Gene: DAGLA

747
C11orf11|DAGL(ALPHA)|DAGLALPHA|NSDDR
diacylglycerol lipase alpha
protein-coding
11q12.2
Ensembl:ENSG00000134780 MIM:614015 Vega:OTTHUMG00000168160 UniprotKB:Q9Y4D2
NC_000011.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.018e-1 (AD)  8.573e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNGR10.951
IQSEC20.946
LRRC40.944
CNTNAP10.943
UNC13A0.942
LINGO10.941
WNK20.94
MYH100.94
KCNMA10.939
KCNB10.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNHG18-0.588
MYL3-0.57
HEY2-0.557
COPZ2-0.547
YES1-0.537
RAB13-0.532
REST-0.526
WWTR1-0.524
FAM114A1-0.522
RAI14-0.519

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane results in decreased activity of DAGLA protein"18657971
C0758091-stearoyl-2-arachidonoylglycerolDAGLA protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol18657971
D001280AtrazineAtrazine results in decreased expression of DAGLA mRNA22378314
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of DAGLA mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of DAGLA mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of DAGLA mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of DAGLA mRNA17484886
D019327Copper SulfateCopper Sulfate results in increased expression of DAGLA mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of DAGLA mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of DAGLA mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DAGLA mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of DAGLA mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of DAGLA mRNA25016146
C069837fullerene C60fullerene C60 results in decreased expression of DAGLA mRNA19167457
C039281furanfuran results in increased expression of DAGLA mRNA27387713
C094503glyceryl 2-arachidonateDAGLA protein results in increased chemical synthesis of glyceryl 2-arachidonate18657971
C094503glyceryl 2-arachidonateDAGLA results in increased chemical synthesis of glyceryl 2-arachidonate20393458
C094503glyceryl 2-arachidonate[GRM5 results in increased activity of DAGLA protein] which results in increased secretion of glyceryl 2-arachidonate20393458
D017313FenretinideFenretinide results in increased expression of DAGLA mRNA28973697
C011890kojic acidkojic acid results in increased expression of DAGLA mRNA16595896
D007854LeadLead affects the expression of DAGLA mRNA28903495
C104810methyl arachidonylfluorophosphonatemethyl arachidonylfluorophosphonate analog results in decreased activity of DAGLA protein16466961
C104810methyl arachidonylfluorophosphonatemethyl arachidonylfluorophosphonate results in decreased activity of DAGLA protein16466961
C104810methyl arachidonylfluorophosphonatemethyl arachidonylfluorophosphonate results in decreased activity of DAGLA protein18657971
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DAGLA mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of DAGLA promoter"26251327
C028007nickel monoxidenickel monoxide results in decreased expression of DAGLA mRNA19167457
C055122orlistatorlistat results in decreased activity of DAGLA protein16466961
C055122orlistatorlistat results in decreased activity of DAGLA protein18657971|2039345
D010634PhenobarbitalPhenobarbital affects the expression of DAGLA mRNA19159669
D011441PropylthiouracilPropylthiouracil results in decreased expression of DAGLA mRNA24780913
C061133tamibarotenetamibarotene affects the expression of DAGLA mRNA15498508
D014212TretinoinTretinoin affects the expression of DAGLA mRNA15498508
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DAGLA mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DAGLA mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of DAGLA gene29154799
D014635Valproic AcidValproic Acid affects the expression of DAGLA mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DAGLA gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0047372acylglycerol lipase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IEA-  
GO:0007405neuroblast proliferation-IEA-  
GO:0019369arachidonic acid metabolic process-IBA21873635  
GO:0019369arachidonic acid metabolic process-IDA14610053  
GO:0022008neurogenesis-IBA21873635  
GO:0042136neurotransmitter biosynthetic process-IBA21873635  
GO:0042136neurotransmitter biosynthetic process-IDA14610053  
GO:0046340diacylglycerol catabolic process-IBA21873635  
GO:0046340diacylglycerol catabolic process-IDA14610053  
GO:0071926endocannabinoid signaling pathway-IBA21873635  
GO:0071926endocannabinoid signaling pathway-IEA-  
GO:0098921retrograde trans-synaptic signaling by endocannabinoid-IBA21873635  
GO:0098921retrograde trans-synaptic signaling by endocannabinoid-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043196varicosity-IEA-  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-426048Arachidonate production from DAGTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29477030Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population. (2018 May)Ishiguro HAlcohol