Gene: WRB

7485
CHD5|GET1
tryptophan rich basic protein
protein-coding
21q22.2
Ensembl:ENSG00000182093 MIM:602915 Vega:OTTHUMG00000066250 UniprotKB:O00258
NG_045002.3
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.212e-1 (AD)  2.945e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00606841chr21:40757691WRBGene body1.948e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD100.95
RAB180.932
VBP10.928
UBL30.92
TSN0.919
MFF0.917
GABARAPL20.916
PRDX30.916
VAPA0.915
COPS80.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.765
OR4F29-0.729
MTRNR2L6-0.325
MTRNR2L10-0.312
MTRNR2L9-0.298
C8orf74-0.297
MTRNR2L3-0.295
KCNJ15-0.289
FOLR3-0.288
TTLL10-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of WRB mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of WRB mRNA"25380136
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of WRB gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of WRB mRNA24449571
D001151ArsenicArsenic affects the methylation of WRB gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WRB mRNA21632981
C044887beta-methylcholinebeta-methylcholine affects the expression of WRB mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WRB mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of WRB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of WRB gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WRB mRNA21297351
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WRB mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of WRB mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of WRB mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of WRB mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of WRB mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of WRB mRNA23300844
C014347decitabinedecitabine results in increased expression of WRB mRNA19151715
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WRB mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WRB mRNA21266533
D002945CisplatinCisplatin affects the expression of WRB mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of WRB mRNA28302478
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of WRB mRNA25380136
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WRB mRNA20227414
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WRB mRNA20938992
D017313FenretinideFenretinide results in decreased expression of WRB mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of WRB mRNA21179406
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WRB mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of WRB mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WRB mRNA28628672
D007854LeadLead results in increased expression of WRB mRNA19921347
C045463leflunomideleflunomide results in decreased expression of WRB mRNA28988120
C015329lycopenelycopene results in decreased expression of WRB mRNA16886892
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WRB mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of WRB mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of WRB mRNA"20188158
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of WRB mRNA25380136
D010795Phthalic AcidsPhthalic Acids results in increased expression of WRB mRNA21061450
D011794QuercetinQuercetin results in decreased expression of WRB mRNA21632981
D012999SomanSoman results in decreased expression of WRB mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WRB mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of WRB mRNA23411599
D014520UrethaneUrethane results in increased expression of WRB mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of WRB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WRB mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of WRB gene29154799
D014635Valproic AcidValproic Acid affects the expression of WRB mRNA17292431
C025643vinclozolinvinclozolin affects the expression of WRB mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of WRB mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0071816tail-anchored membrane protein insertion into ER membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9544840  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal