Gene: LAT2

7462
HSPC046|LAB|NTAL|WBSCR15|WBSCR5|WSCR5
linker for activation of T cells family member 2
protein-coding
7q11.23
Ensembl:ENSG00000086730 MIM:605719 Vega:OTTHUMG00000130151 UniprotKB:Q9GZY6
NG_023256.1
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.858e-2 (AD)  2.428e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGB20.95
LAPTM50.937
SASH30.936
CD300A0.932
PARVG0.93
FCGR3A0.93
ALOX5AP0.928
C1QC0.928
FCER1G0.927
LAIR10.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.458
HES5-0.435
SLC7A4-0.428
MARCH4-0.425
ST6GAL2-0.422
NEUROD6-0.418
KCNIP3-0.41
KREMEN2-0.409
ABCC12-0.408
PPEF1-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphatebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphateixazomib inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphateLAT2 protein results in decreased susceptibility to 10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphatemethyl-beta-cyclodextrin promotes the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]23001822
C0227762-bromopalmitate2-bromopalmitate results in decreased expression of LAT2 protein23001822
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of LAT2 mRNA25716159
D000082AcetaminophenAcetaminophen affects the expression of LAT2 mRNA17562736
D000447AldehydesAldehydes results in increased expression of LAT2 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LAT2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LAT2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LAT2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of LAT2 mRNA19128835
C006632arsenic trioxideLAT2 protein results in decreased susceptibility to arsenic trioxide23001822
C547126AZM551248AZM551248 results in increased expression of LAT2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LAT2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAT2 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]23001822
C006780bisphenol Abisphenol A results in increased methylation of LAT2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of LAT2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LAT2 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of LAT2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of LAT2 promoter22457795
D004390ChlorpyrifosChlorpyrifos results in decreased expression of LAT2 mRNA26299976
D004390ChlorpyrifosLAT2 gene mutant form results in decreased susceptibility to Chlorpyrifos26299976
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAT2 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of LAT2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of LAT2 mRNA27523638
D004041Dietary FatsDietary Fats results in increased expression of LAT2 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of LAT2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LAT2 mRNA21592394
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LAT2 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAT2 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of LAT2 mRNA23649840
C492448ICG 001ICG 001 results in increased expression of LAT2 mRNA26191083
C548400ixazomibixazomib inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]23001822
C548400ixazomibixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]23001822
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LAT2 mRNA26752646
D007854LeadLead results in decreased expression of LAT2 mRNA19921347
C008261lead acetatelead acetate results in increased expression of LAT2 mRNA20542052
D008345ManganeseManganese results in increased expression of LAT2 mRNA18284614
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAT2 mRNA20938992
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin promotes the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]23001822
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LAT2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LAT2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LAT2 mRNA"25554681
D009532NickelNickel results in increased expression of LAT2 mRNA25583101
D010261ParaoxonParaoxon results in increased expression of LAT2 mRNA24413757
C046012pentanalpentanal results in increased expression of LAT2 mRNA26079696
C105905perifosineixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]23001822
C105905perifosineLAT2 protein results in decreased susceptibility to perifosine23001822
C105905perifosineperifosine results in decreased expression of LAT2 protein23001822
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LAT2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of LAT2 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of LAT2 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LAT2 mRNA23806026
C016104sodium bichromatesodium bichromate results in decreased expression of LAT2 mRNA17685462
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LAT2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LAT2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LAT2 mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of LAT2 mRNA23557971|2776080
D014212TretinoinTretinoin results in decreased expression of LAT2 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LAT2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of LAT2 gene29154799
C009687wortmanninwortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]23001822

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14722116  
GO:0042169SH2 domain binding-IMP14722116  
GO:0042169SH2 domain binding-IPI20442417  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0019722calcium-mediated signaling-IGI14722116  
GO:0035556intracellular signal transduction-IGI14722116  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0042113B cell activation-IDA12514734  
GO:0042113B cell activation-TAS14722116  
GO:0043303mast cell degranulation-IEA-  
GO:0050853B cell receptor signaling pathway-IDA12514734  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0042629mast cell granule-IEA-  
GO:0045121membrane raft-IDA12486104  12514734  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationTAS
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26657885Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport. (2015)Day PEPLoS One
24516142Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc. (2014 Feb 25)Rosell AProc Natl Acad Sci U S A