Gene: XPA

7507
XP1|XPAC
XPA, DNA damage recognition and repair factor
protein-coding
9q22.33
Ensembl:ENSG00000136936 MIM:611153 Vega:OTTHUMG00000020330 UniprotKB:P23025
NG_011642.1
PubMed
0   ANCO-SNPs
ND
29   
1.425e-1 (AD)  4.573e-1 (ND)   (Frontal_Cortex)
2.051e-2 (AD)  4.306e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARL0.884
DCTN60.883
PPCS0.869
HTATSF10.858
LSM30.857
FAM204A0.854
HMGB10.85
GABARAPL20.849
HNRNPDL0.848
COMMD30.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.685
OR4F5-0.669
RAX2-0.292
EPPIN-0.284
VHLL-0.272
MTRNR2L6-0.257
CELSR1-0.25
C8orf74-0.242
MTRNR2L9-0.24
MTRNR2L10-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of XPA mRNA"21346803
C5022392-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"XPA protein affects the abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"10755388|1696281
C5022392-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"XPA protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]"10755388
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"XPA protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]"10755388
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"XPA protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"10755388|1128519
C0312782-chloroethyl ethyl sulfideXPA protein affects the susceptibility to 2-chloroethyl ethyl sulfide19111594
C0312782-chloroethyl ethyl sulfideXPA results in decreased susceptibility to 2-chloroethyl ethyl sulfide22119920
C0443012-nitrophenyl selenocyanic acid2-nitrophenyl selenocyanic acid inhibits the reaction [Zinc binds to XPA protein]15265038
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in decreased expression of XPA protein"19553035
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of XPA protein"19553035
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of XPA mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of XPA mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of XPA mRNA12540782
D000082Acetaminophen"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of XPA mRNA]"12540782
C079422acylfulveneXPA mutant form results in increased susceptibility to acylfulvene28076683
C079422acylfulveneXPA mutant form results in increased susceptibility to acylfulvene analog28076683
D016604Aflatoxin B1XPA protein results in decreased susceptibility to Aflatoxin B123153559
C054672antimony trichlorideantimony trichloride binds to XPA protein20509621
C054672antimony trichlorideantimony trichloride inhibits the reaction [XPA protein binds to Zinc]20509621
D001151ArsenicXPA polymorphism affects the susceptibility to Arsenic17687452
C006632arsenic trioxidearsenic trioxide results in decreased expression of XPA mRNA15073043
C015001arseniteXPA protein affects the reaction [arsenite results in decreased expression of AKT1 mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in decreased expression of BAG3 mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in decreased expression of BIRC5 mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of BAG1 mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of BIRC2 mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of BNIP3L mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of GADD45A mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of LTBR mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of MCL1 mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of TNFRSF10B mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of TNFRSF12A mRNA]18585952
C015001arseniteXPA protein affects the reaction [arsenite results in increased expression of TNFRSF1A mRNA]18585952
D001280AtrazineAtrazine results in increased expression of XPA mRNA22378314
D001554BenzeneBenzene results in decreased expression of XPA mRNA18724895
C101202benzeneseleninic acidbenzeneseleninic acid inhibits the reaction [Zinc binds to XPA protein]15265038
C101202benzeneseleninic acidbenzeneseleninic acid results in decreased activity of XPA protein15265038
D001564Benzo(a)pyrene"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in decreased expression of XPA protein"19553035
D001564Benzo(a)pyreneBenzo(a)pyrene affects the localization of XPA protein19748547
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XPA mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of XPA protein19553035|1974854
D001564Benzo(a)pyreneXPA 5' UTR polymorphism affects the susceptibility to Benzo(a)pyrene15471894
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of XPA mRNA"28987381
D001564Benzo(a)pyrene[XPA gene mutant form co-treated with TRP53 gene mutant form] affects the susceptibility to Benzo(a)pyrene23052197
D001564Benzo(a)pyreneXPA gene mutant form results in increased susceptibility to Benzo(a)pyrene21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XPA protein21467743
D004958EstradiolEstradiol affects the expression of XPA mRNA23557687
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of XPA mRNA28628672
C006780bisphenol Abisphenol A affects the expression of XPA mRNA23557687
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XPA mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of XPA mRNA25181051
D002104CadmiumCadmium binds to XPA protein10783332|1751292
D002104CadmiumCadmium results in decreased expression of XPA mRNA18522720
D002104CadmiumCadmium results in decreased activity of XPA protein16677676
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of XPA protein17512921
D019256Cadmium ChlorideZinc inhibits the reaction [Cadmium Chloride results in decreased activity of XPA protein]17512921
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of XPA mRNA11958953
D019256Cadmium ChlorideMT1 affects the reaction [Cadmium Chloride results in decreased expression of XPA mRNA]11958953
D019256Cadmium ChlorideMT2 affects the reaction [Cadmium Chloride results in decreased expression of XPA mRNA]11958953
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of XPA promoter22457795
C037123cadmium sulfatecadmium sulfate results in increased expression of XPA mRNA23770381
C028337cadmium telluridecadmium telluride analog results in increased expression of XPA mRNA23770381
D002220CarbamazepineCarbamazepine affects the expression of XPA mRNA25979313
C094059cisplatin-deoxy(guanosine monophosphate guanosine) adductXPA protein results in decreased abundance of cisplatin-deoxy(guanosine monophosphate guanosine) adduct21385444
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of XPA mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of XPA mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of XPA mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of XPA mRNA25562108
D016572CyclosporineXPA protein affects the susceptibility to Cyclosporine23153559
C017160cypermethrincypermethrin results in increased expression of XPA mRNA25569846
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of XPA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XPA mRNA28628672
D003958DiamideDiamide results in decreased activity of XPA protein15265038
D002945CisplatinCisplatin results in increased expression of XPA protein21696631
D002945CisplatinXPA mRNA results in decreased susceptibility to Cisplatin15882455
D002945CisplatinXPA mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinXPA protein results in decreased susceptibility to Cisplatin21324906
D0151279,10-Dimethyl-1,2-benzanthracene"XPA protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene"10755388
D004317DoxorubicinDoxorubicin results in increased expression of XPA mRNA22712078
C042986ebselenebselen inhibits the reaction [Zinc binds to XPA protein]15265038
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased expression of XPA mRNA18852132
C039281furanfuran results in decreased expression of XPA mRNA22507866
D005839GentamicinsGentamicins results in increased expression of XPA mRNA22061828
D006046Gold[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA28433809
C016517indole-3-carbinolindole-3-carbinol affects the expression of XPA mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of XPA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XPA mRNA28628672
C051890irinotecanirinotecan results in decreased expression of XPA protein11593056
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of XPA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XPA mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of XPA mRNA20003209
D007608Kainic AcidKainic Acid results in increased expression of XPA mRNA19700661
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased expression of XPA mRNA18852132
C008261lead acetatelead acetate results in increased expression of XPA mRNA22609695
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of XPA mRNA"28987381
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of XPA mRNA"19917589
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of XPA protein"19917589
C482199lipopolysaccharide, E coli O55-B5"MPO protein affects the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of XPA protein]"19917589
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of XPA mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of XPA mRNA]19339665
D008148LovastatinLovastatin results in increased expression of XPA mRNA26739623
C008435methyldithiocarbamatemethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of XPA mRNA]19339665
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of XPA mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of XPA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of XPA mRNA23649840
D016685MitomycinXPA protein results in decreased susceptibility to Mitomycin23153559
D009151Mustard GasXPA results in decreased susceptibility to Mustard Gas22119920
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of XPA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of XPA mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of XPA mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of XPA mRNA20971185
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of XPA mRNA]"12540782
C025589ochratoxin Aochratoxin A results in decreased expression of XPA mRNA14994279
C118580octylmethoxycinnamateoctylmethoxycinnamate results in decreased expression of XPA mRNA20071424
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of XPA mRNA19162173
D010615PhenacetinXPA gene mutant form results in increased susceptibility to Phenacetin16464479
C006253pirinixic acidXPA protein affects the susceptibility to pirinixic acid23153559
D010936Plant ExtractsPlant Extracts results in increased expression of XPA mRNA23557933
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA28433809
D018036Selenium CompoundsSelenium Compounds inhibits the reaction [Zinc binds to XPA protein]15265038
D018036Selenium CompoundsSelenium Compounds results in decreased activity of XPA protein15265038
C009226selenocystineselenocystine inhibits the reaction [Zinc binds to XPA protein]15265038
C009226selenocystineselenocystine results in decreased activity of XPA protein15265038
D012645SelenomethionineSelenomethionine inhibits the reaction [Zinc binds to XPA protein]15265038
C002979selenomethylselenocysteineselenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein]15265038
D012834SilverSilver results in decreased expression of XPA mRNA22576574
C017947sodium arsenitesodium arsenite affects the expression of XPA mRNA29319823
C017947sodium arsenitesodium arsenite binds to and results in decreased activity of XPA protein28552776
C017947sodium arsenitesodium arsenite inhibits the reaction [Zinc binds to XPA protein]28552776
C017947sodium arsenitesodium arsenite results in decreased expression of XPA mRNA28237621
C017947sodium arsenitesodium arsenite results in decreased expression of XPA protein28237621
C017947sodium arseniteZinc inhibits the reaction [sodium arsenite results in decreased activity of XPA protein]28552776
C017947sodium arsenitesodium arsenite results in decreased expression of XPA protein28237621
D053260SootSoot results in increased expression of XPA mRNA21914721
D013629TamoxifenTamoxifen results in increased expression of XPA mRNA12841865
C003377taxifolintaxifolin results in increased expression of XPA mRNA17541156
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPA mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XPA mRNA21215274
D014635Valproic AcidValproic Acid results in decreased methylation of XPA gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of XPA gene25560391
D014752Vinyl ChlorideXPA gene polymorphism affects the susceptibility to Vinyl Chloride21216194
C108830Y 27632Y 27632 results in increased expression of XPA mRNA20878077
D015215ZidovudineZidovudine results in increased expression of XPA mRNA21192964
D015215ZidovudineZidovudine results in increased expression of XPA protein23675285
D015032Zinc2-nitrophenyl selenocyanic acid inhibits the reaction [Zinc binds to XPA protein]15265038
D015032Zincantimony trichloride inhibits the reaction [XPA protein binds to Zinc]20509621
D015032Zincbenzeneseleninic acid inhibits the reaction [Zinc binds to XPA protein]15265038
D015032Zincebselen inhibits the reaction [Zinc binds to XPA protein]15265038
D015032ZincSelenium Compounds inhibits the reaction [Zinc binds to XPA protein]15265038
D015032Zincselenocystine inhibits the reaction [Zinc binds to XPA protein]15265038
D015032ZincSelenomethionine inhibits the reaction [Zinc binds to XPA protein]15265038
D015032Zincselenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein]15265038
D015032Zincsodium arsenite inhibits the reaction [Zinc binds to XPA protein]28552776
D015032ZincZinc binds to and results in increased activity of XPA protein28552776
D015032ZincZinc binds to XPA protein10783332|1526503
D015032ZincZinc inhibits the reaction [Cadmium Chloride results in decreased activity of XPA protein]17512921
D015032ZincZinc inhibits the reaction [sodium arsenite results in decreased activity of XPA protein]28552776

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IBA21873635  
GO:0003684damaged DNA binding-IDA7700386  
GO:0005515protein binding-IPI7700386  8197175  8999876  9013642  10944529  10982866  
11058119  12527904  16491090  20304803  20670893  25416956  
GO:0019904protein domain specific binding-IPI17720715  
GO:0042803protein homodimerization activity-IPI8197175  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000715nucleotide-excision repair, DNA damage recognition-IBA21873635  
GO:0006281DNA repair-IDA1601884  
GO:0006281DNA repair-IMP1601884  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006284base-excision repair-IBA21873635  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006979response to oxidative stress-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IEA-  
GO:0009636response to toxic substance-IEA-  
GO:0009650UV protection-IDA1601884  
GO:0009650UV protection-IMP1601884  
GO:0010996response to auditory stimulus-IEA-  
GO:0033683nucleotide-excision repair, DNA incision-IBA21873635  
GO:0033683nucleotide-excision repair, DNA incision-IMP21148310  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0034504protein localization to nucleus-IMP1601884  
GO:0035264multicellular organism growth-IEA-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO:0070914UV-damage excision repair-IBA21873635  
GO:1901255nucleotide-excision repair involved in interstrand cross-link repair-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000110nucleotide-excision repair factor 1 complex-IBA21873635  
GO:0005634nucleus-IDA1601884  
GO:0005654nucleoplasm-TAS-  
GO:0005662DNA replication factor A complexcolocalizes_withIDA7700386  
GO:0005737cytoplasm-IEA-  
GO:0045171intercellular bridge-IDA-  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
Reactome ID Reactome Term Evidence
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26760766Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks. (2016 Feb 9)Liu JOncotarget
25845234[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease]. (2014 Nov-Dec)Korytina GFMol Biol (Mosk)
21195504Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. (2011 Aug)Qian BLung Cancer
21188533An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer. (2011 Nov)Butkiewicz DMol Biol Rep
16103444Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. (2005 Aug)Wei QCancer Epidemiol Biomarkers Prev
25715450[DNA repair XRCC1, XPD genes polymorphism as associated with the development of bladder cancer and renal cell carcinoma]. (2014 Apr)Akhmadishina LZGenetika
17531525Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. (2007 Jul 28)De Ruyck KMutat Res
24582975Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. (2014 May 25)Lu BGene
27460688Association between XPA gene rs1800975 polymorphism and susceptibility to lung cancer: a meta-analysis. (2018 Feb)Liu XClin Respir J
21216194DNA repair gene polymorphisms and micronucleus frequencies in Chinese workers exposed to vinyl chloride monomer. (2011 Jun)Qiu YLInt J Hyg Environ Health
26159902DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival. (2015)Su YCell Physiol Biochem
19444904Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. (2009 Sep 15)Abbasi RInt J Cancer
12376498Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. (2002 Oct)Park JYCancer Epidemiol Biomarkers Prev
12663511XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity. (2003 Mar)Wu XCarcinogenesis
26617899Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population. (2015)Sun YInt J Clin Exp Pathol
16393248Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. (2006 Jan)Sugimura TJ Oral Pathol Med
17913280Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer. (2008 Feb)Raaschou-Nielsen OLung Cancer
29516319Association of XPA Polymorphisms Towards Lung Cancer Susceptibility and its Predictive Role in Overall Survival of North Indians. (2018 Mar 7)Lawania SBiochem Genet
17653764Polymorphisms of the DNA repair gene xeroderma pigmentosum groups A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China. (2008 Feb)Guo WJ Cancer Res Clin Oncol
18442012Relationship between polymorphisms of nucleotide excision repair genes and oral cancer risk in Taiwan: evidence for modification of smoking habit. (2007 Dec 31)Bau DTChin J Physiol
17575242Nucleotide excision repair pathway genes and oral premalignant lesions. (2007 Jun 15)Wang YClin Cancer Res
26228655XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population. (2015 Jul 31)Pei NBMC Cancer
15333465Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. (2004 Dec)Popanda OCarcinogenesis
16806437Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association. (2006 Dec)Weiss JMGynecol Oncol
26767006Polymorphisms in DNA repair genes of XRCC1, XPA, XPC, XPD and associations with lung cancer risk in Chinese people. (2014 May)Mei CThorac Cancer
15598786Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene. (2004 Dec)Butkiewicz DCancer Epidemiol Biomarkers Prev
29528139Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. (2018 Jun)Han PMol Carcinog
17363013XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer. (2007 Jun 1)Hansen RDMutat Res
27622501A Functional Polymorphism (rs10817938) in the XPA Promoter Region Is Associated with Poor Prognosis of Oral Squamous Cell Carcinoma in a Chinese Han Population. (2016)Gao CPLoS One