Gene: XPNPEP2

7512
AEACEI|APP2
X-prolyl aminopeptidase 2
protein-coding
Xq26.1
Ensembl:ENSG00000122121 MIM:300145 Vega:OTTHUMG00000022373 UniprotKB:O43895
NG_011479.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C9orf1350.586
LMO20.539
FUOM0.527
PLAT0.512
TFPI20.51
ELK30.502
IL220.498
CTHRC10.498
KIAA00400.49
TNFSF110.482

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG5-0.39
FLRT2-0.389
CPO-0.381
CCNF-0.376
PPP1R13B-0.374
KCNS1-0.37
PLEKHA6-0.368
WIPF3-0.366
FAM227A-0.366
CCNO-0.365

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of XPNPEP2 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XPNPEP2 mRNA"25614096
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of XPNPEP2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of XPNPEP2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of XPNPEP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of XPNPEP2 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of XPNPEP2 mRNA"20816883
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of XPNPEP2 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of XPNPEP2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of XPNPEP2 mRNA27153756
D000638AmiodaroneAmiodarone results in increased expression of XPNPEP2 mRNA19774075
D000806Angiotensin-Converting Enzyme InhibitorsXPNPEP2 gene SNP affects the susceptibility to Angiotensin-Converting Enzyme Inhibitors16175507
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of XPNPEP2 mRNA24449571
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of XPNPEP2 mRNA17639512
D001280AtrazineAtrazine results in increased expression of XPNPEP2 mRNA22378314
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XPNPEP2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XPNPEP2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of XPNPEP2 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of XPNPEP2 mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XPNPEP2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XPNPEP2 mRNA22228805|2261060
D004958EstradiolEstradiol results in increased expression of XPNPEP2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of XPNPEP2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of XPNPEP2 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of XPNPEP2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of XPNPEP2 mRNA25993096
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of XPNPEP225568306
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of XPNPEP225568306
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of XPNPEP2 mRNA27858113
D003314Corn OilCorn Oil affects the expression of XPNPEP2 mRNA16360708
D016572CyclosporineCyclosporine results in decreased expression of XPNPEP2 mRNA25562108
D004041Dietary FatsDietary Fats results in increased expression of XPNPEP2 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of XPNPEP2 mRNA18164116
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of XPNPEP2 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of XPNPEP2 mRNA25380136
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XPNPEP2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPNPEP2 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of XPNPEP2 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of XPNPEP2 mRNA24136188
C412815GW 4064GW 4064 results in increased expression of XPNPEP2 mRNA26655953
D007840LatexLatex analog results in decreased expression of XPNPEP2 mRNA24768652
D008727MethotrexateMethotrexate affects the expression of XPNPEP2 mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of XPNPEP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of XPNPEP2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of XPNPEP2 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of XPNPEP2 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of XPNPEP2 mRNA22110744
C012655nimesulidenimesulide results in decreased expression of XPNPEP2 mRNA24136188
D009966OrphenadrineOrphenadrine affects the expression of XPNPEP2 mRNA23665939
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of XPNPEP2 mRNA18692542
C006253pirinixic acidpirinixic acid results in decreased expression of XPNPEP2 mRNA17426115
D011192Potassium DichromatePotassium Dichromate results in decreased expression of XPNPEP225568306
D011192Potassium DichromatePotassium Dichromate results in increased expression of XPNPEP225568306
D011374ProgesteroneProgesterone results in increased expression of XPNPEP2 mRNA19126663
D011374ProgesteroneProgesterone results in increased expression of XPNPEP2 protein19126663
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of XPNPEP2 mRNA17639512
C016104sodium bichromatesodium bichromate results in decreased expression of XPNPEP2 mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPNPEP2 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPNPEP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XPNPEP2 mRNA18796159|2121527
C080163trovafloxacintrovafloxacin results in decreased expression of XPNPEP2 mRNA24136188
C406224valdecoxibvaldecoxib results in decreased expression of XPNPEP2 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of XPNPEP2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of XPNPEP2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of XPNPEP2 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004177aminopeptidase activity-TAS9375790  
GO:0046872metal ion binding-IEA-  
GO:0070006metalloaminopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS9375790  
GO:0031225anchored component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0070062extracellular exosome-IDA21082674  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20625347Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. (2010 Sep)Woodard-Grice AVPharmacogenet Genomics