Gene info: ID 7508

Gene: XPC

GENE ID: 7508

Synonyms: RAD4|XP3|XPCC|p125

Description: XPC complex subunit, DNA damage recognition and repair factor

Gene type: protein-coding

Location: 3p25.1

dbXrefs: Ensembl:ENSG00000154767 MIM:613208 Vega:OTTHUMG00000155526 UniprotKB:Q01831

RefSeq: NG_011763.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 64

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.839e-1 (AD) 5.338e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZKSCAN1	0.875
DHX38	0.868
SRRM1	0.867
CLCC1	0.864
RFC1	0.857
DYNC1I2	0.854
TAF1	0.852
NFX1	0.852
DMTF1	0.851
INO80	0.851

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.595
OR4F5	-0.581
MTRNR2L6	-0.344
MTRNR2L9	-0.323
MTRNR2L10	-0.311
MOGAT2	-0.28
OR4F16	-0.263
RNF223	-0.258
C17orf112	-0.254
TTLL10	-0.233

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of XPC mRNA	25596134
C031763	1,3-butadiene	"XPC gene mutant form results in increased susceptibility to 1,3-butadiene"	16730686
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in decreased expression of XPC protein"	19553035
C024370	3,4-epoxy-1-butene	"XPC protein affects the susceptibility to 3,4-epoxy-1-butene"	16094661
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of XPC mRNA	12419474
D000082	Acetaminophen	Acetaminophen results in increased expression of XPC mRNA	22230336
C079422	acylfulvene	XPC mutant form affects the susceptibility to acylfulvene	28076683
C079422	acylfulvene	XPC mutant form results in decreased susceptibility to acylfulvene analog	28076683
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of XPC protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of XPC mRNA	21641981\|2715375
D001151	Arsenic	Arsenic affects the expression of XPC	21235219
D001151	Arsenic	XPC gene SNP affects the susceptibility to Arsenic	25759212
C006632	arsenic trioxide	XPC protein affects the susceptibility to arsenic trioxide	20403967\|2228098
C043372	ascaridole	XPC protein affects the susceptibility to ascaridole	22280988
D001280	Atrazine	Atrazine results in increased expression of XPC mRNA	25929836
D001554	Benzene	Benzene results in decreased expression of XPC mRNA	18724895
D001554	Benzene	Benzene results in increased expression of XPC mRNA	19162166
D001554	Benzene	Benzene results in increased expression of XPC mRNA	15342939
C072019	benzo(a)pyrene diolepoxide I	benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA	27694624
C072019	benzo(a)pyrene diolepoxide I	benzo(a)pyrene diolepoxide I results in increased expression of XPC protein	27694624
C072019	benzo(a)pyrene diolepoxide I	pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA]	27694624
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of XPC mRNA	22209252
D001564	Benzo(a)pyrene	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in decreased expression of XPC protein"	19553035
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of XPC protein	19748547
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of XPC mRNA	23894430\|2769462
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of XPC protein	23894430
D001564	Benzo(a)pyrene	XPC polyA tail polymorphism affects the susceptibility to Benzo(a)pyrene	15471894
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to XPC promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of XPC mRNA	20504355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of XPC mRNA	19428948
D001564	Benzo(a)pyrene	XPC protein affects the susceptibility to Benzo(a)pyrene	16094661
D001564	Benzo(a)pyrene	XPC protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]	21507987
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of XPC mRNA"	28593498
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of XPC protein"	18085531
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XPC protein]	28237621
D004958	Estradiol	decitabine inhibits the reaction [Estradiol results in decreased expression of XPC mRNA]	22082530
D004958	Estradiol	Estradiol results in decreased expression of XPC mRNA	22082530
C006780	bisphenol A	bisphenol A affects the expression of XPC mRNA	25181051
D002065	Buspirone	Buspirone results in decreased expression of XPC mRNA	24136188
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of XPC mRNA	25596134
C037123	cadmium sulfate	cadmium sulfate results in increased expression of XPC mRNA	23770381
C028337	cadmium telluride	cadmium telluride analog results in increased expression of XPC mRNA	23770381
D002227	Carbazoles	XPC protein affects the susceptibility to Carbazoles	22280988
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of XPC mRNA	17484886
D002273	Carcinogens	Carcinogens results in decreased expression of XPC mRNA	22269147
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of XPC mRNA	25596134
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of XPC mRNA	25596134
C059262	cidofovir	cidofovir results in increased expression of XPC mRNA	25596134
D003078	Colchicine	Colchicine results in decreased expression of XPC mRNA	24211769
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of XPC mRNA	15467011
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of XPC mRNA	21878529
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of XPC mRNA	11056294
D016572	Cyclosporine	Cyclosporine results in decreased expression of XPC mRNA	25596134
D016572	Cyclosporine	XPC protein results in decreased susceptibility to Cyclosporine	23153559
D016572	Cyclosporine	Cyclosporine results in decreased expression of XPC mRNA	25596134
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of XPC mRNA	23726867
C014347	decitabine	decitabine inhibits the reaction [Estradiol results in decreased expression of XPC mRNA]	22082530
C014347	decitabine	decitabine results in decreased expression of XPC mRNA	22082530
D015255	Idarubicin	[Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA	28973540
D064730	Dexrazoxane	[Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA	28973540
D016190	Carboplatin	XPC results in decreased susceptibility to Carboplatin	19372135
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of XPC mRNA	21266533
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of XPC mRNA]	21858171
D002945	Cisplatin	Cisplatin results in decreased expression of XPC mRNA	24211769
D002945	Cisplatin	Cisplatin results in increased expression of XPC mRNA	21532991\|2559613
D002945	Cisplatin	Cisplatin results in increased expression of XPC protein	21696631\|2174202
D002945	Cisplatin	RAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of XPC protein]	21742020
D002945	Cisplatin	sodium arsenite inhibits the reaction [Cisplatin results in increased expression of XPC protein]	21696631\|2233149
D002945	Cisplatin	[sodium arsenite results in decreased expression of XPC protein] which results in increased susceptibility to Cisplatin	22331493
D002945	Cisplatin	TP53 protein affects the reaction [Cisplatin results in increased expression of XPC protein]	22331493
D002945	Cisplatin	XPC protein affects the susceptibility to Cisplatin	22331493
D002945	Cisplatin	XPC protein results in decreased susceptibility to Cisplatin	21327329
D002945	Cisplatin	XPC protein results in increased susceptibility to Cisplatin	21324906
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of XPC mRNA	26924002
D004051	Diethylhexyl Phthalate	XPC protein affects the susceptibility to Diethylhexyl Phthalate	24084170
D004054	Diethylstilbestrol	XPC protein results in decreased susceptibility to Diethylstilbestrol	23153559
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of XPC mRNA	26924002
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPC mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of XPC mRNA	23649840
D011345	Fenofibrate	Fenofibrate results in decreased expression of XPC mRNA	25596134
D015073	2-Acetylaminofluorene	XPC protein results in decreased susceptibility to 2-Acetylaminofluorene	23153559
D005557	Formaldehyde	Formaldehyde results in increased expression of XPC mRNA	23649840
C039281	furan	furan results in decreased expression of XPC mRNA	22507866
D005839	Gentamicins	Gentamicins results in increased expression of XPC mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of XPC mRNA	24136188
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of XPC mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of XPC mRNA	15458575
D006918	Hydroxyurea	Hydroxyurea results in increased expression of XPC mRNA	18647660
D007069	Ifosfamide	Ifosfamide results in increased expression of XPC mRNA	25596134
C056493	imiquimod	imiquimod results in increased expression of XPC mRNA	21878529
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of XPC mRNA	25613284
C411319	kurarinone	XPC protein affects the susceptibility to kurarinone	22280988
D008687	Metformin	Metformin results in decreased expression of XPC mRNA	25596134
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of XPC mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of XPC mRNA	23649840
C059539	midostaurin	midostaurin results in decreased expression of XPC mRNA	20980353
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of XPC mRNA	19382146
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of XPC protein	19382146
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of XPC mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of XPC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of XPC mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of XPC mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of XPC mRNA	24136188
D015376	Nimustine	Nimustine results in increased expression of XPC mRNA	18089819
D015376	Nimustine	TP53 affects the reaction [Nimustine results in increased expression of XPC mRNA]	18089819
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of XPC mRNA	26552463
C572712	norkurarinol	XPC protein affects the susceptibility to norkurarinol	22280988
D010100	Oxygen	Oxygen deficiency results in decreased expression of XPC mRNA	25596134
D010126	Ozone	Ozone results in increased expression of XPC mRNA	27206323
D010269	Paraquat	Paraquat results in increased expression of XPC mRNA	15458575
D010269	Paraquat	XPC protein affects the susceptibility to Paraquat	24084170
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of XPC mRNA	21061450
C121565	pifithrin	pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA]	27694624
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of XPC mRNA	19710929
C006253	pirinixic acid	XPC protein affects the susceptibility to pirinixic acid	23153559
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of XPC mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of XPC mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of XPC mRNA	23557933
C043680	ptaquiloside	ptaquiloside results in increased expression of XPC mRNA	22143989
D011794	Quercetin	Quercetin results in increased expression of XPC mRNA	21632981
D011794	Quercetin	XPC protein affects the susceptibility to Quercetin	22280988
D011794	Quercetin	Quercetin results in increased expression of XPC mRNA	17103110
D012603	Scopoletin	XPC protein affects the susceptibility to Scopoletin	22280988
D012906	Smoke	XPC gene SNP affects the susceptibility to Smoke	20106949
C017947	sodium arsenite	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XPC protein]	28237621
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Cisplatin results in increased expression of XPC protein]	21696631\|2233149
C017947	sodium arsenite	sodium arsenite results in decreased expression of XPC mRNA	12377979\|1276083
C017947	sodium arsenite	sodium arsenite results in decreased expression of XPC protein	19382146\|2823762
C017947	sodium arsenite	[sodium arsenite results in decreased expression of XPC protein] which results in increased susceptibility to Cisplatin	22331493
C017947	sodium arsenite	sodium arsenite results in decreased expression of XPC mRNA	17558810
C017947	sodium arsenite	sodium arsenite results in decreased expression of XPC protein	28237621
C017947	sodium arsenite	sodium arsenite results in increased expression of XPC mRNA	25787150
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of XPC mRNA	23296099
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of XPC mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPC mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of XPC mRNA	19428948
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of XPC mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of XPC mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of XPC mRNA	27694624\|2786577
C057693	troglitazone	troglitazone results in decreased expression of XPC mRNA	25596134
D014415	Tunicamycin	Tunicamycin results in increased expression of XPC mRNA	15458575
C406224	valdecoxib	valdecoxib results in decreased expression of XPC mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of XPC mRNA	25979313
D014635	Valproic Acid	Valproic Acid promotes the reaction [CREB1 protein binds to XPC promoter]	21507255
D014635	Valproic Acid	Valproic Acid promotes the reaction [SP1 protein binds to XPC promoter]	21507255
D014635	Valproic Acid	Valproic Acid results in increased expression of XPC mRNA	21507255
D014752	Vinyl Chloride	XPC gene polymorphism affects the susceptibility to Vinyl Chloride	21216194
D000225	Adenine	Adenine results in decreased expression of XPC mRNA	24211769
C108830	Y 27632	Y 27632 results in increased expression of XPC mRNA	20878077
D015215	Zidovudine	XPC protein results in decreased susceptibility to Zidovudine	21192964
D015215	Zidovudine	Zidovudine results in increased expression of XPC mRNA	21192964\|2367528
D015215	Zidovudine	Zidovudine results in increased expression of XPC protein	21192964

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000404	heteroduplex DNA loop binding	-	TAS	19941824
GO:0000405	bubble DNA binding	-	TAS	19941824
GO:0003684	damaged DNA binding	-	IBA	21873635
GO:0003684	damaged DNA binding	-	IDA	10873465 12509299
GO:0003697	single-stranded DNA binding	-	IBA	21873635
GO:0003697	single-stranded DNA binding	-	IDA	12509299
GO:0005515	protein binding	-	IPI	10488153 10734143 17693435 18024891 21962512 26638075

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	IDA	10873465 19941824
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	-
GO:0006281	DNA repair	-	TAS	1522891
GO:0006289	nucleotide-excision repair	-	IBA	21873635
GO:0006289	nucleotide-excision repair	-	IDA	8168482 9734359
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006298	mismatch repair	-	IBA	21873635
GO:0010224	response to UV-B	-	IEA	-
GO:0010996	response to auditory stimulus	-	IEA	-
GO:0031573	intra-S DNA damage checkpoint	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0070911	global genome nucleotide-excision repair	-	TAS	-
GO:0070914	UV-damage excision repair	-	IDA	8077226
GO:1901990	regulation of mitotic cell cycle phase transition	-	IMP	17088560

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000111	nucleotide-excision repair factor 2 complex	-	IBA	21873635
GO:0005634	nucleus	-	IDA	18682493
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	18682493
GO:0005739	mitochondrion	-	IDA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0071942	XPC complex	-	IBA	21873635
GO:0071942	XPC complex	-	IDA	11279143

KEGG ID	KEGG Term
hsa03420	Nucleotide excision repair

Reactome ID	Reactome Term	Evidence
R-HSA-2990846	SUMOylation	TAS
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5696394	DNA Damage Recognition in GG-NER	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73894	DNA Repair	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17575242	Nucleotide excision repair pathway genes and oral premalignant lesions. (2007 Jun 15)	Wang Y	Clin Cancer Res
27694624	Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations. (2016 Dec 15)	Christmann M	Nucleic Acids Res
17913280	Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer. (2008 Feb)	Raaschou-Nielsen O	Lung Cancer
28540485	XPC Polymorphism and Risk for Lung Cancer in North Indian Patients Treated with Platinum Based Chemotherapy and Its Association with Clinical Outcomes. (2018 Apr)	Lawania S	Pathol Oncol Res
16399771	Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. (2006 Jul)	Mechanic LE	Carcinogenesis
15878910	Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. (2005 Sep)	Casson AG	Carcinogenesis
17855160	Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workers. (2007 Dec 1)	Slyskova J	Mutat Res
23144912	DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. (2012)	Budworth H	PLoS One
22505326	Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk. (2012 Jul)	Liu Y	Oncol Rep
25400036	DNA repair gene polymorphisms in B cell non-Hodgkin's lymphoma. (2015 Mar)	Bahceci A	Tumour Biol
22682619	Poly (AT) polymorphism in the XPC gene and smoking enhance the risk of prostate cancer in a low-risk Chinese population. (2012 May)	Liu Y	Cancer Genet
15700316	DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population. (2005 Jun 20)	Hu Z	Int J Cancer
16086280	[Association of two exonic genetic polymorphisms in the DNA repair gene XPC with risk of lung cancer in Chinese population]. (2005 Aug)	Hu ZB	Zhonghua Yi Xue Yi Chuan Xue Za Zhi
16103444	Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. (2005 Aug)	Wei Q	Cancer Epidemiol Biomarkers Prev
23801864	XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians. (2013 Jun 21)	Ahmad Aizat AA	World J Gastroenterol
27669310	Association of XPC Gene Polymorphisms with Colorectal Cancer Risk in a Southern Chinese Population: A Case-Control Study and Meta-Analysis. (2016 Sep 24)	Hua RX	Genes (Basel)
19444904	Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. (2009 Sep 15)	Abbasi R	Int J Cancer
18771913	Associations between XPC polymorphisms and risk of cancers: A meta-analysis. (2008 Oct)	Qiu L	Eur J Cancer
11309287	An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study. (2001 Apr 15)	Shen H	Cancer Res
17531525	Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. (2007 Jul 28)	De Ruyck K	Mutat Res
14644313	Functional characterization of global genomic DNA repair and its implications for cancer. (2003 Nov)	Hanawalt PC	Mutat Res
15533908	Poly (AT) polymorphism in intron 11 of the XPC DNA repair gene enhances the risk of lung cancer. (2004 Nov)	Marin MS	Cancer Epidemiol Biomarkers Prev
16537713	Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. (2006 Mar)	Garcia-Closas M	Cancer Epidemiol Biomarkers Prev
23246108	Study on bladder cancer susceptibility and genetic polymorphisms of XPC, XPG, and CYP in smokers and non-smokers. (2013 May)	Wen H	Actas Urol Esp
14690560	[Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk]. (2003 Nov)	Wang YG	Zhonghua Zhong Liu Za Zhi
21216194	DNA repair gene polymorphisms and micronucleus frequencies in Chinese workers exposed to vinyl chloride monomer. (2011 Jun)	Qiu YL	Int J Hyg Environ Health
26760766	Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks. (2016 Feb 9)	Liu J	Oncotarget
25845234	[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease]. (2014 Nov-Dec)	Korytina GF	Mol Biol (Mosk)
15729698	XPC polymorphisms and lung cancer risk. (2005 Jul 10)	Lee GY	Int J Cancer
23269608	An association between XPC Lys939Gln polymorphism and the risk of bladder cancer: a meta-analysis. (2013 Apr)	Zhang Y	Tumour Biol
22821704	Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. (2013 Dec)	Liu L	Mol Carcinog
19350405	Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai. (2009 Dec)	Wen H	Int Urol Nephrol
26617899	Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population. (2015)	Sun Y	Int J Clin Exp Pathol
29139108	A 3' untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma. (2018 Mar)	Ahmed T	Ann Hum Genet
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