Gene: XPNPEP1

7511
APP1|SAMP|XPNPEP|XPNPEPL|XPNPEPL1
X-prolyl aminopeptidase 1
protein-coding
10q25.1
Ensembl:ENSG00000108039 MIM:602443 Vega:OTTHUMG00000019029 UniprotKB:Q9NQW7
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.527e-1 (AD)  6.083e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF2B10.945
KDM1A0.937
HDAC30.936
GLE10.934
CDK5RAP10.934
QRICH10.933
GTF3C20.931
TRPC4AP0.929
VCP0.929
XRCC60.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.693
OR4F29-0.648
MTRNR2L9-0.305
MTRNR2L6-0.302
MTRNR2L10-0.257
KLRB1-0.241
TTLL10-0.233
OR4F16-0.218
IFNG-0.214
HMHB1-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of XPNPEP1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of XPNPEP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of XPNPEP1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of XPNPEP1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of XPNPEP1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of XPNPEP1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of XPNPEP1 mRNA17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of XPNPEP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of XPNPEP1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of XPNPEP1 mRNA20458559
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of XPNPEP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XPNPEP1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of XPNPEP1 mRNA17823450
C006780bisphenol Abisphenol A affects the expression of XPNPEP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of XPNPEP1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPNPEP1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of XPNPEP1 mRNA15336504
C100187chloropicrinchloropicrin results in increased expression of XPNPEP1 mRNA26352163
D002994ClofibrateClofibrate results in decreased expression of XPNPEP1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of XPNPEP1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of XPNPEP1 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of XPNPEP1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPNPEP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of XPNPEP1 mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of XPNPEP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XPNPEP1 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPNPEP1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XPNPEP1 mRNA16174780
D005485FlutamideFlutamide results in decreased expression of XPNPEP1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of XPNPEP1 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of XPNPEP1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPNPEP1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of XPNPEP1 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPNPEP1 mRNA28628672
C410337K 7174K 7174 results in increased expression of XPNPEP1 mRNA24086573
D008731MethoxychlorMethoxychlor results in increased expression of XPNPEP1 mRNA21276474
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of XPNPEP1 mRNA"20188158
D015741MetriboloneMetribolone results in increased expression of XPNPEP1 protein17152098
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of XPNPEP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of XPNPEP1 mRNA"25554681
D009532NickelNickel results in decreased expression of XPNPEP1 mRNA25583101
C006253pirinixic acidpirinixic acid results in decreased expression of XPNPEP1 mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of XPNPEP1 mRNA23018184
C079198S 1 (combination)XPNPEP1 protein results in increased susceptibility to S 1 (combination)16734730
C010327salinomycinsalinomycin results in decreased expression of XPNPEP1 mRNA19682730
C009277sodium arsenatesodium arsenate results in increased expression of XPNPEP1 mRNA23922661
D013629TamoxifenTamoxifen affects the expression of XPNPEP1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPNPEP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of XPNPEP1 mRNA19465110
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPNPEP1 mRNA17942748
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of XPNPEP1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of XPNPEP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of XPNPEP1 mRNA28001369
D014638VanadatesVanadates results in increased expression of XPNPEP1 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004177aminopeptidase activity-IDA11106490  
GO:0030145manganese ion binding-IDA18515364  
GO:0042803protein homodimerization activity-IPI18515364  
GO:0070006metalloaminopeptidase activity-IDA18515364  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA11106490  
GO:0010815bradykinin catabolic process-IDA18515364  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24964093Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (2014)Breton CVPLoS One