovanin results in decreased expression of WARS protein21419150
C584509C646 compoundC646 compound results in increased expression of WARS mRNA26191083
D019256Cadmium ChlorideCadmium Chloride affects the localization of WARS protein18261755
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WARS mRNA25596134
D019256Cadmium ChlorideCadmium Chloride affects the expression of WARS mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WARS mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of WARS mRNA25979313
C004656chloroacetaldehydechloroacetaldehyde affects the expression of WARS mRNA25596134
D002746ChlorpromazineChlorpromazine results in increased expression of WARS mRNA25596134
C059262cidofovircidofovir results in increased expression of WARS mRNA25596134
D004002Clodronic AcidClodronic Acid affects the expression of WARS mRNA25596134
D002995Clofibric AcidClofibric Acid affects the expression of WARS mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of WARS mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of WARS mRNA24386269
D003042CocaineCocaine affects the expression of WARS mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of WARS mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of WARS mRNA15755911
D016572CyclosporineCyclosporine results in increased expression of WARS mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of WARS mRNA23830897
D016572CyclosporineCyclosporine results in increased expression of WARS mRNA25596134
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of WARS mRNA17823450
D013759DronabinolDronabinol results in decreased expression of WARS mRNA18454173
D003907DexamethasoneDexamethasone results in decreased expression of WARS mRNA25047013
D002945CisplatinCisplatin results in increased expression of WARS mRNA25596134
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of WARS mRNA15784690
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of WARS mRNA15159206
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of WARS mRNA"22485181
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of WARS protein"18422750
D004610Ellagic AcidEllagic Acid results in increased expression of WARS mRNA12002526
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of WARS protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of WARS mRNA22079256
D004964EstriolEstriol results in increased expression of WARS mRNA15159206
D004970EstroneEstrone results in increased expression of WARS mRNA15159206
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WARS mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WARS protein20227414
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WARS mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WARS mRNA23550701
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of WARS mRNA23649840
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of WARS mRNA]15016801
D019833GenisteinGenistein results in increased expression of WARS mRNA15159206|1575766
D005839GentamicinsGentamicins results in increased expression of WARS mRNA22061828
D005897GlafenineGlafenine results in increased expression of WARS mRNA24136188
D017313FenretinideFenretinide results in increased expression of WARS mRNA16671099
D017313FenretinideFenretinide results in increased expression of WARS mRNA28973697
D007052IbuprofenIbuprofen results in decreased expression of WARS mRNA25596134
C492448ICG 001ICG 001 results in increased expression of WARS mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of WARS mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of WARS mRNA25613284
D007657Ketone BodiesKetone Bodies results in increased expression of WARS mRNA16807920
C008261lead acetatelead acetate results in increased expression of WARS mRNA11578147
D008687MetforminMetformin results in increased expression of WARS mRNA25596134
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of WARS mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of WARS protein18959786
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of WARS mRNA12634122
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of WARS mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of WARS mRNA16026605
D008777MethyltestosteroneMethyltestosterone results in decreased expression of WARS mRNA29191790
D015741MetriboloneMetribolone results in increased expression of WARS protein17152098
D008942MitoxantroneWARS protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WARS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WARS mRNA"25554681|2562005
D009532NickelNickel results in increased expression of WARS mRNA24768652|2558310
C025256nonylphenolnonylphenol results in increased expression of WARS mRNA15159206
D010100OxygenOxygen deficiency results in decreased expression of WARS mRNA25596134
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of WARS mRNA26705709
D010416PentachlorophenolPentachlorophenol results in decreased expression of WARS mRNA24642059
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of WARS mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of WARS protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WARS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of WARS mRNA26272509
D010894PiroxicamPiroxicam results in decreased expression of WARS mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of WARS mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of WARS mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of WARS mRNA23012394
C015586propiverinepropiverine binds to WARS protein29273565
C059514resveratrolresveratrol results in increased expression of WARS mRNA12002526|1256957
C059514resveratrolresveratrol results in increased expression of WARS protein25505154
D012402RotenoneRotenone results in increased expression of WARS mRNA27900601
D012715Sesame OilSesame Oil results in increased expression of WARS mRNA29191790
C009277sodium arsenatesodium arsenate results in increased expression of WARS mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of WARS mRNA28595984
D012969Sodium FluorideSodium Fluoride results in decreased expression of WARS protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of WARS mRNA24383545
D053260SootSoot results in increased expression of WARS mRNA26551751
C061133tamibarotenetamibarotene results in increased expression of WARS mRNA15498508
D013629TamoxifenTamoxifen results in increased expression of WARS mRNA19155303
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WARS mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of WARS mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of WARS mRNA22378314
D013893ThiramThiram results in decreased expression of WARS mRNA20530235
D014212TretinoinTretinoin results in increased expression of WARS mRNA15498508|1721838
D014303TrinitrotolueneTrinitrotoluene affects the expression of WARS mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of WARS mRNA"26179874
D014315TriterpenesTriterpenes results in decreased expression of WARS protein18422750
D014415TunicamycinTunicamycin results in increased expression of WARS mRNA22378314
D014520UrethaneUrethane results in decreased expression of WARS mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WARS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of WARS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WARS mRNA23179753|2519280
D014635Valproic AcidValproic Acid affects the expression of WARS mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of WARS mRNA23034163
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of WARS mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004830tryptophan-tRNA ligase activity-IBA21873635  
GO:0004830tryptophan-tRNA ligase activity-IMP28369220  
GO:0004830tryptophan-tRNA ligase activity-NAS8496617  
GO:0004830tryptophan-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI15628863  20010843  21044950  22504299  
GO:0005524ATP binding-IEA-  
GO:0019210kinase inhibitor activity-IDA22504299  
GO:0019901protein kinase binding-IPI22504299  
GO:0019904protein domain specific binding-IPI22504299  
GO:0042803protein homodimerization activity-IDA22504299  28369220  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001933negative regulation of protein phosphorylation-IDA22504299  
GO:0006412translation-TAS1761529  
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006436tryptophanyl-tRNA aminoacylation-IBA21873635  
GO:0006436tryptophanyl-tRNA aminoacylation-NAS8496617  
GO:0006469negative regulation of protein kinase activity-IDA22504299  
GO:0008285negative regulation of cell proliferation-TAS1761529  
GO:0010628positive regulation of gene expression-IDA22504299  
GO:0010835regulation of protein ADP-ribosylation-IDA22504299  
GO:0031334positive regulation of protein complex assembly-IMP22504299  
GO:0045765regulation of angiogenesis-IDA11773625  11773626  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA22504299  
GO:0005737cytoplasm-TAS16130169  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IMP22504299  
GO:0070062extracellular exosome-HDA20458337  23533145  
KEGG ID KEGG Term
hsa00380Tryptophan metabolism
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15939065Tryptophanyl-tRNA synthetase gene polymorphisms and risk of incident myocardial infarction. (2005 Jul)Zee RYAtherosclerosis
15074566Women's death in Scandinavia--what makes Denmark different? (2004)Jacobsen REur J Epidemiol
27659441Cigarette Smoking Status and Receipt of an Opioid Prescription Among Veterans of Recent Wars. (2017 Jun 1)Bastian LAPain Med
16165099Decreased anterior cingulate volume in combat-related PTSD. (2006 Apr 1)Woodward SHBiol Psychiatry
27136656Increasing Prevalence of Chronic Lung Disease in Veterans of the Wars in Iraq and Afghanistan. (2016 May)Pugh MJMil Med
28808856Validation of Veterans Affairs Electronic Medical Record Smoking Data Among Iraq- and Afghanistan-Era Veterans. (2017 Nov)Calhoun PSJ Gen Intern Med
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum