Gene info: ID 7471

Gene: WNT1

GENE ID: 7471

Synonyms: BMND16|INT1|OI15

Description: Wnt family member 1

Gene type: protein-coding

Location: 12q13.12

dbXrefs: Ensembl:ENSG00000125084 MIM:164820 Vega:OTTHUMG00000170403 UniprotKB:P04628

RefSeq: NG_033141.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.930e-1 (AD) 9.725e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HTR6	0.847
KIAA1324	0.846
CACNA1D	0.846
TRANK1	0.837
SH3D21	0.829
DRP2	0.825
CHRM4	0.823
EPHA10	0.822
PTPN5	0.822
PCDHGC5	0.821

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COPZ2	-0.55
MYL3	-0.539
YES1	-0.519
RAB13	-0.518
AKR1C3	-0.506
ROM1	-0.506
HEY2	-0.498
RNF135	-0.475
CSAG1	-0.471
HEBP2	-0.466

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of WNT1 mRNA"	26377693
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of WNT1 protein"	22094457
D000082	Acetaminophen	Acetaminophen affects the expression of WNT1 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [quinocetone results in decreased expression of WNT1 protein]	28343033
C015001	arsenite	arsenite results in increased methylation of WNT1 promoter	23974009
D001554	Benzene	Benzene results in increased expression of WNT1	15935813
D001554	Benzene	Benzene results in increased expression of WNT1 mRNA	12928149
D001554	Benzene	TRP53 protein affects the reaction [Benzene results in increased expression of WNT1 mRNA]	12928149
D001554	Benzene	TRP53 protein promotes the reaction [Benzene results in increased expression of WNT1]	15935813
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of WNT1 protein	21467743
C006780	bisphenol A	bisphenol A affects the methylation of WNT1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of WNT1 mRNA	25381574\|2596372
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA]	25963729
D002101	Cacodylic Acid	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA	23192986
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA	12634122
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of WNT1 mRNA	18502319
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA	12634122
D019327	Copper Sulfate	Copper Sulfate results in increased expression of WNT1 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA]	25963729
D003474	Curcumin	Curcumin results in increased expression of WNT1 mRNA	25963729
C014347	decitabine	decitabine results in increased expression of WNT1 mRNA	27915011
D003907	Dexamethasone	APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 protein]	28242765
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 mRNA	28242765
C016366	dibenzothiophene	dibenzothiophene results in increased expression of WNT1 mRNA	23656968
D004041	Dietary Fats	Dietary Fats results in increased expression of WNT1 mRNA	25016146
D005013	Ethosuximide	Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]	26420483
D005013	Ethosuximide	Ethosuximide results in increased expression of WNT1 mRNA	26420483
D005492	Folic Acid	[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT1 mRNA	22959928
D005947	Glucose	Glucose results in increased expression of WNT1 mRNA	29163160
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of WNT1 mRNA	17183730
D006861	Hydrogen Peroxide	[Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of WNT1 mRNA	24489904
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]	28578904
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]	28578904
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of WNT1 protein]	28578904
D015056	1-Methyl-3-isobutylxanthine	APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 protein]	28242765
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 mRNA	28242765
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA	12634122
C018584	linalool	linalool results in increased expression of WNT1 mRNA	19922762
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [quinocetone results in decreased expression of WNT1 protein]	28343033
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]	28578904
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]	28578904
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]	28578904
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]	28578904
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of WNT1 mRNA	21613230
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of WNT1 mRNA	21385734
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of WNT1 mRNA	26011545
C020300	monomethylarsonic acid	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA	23192986
D009151	Mustard Gas	Mustard Gas results in decreased expression of WNT1 mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of WNT1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of WNT1 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of WNT1 mRNA	19130878
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of WNT1 mRNA	27001416
D010672	Phenytoin	Phenytoin results in decreased expression of WNT1 mRNA	7841657
D010936	Plant Extracts	Plant Extracts results in decreased expression of WNT1 mRNA	23557933
C502851	quinocetone	Acetylcysteine inhibits the reaction [quinocetone results in decreased expression of WNT1 protein]	28343033
C502851	quinocetone	Lithium Chloride inhibits the reaction [quinocetone results in decreased expression of WNT1 protein]	28343033
C502851	quinocetone	quinocetone results in decreased expression of WNT1 protein	28343033
D017382	Reactive Oxygen Species	[Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of WNT1 mRNA	24489904
C059514	resveratrol	resveratrol results in increased expression of WNT1 mRNA	23848300
D012839	Simazine	Simazine results in increased expression of WNT1 mRNA	27513680
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA	12634122
C017947	sodium arsenite	[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA	23192986
C017947	sodium arsenite	[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT1 mRNA	22959928
C082097	tocotrienol, delta	"tocotrienol, delta results in decreased expression of WNT1 protein"	21453743
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of WNT1 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of WNT1 mRNA	24849673
D014635	Valproic Acid	Valproic Acid results in decreased methylation of WNT1 promoter	20734317
D014635	Valproic Acid	Valproic Acid results in increased expression of WNT1 mRNA	20734317
D014635	Valproic Acid	Valproic Acid results in increased expression of WNT1 protein	20734317
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of WNT1 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005109	frizzled binding	-	IBA	21873635
GO:0005109	frizzled binding	-	IC	19756656
GO:0005109	frizzled binding	-	NAS	23461676
GO:0005125	cytokine activity	-	ISS	-
GO:0016015	morphogen activity	-	TAS	24431302
GO:0019904	protein domain specific binding	-	IEA	-
GO:0044212	transcription regulatory region DNA binding	-	IDA	19847889
GO:0048018	receptor ligand activity	-	IC	19778454
GO:0048018	receptor ligand activity	-	IDA	28733458
GO:0048018	receptor ligand activity	-	NAS	23461676

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000578	embryonic axis specification	-	ISS	-
GO:0001658	branching involved in ureteric bud morphogenesis	-	IEA	-
GO:0001934	positive regulation of protein phosphorylation	-	IEA	-
GO:0007267	cell-cell signaling	-	ISS	-
GO:0007520	myoblast fusion	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IDA	16501043
GO:0008284	positive regulation of cell proliferation	-	IMP	19778454
GO:0009611	response to wounding	-	IEP	17982423
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010592	positive regulation of lamellipodium assembly	-	IMP	19756656
GO:0010812	negative regulation of cell-substrate adhesion	-	IDA	16501043
GO:0016055	Wnt signaling pathway	-	IBA	21873635
GO:0016055	Wnt signaling pathway	-	IDA	10644691
GO:0016055	Wnt signaling pathway	-	TAS	-
GO:0021527	spinal cord association neuron differentiation	-	IEA	-
GO:0021536	diencephalon development	-	IEA	-
GO:0021551	central nervous system morphogenesis	-	ISS	-
GO:0021588	cerebellum formation	-	ISS	-
GO:0021797	forebrain anterior/posterior pattern specification	-	IEA	-
GO:0022004	midbrain-hindbrain boundary maturation during brain development	-	IEA	-
GO:0022408	negative regulation of cell-cell adhesion	-	IMP	17072303
GO:0030182	neuron differentiation	-	IBA	21873635
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IEA	-
GO:0030514	negative regulation of BMP signaling pathway	-	IMP	16194878
GO:0030579	ubiquitin-dependent SMAD protein catabolic process	-	IEA	-
GO:0030901	midbrain development	-	ISS	-
GO:0031100	animal organ regeneration	-	IEA	-
GO:0033077	T cell differentiation in thymus	-	IEA	-
GO:0033278	cell proliferation in midbrain	-	IEA	-
GO:0036520	astrocyte-dopaminergic neuron signaling	-	IEA	-
GO:0042472	inner ear morphogenesis	-	IEA	-
GO:0042770	signal transduction in response to DNA damage	-	IDA	16501043
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	-	IDA	12154096
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	-	IMP	12154096
GO:0045165	cell fate commitment	-	IBA	21873635
GO:0045599	negative regulation of fat cell differentiation	-	ISS	-
GO:0045747	positive regulation of Notch signaling pathway	-	IDA	16501043
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	10644691
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	19847889
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048146	positive regulation of fibroblast proliferation	-	IMP	19734317
GO:0048664	neuron fate determination	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	ISS	-
GO:0060061	Spemann organizer formation	-	ISS	-
GO:0060070	canonical Wnt signaling pathway	-	IDA	28733458
GO:0060070	canonical Wnt signaling pathway	-	IMP	19756656 19778454
GO:0060070	canonical Wnt signaling pathway	-	NAS	23461676
GO:0060070	canonical Wnt signaling pathway	-	TAS	24431302 26049140
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	-
GO:0060348	bone development	-	IMP	23499309
GO:0061184	positive regulation of dermatome development	-	IDA	10654605
GO:0070365	hepatocyte differentiation	-	IEA	-
GO:0071375	cellular response to peptide hormone stimulus	-	IEA	-
GO:0071425	hematopoietic stem cell proliferation	-	IEA	-
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IEA	-
GO:0090344	negative regulation of cell aging	-	IDA	16501043
GO:1903204	negative regulation of oxidative stress-induced neuron death	-	IEA	-
GO:1904886	beta-catenin destruction complex disassembly	-	TAS	-
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	-	NAS	23461676
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	-	TAS	24431302
GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	-	TAS	22988876
GO:1990403	embryonic brain development	-	IEA	-
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	11793365 19756656
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005796	Golgi lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	IEA	-
GO:0030666	endocytic vesicle membrane	-	TAS	-
GO:0070062	extracellular exosome	-	TAS	-

KEGG ID	KEGG Term
hsa04310	Wnt signaling pathway
hsa04340	Hedgehog signaling pathway
hsa04916	Melanogenesis
hsa05200	Pathways in cancer
hsa05217	Basal cell carcinoma

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-3238698	WNT ligand biogenesis and trafficking	TAS
R-HSA-3238698	WNT ligand biogenesis and trafficking	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-373080	Class B/2 (Secretin family receptors)	IEA
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-4086400	PCP/CE pathway	IEA
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-HSA-500792	GPCR ligand binding	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28426731	Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility. (2017)	Lau HK	PLoS One