Gene: WFS1

7466
CTRCT41|WFRS|WFS|WFSL
wolframin ER transmembrane glycoprotein
protein-coding
4p16.1
Ensembl:ENSG00000109501 MIM:606201 Vega:OTTHUMG00000090431 UniprotKB:O76024
NG_011700.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.933e-1 (AD)  6.249e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC8A0.883
SLC1A40.868
PPP1R1B0.857
PC0.855
ADCYAP1R10.841
CADM10.841
CPE0.84
TTYH10.839
TPCN10.838
DAG10.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.548
GADL1-0.426
CETP-0.424
FER1L6-0.398
GSDMA-0.374
C2orf83-0.373
GALR1-0.371
LY9-0.369
KRTAP4-5-0.364

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of WFS1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of WFS1 mRNA"27291303
D000082AcetaminophenAcetaminophen results in increased expression of WFS1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of WFS1 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of WFS1 mRNA]21233418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WFS1 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of WFS1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WFS1 mRNA22228805
D004958EstradiolEstradiol affects the expression of WFS1 mRNA14699072
C044887beta-methylcholinebeta-methylcholine affects the expression of WFS1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of WFS1 mRNA20678512
C584509C646 compoundC646 compound results in increased expression of WFS1 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of WFS1 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of WFS1 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of WFS1 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of WFS1 mRNA24650576
D003471CuprizoneCuprizone results in decreased expression of WFS1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of WFS1 mRNA20106945|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of WFS1 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of WFS1 mRNA12782123
D003907DexamethasoneDexamethasone results in decreased expression of WFS1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WFS1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of WFS1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of WFS1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of WFS1 mRNA18042831
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of WFS1 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of WFS1 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WFS1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WFS1 mRNA17942748
D005473FluoxetineFluoxetine results in decreased expression of WFS1 mRNA17033635
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of WFS1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of WFS1 mRNA27392435
D007608Kainic AcidKainic Acid results in increased expression of WFS1 mRNA17997037
D007649KetamineKetamine results in increased expression of WFS1 mRNA20080153
D007854LeadLead affects the expression of WFS1 mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of WFS1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WFS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WFS1 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of WFS1 mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of WFS1 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of WFS1 protein26879310
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WFS1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of WFS1 mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of WFS1 mRNA]20059764
D011192Potassium DichromatePotassium Dichromate results in decreased expression of WFS1 protein23718831
D011374ProgesteroneProgesterone results in increased expression of WFS1 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of WFS1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of WFS1 mRNA24780913
C059514resveratrolresveratrol results in increased expression of WFS1 protein25505154
C089730rosiglitazonerosiglitazone results in increased expression of WFS1 mRNA16982809
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of WFS1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in increased expression of WFS1 mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WFS1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WFS1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WFS1 mRNA19933214
D019284ThapsigarginThapsigargin results in increased expression of WFS1 mRNA22378314
C066340tolcaponetolcapone binds to WFS1 protein19783845
D014415TunicamycinTunicamycin results in increased expression of WFS1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of WFS1 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of WFS1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WFS1 mRNA23179753|2915479
D014635Valproic AcidValproic Acid inhibits the reaction [WFS1 protein binds to HSP90B1 protein]19125190
D014635Valproic AcidValproic Acid results in increased expression of WFS1 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of WFS1 protein19125190
C025643vinclozolinvinclozolin results in decreased expression of WFS1 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of WFS1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21044950  
GO:0005516calmodulin binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IDA20160352  
GO:0033613activating transcription factor binding-IEA-  
GO:0048306calcium-dependent protein binding-IEA-  
GO:0051117ATPase binding-IPI17947299  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20160352  
GO:0001822kidney development-IMP9817917  
GO:0003091renal water homeostasis-IMP9817917  
GO:0006983ER overload response-IC16989814  
GO:0006983ER overload response-TAS17947299  
GO:0007601visual perception-IMP9771706  9817917  
GO:0007605sensory perception of sound-IMP17492394  
GO:0022417protein maturation by protein folding-IC16989814  
GO:0030433ubiquitin-dependent ERAD pathway-IDA20160352  
GO:0030433ubiquitin-dependent ERAD pathway-ISS-  
GO:0031016pancreas development-IEA-  
GO:0031398positive regulation of protein ubiquitination-IDA20160352  
GO:0031398positive regulation of protein ubiquitination-ISS-  
GO:0032469endoplasmic reticulum calcium ion homeostasis-IDA16989814  
GO:0034976response to endoplasmic reticulum stress-IDA15994758  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0042048olfactory behavior-IEA-  
GO:0042593glucose homeostasis-IMP9817917  
GO:0043069negative regulation of programmed cell death-IMP9771706  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA20160352  
GO:0043524negative regulation of neuron apoptotic process-IMP9771706  9817917  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045927positive regulation of growth-ISS-  
GO:0050821protein stabilization-IDA20160352  
GO:0050821protein stabilization-ISS-  
GO:0050821protein stabilization-TAS23710284  
GO:0050877nervous system process-IMP9817917  
GO:0051247positive regulation of protein metabolic process-IDA17947299  
GO:0051928positive regulation of calcium ion transport-IDA16989814  
GO:0055074calcium ion homeostasis-IDA14527944  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1903892negative regulation of ATF6-mediated unfolded protein response-IDA20160352  
GO:2000675negative regulation of type B pancreatic cell apoptotic process-IMP16087305  
GO ID GO Term Qualifier Evidence PubMed
GO:0000502proteasome complex-IEA-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005789endoplasmic reticulum membrane-NAS20160352  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0030176integral component of endoplasmic reticulum membrane-IDA11181571  14527944  
GO:0030425dendrite-ISS11181571  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med