Gene: WT1

7490
AWT1|GUD|NPHS4|WAGR|WIT-2|WT33
Wilms tumor 1
protein-coding
11p13
Ensembl:ENSG00000184937 MIM:607102 Vega:OTTHUMG00000039556 UniprotKB:P19544
NG_009272.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.817e-1 (AD)  7.916e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22533573chr11:32452771WT11.700e-11Smoking27651444
cg05222924chr11:32450486WT14.900e-10Smoking27651444
cg19211915chr11:32452513WT11.900e-9Smoking27651444
cg21769619chr11:32454768WT11.400e-8Smoking27651444
cg08787968chr11:32451777WT19.000e-8Smoking27651444
cg20204986chr11:32448067WT17.500e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD30.875
GPR1010.875
ENTHD10.873
SAG0.868
DGKK0.853
AMBN0.853
TMPRSS60.848
GPR10.838
CHAT0.837
ZBED20.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.366
SYTL2-0.333
NANOS3-0.323
GALNT9-0.323
NEUROD2-0.302
SOHLH1-0.291
MEIS3-0.277
ZBTB7C-0.269
TNNT2-0.263
FUT1-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of WT1 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of WT1 mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WT1 mRNA19933214
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of WT1 mRNA19643169
D019342Acetic AcidAcetic Acid results in increased expression of WT1 protein21296659
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in decreased expression of WT1 protein]28578904
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WT1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of WT1 mRNA16966277|2047151
C006632arsenic trioxidearsenic trioxide results in decreased expression of WT1 protein16966277
C006632arsenic trioxidearsenic trioxide results in increased expression of WT1 mRNA11940349
C015001arsenitearsenite results in increased methylation of WT1 promoter23974009
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of WT1 mRNA"22251266
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of WT1 mRNA"23917077
C547126AZM551248AZM551248 results in increased expression of WT1 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of WT1 mRNA26377693
D001564Benzo(a)pyreneAHR affects the reaction [Benzo(a)pyrene affects the splicing of WT1 mRNA]21803694
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of WT1 mRNA21803694
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of WT1 mRNA19530133
C038328BEP protocolBEP protocol results in increased expression of WT1 mRNA18987330
D004958EstradiolWT1 protein results in decreased susceptibility to Estradiol20204298
D004958EstradiolEstradiol results in increased expression of WT1 mRNA21632026
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 mRNA18034345
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 protein18034345
C006780bisphenol Abisphenol A results in increased expression of WT1 mRNA21632026
C006780bisphenol Abisphenol A affects the methylation of WT1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of WT1 mRNA25434310
C006780bisphenol Abisphenol A results in decreased expression of WT1 protein25434310
C006780bisphenol Abisphenol A results in increased expression of WT1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of WT1 mRNA20471514|2097792
D000069286BortezomibBortezomib results in decreased expression of WT1 protein17629554
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of WT1 protein21296659
D002220CarbamazepineCarbamazepine affects the expression of WT1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of WT1 mRNA17484886
D002330CarmustineWT1 results in decreased susceptibility to Carmustine20820871
D002737ChloropreneChloroprene results in decreased expression of WT1 mRNA23125180
C031180chrysenechrysene results in increased expression of WT1 mRNA26377693
C018021cobaltous chloride[cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNA12738801
D005576ColforsinColforsin results in increased expression of WT1 mRNA15961562
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of WT1 mRNA20971185
D003474CurcuminCurcumin results in decreased expression of WT1 mRNA18034345|1919650
D003474CurcuminCurcumin results in decreased expression of WT1 protein18034345|1919650
D003676Deferoxamine[cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNA12738801
C050229demethoxycurcumindemethoxycurcumin results in decreased expression of WT1 mRNA18034345
C050229demethoxycurcumindemethoxycurcumin results in decreased expression of WT1 protein18034345
D003907DexamethasoneDexamethasone results in increased expression of WT1 mRNA22733784
D003976DiazinonDiazinon affects the expression of WT1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WT1 mRNA25434310
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WT1 protein25434310
D002945CisplatinWT1 results in decreased susceptibility to Cisplatin20820871
D004026DieldrinDieldrin affects the expression of WT1 mRNA22546817
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of WT1 mRNA25031359
D004237DiuronDiuron results in decreased expression of WT1 mRNA21551480|2515243
D004726EndosulfanEndosulfan results in decreased expression of WT1 mRNA22307005
D004726Endosulfan[Flutamide co-treated with Endosulfan] results in decreased expression of WT1 mRNA22307005
C015860ergosta-4,6,8(14),22-tetraen-3-one"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein]"28578904
D015025ZearalenoneZearalenone results in decreased expression of WT1 mRNA24412631
D005419FlavonoidsFlavonoids results in decreased expression of WT1 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of WT1 protein21296659
D005485Flutamide[Flutamide co-treated with Endosulfan] results in decreased expression of WT1 mRNA22307005
D005485FlutamideFlutamide results in decreased expression of WT1 mRNA22307005
D005557FormaldehydeFormaldehyde results in increased expression of WT1 mRNA12679049
C070081fulvestrantWT1 protein results in decreased susceptibility to fulvestrant20204298
C039281furanfuran results in increased expression of WT1 mRNA27387713
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of WT1 mRNA25031359
D005839GentamicinsGentamicins results in decreased expression of WT1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of WT1 mRNA28973697
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in decreased expression of WT1 protein]28578904
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of WT1 mRNA15329907
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of WT1 mRNA"26377693
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of WT1 mRNA24435446|2479639
D019808LosartanLosartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]28578904
D008345ManganeseManganese results in decreased expression of WT1 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of WT1 mRNA17175027
D015122MercaptopurineMercaptopurine results in increased expression of WT1 mRNA23358152
C005219methyl cellosolvemethyl cellosolve results in increased expression of WT1 mRNA19643169
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of WT1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of WT1 mRNA"25554681
C017557nickel subsulfidenickel subsulfide results in decreased expression of WT1 mRNA12729255
D009569Nitric Oxide[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA21443142
D009569Nitric OxideNitric Oxide results in increased expression of WT1 mRNA21443142
C007350nitrofennitrofen results in decreased expression of WT1 mRNA21072664
C007350nitrofennitrofen results in decreased expression of WT1 protein21072664
D009599Nitroprusside[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA21443142
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of WT1 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of WT1 mRNA17175027
D010100OxygenOxygen deficiency results in increased expression of WT1 mRNA12738801
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in decreased expression of WT1 protein]28578904
D010269ParaquatParaquat results in increased expression of WT1 mRNA16797015
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of WT1 mRNA20580666
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of WT1 protein20580666
D015232DinoprostoneDinoprostone inhibits the reaction [WT1 protein binds to CYP19A1 promoter]19001523
D015232DinoprostoneDinoprostone inhibits the reaction [WT1 protein binds to STAR promoter]19001523
D010936Plant ExtractsPlant Extracts results in decreased expression of WT1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of WT1 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of WT1 mRNA14662165
D011374ProgesteroneProgesterone results in increased expression of WT1 mRNA alternative form14662165
D011374ProgesteroneProgesterone results in increased expression of WT1 protein14662165
D000068718Rosuvastatin CalciumRosuvastatin Calcium results in increased expression of WT1 mRNA21443142
D020123SirolimusSirolimus results in decreased expression of WT1 mRNA18927120
D020123SirolimusSirolimus results in decreased expression of WT1 protein18927120
D020123SirolimusSirolimus results in decreased expression of WT1 protein mutant form15782132
C017947sodium arseniteMIR191 mRNA promotes the reaction [sodium arsenite results in increased expression of WT1 protein]29277653
C017947sodium arsenitesodium arsenite results in decreased expression of WT1 mRNA16966277
C017947sodium arsenitesodium arsenite results in decreased expression of WT1 protein16966277
C017947sodium arsenitesodium arsenite results in increased expression of WT1 mRNA12016162
C017947sodium arsenitesodium arsenite results in increased expression of WT1 protein29277653
C017947sodium arsenitesodium arsenite affects the expression of WT1 mRNA23137061
C017947sodium arsenitesodium arsenite results in increased expression of WT1 mRNA11241755|1687621
C017947sodium arsenitesodium arsenite results in increased expression of WT1 protein16876216
D053260SootSoot results in decreased expression of WT1 mRNA26551751
D019311StaurosporineStaurosporine results in increased expression of WT1 protein12914969
D013629TamoxifenWT1 protein results in decreased susceptibility to Tamoxifen20204298|2094414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WT1 mRNA19933214|2405805
D014212TretinoinPDCD4 protein promotes the reaction [Tretinoin results in decreased expression of WT1 protein]17259349
D014212TretinoinTretinoin results in decreased expression of WT1 mRNA15749674|1577063
D014212TretinoinTretinoin results in decreased expression of WT1 mRNA alternative form15749674
D014212TretinoinTretinoin results in decreased expression of WT1 protein15770638
D014212TretinoinTretinoin results in increased expression of WT1 mRNA14646600|2193413
D014212TretinoinTretinoin results in increased expression of WT1 protein12644474
D014212TretinoinTretinoin results in decreased expression of WT1 protein15855632
D014212TretinoinTretinoin results in increased expression of WT1 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of WT1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased methylation of WT1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of WT1 mRNA28001369
D014638VanadatesVanadates results in decreased expression of WT1 mRNA22714537
D014810Vitamin EVitamin E affects the expression of WT1 mRNA15370891

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0003700DNA-binding transcription factor activity-NAS7862533  8393820  
GO:0003723RNA binding-IEA-  
GO:0005515protein binding-IPI7720589  8119964  9178767  9553041  14701728  16934801  
21390327  25416956  
GO:0008270zinc ion binding-IDA15518539  25258363  
GO:0010385double-stranded methylated DNA binding-IDA25258363  
GO:0043565sequence-specific DNA binding-IDA1662794  7720589  8119964  25258363  
GO:0044212transcription regulatory region DNA binding-IDA1332065  7585606  7588596  9815658  16467207  
GO:0044729hemi-methylated DNA-binding-IDA25258363  
GO:0070742C2H2 zinc finger domain binding-IPI8119964  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA7585606  
GO:0001570vasculogenesis-ISS-  
GO:0001657ureteric bud development-ISS-  
GO:0001658branching involved in ureteric bud morphogenesis-IGI10101119  
GO:0001822kidney development-IGI11912180  
GO:0003156regulation of animal organ formation-ISS-  
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0006355regulation of transcription, DNA-templated-NAS7862533  8393820  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-ISS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007281germ cell development-ISS-  
GO:0007356thorax and anterior abdomen determination-ISS-  
GO:0007507heart development-IGI10101119  
GO:0007530sex determination-IDA9815658  
GO:0008285negative regulation of cell proliferation-IBA21873635  
GO:0008285negative regulation of cell proliferation-IDA9553041  9765217  
GO:0008380RNA splicing-ISS-  
GO:0008406gonad development-ISS-  
GO:0008584male gonad development-IEP17848411  
GO:0009888tissue development-ISS-  
GO:0030308negative regulation of cell growth-IDA9553041  9765217  
GO:0030325adrenal gland development-IGI10101119  
GO:0030539male genitalia development-ISS-  
GO:0030855epithelial cell differentiation-ISS-  
GO:0032835glomerulus development-IGI10101119  
GO:0032836glomerular basement membrane development-IMP19205749  
GO:0035802adrenal cortex formation-ISS-  
GO:0043010camera-type eye development-ISS-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IGI10101119  
GO:0045892negative regulation of transcription, DNA-templated-IDA1332065  7585606  7720589  8119964  12802290  14701728  19050011  
GO:0045893positive regulation of transcription, DNA-templated-IDA8132626  9178767  9553041  9765217  12802290  14701728  16467207  21390327  
GO:0045893positive regulation of transcription, DNA-templated-IGI11912180  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0060231mesenchymal to epithelial transition-ISS-  
GO:0060421positive regulation of heart growth-ISS-  
GO:0060539diaphragm development-ISS-  
GO:0060923cardiac muscle cell fate commitment-ISS-  
GO:0061032visceral serous pericardium development-IGI10101119  
GO:0071320cellular response to cAMP-IBA21873635  
GO:0071320cellular response to cAMP-IEP15961562  
GO:0071371cellular response to gonadotropin stimulus-IBA21873635  
GO:0071371cellular response to gonadotropin stimulus-IDA15961562  
GO:0072075metanephric mesenchyme development-ISS-  
GO:0072112glomerular visceral epithelial cell differentiation-IBA21873635  
GO:0072112glomerular visceral epithelial cell differentiation-ISS-  
GO:0072166posterior mesonephric tubule development-ISS-  
GO:0072207metanephric epithelium development-IEP7856737  
GO:0072284metanephric S-shaped body morphogenesis-IGI10101119  
GO:0072302negative regulation of metanephric glomerular mesangial cell proliferation-ISS-  
GO:2000020positive regulation of male gonad development-ISS-  
GO:2000195negative regulation of female gonad development-ISS-  
GO:2001076positive regulation of metanephric ureteric bud development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA1662794  7588596  8306891  14701728  15961562  16934801  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0016607nuclear speck-IDA9553041  16934801  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
22199344Clinical significance of hypermethylation status in NSCLC: evaluation of a 30-gene panel in patients with advanced disease. (2011 Dec)Pesek MAnticancer Res
9263533Microsatellite instability in lung cancer patients 40 years of age or younger. (1997 Jun)Sekine IJpn J Cancer Res
22962272DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. (2012 Nov 15)Nikolaidis GCancer Res