Gene info: ID 7490

Gene: WT1

GENE ID: 7490

Synonyms: AWT1|GUD|NPHS4|WAGR|WIT-2|WT33

Description: Wilms tumor 1

Gene type: protein-coding

Location: 11p13

dbXrefs: Ensembl:ENSG00000184937 MIM:607102 Vega:OTTHUMG00000039556 UniprotKB:P19544

RefSeq: NG_009272.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.817e-1 (AD) 7.916e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg22533573	chr11:32452771	WT1		1.700e-11	Smoking	27651444
cg05222924	chr11:32450486	WT1		4.900e-10	Smoking	27651444
cg19211915	chr11:32452513	WT1		1.900e-9	Smoking	27651444
cg21769619	chr11:32454768	WT1		1.400e-8	Smoking	27651444
cg08787968	chr11:32451777	WT1		9.000e-8	Smoking	27651444
cg20204986	chr11:32448067	WT1		7.500e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DRD3	0.875
GPR101	0.875
ENTHD1	0.873
SAG	0.868
DGKK	0.853
AMBN	0.853
TMPRSS6	0.848
GPR1	0.838
CHAT	0.837
ZBED2	0.824

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC17A7	-0.366
SYTL2	-0.333
NANOS3	-0.323
GALNT9	-0.323
NEUROD2	-0.302
SOHLH1	-0.291
MEIS3	-0.277
ZBTB7C	-0.269
TNNT2	-0.263
FUT1	-0.261

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of WT1 mRNA"	22101062
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of WT1 mRNA"	20453058
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WT1 mRNA	19933214
C021296	2-ethoxyethanol	2-ethoxyethanol results in increased expression of WT1 mRNA	19643169
D019342	Acetic Acid	Acetic Acid results in increased expression of WT1 protein	21296659
C526957	alisol B 23-acetate	alisol B 23-acetate inhibits the reaction [AGT protein results in decreased expression of WT1 protein]	28578904
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of WT1 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of WT1 mRNA	16966277\|2047151
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of WT1 protein	16966277
C006632	arsenic trioxide	arsenic trioxide results in increased expression of WT1 mRNA	11940349
C015001	arsenite	arsenite results in increased methylation of WT1 promoter	23974009
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of WT1 mRNA"	22251266
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of WT1 mRNA"	23917077
C547126	AZM551248	AZM551248 results in increased expression of WT1 mRNA	22323515
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of WT1 mRNA	26377693
D001564	Benzo(a)pyrene	AHR affects the reaction [Benzo(a)pyrene affects the splicing of WT1 mRNA]	21803694
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the splicing of WT1 mRNA	21803694
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the splicing of WT1 mRNA	19530133
C038328	BEP protocol	BEP protocol results in increased expression of WT1 mRNA	18987330
D004958	Estradiol	WT1 protein results in decreased susceptibility to Estradiol	20204298
D004958	Estradiol	Estradiol results in increased expression of WT1 mRNA	21632026
C034786	bis(4-hydroxycinnamoyl)methane	bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 mRNA	18034345
C034786	bis(4-hydroxycinnamoyl)methane	bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 protein	18034345
C006780	bisphenol A	bisphenol A results in increased expression of WT1 mRNA	21632026
C006780	bisphenol A	bisphenol A affects the methylation of WT1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of WT1 mRNA	25434310
C006780	bisphenol A	bisphenol A results in decreased expression of WT1 protein	25434310
C006780	bisphenol A	bisphenol A results in increased expression of WT1 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of WT1 mRNA	20471514\|2097792
D000069286	Bortezomib	Bortezomib results in decreased expression of WT1 protein	17629554
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of WT1 protein	21296659
D002220	Carbamazepine	Carbamazepine affects the expression of WT1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of WT1 mRNA	17484886
D002330	Carmustine	WT1 results in decreased susceptibility to Carmustine	20820871
D002737	Chloroprene	Chloroprene results in decreased expression of WT1 mRNA	23125180
C031180	chrysene	chrysene results in increased expression of WT1 mRNA	26377693
C018021	cobaltous chloride	[cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNA	12738801
D005576	Colforsin	Colforsin results in increased expression of WT1 mRNA	15961562
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of WT1 mRNA	20971185
D003474	Curcumin	Curcumin results in decreased expression of WT1 mRNA	18034345\|1919650
D003474	Curcumin	Curcumin results in decreased expression of WT1 protein	18034345\|1919650
D003676	Deferoxamine	[cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNA	12738801
C050229	demethoxycurcumin	demethoxycurcumin results in decreased expression of WT1 mRNA	18034345
C050229	demethoxycurcumin	demethoxycurcumin results in decreased expression of WT1 protein	18034345
D003907	Dexamethasone	Dexamethasone results in increased expression of WT1 mRNA	22733784
D003976	Diazinon	Diazinon affects the expression of WT1 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of WT1 mRNA	25434310
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of WT1 protein	25434310
D002945	Cisplatin	WT1 results in decreased susceptibility to Cisplatin	20820871
D004026	Dieldrin	Dieldrin affects the expression of WT1 mRNA	22546817
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of WT1 mRNA	25031359
D004237	Diuron	Diuron results in decreased expression of WT1 mRNA	21551480\|2515243
D004726	Endosulfan	Endosulfan results in decreased expression of WT1 mRNA	22307005
D004726	Endosulfan	[Flutamide co-treated with Endosulfan] results in decreased expression of WT1 mRNA	22307005
C015860	ergosta-4,6,8(14),22-tetraen-3-one	"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein]"	28578904
D015025	Zearalenone	Zearalenone results in decreased expression of WT1 mRNA	24412631
D005419	Flavonoids	Flavonoids results in decreased expression of WT1 mRNA	18035473
D005472	Fluorouracil	Fluorouracil results in decreased expression of WT1 protein	21296659
D005485	Flutamide	[Flutamide co-treated with Endosulfan] results in decreased expression of WT1 mRNA	22307005
D005485	Flutamide	Flutamide results in decreased expression of WT1 mRNA	22307005
D005557	Formaldehyde	Formaldehyde results in increased expression of WT1 mRNA	12679049
C070081	fulvestrant	WT1 protein results in decreased susceptibility to fulvestrant	20204298
C039281	furan	furan results in increased expression of WT1 mRNA	27387713
D019833	Genistein	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of WT1 mRNA	25031359
D005839	Gentamicins	Gentamicins results in decreased expression of WT1 mRNA	22061828
D017313	Fenretinide	Fenretinide results in increased expression of WT1 mRNA	28973697
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in decreased expression of WT1 protein]	28578904
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of WT1 mRNA	15329907
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of WT1 mRNA"	26377693
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of WT1 mRNA	24435446\|2479639
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]	28578904
D008345	Manganese	Manganese results in decreased expression of WT1 mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of WT1 mRNA	17175027
D015122	Mercaptopurine	Mercaptopurine results in increased expression of WT1 mRNA	23358152
C005219	methyl cellosolve	methyl cellosolve results in increased expression of WT1 mRNA	19643169
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of WT1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of WT1 mRNA"	25554681
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of WT1 mRNA	12729255
D009569	Nitric Oxide	[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA	21443142
D009569	Nitric Oxide	Nitric Oxide results in increased expression of WT1 mRNA	21443142
C007350	nitrofen	nitrofen results in decreased expression of WT1 mRNA	21072664
C007350	nitrofen	nitrofen results in decreased expression of WT1 protein	21072664
D009599	Nitroprusside	[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA	21443142
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of WT1 mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in decreased expression of WT1 mRNA	17175027
D010100	Oxygen	Oxygen deficiency results in increased expression of WT1 mRNA	12738801
C102487	pachymic acid	pachymic acid analog inhibits the reaction [AGT protein results in decreased expression of WT1 protein]	28578904
D010269	Paraquat	Paraquat results in increased expression of WT1 mRNA	16797015
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of WT1 mRNA	20580666
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of WT1 protein	20580666
D015232	Dinoprostone	Dinoprostone inhibits the reaction [WT1 protein binds to CYP19A1 promoter]	19001523
D015232	Dinoprostone	Dinoprostone inhibits the reaction [WT1 protein binds to STAR promoter]	19001523
D010936	Plant Extracts	Plant Extracts results in decreased expression of WT1 mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of WT1 mRNA	23608068
D011374	Progesterone	Progesterone results in increased expression of WT1 mRNA	14662165
D011374	Progesterone	Progesterone results in increased expression of WT1 mRNA alternative form	14662165
D011374	Progesterone	Progesterone results in increased expression of WT1 protein	14662165
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium results in increased expression of WT1 mRNA	21443142
D020123	Sirolimus	Sirolimus results in decreased expression of WT1 mRNA	18927120
D020123	Sirolimus	Sirolimus results in decreased expression of WT1 protein	18927120
D020123	Sirolimus	Sirolimus results in decreased expression of WT1 protein mutant form	15782132
C017947	sodium arsenite	MIR191 mRNA promotes the reaction [sodium arsenite results in increased expression of WT1 protein]	29277653
C017947	sodium arsenite	sodium arsenite results in decreased expression of WT1 mRNA	16966277
C017947	sodium arsenite	sodium arsenite results in decreased expression of WT1 protein	16966277
C017947	sodium arsenite	sodium arsenite results in increased expression of WT1 mRNA	12016162
C017947	sodium arsenite	sodium arsenite results in increased expression of WT1 protein	29277653
C017947	sodium arsenite	sodium arsenite affects the expression of WT1 mRNA	23137061
C017947	sodium arsenite	sodium arsenite results in increased expression of WT1 mRNA	11241755\|1687621
C017947	sodium arsenite	sodium arsenite results in increased expression of WT1 protein	16876216
D053260	Soot	Soot results in decreased expression of WT1 mRNA	26551751
D019311	Staurosporine	Staurosporine results in increased expression of WT1 protein	12914969
D013629	Tamoxifen	WT1 protein results in decreased susceptibility to Tamoxifen	20204298\|2094414
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of WT1 mRNA	19933214\|2405805
D014212	Tretinoin	PDCD4 protein promotes the reaction [Tretinoin results in decreased expression of WT1 protein]	17259349
D014212	Tretinoin	Tretinoin results in decreased expression of WT1 mRNA	15749674\|1577063
D014212	Tretinoin	Tretinoin results in decreased expression of WT1 mRNA alternative form	15749674
D014212	Tretinoin	Tretinoin results in decreased expression of WT1 protein	15770638
D014212	Tretinoin	Tretinoin results in increased expression of WT1 mRNA	14646600\|2193413
D014212	Tretinoin	Tretinoin results in increased expression of WT1 protein	12644474
D014212	Tretinoin	Tretinoin results in decreased expression of WT1 protein	15855632
D014212	Tretinoin	Tretinoin results in increased expression of WT1 mRNA	16604517
C012589	trichostatin A	trichostatin A results in increased expression of WT1 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in decreased methylation of WT1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of WT1 mRNA	28001369
D014638	Vanadates	Vanadates results in decreased expression of WT1 mRNA	22714537
D014810	Vitamin E	Vitamin E affects the expression of WT1 mRNA	15370891

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0003700	DNA-binding transcription factor activity	-	ISS	-
GO:0003700	DNA-binding transcription factor activity	-	NAS	7862533 8393820
GO:0003723	RNA binding	-	IEA	-
GO:0005515	protein binding	-	IPI	7720589 8119964 9178767 9553041 14701728 16934801 21390327 25416956
GO:0008270	zinc ion binding	-	IDA	15518539 25258363
GO:0010385	double-stranded methylated DNA binding	-	IDA	25258363
GO:0043565	sequence-specific DNA binding	-	IDA	1662794 7720589 8119964 25258363
GO:0044212	transcription regulatory region DNA binding	-	IDA	1332065 7585606 7588596 9815658 16467207
GO:0044729	hemi-methylated DNA-binding	-	IDA	25258363
GO:0070742	C2H2 zinc finger domain binding	-	IPI	8119964

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	7585606
GO:0001570	vasculogenesis	-	ISS	-
GO:0001657	ureteric bud development	-	ISS	-
GO:0001658	branching involved in ureteric bud morphogenesis	-	IGI	10101119
GO:0001822	kidney development	-	IGI	11912180
GO:0003156	regulation of animal organ formation	-	ISS	-
GO:0006355	regulation of transcription, DNA-templated	-	ISS	-
GO:0006355	regulation of transcription, DNA-templated	-	NAS	7862533 8393820
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0006357	regulation of transcription by RNA polymerase II	-	ISS	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007281	germ cell development	-	ISS	-
GO:0007356	thorax and anterior abdomen determination	-	ISS	-
GO:0007507	heart development	-	IGI	10101119
GO:0007530	sex determination	-	IDA	9815658
GO:0008285	negative regulation of cell proliferation	-	IBA	21873635
GO:0008285	negative regulation of cell proliferation	-	IDA	9553041 9765217
GO:0008380	RNA splicing	-	ISS	-
GO:0008406	gonad development	-	ISS	-
GO:0008584	male gonad development	-	IEP	17848411
GO:0009888	tissue development	-	ISS	-
GO:0030308	negative regulation of cell growth	-	IDA	9553041 9765217
GO:0030325	adrenal gland development	-	IGI	10101119
GO:0030539	male genitalia development	-	ISS	-
GO:0030855	epithelial cell differentiation	-	ISS	-
GO:0032835	glomerulus development	-	IGI	10101119
GO:0032836	glomerular basement membrane development	-	IMP	19205749
GO:0035802	adrenal cortex formation	-	ISS	-
GO:0043010	camera-type eye development	-	ISS	-
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IGI	10101119
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	1332065 7585606 7720589 8119964 12802290 14701728 19050011
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	8132626 9178767 9553041 9765217 12802290 14701728 16467207 21390327
GO:0045893	positive regulation of transcription, DNA-templated	-	IGI	11912180
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0060231	mesenchymal to epithelial transition	-	ISS	-
GO:0060421	positive regulation of heart growth	-	ISS	-
GO:0060539	diaphragm development	-	ISS	-
GO:0060923	cardiac muscle cell fate commitment	-	ISS	-
GO:0061032	visceral serous pericardium development	-	IGI	10101119
GO:0071320	cellular response to cAMP	-	IBA	21873635
GO:0071320	cellular response to cAMP	-	IEP	15961562
GO:0071371	cellular response to gonadotropin stimulus	-	IBA	21873635
GO:0071371	cellular response to gonadotropin stimulus	-	IDA	15961562
GO:0072075	metanephric mesenchyme development	-	ISS	-
GO:0072112	glomerular visceral epithelial cell differentiation	-	IBA	21873635
GO:0072112	glomerular visceral epithelial cell differentiation	-	ISS	-
GO:0072166	posterior mesonephric tubule development	-	ISS	-
GO:0072207	metanephric epithelium development	-	IEP	7856737
GO:0072284	metanephric S-shaped body morphogenesis	-	IGI	10101119
GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	-	ISS	-
GO:2000020	positive regulation of male gonad development	-	ISS	-
GO:2000195	negative regulation of female gonad development	-	ISS	-
GO:2001076	positive regulation of metanephric ureteric bud development	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	1662794 7588596 8306891 14701728 15961562 16934801
GO:0005654	nucleoplasm	-	IDA	-
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	ISS	-
GO:0005829	cytosol	-	IDA	-
GO:0016607	nuclear speck	-	IDA	9553041 16934801

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28592245	In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)	El-Aarag SA	BMC Med Genomics
22199344	Clinical significance of hypermethylation status in NSCLC: evaluation of a 30-gene panel in patients with advanced disease. (2011 Dec)	Pesek M	Anticancer Res
9263533	Microsatellite instability in lung cancer patients 40 years of age or younger. (1997 Jun)	Sekine I	Jpn J Cancer Res
22962272	DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. (2012 Nov 15)	Nikolaidis G	Cancer Res