Gene: WNT7A

7476
-
Wnt family member 7A
protein-coding
3p25.1
Ensembl:ENSG00000154764 MIM:601570 Vega:OTTHUMG00000129803 UniprotKB:O00755
NG_008088.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.213e-1 (AD)  9.362e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP30.792
EPHB30.74
KIF21B0.739
LRRN20.738
C15orf590.732
FLRT10.723
ASIC10.711
RTN4R0.711
EXTL10.705
SPATA2L0.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MPZL2-0.574
ANG-0.562
SLC11A1-0.557
IL1R1-0.556
CTBS-0.55
IL4R-0.547
CLEC4E-0.547
RNASE4-0.545
CDK2-0.545
OSMR-0.542

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of WNT7A mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WNT7A mRNA16483693
D000968Antimycin AAntimycin A results in increased expression of WNT7A mRNA19304788
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WNT7A mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WNT7A mRNA22610609
D004958EstradiolEstradiol results in decreased expression of WNT7A mRNA16534752
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT7A mRNA]16534752
C006780bisphenol Abisphenol A results in decreased expression of WNT7A mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of WNT7A protein26898831
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WNT7A mRNA20478370
D002211CapsaicinCapsaicin results in decreased expression of WNT7A mRNA16278290
D002737ChloropreneChloroprene results in decreased expression of WNT7A mRNA23125180
C014347decitabinedecitabine results in increased expression of WNT7A mRNA27915011
D004026DieldrinDieldrin results in decreased expression of WNT7A mRNA19130878
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of WNT7A mRNA16534752
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of WNT7A mRNA15070830|1545879
D004054DiethylstilbestrolESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]15458790
D004054DiethylstilbestrolWNT5A protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]15073149
D004054DiethylstilbestrolWNT7A gene mutant form results in increased susceptibility to Diethylstilbestrol15070830
D004054DiethylstilbestrolWNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]15070830
D004054DiethylstilbestrolWNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]15070830
C042080diisodecyl phthalatediisodecyl phthalate results in decreased expression of WNT7A mRNA22112501
C027387di-n-hexyl phthalatedi-n-hexyl phthalate results in decreased expression of WNT7A mRNA22112501
D004726EndosulfanEndosulfan affects the expression of WNT7A protein26911934
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of WNT7A mRNA16551644
D015025ZearalenoneZearalenone results in decreased expression of WNT7A mRNA16534752
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT7A mRNA22959928
C069837fullerene C60fullerene C60 results in increased expression of WNT7A mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT7A mRNA]16534752
D019833GenisteinGenistein results in decreased expression of WNT7A mRNA16534752|2686566
D019833GenisteinGenistein results in decreased expression of WNT7A mRNA21810550
C010974glyphosateglyphosate results in decreased expression of WNT7A protein28780397
C010974glyphosateglyphosate results in increased expression of WNT7A protein27287056
D048628KetolidesKetolides analog results in decreased expression of WNT7A mRNA24967691
C008261lead acetateWNT7A protein inhibits the reaction [lead acetate results in increased phosphorylation of CTNNB1 protein]24999626
C008261lead acetatelead acetate results in decreased expression of WNT7A protein24999626
C008261lead acetatelead acetate results in increased expression of WNT7A mRNA11578147
C008493methylselenic acidmethylselenic acid results in decreased expression of WNT7A mRNA12517777
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of WNT7A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WNT7A mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of WNT7A mRNA19167457
C017557nickel subsulfidenickel subsulfide results in increased expression of WNT7A mRNA24952340
D009534NiclosamideNiclosamide results in decreased activity of WNT7A protein25174399
D009534NiclosamideWNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]25174399
D009534NiclosamideWNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]25174399
D009534NiclosamideWNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]25174399
D009534NiclosamideWNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]25174399
D009534NiclosamideWNT7A protein results in increased susceptibility to Niclosamide25174399
C534585NSC 668036NSC 668036 results in decreased activity of WNT7A protein25174399
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene mutant form affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of WNT7A mRNA]"21673326
D010126OzoneOzone results in decreased expression of WNT7A mRNA17460151
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WNT7A mRNA19710929
D011374ProgesteroneProgesterone affects the expression of WNT7A mRNA21291521
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in decreased expression of WNT7A mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of WNT7A mRNA17556502|2223828
D011441PropylthiouracilPropylthiouracil results in increased expression of WNT7A mRNA24780913
C024631pyrviniumpyrvinium results in decreased activity of WNT7A protein25174399
D012402RotenoneRotenone results in increased expression of WNT7A mRNA19304788
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of WNT7A mRNA25895662
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT7A mRNA22959928
D012969Sodium FluorideSodium Fluoride results in decreased expression of WNT7A mRNA27257137
D012999SomanSoman results in decreased expression of WNT7A mRNA19281266
D014212TretinoinTretinoin results in increased expression of WNT7A mRNA17064353
C544261XAV939XAV939 results in decreased activity of WNT7A protein25174399

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI12857724  
GO:0005109frizzled binding-IBA21873635  
GO:0005125cytokine activity-IDA18986540  
GO:0005515protein binding-IPI22986341  26342861  
GO:0048018receptor ligand activity-IC15802269  
GO:0048018receptor ligand activity-IDA18986540  28733458  
GO ID GO Term Qualifier Evidence PubMed
GO:0000578embryonic axis specification-IMP16826533  
GO:0001502cartilage condensation-IDA17202865  
GO:0001525angiogenesis-IEA-  
GO:0002062chondrocyte differentiation-IDA17202865  
GO:0007269neurotransmitter secretion-IEA-  
GO:0007409axonogenesis-TAS24449494  
GO:0007548sex differentiation-TAS9790192  
GO:0009953dorsal/ventral pattern formation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010595positive regulation of endothelial cell migration-IEA-  
GO:0014719skeletal muscle satellite cell activation-IEA-  
GO:0014834skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration-IEA-  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0016055Wnt signaling pathway-TAS-  
GO:0021707cerebellar granule cell differentiation-IEA-  
GO:0021846cell proliferation in forebrain-IDA12843296  
GO:0022009central nervous system vasculogenesis-IEA-  
GO:0030010establishment of cell polarity-IEA-  
GO:0030182neuron differentiation-IBA21873635  
GO:0031133regulation of axon diameter-IEA-  
GO:0032270positive regulation of cellular protein metabolic process-IDA16805831  
GO:0032355response to estradiol-IEA-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035115embryonic forelimb morphogenesis-IMP16826533  
GO:0035116embryonic hindlimb morphogenesis-IMP16826533  
GO:0035567non-canonical Wnt signaling pathway-IEA-  
GO:0035659Wnt signaling pathway involved in wound healing, spreading of epidermal cells-IDA15802269  
GO:0036465synaptic vesicle recycling-TAS22988876  
GO:0042733embryonic digit morphogenesis-IMP16826533  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0045165cell fate commitment-IBA21873635  
GO:0045167asymmetric protein localization involved in cell fate determination-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA15802269  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12857724  
GO:0046330positive regulation of JNK cascade-IBA21873635  
GO:0046330positive regulation of JNK cascade-IEA-  
GO:0048103somatic stem cell division-IEA-  
GO:0048864stem cell development-IDA12843296  
GO:0050768negative regulation of neurogenesis-IDA12843296  
GO:0051965positive regulation of synapse assembly-IDA18986540  
GO:0060054positive regulation of epithelial cell proliferation involved in wound healing-IDA15802269  
GO:0060066oviduct development-IEA-  
GO:0060070canonical Wnt signaling pathway-IDA12857724  15802269  18986540  28733458  
GO:0060997dendritic spine morphogenesis-IDA21670302  
GO:0061038uterus morphogenesis-IEA-  
GO:0062009secondary palate development-IMP18413325  
GO:0070307lens fiber cell development-ISS16258938  
GO:0071560cellular response to transforming growth factor beta stimulus-IEP15040835  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA16805831  
GO:0099054presynapse assembly-TAS24449494  
GO:0099068postsynapse assembly-TAS24449494  
GO:1904861excitatory synapse assembly-TAS24449494  
GO:1904891positive regulation of excitatory synapse assembly-IDA21670302  
GO:1905386positive regulation of protein localization to presynapse-TAS24449494  
GO:2000463positive regulation of excitatory postsynaptic potential-IDA21670302  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0070062extracellular exosome-TAS-  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-3238698WNT ligand biogenesis and traffickingTAS
R-HSA-3238698WNT ligand biogenesis and traffickingIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-373080Class B/2 (Secretin family receptors)IEA
R-HSA-500792GPCR ligand bindingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25653486Clinical significance of aberrant Wnt7a promoter methylation in human non-small cell lung cancer in Koreans. (2015 Feb)Kim THJ Korean Med Sci
25632963Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma. (2015 Apr)Hirata TOncol Rep