Gene: WRN

7486
RECQ3|RECQL2|RECQL3
Werner syndrome RecQ like helicase
protein-coding
8p12
Ensembl:ENSG00000165392 MIM:604611 Vega:OTTHUMG00000163894 UniprotKB:Q14191
NG_008870.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.922e-1 (AD)  2.999e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTAF10.845
ZKSCAN80.841
DENND4C0.832
AQR0.832
MCM90.831
ZSCAN120.827
ANKHD10.826
PHC30.817
THAP60.813
SLC30A70.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.329
NANOS3-0.328
OR4F29-0.309
LCN1-0.283
NPW-0.269
APOA1-0.265
C4orf48-0.263
ADRA2C-0.251
ASPDH-0.236
MUC12-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5577411-(propoxymethyl)maleimide1-(propoxymethyl)maleimide results in decreased activity of WRN protein21220316
C0248298-hydroxyguanineWRN protein results in decreased susceptibility to 8-hydroxyguanine25730140
D000677AmsacrineWRN gene mutant form results in increased susceptibility to Amsacrine10725663
D001151ArsenicArsenic results in increased expression of WRN mRNA25460668
D001280AtrazineAtrazine results in increased expression of WRN mRNA25929836
D001280AtrazineAtrazine results in decreased expression of WRN mRNA22378314
D001554BenzeneWRN gene SNP results in increased susceptibility to Benzene16728435
D001554BenzeneWRN SNP affects the susceptibility to Benzene18978339
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of WRN mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WRN mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WRN mRNA"19150397
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WRN mRNA28628672
C074702chromium hexavalent ionchromium hexavalent ion affects the localization of WRN protein19487340
C074702chromium hexavalent ionWRN protein mutant form results in increased susceptibility to chromium hexavalent ion19487340
C074702chromium hexavalent ionWRN protein results in decreased susceptibility to chromium hexavalent ion20585393
D003471CuprizoneCuprizone results in decreased expression of WRN mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of WRN mRNA20106945|2556210
C017160cypermethrincypermethrin results in increased expression of WRN mRNA21142847
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WRN mRNA28628672
D002945CisplatinCisplatin results in decreased expression of WRN mRNA27594783
D002945CisplatinCisplatin results in increased expression of WRN mRNA21151649
D002945CisplatinCisplatin results in increased expression of WRN protein21416250
C000944dicrotophosdicrotophos results in decreased expression of WRN mRNA28302478
D005047EtoposideWRN gene mutant form results in increased susceptibility to Etoposide10725663
C031927hydroquinoneWRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AFX protein alternative form]21267443
C031927hydroquinoneWRN gene mutant form results in increased susceptibility to hydroquinone21267443
C031927hydroquinoneWRN protein affects the reaction [hydroquinone results in increased acetylation of TP53 protein]17875398
C031927hydroquinoneWRN protein affects the reaction [hydroquinone results in increased expression of H2AFX protein]17875398
C031927hydroquinoneWRN protein affects the reaction [hydroquinone results in increased expression of TP53 protein]17875398
C031927hydroquinoneWRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein]19064679
C031927hydroquinoneWRN protein inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein]19064679
C031927hydroquinoneWRN protein results in decreased susceptibility to hydroquinone17875398|1897833
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WRN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WRN mRNA28628672
C544151jinfukangjinfukang results in decreased expression of WRN mRNA27392435
D007649KetamineKetamine results in decreased expression of WRN mRNA20080153
C017096n-butoxyethanoln-butoxyethanol results in increased expression of WRN mRNA19812364
D010416PentachlorophenolPentachlorophenol results in increased expression of WRN mRNA23892564
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WRN mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of WRN mRNA23557933
C059514resveratrolresveratrol affects the localization of WRN protein19559722
C017947sodium arsenitesodium arsenite results in increased expression of WRN protein19072884
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WRN mRNA21354282
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of WRN mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of WRN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of WRN mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of WRN mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IBA21873635  
GO:0000287magnesium ion binding-IDA16622405  
GO:0000400four-way junction DNA binding-IBA21873635  
GO:0000400four-way junction DNA binding-IDA11735402  
GO:0000403Y-form DNA binding-IBA21873635  
GO:0000403Y-form DNA binding-IDA11735402  17715146  26420422  
GO:0000405bubble DNA binding-IBA21873635  
GO:0000405bubble DNA binding-IDA11433031  11735402  
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IDA9288107  
GO:0003678DNA helicase activity-IDA12944467  19734539  26420422  
GO:0003678DNA helicase activity-IMP10871376  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0004003ATP-dependent DNA helicase activity-IDA9288107  15200954  
GO:0004386helicase activity-IDA12181313  
GO:0004527exonuclease activity-IDA12944467  
GO:0004527exonuclease activity-IMP15200954  
GO:0005515protein binding-IPI10373438  10783163  11328876  11427532  11598021  11919194  
12181313  12750383  14596914  14657243  14688284  14734561  
15733840  15735006  15965237  16030011  17498979  17611195  
17715146  17961633  18203716  19343720  20802463  21639834  
24126761  25931448  26496610  
GO:0005524ATP binding-IEA-  
GO:00084083'-5' exonuclease activity-IBA21873635  
GO:00084083'-5' exonuclease activity-IDA10783163  10871373  12181313  16622405  
GO:0009378four-way junction helicase activity-IBA21873635  
GO:0009378four-way junction helicase activity-IDA11433031  11735402  
GO:0016887ATPase activity-IDA10373438  10871376  
GO:0030145manganese ion binding-IBA21873635  
GO:0030145manganese ion binding-IDA16622405  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0042803protein homodimerization activity-IDA10783163  
GO:00431383'-5' DNA helicase activity-IDA17715146  
GO:0043140ATP-dependent 3'-5' DNA helicase activity-IBA21873635  
GO:0044877protein-containing complex binding-IDA10783163  
GO:0051880G-quadruplex DNA binding-IDA11433031  11735402  
GO:0061749forked DNA-dependent helicase activity-IBA21873635  
GO:0061749forked DNA-dependent helicase activity-IDA11735402  
GO:0061821telomeric D-loop binding-IBA21873635  
GO:0061821telomeric D-loop binding-IDA19734539  26420422  
GO:0061849telomeric G-quadruplex DNA binding-IC19734539  
GO:00703373'-flap-structured DNA binding-IBA21873635  
GO:00703373'-flap-structured DNA binding-IDA26420422  
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding-IBA21873635  
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding-IDA19734539  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP18212065  
GO:0000723telomere maintenance-TAS25801465  
GO:0000724double-strand break repair via homologous recombination-IBA21873635  
GO:0000731DNA synthesis involved in DNA repair-IBA21873635  
GO:0000731DNA synthesis involved in DNA repair-IDA17563354  
GO:0001302replicative cell aging-IBA21873635  
GO:0001302replicative cell aging-IEA-  
GO:0006259DNA metabolic process-IDA16622405  
GO:0006260DNA replication-IMP12882351  
GO:0006260DNA replication-ISS-  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-IBA21873635  
GO:0006284base-excision repair-IBA21873635  
GO:0006284base-excision repair-IDA17611195  
GO:0006302double-strand break repair-IMP21639834  
GO:0006310DNA recombination-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA18203716  
GO:0006979response to oxidative stress-IBA21873635  
GO:0006979response to oxidative stress-IDA17611195  
GO:0007420brain development-IEA-  
GO:0007568aging-NAS9288107  
GO:0007569cell aging-IBA21873635  
GO:0007569cell aging-IMP18212065  
GO:0008340determination of adult lifespan-IBA21873635  
GO:0009267cellular response to starvation-IBA21873635  
GO:0009267cellular response to starvation-IDA11420665  
GO:0010225response to UV-C-IBA21873635  
GO:0010225response to UV-C-IDA17563354  
GO:0010259multicellular organism aging-IBA21873635  
GO:0010259multicellular organism aging-IMP16673358  
GO:0031297replication fork processing-IBA21873635  
GO:0031297replication fork processing-IDA17115688  
GO:0031297replication fork processing-IMP12882351  
GO:0032508DNA duplex unwinding-IBA21873635  
GO:0032508DNA duplex unwinding-IDA11735402  26420422  
GO:0040009regulation of growth rate-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0042981regulation of apoptotic process-IGI9681877  
GO:0044806G-quadruplex DNA unwinding-IBA21873635  
GO:0044806G-quadruplex DNA unwinding-IDA11735402  
GO:0044806G-quadruplex DNA unwinding-ISS-  
GO:0051345positive regulation of hydrolase activity-IBA21873635  
GO:0051345positive regulation of hydrolase activity-IDA17611195  
GO:0061820telomeric D-loop disassembly-IBA21873635  
GO:0061820telomeric D-loop disassembly-IDA15200954  19734539  26420422  
GO:0061820telomeric D-loop disassembly-IGI22039056  
GO:0061820telomeric D-loop disassembly-TAS22039056  
GO:0071480cellular response to gamma radiation-IBA21873635  
GO:0071480cellular response to gamma radiation-IDA21639834  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO:0090656t-circle formation-TAS27918544  
GO:0098530positive regulation of strand invasion-IBA21873635  
GO:0098530positive regulation of strand invasion-IDA26420422  
GO:1902570protein localization to nucleolus-IDA11420665  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IBA21873635  
GO:0000781chromosome, telomeric region-IDA15200954  26420422  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA11420665  12944467  17498979  21639834  25801465  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication forkCOLOCALIZES_WITHIBA21873635  
GO:0005657replication fork-ISS-  
GO:0005662DNA replication factor A complexCOLOCALIZES_WITHIBA21873635  
GO:0005694chromosome-IBA21873635  
GO:0005730nucleolus-IDA9618508  11420665  12181313  12944467  15200954  17498979  21639834  25801465  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA17498979  
GO:0016607nuclear speck-IDA-  
GO:0032389MutLalpha complexCOLOCALIZES_WITHIBA21873635  
GO:0032389MutLalpha complexcolocalizes_withIDA17715146  
GO:0035861site of double-strand break-IBA21873635  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21942242Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status. (2012 Apr)Kim HNLeuk Lymphoma
24924712[Study on gene-gene, gene-environmental interactions of DNA repair genes related with age-related cataract]. (2014 Apr 22)Yang MZhonghua Yi Xue Za Zhi