Gene: XBP1

7494
TREB-5|TREB5|XBP-1|XBP2
X-box binding protein 1
protein-coding
22q12.1|22q12
Ensembl:ENSG00000100219 MIM:194355 Vega:OTTHUMG00000151094 UniprotKB:P17861
NG_012266.1
PubMed
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.217e-1 (AD)  1.690e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA50.872
DNAJB110.862
TARS0.859
PDIA60.852
MANF0.85
NFIL30.844
CHIC20.837
ZNF4100.828
SESN20.819
CEBPG0.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.464
OR4F29-0.432
SNX22-0.346
HES5-0.315
ALDH1L1-AS2-0.271
REM1-0.267
RERGL-0.254
TCL1A-0.253
GPR17-0.252
P2RY14-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form"24515801
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]"24515801
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"NR4A1 protein inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]"24515801
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased expression of XBP1 protein23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein]23576437
C4630401-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole"1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA"21525939
C4630401-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole"gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]"21525939
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of XBP1 mRNA"26377693
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester results in increased splicing of XBP1 mRNA"25324550
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone affects the activity of XBP1 protein25596134
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of XBP1 mRNA25596134
C5277421-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone"1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased splicing of XBP1 mRNA]"28962527
C5602961,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one"1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one results in increased expression of XBP1 mRNA"21504179
C5602961,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one"1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one results in increased expression of XBP1 protein"21504179
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of XBP1 mRNA]25827057
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of XBP1 protein]25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XBP1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of XBP1 mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XBP1 mRNA"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XBP1 mRNA modified form"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XBP1 mRNA modified form]"22543052
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of XBP1 mRNA"25950987
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased splicing of XBP1 mRNA"27853103
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased splicing of XBP1 mRNA"25160872|2785310
C0261142-xylene2-xylene results in increased expression of XBP1 mRNA20359517
C0328923,5-dibromosalicylaldehyde"3,5-dibromosalicylaldehyde analog inhibits the reaction [Quercetin results in increased splicing of XBP1 mRNA]"25611565
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of XBP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of XBP1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of XBP1 mRNA"19561079
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of XBP1 mRNA alternative form"19561079
C0267294-aminophenol4-aminophenol results in increased expression of XBP1 mRNA17567590
C0267294-aminophenol4-aminophenol results in increased expression of XBP1 protein17567590|1756759
C0267294-aminophenolPD 150606 inhibits the reaction [4-aminophenol results in increased expression of XBP1 protein]17567592
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased splicing of XBP1 mRNA24291486
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of XBP1 mRNA alternative form23883479
C0248364-nitrophenol4-nitrophenol results in increased expression of XBP1 mRNA23997041
C0248364-nitrophenolQuercetin inhibits the reaction [4-nitrophenol results in increased expression of XBP1 mRNA]23997041
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]28245985
C0757734-phenylbutyric acid4-phenylbutyric acid affects the reaction [LEPR gene mutant form affects the splicing of XBP1 mRNA]23274897
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]27578021
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of XBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of XBP1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of XBP1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of XBP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XBP1 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased splicing of XBP1 mRNA]27511942
D000111AcetylcysteineAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]]21138464
D000111AcetylcysteineAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]21138464
D000111AcetylcysteineAcetylcysteine results in increased splicing of XBP1 mRNA19722195
D000111AcetylcysteineAcetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]25451595
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein alternative form]21911445
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of XBP1 protein]21145380
D000171AcroleinAcrolein affects the splicing of XBP1 mRNA18951912
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of XBP1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of XBP1 mRNA27153756
C430898AGN 194204AGN 194204 results in increased expression of XBP1 mRNA16339527
D000393Air PollutantsAir Pollutants analog results in decreased expression of XBP1 mRNA21757418
C518327aloe emodinaloe emodin results in increased splicing of XBP1 mRNA22210228
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of XBP1 mRNA28522335
D024502alpha-Tocopherolalpha-Tocopherol analog results in increased expression of XBP1 mRNA20686688
C103505AM 251AM 251 results in increased expression of XBP1 mRNA16500647
D000584AmilorideAmiloride inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]20015086
D006710HomocysteineGlycine affects the reaction [Homocysteine results in increased splicing of XBP1 mRNA]27064126
D006710HomocysteineHomocysteine results in decreased expression of XBP1 protein22964297
D006710HomocysteineHomocysteine results in increased expression of XBP1 mRNA alternative form19960509
D006710HomocysteineHomocysteine results in increased splicing of XBP1 mRNA27064126
D000638AmiodaroneAmiodarone results in increased expression of XBP1 mRNA19774075
D000638Amiodarone"1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased splicing of XBP1 mRNA]"28962527
D000638AmiodaroneAmiodarone affects the localization of XBP1 protein28962527
D000638AmiodaroneAmiodarone results in increased splicing of XBP1 mRNA28962527
D000638AmiodaroneDDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased splicing of XBP1 mRNA]28962527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of XBP1 mRNA16483693
D000841AnisomycinAnisomycin results in decreased splicing of XBP1 mRNA25324550
D000968Antimycin AAntimycin A results in increased expression of XBP1 protein21337367
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of XBP1 mRNA24449571
C119324arachidonylcyclopropylamidearachidonylcyclopropylamide results in increased expression of XBP1 mRNA21525939
C119324arachidonylcyclopropylamidegemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]21525939
C000228aristolochic acid Iaristolochic acid I results in increased splicing of XBP1 mRNA22445861
C006632arsenic trioxideAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]]21138464
C006632arsenic trioxidearsenic trioxide results in increased expression of XBP1 mRNA22959511
C006632arsenic trioxidearsenic trioxide results in increased expression of XBP1 mRNA alternative form23883479
C006632arsenic trioxidearsenic trioxide results in increased expression of XBP1 protein22959511
C006632arsenic trioxidearsenic trioxide results in increased splicing of XBP1 mRNA22922937
C006632arsenic trioxidesulforafan promotes the reaction [arsenic trioxide results in increased splicing of XBP1 mRNA]22922937
C006632arsenic trioxideXBP1 protein inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]21138464
C006632arsenic trioxidearsenic trioxide results in increased expression of XBP1 mRNA24157283
C006632arsenic trioxidearsenic trioxide results in increased expression of XBP1 protein24157283
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of XBP1 protein]21145380
C006632arsenic trioxidearsenic trioxide results in increased expression of XBP1 protein21145380
C015001arsenitearsenite results in increased splicing of XBP1 mRNA22215663
C015001arseniteSirolimus inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]22215663
C015001arseniteSLC38A2 mutant form inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]22215663
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of and affects the splicing of XBP1 mRNA"23885834
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of XBP1 protein alternative form"23885834
D017639Asbestos, Amosite"BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of XBP1 protein alternative form]"23885834
D001280AtrazineAtrazine results in increased expression of XBP1 mRNA22378314
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XBP1 mRNA27858113
D001554BenzeneBenzene results in increased expression of XBP1 mRNA20359517
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XBP1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of XBP1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of XBP1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XBP1 mRNA21632981
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XBP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of XBP1 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of XBP1 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein]25568320
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeXBP1 protein results in decreased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde19135031
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]20068169
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]25721606
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]25721606
D004958EstradiolEstradiol results in increased expression of XBP1 mRNA14605097|2006816
D004958Estradiol(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]]25721606
D004958Estradiol(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]]25721606
D004958Estradiol(+)-JQ1 compound inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA]25721606
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]]20068169
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA]20068169
C095105bexarotenebexarotene results in decreased expression of XBP1 mRNA17178900
D001663BilirubinBilirubin results in increased expression of XBP1 mRNA27578021
D001663Bilirubin4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]27578021
C006780bisphenol Abisphenol A affects the methylation of XBP1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of XBP1 mRNA28938450
C006780bisphenol Abisphenol A affects the expression of XBP1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of XBP1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of XBP1 mRNA21601586
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of XBP1 mRNA22434021
C032688boric acidboric acid results in increased expression of XBP1 mRNA27587023
D000069286BortezomibBortezomib inhibits the reaction [Brefeldin A results in increased activity of XBP1 protein]18723477
D000069286BortezomibBortezomib results in increased activity of XBP1 protein18723477
D020126Brefeldin ABortezomib inhibits the reaction [Brefeldin A results in increased activity of XBP1 protein]18723477
D020126Brefeldin ABrefeldin A results in increased activity of XBP1 protein18723477
D020126Brefeldin ABrefeldin A results in increased expression of XBP1 protein27358234
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of XBP1 mRNA22079614
D016642BupropionBupropion results in decreased splicing of XBP1 mRNA21354251
C018475butyraldehydebutyraldehyde results in decreased expression of XBP1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of XBP1 mRNA26191083
D002101Cacodylic AcidCacodylic Acid results in increased expression of XBP1 mRNA23221991
D002101Cacodylic AcidCacodylic Acid results in increased expression of XBP1 mRNA alternative form23221991
D002104CadmiumCadmium results in increased activity of XBP1 protein20600546
D019256Cadmium ChlorideCadmium Chloride affects the activity of XBP1 protein25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of XBP1 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of XBP1 mRNA alternative form19426795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of XBP1 mRNA alternative form21908765
D019256Cadmium ChlorideCadmium Chloride results in increased splicing of XBP1 mRNA17588656
D019256Cadmium ChloridePhenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 mRNA alternative form]21908765
D019256Cadmium Chloride[lead chloride co-treated with Cadmium Chloride] results in increased expression of XBP1 mRNA25016106
D019256Cadmium ChlorideCadmium Chloride results in increased splicing of XBP1 mRNA17464326|1808666
D019256Cadmium ChlorideSOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]18086661
D019256Cadmium ChlorideXBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]18086661
D000001CalcimycinCalcimycin results in increased splicing of XBP1 mRNA19428936
D000001CalcimycinQuercetin inhibits the reaction [Calcimycin results in increased splicing of XBP1 mRNA]19428936
D002220CarbamazepineCarbamazepine affects the expression of XBP1 mRNA25979313
D012721CarbarylCarbaryl results in increased expression of XBP1 mRNA27829164
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of XBP1 mRNA]25827057
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of XBP1 protein]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of XBP1 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of XBP1 protein25827057
C054133casticincasticin results in increased expression of XBP1 mRNA27862857
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of XBP1 mRNA24763279
D012844Sincalide[Palmitic Acid co-treated with Sincalide] results in increased expression of XBP1 mRNA alternative form26873426
D012844Sincalide[Palmitic Acid co-treated with Sincalide] results in increased expression of XBP1 protein alternative form26873426
D012844SincalideQuercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of XBP1 protein alternative form]26873426
D002569CeruleninCerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]17283163
D002108CeruletideCeruletide results in increased expression of XBP1 mRNA alternative form26873426
D002108CeruletideCeruletide results in increased expression of XBP1 protein alternative form26873426
D002108CeruletideDietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]26873426
D002108CeruletideDietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]26873426
D002108CeruletideQuercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]26873426
D002108CeruletideQuercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]26873426
C004656chloroacetaldehydechloroacetaldehyde affects the activity of XBP1 protein25596134
C004656chloroacetaldehydechloroacetaldehyde affects the expression of XBP1 mRNA25596134
C006972chloroacetic acidAcetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]25451595
C006972chloroacetic acidchloroacetic acid results in increased expression of XBP1 mRNA alternative form25451595
C006972chloroacetic acidchloroacetic acid results in increased expression of XBP1 protein alternative form25451595
C100187chloropicrinchloropicrin affects the expression of XBP1 mRNA26352163
D002746ChlorpromazineChlorpromazine affects the activity of XBP1 protein25596134
D002746ChlorpromazineChlorpromazine results in decreased expression of XBP1 mRNA25596134
D004390ChlorpyrifosChlorpyrifos results in increased splicing of XBP1 mRNA27993609
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of XBP1 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XBP1 mRNA27858113
C059262cidofovircidofovir affects the activity of XBP1 protein25596134
C059262cidofovircidofovir results in increased expression of XBP1 mRNA25596134
D004002Clodronic AcidClodronic Acid affects the activity of XBP1 protein25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of XBP1 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of XBP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XBP1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of XBP1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of XBP1 protein21337367
D003042CocaineCocaine results in increased expression of XBP1 mRNA23644055
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of XBP1 mRNA20971185
C464760copper-1,10-phenanthroline"copper-1,10-phenanthroline results in increased expression of XBP1 protein"24638265
D019327Copper SulfateCopper Sulfate results in decreased expression of XBP1 mRNA19549813
D016572CyclosporineCyclosporine affects the activity of XBP1 protein25596134
D016572CyclosporineCyclosporine results in increased expression of XBP1 mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of and affects the localization of XBP1 protein modified form23958496
D016572CyclosporineCyclosporine results in increased expression of XBP1 mRNA25270620
D016572CyclosporineCyclosporine results in increased expression of XBP1 protein modified form23958496
D016572CyclosporineCyclosporine affects the activity of XBP1 protein25596134
D016572CyclosporineCyclosporine results in decreased expression of XBP1 mRNA25596134
D003603CytotoxinsCytotoxins results in increased splicing of XBP1 mRNA21147958
C515055darinaparsindarinaparsin results in increased expression of XBP1 protein22535156
C055818d,d-T80-prallethrin"d,d-T80-prallethrin results in increased activity of XBP1 protein"20143881
C007262deoxynivalenoldeoxynivalenol results in increased expression of XBP1 protein19336499
C007262deoxynivalenoldeoxynivalenol results in increased splicing of XBP1 mRNA19336499
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of XBP1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of XBP1 mRNA21266533
D002945CisplatinCisplatin affects the activity of XBP1 protein25596134
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of XBP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of XBP1 mRNA25596134
D002945CisplatinCisplatin results in increased expression of XBP1 mRNA19561079
D002945CisplatinCisplatin results in decreased expression of XBP1 mRNA21151649
D002945CisplatinCisplatin results in increased expression of XBP1 protein17567590
D004008DiclofenacDiclofenac results in increased expression of XBP1 mRNA26934552
D004041Dietary Fats[APOE protein affects the susceptibility to [Dietary Fats co-treated with Particulate Matter]] which affects the expression of XBP1 mRNA17655762
D004041Dietary FatsDietary Fats affects the splicing of XBP1 mRNA23106379
D004041Dietary FatsDietary Fats results in decreased expression of XBP1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of XBP1 protein modified form23576437
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of XBP1 protein22509299
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased splicing of XBP1 mRNA22509299
D004041Dietary FatsDietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]26873426
D004041Dietary FatsDietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]26873426
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of XBP1 mRNA18164116
D004237DiuronDiuron results in decreased expression of XBP1 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of XBP1 mRNA15205334
C042986ebselenebselen results in increased phosphorylation of XBP1 protein27282967
C118739entinostatentinostat results in increased expression of XBP1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of XBP1 mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of XBP1 mRNA20064776
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of XBP1 protein modified form24768708
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of XBP1 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of XBP1 mRNA21233418
D000431EthanolEthanol results in decreased splicing of XBP1 mRNA28119953
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of XBP1 mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XBP1 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XBP1 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XBP1 mRNA17942748
C004912ethylbenzeneethylbenzene results in increased expression of XBP1 mRNA20359517
D005031EthylenethioureaEthylenethiourea results in increased expression of XBP1 mRNA18801409
D005035Ethylmercury CompoundsAcetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased splicing of XBP1 mRNA]27511942
D005035Ethylmercury CompoundsEthylmercury Compounds results in increased splicing of XBP1 mRNA27511942
D015025ZearalenoneZearalenone results in increased expression of XBP1 mRNA28965971
D011345FenofibrateFenofibrate affects the activity of XBP1 protein25596134
D011345FenofibrateFenofibrate affects the activity of XBP1 protein25596134
D011345FenofibrateFenofibrate results in decreased expression of XBP1 mRNA25596134
D005459FluoridesFluorides affects the expression of XBP1 mRNA20709135
D005472FluorouracilFluorouracil results in increased expression of XBP1 mRNA15205334
D005485FlutamideFlutamide results in decreased expression of XBP1 mRNA21126777
D005485FlutamideFlutamide results in decreased expression of XBP1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of XBP1 gene20938992
D005632FructoseFructose affects the localization of XBP1 protein22698815
C039281furanfuran results in increased methylation of XBP1 gene22079235
C038958gadolinium chloridegadolinium chloride results in increased splicing of XBP1 mRNA21198628
C056507gemcitabine"gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]"21525939
C056507gemcitabinegemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]21525939
C056507gemcitabinegemcitabine promotes the reaction [rimonabant results in increased expression of XBP1 mRNA]21525939
D005839GentamicinsGentamicins results in increased expression of XBP1 mRNA17567590
D005839GentamicinsGentamicins results in increased expression of XBP1 protein17567590
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
D005944GlucosamineGlucosamine results in decreased splicing of XBP1 mRNA19383982
D005944GlucosamineGlucosamine results in increased expression of XBP1 mRNA20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
D005944GlucosamineGlucosamine results in increased expression of XBP1 mRNA20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
D005947GlucoseGlucose results in decreased expression of XBP1 mRNA17178593
D005947GlucoseGlucose deficiency results in increased expression of XBP1 protein21337367
D005947GlucoseGlucose results in decreased expression of XBP1 mRNA24349266
D005978Glutathione"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]"24515801
D005978GlutathioneGlutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form]24515801
D005998GlycineGlycine affects the reaction [Homocysteine results in increased splicing of XBP1 mRNA]27064126
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of XBP1 mRNA24763279
D017313FenretinideFenretinide results in increased splicing of XBP1 mRNA17353921
D017313FenretinideFenretinide results in decreased expression of XBP1 mRNA28973697
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]21138464
D006861Hydrogen PeroxideHydrogen Peroxide affects the splicing of XBP1 mRNA23885834
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of XBP1 protein alternative form23885834
D006861Hydrogen PeroxideXBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]21138464
D006861Hydrogen PeroxideXBP1 protein results in decreased susceptibility to Hydrogen Peroxide21138464
D007052IbuprofenIbuprofen affects the activity of XBP1 protein25596134
C492448ICG 001ICG 001 results in increased expression of XBP1 mRNA26191083
D007069IfosfamideIfosfamide affects the activity of XBP1 protein25596134
D007213IndomethacinIndomethacin results in increased activity of XBP1 protein15131590
D007213IndomethacinIndomethacin results in increased expression of XBP1 mRNA17401462
D007213IndomethacinIndomethacin results in increased expression of XBP1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of XBP1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of XBP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of XBP1 mRNA23086925|2479639
C067713lactacystinXBP1 protein results in decreased susceptibility to lactacystin19135031
D007811LanthanumLanthanum results in increased expression of XBP1 mRNA alternative form18773883
C029891lead chloride[lead chloride co-treated with Cadmium Chloride] results in increased expression of XBP1 mRNA25016106
C029891lead chloridelead chloride results in increased expression of XBP1 mRNA25016106
C045463leflunomideleflunomide results in increased expression of XBP1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of XBP1 protein alternative form28988120
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein alternative form]28245985
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of XBP1 protein alternative form28245985
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of XBP1 mRNA18483191|1967514
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of XBP1 protein14600275
D008070LipopolysaccharidesLipopolysaccharides results in increased splicing of XBP1 mRNA18483191
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 mRNA]18483191|1967514
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein]14600275
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased splicing of XBP1 mRNA]18483191
C025340manganese chloridemanganese chloride results in increased expression of and results in increased splicing of XBP1 mRNA23934647
C025340manganese chloridemanganese chloride results in increased splicing of XBP1 mRNA23948121
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased splicing of XBP1 mRNA]23934647
D008550MelatoninMelatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]28070110
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein]17645694
D008687MetforminMetformin affects the activity of XBP1 protein25596134
D008687MetforminMetformin affects the expression of XBP1 mRNA25596134
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 mRNA]27323860
D008694MethamphetamineATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 protein]27323860
D008694MethamphetamineMethamphetamine results in increased expression of XBP1 mRNA27323860
D008694MethamphetamineMethamphetamine results in increased expression of XBP1 protein27323860
D008694MethamphetamineMethamphetamine results in increased expression of XBP1 protein27323860
D008694MethamphetamineMelatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]28070110
D008694MethamphetamineMethamphetamine results in increased expression of and results in increased splicing of XBP1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of XBP1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of XBP1 mRNA alternative form28070110
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased splicing of XBP1 mRNA]19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of XBP1 gene20938992
D008752Methylene ChlorideMethylene Chloride results in increased expression of XBP1 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of XBP1 mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of XBP1 mRNA16966085
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of XBP1 mRNA24810058
D0156551-Methyl-4-phenylpyridiniumXBP1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium19135031
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"XBP1 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"19135031
C008493methylselenic acidmethylselenic acid results in increased splicing of XBP1 mRNA16205645|2816141
D008777MethyltestosteroneMethyltestosterone results in decreased expression of XBP1 mRNA29191790
C012258mevastatinTunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein]16330322
D008911MinocyclineMinocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein]22245251
C000604516MKC9989MKC9989 inhibits the reaction [Thapsigargin results in increased splicing of XBP1 mRNA]25164867
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of XBP1 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of XBP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of XBP1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased splicing of XBP1 mRNA27613715
C028007nickel monoxidenickel monoxide results in increased splicing of XBP1 mRNA28945320
D009538NicotineNicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]18477628
C063998nodularinnodularin results in increased expression of XBP1 mRNA alternative form27061667
D009638NorepinephrineNorepinephrine affects the localization of XBP1 protein16338971
D009638NorepinephrineCAT protein inhibits the reaction [Norepinephrine affects the localization of XBP1 protein]16338971
D009638NorepinephrineNGF protein inhibits the reaction [Norepinephrine affects the localization of XBP1 protein]16338971
C570897NSC668394NSC668394 results in increased expression of XBP1 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of XBP1 mRNA20971185
D019319Okadaic AcidOkadaic Acid results in increased expression of XBP1 protein26732598
C055122orlistatorlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]17283163
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of XBP1 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of XBP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of XBP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of XBP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of XBP1 mRNA]17655762
D010100OxygenOxygen deficiency affects the activity of XBP1 protein25596134
D010100OxygenOxygen deficiency results in decreased expression of XBP1 mRNA25596134
D010100OxygenOxygen deficiency results in increased expression of XBP1 protein21337367
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of XBP1 mRNA"23246600
D019308Palmitic Acid[Palmitic Acid co-treated with Sincalide] results in increased expression of XBP1 mRNA alternative form26873426
D019308Palmitic Acid[Palmitic Acid co-treated with Sincalide] results in increased expression of XBP1 protein alternative form26873426
D019308Palmitic AcidQuercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of XBP1 protein alternative form]26873426
D000073878Palm OilPalm Oil results in decreased expression of XBP1 mRNA18042831
D010269ParaquatMinocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein]22245251
D010269ParaquatParaquat results in increased expression of XBP1 protein22245251
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of XBP1 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of XBP1 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of XBP1 mRNA]17655762
D052638Particulate MatterParticulate Matter results in decreased expression of XBP1 mRNA22178795
D052638Particulate Matter[APOE protein affects the susceptibility to [Dietary Fats co-treated with Particulate Matter]] which affects the expression of XBP1 mRNA17655762
D052638Particulate MatterParticulate Matter results in increased expression of XBP1 mRNA23892126
D010365PatulinPatulin results in increased splicing of XBP1 mRNA21844328|2557719
C100442PD 150606PD 150606 inhibits the reaction [4-aminophenol results in increased expression of XBP1 protein]17567592
D010396PenicillaminePenicillamine results in increased splicing of XBP1 mRNA19722195
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of XBP1 mRNA19095052
D010433PentylenetetrazolePentylenetetrazole affects the expression of XBP1 mRNA21503142
C494474perchlorateperchlorate results in increased expression of XBP1 mRNA18801409
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of XBP1 mRNA18804290
D010578PetroleumPetroleum affects the expression of XBP1 mRNA25208076
C031181phenanthrenephenanthrene results in decreased expression of XBP1 mRNA20589742
D010634PhenobarbitalPhenobarbital affects the expression of XBP1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of XBP1 mRNA25270620
D010654PhenylbutyratesPhenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 mRNA alternative form]21908765
D010795Phthalic AcidsPhthalic Acids results in increased expression of XBP1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of XBP1 mRNA20813756|2381119
D011193Potassium IodidePotassium Iodide inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA]24231001
D011374ProgesteroneProgesterone results in increased expression of XBP1 mRNA18037150
D011718PyrazinamidePyrazinamide results in increased expression of XBP1 mRNA alternative form28063906
D011794Quercetin"3,5-dibromosalicylaldehyde analog inhibits the reaction [Quercetin results in increased splicing of XBP1 mRNA]"25611565
D011794QuercetinQuercetin inhibits the reaction [Calcimycin results in increased splicing of XBP1 mRNA]19428936
D011794QuercetinQuercetin results in decreased expression of XBP1 mRNA21632981
D011794QuercetinQuercetin results in increased splicing of XBP1 mRNA19017364|1942893
D011794Quercetin[Quercetin results in increased splicing of XBP1 mRNA] which results in increased expression of XBP1 protein alternative form19017364|1901736
D011794Quercetintauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased splicing of XBP1 mRNA]25611565
D011794QuercetinQuercetin inhibits the reaction [4-nitrophenol results in increased expression of XBP1 mRNA]23997041
D011794QuercetinQuercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]26873426
D011794QuercetinQuercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]26873426
D011794QuercetinQuercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of XBP1 protein alternative form]26873426
D017382Reactive Oxygen SpeciesAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]]21138464
D017382Reactive Oxygen SpeciesAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]21138464
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of XBP1 mRNA25800948
D017382Reactive Oxygen SpeciesXBP1 protein inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]21138464
D017382Reactive Oxygen SpeciesXBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]21138464
C059514resveratrolresveratrol results in increased splicing of XBP1 mRNA17914584|2019834
C059514resveratrol[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]21321189
C089032rimonabantgemcitabine promotes the reaction [rimonabant results in increased expression of XBP1 mRNA]21525939
C089032rimonabantrimonabant results in increased expression of XBP1 mRNA21525939
C089730rosiglitazonerosiglitazone affects the activity of XBP1 protein25596134
C089730rosiglitazonerosiglitazone results in increased activity of XBP1 protein20816668
C089730rosiglitazonerosiglitazone results in decreased expression of XBP1 mRNA25596134
C089730rosiglitazonerosiglitazone results in increased activity of XBP1 protein20816668
D012402RotenoneMIR384 mRNA promotes the reaction [Rotenone results in increased expression of XBP1 protein]26864693
D012402RotenoneRotenone results in increased expression of XBP1 protein26864693
D012402RotenoneRotenone results in decreased expression of XBP1 mRNA23186747
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased splicing of XBP1 mRNA]19564919
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased splicing of XBP1 mRNA"25324550
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased splicing of XBP1 mRNA"25324550
D020280SertralineSertraline results in increased splicing of XBP1 mRNA24865413
D012822Silicon Dioxide[Silicon Dioxide analog co-treated with Silver] results in increased splicing of XBP1 mRNA22245057
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of XBP1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased splicing of XBP1 mRNA22245057
D012834SilverSilver analog results in increased expression of and results in increased splicing of XBP1 mRNA23800688
D012834Silver[Silicon Dioxide analog co-treated with Silver] results in increased splicing of XBP1 mRNA22245057
D019821SimvastatinSimvastatin results in decreased expression of XBP1 protein18807172
D020123SirolimusSirolimus inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]22215663
C009277sodium arsenatesodium arsenate analog results in increased expression of XBP1 mRNA23221991
C009277sodium arsenatesodium arsenate analog results in increased expression of XBP1 mRNA alternative form23221991
C017947sodium arsenitesodium arsenite promotes the reaction [XBP1 protein binds to HIF1A protein]28973481
C017947sodium arsenitesodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to ACE enhancer]28973481
C017947sodium arsenitesodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to AGT enhancer]28973481
C017947sodium arsenitesodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to AGTR1 enhancer]28973481
C017947sodium arsenitesodium arsenite results in decreased expression of XBP1 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased splicing of XBP1 mRNA28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of ACE mRNA]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of AGT mRNA]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of and results in increased secretion of AGT protein modified form]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of HIF1A protein]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of SELE protein]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased secretion of CCL2 protein]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased secretion of CXCL8 protein]28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased secretion of ICAM1 protein]28973481
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein alternative form]21911445
C017947sodium arsenitesodium arsenite affects the localization of XBP1 protein21911445
C017947sodium arsenitesodium arsenite affects the splicing of XBP1 mRNA21911445
C017947sodium arsenitesodium arsenite results in decreased expression of XBP1 mRNA19822182
C017947sodium arsenitesodium arsenite results in increased expression of XBP1 mRNA23221991
C017947sodium arsenitesodium arsenite results in increased expression of XBP1 mRNA alternative form23221991
C017947sodium arsenitesodium arsenite results in increased expression of XBP1 protein alternative form21911445
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein]17645694
C017947sodium arsenitesodium arsenite results in increased expression of XBP1 protein17645694|1768157
D012969Sodium FluoridePotassium Iodide inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA]24231001
D012969Sodium FluorideSodium Fluoride results in increased splicing of XBP1 mRNA24231001
D012969Sodium FluorideSodium Fluoride results in increased expression of XBP1 mRNA21626649
D012969Sodium FluorideSodium Fluoride results in increased expression of XBP1 protein21626649
D012969Sodium FluorideSodium Fluoride affects the expression of XBP1 mRNA25132241
D012969Sodium FluorideSodium Fluoride results in decreased expression of XBP1 protein modified form18696052
D018038Sodium SeleniteSodium Selenite results in increased expression of XBP1 mRNA18175754
C471405sorafenibsorafenib results in increased splicing of XBP1 mRNA17548474
C559087SR 1078SR 1078 results in increased splicing of XBP1 mRNA28698385
C016766sulforafansulforafan promotes the reaction [arsenic trioxide results in increased splicing of XBP1 mRNA]22922937
D013467SulindacSulindac results in increased expression of XBP1 mRNA11906190
D016559TacrolimusTacrolimus results in increased expression of and affects the localization of XBP1 protein modified form23958496
D016559TacrolimusTacrolimus results in increased expression of XBP1 mRNA25270620
C061133tamibarotenetamibarotene results in increased expression of XBP1 mRNA17229644
D013629TamoxifenTamoxifen affects the expression of XBP1 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased splicing of XBP1 mRNA]25611565
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]20165829
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide affects the expression of XBP1 mRNA19208803
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased splicing of XBP1 mRNA28823167
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XBP1 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XBP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 mRNA]18483191|1967514
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of XBP1 protein]14600275
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased splicing of XBP1 mRNA]18483191
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to XBP1 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of XBP1 mRNA17942748|2081990
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of XBP1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased activity of XBP1 protein15131590
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein]23576437
D019284ThapsigarginBCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein alternative form]23885834
D019284ThapsigarginMKC9989 inhibits the reaction [Thapsigargin results in increased splicing of XBP1 mRNA]25164867
D019284ThapsigarginThapsigargin affects the splicing of XBP1 mRNA23885834
D019284ThapsigarginThapsigargin results in increased activity of XBP1 protein20816668|2338308
D019284ThapsigarginThapsigargin results in increased expression of XBP1 mRNA22378314|2758702
D019284ThapsigarginThapsigargin results in increased expression of XBP1 mRNA alternative form18773883|2528977
D019284ThapsigarginThapsigargin results in increased expression of XBP1 protein23576437|2735823
D019284ThapsigarginThapsigargin results in increased splicing of XBP1 mRNA17353921|1942893
D019284ThapsigarginXBP1 protein results in decreased susceptibility to Thapsigargin19135031
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein]23576437
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of XBP1 mRNA]22509299
D019284ThapsigarginThapsigargin results in increased expression of XBP1 mRNA22509299
D019284ThapsigarginThapsigargin results in increased expression of XBP1 protein20589738|2357643
D019284ThapsigarginThapsigargin results in increased splicing of XBP1 mRNA25324550
D019284ThapsigarginXBP1 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of SIRT7 mRNA]24210820
D019284ThapsigarginXBP1 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of SIRT7 protein]24210820
D019284ThapsigarginThapsigargin affects the localization of XBP1 protein16338971
D019284ThapsigarginThapsigargin results in increased splicing of XBP1 mRNA18477628|2463803
C009495titanium dioxidetitanium dioxide results in increased expression of XBP1 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of XBP1 protein25568320
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased splicing of XBP1 mRNA25568320
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of XBP1 mRNA28065790
D014028Tobacco Smoke Pollution[XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
D014028Tobacco Smoke Pollution[XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein]25568320
D014028Tobacco Smoke PollutionXBP1 protein results in decreased susceptibility to Tobacco Smoke Pollution analog25568320
D014050TolueneToluene results in increased expression of XBP1 mRNA20359517
D014212TretinoinMGAT5 protein inhibits the reaction [Tretinoin results in increased expression of XBP1 protein alternative form]17031849
D014212TretinoinTretinoin results in increased expression of XBP1 mRNA alternative form19960509
D014212TretinoinTretinoin results in increased expression of XBP1 protein alternative form17031849
D014212TretinoinTretinoin results in increased expression of XBP1 mRNA22498432
D014212TretinoinTretinoin results in increased expression of XBP1 protein22498432
C011559tributyltintributyltin results in decreased expression of XBP1 mRNA25499138
C011559tributyltintributyltin results in increased splicing of XBP1 mRNA23743301
D014241TrichloroethyleneTrichloroethylene results in increased expression of XBP1 mRNA20359517
C012589trichostatin Atrichostatin A affects the expression of XBP1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of XBP1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of XBP1 mRNA25596134
C080163trovafloxacintrovafloxacin results in increased expression of XBP1 mRNA24136188
D014415TunicamycinSIRT7 protein inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]24210820
D014415TunicamycinTunicamycin results in increased expression of XBP1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of XBP1 protein22959463|2735823
D014415TunicamycinTunicamycin results in increased splicing of and results in increased expression of XBP1 mRNA alternative form24312631
D014415TunicamycinTunicamycin results in increased splicing of XBP1 mRNA19135031|2421082
D014415TunicamycinAmiloride inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]20015086
D014415Tunicamycin[resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]21321189
D014415TunicamycinTunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein]16330322
D014415TunicamycinTunicamycin results in increased expression of XBP1 mRNA22414386|2250929
D014415TunicamycinTunicamycin results in increased expression of XBP1 mRNA alternative form21321189
D014415TunicamycinTunicamycin results in increased splicing of XBP1 mRNA16330322|2001508
D014415TunicamycinNicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]18477628
D014415TunicamycinTunicamycin results in increased splicing of XBP1 mRNA18477628|2429148
D017974Uranium CompoundsUranium Compounds results in decreased expression of XBP1 mRNA19654044
D014520UrethaneUrethane results in decreased expression of XBP1 mRNA28818685
C073339usnic acidusnic acid results in increased splicing of XBP1 mRNA25870318
D014635Valproic AcidValproic Acid affects the expression of XBP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of XBP1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of XBP1 mRNA17292431
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of XBP1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of XBP1 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of XBP1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of XBP1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of XBP1 mRNA21126777
D014800VitalliumVitallium analog results in increased expression of XBP1 mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of XBP1 mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in increased splicing of XBP1 mRNA18086661
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of XBP1 mRNA"25208076
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of XBP1 mRNA"23246600
C009684withaferin Awithaferin A results in increased expression of XBP1 protein21266191
C009684withaferin Awithaferin A results in increased splicing of XBP1 mRNA21266191
C029659zearalenolzearalenol results in increased splicing of XBP1 mRNA26584763
D015034Zinc OxideZinc Oxide affects the expression of XBP1 mRNA28648595
D015034Zinc OxideZinc Oxide analog results in increased expression of XBP1 mRNA25680694

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001085RNA polymerase II transcription factor binding-IEA-  
GO:0001158enhancer sequence-specific DNA binding-IDA2196176  
GO:0003677DNA binding-TAS1718857  
GO:0003700DNA-binding transcription factor activity-IDA1903538  8657566  
GO:0005515protein binding-IPI20102225  24670641  
GO:0042802identical protein binding-IPI12805554  20102225  
GO:0046982protein heterodimerization activity-IDA1903538  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-ISS-  
GO:0001889liver development-ISS-  
GO:0001935endothelial cell proliferation-IEA-  
GO:0002639positive regulation of immunoglobulin production-IDA11460154  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0006511ubiquitin-dependent protein catabolic process-ISS-  
GO:0006633fatty acid biosynthetic process-TAS22013210  
GO:0006914autophagy-IEA-  
GO:0006955immune response-TAS22013210  
GO:0006990positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response-IBA21873635  
GO:0006990positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response-ISS-  
GO:0007517muscle organ development-IEA-  
GO:0008284positive regulation of cell proliferation-IDA25656649  
GO:0008284positive regulation of cell proliferation-IGI25656649  
GO:0010506regulation of autophagy-IEA-  
GO:0010832negative regulation of myotube differentiation-ISS-  
GO:0015031protein transport-IEA-  
GO:0030335positive regulation of cell migration-IDA25656649  
GO:0030968endoplasmic reticulum unfolded protein response-ISS-  
GO:0031017exocrine pancreas development-IEA-  
GO:0031648protein destabilization-IEA-  
GO:0031670cellular response to nutrient-ISS-  
GO:0032869cellular response to insulin stimulus-ISS-  
GO:0035356cellular triglyceride homeostasis-ISS-  
GO:0035470positive regulation of vascular wound healing-IDA25656649  
GO:0036498IRE1-mediated unfolded protein response-TAS22013210  22934019  
GO:0036500ATF6-mediated unfolded protein response-TAS-  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0042632cholesterol homeostasis-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0045348positive regulation of MHC class II biosynthetic process-IMP1903538  
GO:0045579positive regulation of B cell differentiation-IDA11460154  
GO:0045582positive regulation of T cell differentiation-IDA11460154  
GO:0045600positive regulation of fat cell differentiation-ISS-  
GO:0045766positive regulation of angiogenesis-IMP25656649  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8657566  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP1903538  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048666neuron development-ISS-  
GO:0051024positive regulation of immunoglobulin secretion-ISS-  
GO:0055089fatty acid homeostasis-ISS-  
GO:0055092sterol homeostasis-ISS-  
GO:0060612adipose tissue development-ISS-  
GO:0060691epithelial cell maturation involved in salivary gland development-IEA-  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-IEA-  
GO:0071222cellular response to lipopolysaccharide-IDA11460154  
GO:0071230cellular response to amino acid stimulus-ISS-  
GO:0071332cellular response to fructose stimulus-ISS-  
GO:0071333cellular response to glucose stimulus-ISS-  
GO:0071353cellular response to interleukin-4-ISS-  
GO:0071375cellular response to peptide hormone stimulus-ISS-  
GO:1900100positive regulation of plasma cell differentiation-IDA11460154  
GO:1900103positive regulation of endoplasmic reticulum unfolded protein response-IMP16645094  
GO:1901800positive regulation of proteasomal protein catabolic process-IEA-  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IDA19135031  
GO:1903489positive regulation of lactation-ISS-  
GO:1990418response to insulin-like growth factor stimulus-ISS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2000347positive regulation of hepatocyte proliferation-ISS-  
GO:2000778positive regulation of interleukin-6 secretion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0005783endoplasmic reticulum-IDA23529610  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-381033ATF6 (ATF6-alpha) activates chaperonesTAS
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381183ATF6 (ATF6-alpha) activates chaperone genesTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26740650Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. (2016 Jan 6)Srinivasan RJ Neurosci
28070146Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. (2016)Geraghty PMediators Inflamm
25568320Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2. (2015 Feb 27)Huang CJ Biol Chem
21354251Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells. (2011 Jul 11)Jang EHToxicology
24053669Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. (2014 May 10)Chen CAntioxid Redox Signal
28119953Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. (2016 Sep)Chen WYCell Mol Gastroenterol Hepatol
21525762Alcohol abuse, endoplasmic reticulum stress and pancreatitis. (2010)Pandol SJDig Dis