Gene: XRCC1

7515
RCC|SCAR26
X-ray repair cross complementing 1
protein-coding
19q13.31
Ensembl:ENSG00000073050 MIM:194360 Vega:OTTHUMG00000182699 UniprotKB:P18887
NG_033799.1
PubMed
ND|AD
191   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.326e-1 (AD)  7.064e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STRADA0.922
NCAPH20.917
PSMD30.916
GPS10.916
CCAR20.915
IDH3G0.915
MRPL20.913
AIFM10.912
AP1M10.912
MAN1B10.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.641
OR4F29-0.603
MTRNR2L6-0.451
MTRNR2L9-0.436
MTRNR2L10-0.387
TTLL10-0.333
MTRNR2L2-0.332
MTRNR2L8-0.332
KCNJ15-0.316
TTLL10-AS1-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0317631,3-butadiene"XRCC1 gene polymorphism affects the susceptibility to 1,3-butadiene"26339595
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of XRCC1 mRNA17690111
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of XRCC1 mRNA"18948301
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XRCC1 mRNA"18948301
C5112952,2',4,4'-tetrabromodiphenyl ether"Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XRCC1 mRNA]"18948301
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of XRCC1 mRNA"18948301
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]26046675
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]26046675
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased stability of XRCC1 mRNA26046675
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased stability of XRCC1 protein26046675
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of XRCC1 mRNA"15215175
C0312782-chloroethyl ethyl sulfideXRCC1 results in decreased susceptibility to 2-chloroethyl ethyl sulfide22119920
C0815104-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanoneXRCC1 protein affects the susceptibility to 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone19601657
C0815104-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanoneXRCC1 protein affects the susceptibility to [4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone results in increased mutagenesis of HPRT1 gene]19601657
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of XRCC1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XRCC1 mRNA]17585979
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XRCC1 mRNA]"18948301
D000348AflatoxinsXRCC1 gene polymorphism results in increased susceptibility to Aflatoxins15734960
D000393Air PollutantsAir Pollutants results in increased expression of XRCC1 protein28389379
D000643Ammonium ChlorideAmmonium Chloride affects the expression of XRCC1 mRNA16483693
D001151ArsenicArsenic affects the expression of XRCC1 mRNA17450239
D001151ArsenicArsenic results in decreased expression of XRCC1 mRNA21332098
D001151ArsenicArsenic results in decreased expression of XRCC1 protein21332098
D001151ArsenicArsenic results in increased expression of XRCC1 mRNA12773770
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein]21332098
D001151ArsenicXRCC1 gene polymorphism affects the susceptibility to Arsenic17374727|2501805
D001151ArsenicXRCC1 protein polymorphism affects the susceptibility to Arsenic28733204
C015001arsenitearsenite results in increased methylation of XRCC1 promoter23974009
D001194AsbestosXRCC1 gene polymorphism results in increased susceptibility to Asbestos16564556
D001194AsbestosXRCC1 protein affects the susceptibility to Asbestos16944782
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of XRCC1 protein"20855422
D017636Asbestos, Amphibole"XRCC1 results in decreased susceptibility to Asbestos, Amphibole"20705543
D017638Asbestos, Crocidolite"XRCC1 results in decreased susceptibility to Asbestos, Crocidolite"20705543
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Fenretinide results in decreased expression of XRCC1 protein]16124896
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Reactive Oxygen Species results in decreased expression of XRCC1 protein]16124896
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [XRCC1 mutant form results in increased susceptibility to chromium hexavalent ion]22241526
D001280AtrazineAtrazine results in increased expression of XRCC1 mRNA25929836
D001554BenzeneXRCC1 gene polymorphism affects the susceptibility to Benzene17095285|1821480
D001554BenzeneXRCC1 gene SNP affects the susceptibility to Benzene15612468|2668119
D001554BenzeneXRCC1 gene SNP results in decreased susceptibility to Benzene16284386
D001554BenzeneXRCC1 gene SNP results in increased susceptibility to Benzene16284386
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of XRCC1 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of XRCC1 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of XRCC1 mRNA28461126
C006780bisphenol Abisphenol A affects the expression of XRCC1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XRCC1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of XRCC1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of XRCC1 mRNA25181051
D001761BleomycinXRCC1 gene polymorphism affects the susceptibility to Bleomycin12082022
D001761BleomycinXRCC1 results in decreased susceptibility to Bleomycin20705543
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of XRCC1 mRNA22112500|2647268
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of XRCC1 protein22112500
D019256Cadmium Chloride[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of XRCC1 mRNA22112500
D019256Cadmium Chloride[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of XRCC1 promoter22112500
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of XRCC1 promoter22112500
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of XRCC1 mRNA]22112500
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of XRCC1 protein]22112500
D002220CarbamazepineCarbamazepine affects the expression of XRCC1 mRNA25979313
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [XRCC1 mutant form results in increased susceptibility to chromium hexavalent ion]22241526
C074702chromium hexavalent ionXRCC1 mutant form results in increased susceptibility to chromium hexavalent ion22241526
C074702chromium hexavalent ionXRCC1 protein polymorphism results in increased susceptibility to chromium hexavalent ion22642904
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of XRCC1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of XRCC1 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XRCC1 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of XRCC1 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of XRCC1 mRNA21878529
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]21332098
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein]21332098
D003520CyclophosphamideCyclophosphamide results in decreased expression of XRCC1 mRNA11056294
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of XRCC1 mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of XRCC1 mRNA29038839
D003561CytarabineCytarabine results in increased expression of XRCC1 mRNA19194470
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of XRCC1 mRNA]22112500
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of XRCC1 protein]22112500
D013759DronabinolDronabinol results in decreased expression of XRCC1 mRNA16039398
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]28973540
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein]28973540
D015255IdarubicinIdarubicin results in decreased expression of XRCC1 mRNA28973540
D015255IdarubicinIdarubicin results in decreased expression of XRCC1 protein28973540
C007262deoxynivalenoldeoxynivalenol results in increased expression of XRCC1 mRNA24355168
C007262deoxynivalenoldeoxynivalenol results in increased expression of XRCC1 protein24355168
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XRCC1 mRNA28628672
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]28973540
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein]28973540
D002945CisplatinCisplatin results in increased expression of XRCC1 mRNA27594783
D002945CisplatinXRCC1 mRNA results in decreased susceptibility to Cisplatin15882455
D002945CisplatinXRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]22452940
D002945CisplatinXRCC1 protein results in decreased susceptibility to Cisplatin19853026
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"epigallocatechin gallate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
D004642EmodinEmodin affects the expression of XRCC1 protein19549930
C045651epigallocatechin gallate"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
C045651epigallocatechin gallate"epigallocatechin gallate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of XRCC1 mRNA29038839
D000431EthanolEthanol results in increased expression of XRCC1 mRNA22056336
D000431EthanolEthanol results in increased expression of XRCC1 protein22056336
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of XRCC1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of XRCC1 mRNA23550701
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of XRCC1 mRNA21071726
D005038EthylnitrosoureaEthylnitrosourea results in decreased expression of XRCC1 mRNA21071726
C026098etiracetametiracetam results in decreased expression of XRCC1 mRNA20345932
D005047Etoposide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]26046675
D005047Etoposide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]26046675
D005047EtoposideEtoposide results in increased expression of XRCC1 mRNA26046675
D005047EtoposideEtoposide results in increased expression of XRCC1 protein26046675
D005047Etoposideresveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]26046675
D005047Etoposideresveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]26046675
D005047EtoposideU 0126 inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]26046675
D005047EtoposideU 0126 inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]26046675
D005047EtoposideXRCC1 protein affects the susceptibility to Etoposide26046675
C082360fipronilfipronil results in increased expression of XRCC1 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of XRCC1 mRNA15465739
D005467FloxuridineXRCC1 protein results in decreased susceptibility to Floxuridine21613406|2219493
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of XRCC1 mRNA17690111
D005472FluorouracilXRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]22452940
D005472FluorouracilXRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]22452940
D005557FormaldehydeXRCC1 gene polymorphism affects the susceptibility to Formaldehyde17290738
D002955LeucovorinXRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]22452940
D002955LeucovorinXRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]22452940
C039281furanfuran results in increased expression of XRCC1 mRNA20194422
C039281furanfuran results in increased expression of XRCC1 mRNA25539665
C419708gefitinibXRCC1 protein polymorphism affects the susceptibility to gefitinib21264830
D019833GenisteinGenistein results in decreased expression of XRCC1 mRNA16169203
D017313FenretinideAscorbic Acid inhibits the reaction [Fenretinide results in decreased expression of XRCC1 protein]16124896
D017313FenretinideFenretinide results in decreased expression of XRCC1 protein16124896
D017313Fenretinide[Fenretinide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XRCC1 protein16124896
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of XRCC1 mRNA15458575
D006861Hydrogen PeroxideXRCC1 results in decreased susceptibility to Hydrogen Peroxide20705543
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XRCC1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of XRCC1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of XRCC1 mRNA28628672
C544151jinfukangjinfukang results in increased expression of XRCC1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of XRCC1 mRNA23086925
D007854LeadLead results in decreased expression of XRCC1 mRNA19921347
C031895lead chromateXRCC1 protein results in decreased susceptibility to lead chromate16714390
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of XRCC1 mRNA"24972896
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA22777745
C010480lupeollupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]27235710
C013099mancozeblupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]27235710
C013099mancozebmancozeb results in decreased expression of XRCC1 mRNA27235710
D008694MethamphetamineMethamphetamine results in increased expression of XRCC1 mRNA26307267
D008741Methyl MethanesulfonateXRCC1 mutant form results in increased susceptibility to Methyl Methanesulfonate26208482
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of XRCC1 mRNA23649840
D008741Methyl MethanesulfonateXRCC1 mutant form results in increased susceptibility to Methyl Methanesulfonate26208482
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of XRCC1 protein26558463
C028577monobutyl phthalatemonobutyl phthalate affects the expression of XRCC1 mRNA20864626
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of XRCC1 mRNA17616710
C030110oxaliplatinXRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]22452940
D010269ParaquatParaquat results in increased expression of XRCC1 mRNA15458575
D010269ParaquatParaquat results in increased expression of XRCC1 protein28428137
D010269ParaquatParaquat results in increased expression of XRCC128428137
C011272perfosfamideperfosfamide results in decreased expression of XRCC1 mRNA11754170
D010575PesticidesXRCC1 gene polymorphism affects the susceptibility to Pesticides18603015
D010862PilocarpinePilocarpine results in increased expression of XRCC1 mRNA17971868
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of XRCC1 mRNA17014948
D010936Plant ExtractsPlant Extracts results in decreased expression of XRCC1 mRNA15465739
D010984PlatinumXRCC1 gene polymorphism affects the susceptibility to Platinum18851872
D011084Polycyclic Aromatic HydrocarbonsXRCC1 gene affects the susceptibility to Polycyclic Aromatic Hydrocarbons15938845
D011084Polycyclic Aromatic HydrocarbonsXRCC1 gene SNP results in increased susceptibility to Polycyclic Aromatic Hydrocarbons20957144
D011084Polycyclic Aromatic HydrocarbonsXRCC1 protein polymorphism affects the susceptibility to Polycyclic Aromatic Hydrocarbons20395310
C043435polylactic acid-polyglycolic acid copolymer"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
C043435polylactic acid-polyglycolic acid copolymer"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
D059808PolyphenolsPolyphenols results in decreased expression of XRCC1 mRNA15465739
D011441PropylthiouracilPropylthiouracil results in increased expression of XRCC1 mRNA18077114|2478091
D017382Reactive Oxygen SpeciesAscorbic Acid inhibits the reaction [Reactive Oxygen Species results in decreased expression of XRCC1 protein]16124896
D017382Reactive Oxygen Species[Fenretinide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XRCC1 protein16124896
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of XRCC1 protein16124896
C059514resveratrolMAP2K1 protein inhibits the reaction [resveratrol results in decreased expression of XRCC1 protein]26046675
C059514resveratrolresveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]26046675
C059514resveratrolresveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]26046675
C059514resveratrolresveratrol results in decreased expression of XRCC1 protein26046675
C059514resveratrolresveratrol results in increased expression of XRCC1 mRNA22056336
C059514resveratrolresveratrol results in increased expression of XRCC1 protein22056336
C017947sodium arsenitesodium arsenite results in increased expression of XRCC1 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of XRCC1 mRNA16014739
D053260SootSoot results in decreased expression of XRCC1 mRNA21914721
D020058StyreneStyrene results in increased expression of XRCC1 mRNA21030303
D020058StyreneXRCC1 gene polymorphism results in increased susceptibility to Styrene15992842
D020058StyreneXRCC1 protein polymorphism affects the susceptibility to Styrene15468052
C013690styrene oxideXRCC1 protein polymorphism affects the susceptibility to styrene oxide15468052
D013629TamoxifenTamoxifen affects the expression of XRCC1 mRNA17555576
D013662TeaTea results in increased expression of XRCC1 mRNA22181980
D013662TeaTea results in increased expression of XRCC1 protein22181980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XRCC1 mRNA16039398|1876217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XRCC1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XRCC1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of XRCC1 mRNA25613284
C056068theaflavin"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]"23717041
C523062thio-dimethylarsinatethio-dimethylarsinate results in increased expression of XRCC1 mRNA27320638
D014028Tobacco Smoke PollutionXRCC1 gene SNP affects the susceptibility to Tobacco Smoke Pollution27592400
D014212TretinoinTretinoin results in decreased expression of XRCC1 mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in increased methylation of XRCC1 gene27618143
C057693troglitazonetroglitazone results in decreased expression of XRCC1 mRNA19631733
D014415TunicamycinTunicamycin results in decreased expression of XRCC1 mRNA15458575
D014415TunicamycinTunicamycin results in increased expression of XRCC1 mRNA22378314
C113580U 0126U 0126 inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]26046675
C113580U 0126U 0126 inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]26046675
C113580U 0126U 0126 results in decreased stability of XRCC1 mRNA26046675
C113580U 0126U 0126 results in decreased stability of XRCC1 protein26046675
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA]23619996
D014527Uric AcidUric Acid results in decreased expression of XRCC1 mRNA23619996
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA22777745
D014635Valproic AcidValproic Acid results in increased methylation of XRCC1 gene29154799
D014752Vinyl ChlorideGSTM1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]16097394
D014752Vinyl ChlorideGSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]16097394
D014752Vinyl ChlorideXRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]16097394
D014752Vinyl ChlorideXRCC1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]14602524
D014752Vinyl ChlorideXRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]16881598
D014752Vinyl ChlorideXRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]12010862|1688159
D014752Vinyl ChlorideXRCC1 gene SNP results in increased susceptibility to Vinyl Chloride17555083|1842036
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of XRCC1 protein15256147

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003909DNA ligase activity-TAS-  
GO:0005515protein binding-IPI12198176  14755728  15044383  15367657  15380105  15555565  
16713569  17353262  17353931  17396150  18923427  18971944  
19155274  19934257  20351257  21637298  23178593  24778456  
25456813  25609649  26496610  
GO:0019899enzyme binding-IPI8532526  
GO:0032356oxidized DNA binding-IMP28002403  
GO:19905993' overhang single-stranded DNA endodeoxyribonuclease activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000012single strand break repair-IEA-  
GO:0000724double-strand break repair via homologous recombination-TAS-  
GO:0001666response to hypoxia-IEA-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006284base-excision repair-IBA21873635  
GO:0006288base-excision repair, DNA ligation-TAS-  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0006303double-strand break repair via nonhomologous end joining-IEA-  
GO:0010033response to organic substance-IEA-  
GO:0010836negative regulation of protein ADP-ribosylation-IMP28002403  
GO:0021587cerebellum morphogenesis-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0033194response to hydroperoxide-IDA28002403  
GO:0042493response to drug-IEA-  
GO:0050882voluntary musculoskeletal movement-IMP28002403  
GO:0061819telomeric DNA-containing double minutes formation-IEA-  
GO:1903518positive regulation of single strand break repair-IGI28002403  
GO:1903518positive regulation of single strand break repair-IMP28002403  
GO:1904877positive regulation of DNA ligase activity-IMP28002403  
GO:1905765negative regulation of protection from non-homologous end joining at telomere-IEA-  
GO:1990414replication-born double-strand break repair via sister chromatid exchange-IMP28002403  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IEA-  
GO:0000790nuclear chromatin-IDA28002403  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA28002403  
GO:0070522ERCC4-ERCC1 complex-IEA-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110381Resolution of AP sites via the single-nucleotide replacement pathwayTAS
R-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayTAS
R-HSA-5685939HDR through MMEJ (alt-NHEJ)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14698416DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns. (2004 Jan 12)Relton CLMutat Res
28397463Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population. (2017 Apr 1)Procopciuc LMClin Lab
27668351Study of association between pre-senile cataracts and rs11615 of ERCC1, rs13181 of ERCC2, and rs25487 of XRCC1 polymorphisms in a Spanish population. (2017 Jul-Aug)Lopez-Valverde GOphthalmic Genet
15468052Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers. (2004)Godderis LEnviron Mol Mutagen
26936466The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke. (2016 Jun)Orhan GNeurol Sci
16038584Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. (2005 Aug)Rzeszowska-Wolny JRadiat Res
16280050XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study. (2005)Metsola KBreast Cancer Res
25025378ERCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma. (2014)Jin HPLoS One
24020925DNA repair gene polymorphisms and risk of head and neck cancer in the Tunisian population. (2014 Mar)Khlifi RJ Oral Pathol Med
15896924X-ray repair cross-complementing group 1 polymorphisms and cancer risks in Asian populations: a mini review. (2005)Qu TCancer Detect Prev
25715450[DNA repair XRCC1, XPD genes polymorphism as associated with the development of bladder cancer and renal cell carcinoma]. (2014 Apr)Akhmadishina LZGenetika
11303590Polymorphisms in the DNA repair gene XRCC1 and breast cancer. (2001 Mar)Duell EJCancer Epidemiol Biomarkers Prev
14679022A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. (2003 Dec 1)Han JCancer Res
16284380Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study. (2005 Nov)Matullo GCancer Epidemiol Biomarkers Prev
16483478[Association of genetic polymorphism in the DNA repair gene XRCC1 with susceptibility to lung cancer in non-smoking women]. (2005 Dec)Li MCZhonghua Zhong Liu Za Zhi
20935063Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis. (2010 Dec)Hodgson MECancer Epidemiol Biomarkers Prev
15840879Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study. (2005 Apr 20)Hung RJJ Natl Cancer Inst
26011347Detection of XRCC1 gene polymorphisms in Turkish head and neck squamous cell carcinoma patients: a comparative analysis with different populations. (2015 Mar-Apr)Mutlu PJ BUON
22277767Polymorphisms of DNA repair pathway genes and cigarette smoking in relation to susceptibility to large artery atherosclerotic stroke among ethnic Chinese in Taiwan. (2012)Shyu HYJ Atheroscler Thromb
15066937No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer. (2004 Apr)Gao WMCancer Epidemiol Biomarkers Prev
16510609XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. (2006 Mar 1)Pachkowski BFCancer Res
22821704Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. (2013 Dec)Liu LMol Carcinog
15199549Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer. (2004)Harms CEnviron Mol Mutagen
19628051Effects of cigarette smoking, XRCC1 genetic polymorphisms, and age on basal DNA damage in human blood mononuclear cells. (2009 Sep-Oct)Weng HMutat Res
25308691Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non-small cell lung cancer in East Chinese Han population. (2016 May)Du YClin Respir J
23479765XRCC1 Arg399Gln polymorphism and bladder cancer risk: updated meta-analyses based on 5767 cases and 6919 controls. (2013 Jan)Zhuo WExp Biol Med (Maywood)
17922186Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. (2008 Sep)Sangrajrang SBreast Cancer Res Treat
12750239The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas. (2003 May)Hsieh LLCancer Epidemiol Biomarkers Prev
29095251Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study. (2017 Nov)Chen HMedicine (Baltimore)
20003463Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. (2009 Dec 15)Yin ZBMC Cancer
26768611Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India. (2016 Jul)Ghosh STumour Biol
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet
16052427Molecular epidemiology of non-small cell lung cancer. (2005 Jun)Liu GSemin Respir Crit Care Med
15333465Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. (2004 Dec)Popanda OCarcinogenesis
23435956Decreased expression of DNA repair genes (XRCC1, ERCC1, ERCC2, and ERCC4) in squamous intraepithelial lesion and invasive squamous cell carcinoma of the cervix. (2013 May)Bajpai DMol Cell Biochem
16191433Possible genetic damage in the Czech nuclear power plant workers. (2006 Jan 29)Sram RJMutat Res
16308313DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. (2006 May)Matullo GCarcinogenesis
28241694[A association of genetic polymorphisms of XRCC1 and damage levels in workers exposed to coal tar pitch]. (2017 Jan 20)Zhang FZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
18006925DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. (2007 Nov)Stern MCCancer Epidemiol Biomarkers Prev
17855160Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workers. (2007 Dec 1)Slyskova JMutat Res
19393248Genetic polymorphisms in XRCC1, OGG1, APE1 and XRCC3 DNA repair genes, ionizing radiation exposure and chromosomal DNA damage in interventional cardiologists. (2009 Jun 18)Andreassi MGMutat Res
24084248The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. (2013 Dec 12)Molina EMutat Res
17264068XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk. (2007 Jun)Liu GCarcinogenesis
12223443DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. (2002 Sep)Stern MCCancer Epidemiol Biomarkers Prev
21518531[Interaction between polymorphisms in NQO1(C609T) and XRCC1(G28152A) and their correlation with smoking on gastric cancer]. (2011 Jan)Chen DJZhonghua Liu Xing Bing Xue Za Zhi
18393249[Association of the XRCC1 and hOGG1 polymorphisms with the risk of laryngeal carcinoma]. (2008 Apr)Yang YZhonghua Yi Xue Yi Chuan Xue Za Zhi
26782595Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility. (2016 Jan 4)Xie YQGenet Mol Res
21622940Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study. (2011 Aug)Roberts MRCarcinogenesis
24313652Classifying squamous cell carcinoma of the head and neck: prognosis, prediction and implications for therapy. (2014 Feb)Weiss JExpert Rev Anticancer Ther
17220334High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. (2007 Jan)Huang MCancer Epidemiol Biomarkers Prev
12183419A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. (2002 Aug 15)Duell EJCancer Res
28511303[Association of XRCC1 gene polymorphism and low dose ionizing radiation with peripheral blood lymphocyte micronucleus]. (2017 Mar 20)Yang FZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
16463309A maximum likelihood method for studying gene-environment interactions under conditional independence of genotype and exposure. (2006 Sep 30)Cheng KFStat Med
20429839Polymorphisms in DNA damage response genes and head and neck cancer risk. (2010 Aug)Flores-Obando REBiomarkers
24175791Association of DNA base-excision repair XRCC1, OGG1 and APE1 gene polymorphisms with nasopharyngeal carcinoma susceptibility in a Chinese population. (2013)Li QAsian Pac J Cancer Prev
21198260APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese. (2010)Osawa KAsian Pac J Cancer Prev
22792228Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes. (2012)Yu HPLoS One
22730687[The polymorphisms of XRCC1 gene and susceptibility to pulmonary cancer]. (2012 Jan)Wang NZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
24175795No association of XRCC1 and CLPTM1L polymorphisms with non-small cell lung cancer in a non-smoking Han Chinese population. (2013)Sun YAsian Pac J Cancer Prev
17614107Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. (2007 Aug 15)Li CCancer
26101477Impact of polymorphisms of the DNA repair gene XRCC1 and their role in the risk of prostate cancer. (2015 Mar-Apr)Zhu HPak J Med Sci
16457697A prospective study of XRCC1 (X-ray cross-complementing group 1) polymorphisms and breast cancer risk. (2005)Patel AVBreast Cancer Res
29110586Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population. (2017 Nov)Tasnim TTumour Biol
17418242Chromosomal aberrations in environmentally exposed population in relation to metabolic and DNA repair genes polymorphisms. (2007 Jul 1)Sram RJMutat Res
17290738[Association between XRCC1 gene polymorphisms and DNA damage of workers exposed to formaldehyde]. (2006 Nov)Jiang SFWei Sheng Yan Jiu
23271343A comprehensive analysis of plausible genotoxic covariates among workers of a polyvinyl chloride plant exposed to vinyl chloride monomer. (2013 May)Kumar AKArch Environ Contam Toxicol
27166553Association of Polymorphisms (rs 1799782, rs25489 and rs25487) in XRCC1 and (rs 13181) XPD genes with Acute Coronary Artery Syndrome in Subjects from Multan, Pakistan. (2016 May)Hameed HPak J Pharm Sci
22740911Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study. (2012 Feb)Zhang LOncol Lett
26159902DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival. (2015)Su YCell Physiol Biochem
27754415Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer. (2016 Oct 14)Verde ZInt J Mol Sci
15093278Cytogenetic biomarkers and genetic polymorphisms. (2004 Apr 1)Norppa HToxicol Lett
27356695Polymorphisms of XRCC1 and XRCC2 DNA Repair genes and Interaction with Environmental Factors Influence the Risk of Nasopharyngeal Carcinoma in Northeast India. (2016)Singh SAAsian Pac J Cancer Prev
17971348hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo. (2008 Jan)Mateuca RAMutagenesis
22970032Relationship between XRCC1 and XPD polymorphisms and the risk of the development of hepatocellular carcinoma: A case-control study. (2012 Aug)Yuan TExp Ther Med
29139108A 3' untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma. (2018 Mar)Ahmed TAnn Hum Genet
18037339Genetic polymorphisms and micronucleus formation: a review of the literature. (2008 Mar-Apr)Iarmarcovai GMutat Res
16142409XRCC1 polymorphism and lung cancer risk in relation to tobacco smoking. (2005 Oct)Schneider JInt J Mol Med
17034901Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. (2006 Dec)Ryk CLung Cancer
24515656Lung cancer risk and genetic variants in East Asians: a meta-analysis. (2014 Jun)Zhang QTumour Biol
11219769DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk. (2001 Feb)Stern MCCancer Epidemiol Biomarkers Prev
26562193The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis. (2015 Dec)Karahalil BClin Neurol Neurosurg
29721061The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. (2018)Du LJ Cancer
21188533An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer. (2011 Nov)Butkiewicz DMol Biol Rep
16924699[Association of single nucleotide polymorphisms and haplotypes in DNA repair gene XRCC1 with susceptibility of breast cancer]. (2006 Jul)Jin MJZhejiang Da Xue Xue Bao Yi Xue Ban
10974407The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK. (2000 Oct 16)Abdel-Rahman SZCancer Lett
11285194Genetic polymorphisms in DNA repair genes and risk of lung cancer. (2001 Apr)Butkiewicz DCarcinogenesis
17953974Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. (2008 Feb 1)Angelini SMutat Res
18199464SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan. (2008 Apr 15)Hsu LIToxicol Appl Pharmacol
11815397Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. (2002 Jan)Park JYCancer Epidemiol Biomarkers Prev
22686320Modulation of oxidative DNA damage by repair enzymes XRCC1 and hOGG1. (2012)Rihs HPJ Toxicol Environ Health A
25024628APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans. (2014 Jul 14)Zhang SHWorld J Gastroenterol
27592400Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study. (2016 Oct)Kobayashi SReprod Toxicol
18544627Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. (2008 Jun 15)McWilliams RRCancer Res
19174490Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. (2009 Apr)Cote MLCarcinogenesis
24177223Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns. (2014 Jan)Iyer SCarcinogenesis
19493423hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease. (2009 Apr 20)Yang SFChin Med J (Engl)
12160895Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. (2002 Aug 26)Lei YCMutat Res
12082022Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. (2002 Jun)Tuimala JCarcinogenesis
17164360XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. (2006 Dec)Stern MCCancer Epidemiol Biomarkers Prev
25169084[Effects of polymorphisms in XRCC1 and APE1 on vinyl chloride-induced chromosome damage]. (2014 May)Wang JZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
20976253Smoking, DNA adducts and number of risk DNA repair alleles in lung cancer cases, in subjects with benign lung diseases and in controls. (2010 Oct 4)Peluso MJ Nucleic Acids
19733688Micronucleus-centromere assay and DNA repair gene polymorphism in lymphocytes of industrial radiographers. (2009 Nov-Dec)Cho YHMutat Res
17302182Genetic risk profiles for cancer susceptibility and therapy response. (2007)Bartsch HRecent Results Cancer Res
28664594Evaluation of baseline frequency of sister chromatid exchanges in an Italian population according to age, sex, smoking habits, and gene polymorphisms. (2017 Nov)Santovito AAm J Hum Biol
15800678Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer. (2005)Demokan SPathol Oncol Res
18214807Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery. (2008)Kim YJJ Toxicol Environ Health A
14568296Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers. (2003 Nov 10)Ishikawa HMutat Res
25335960Gene-environment interaction involved in cholangiocarcinoma in the Thai population: polymorphisms of DNA repair genes, smoking and use of alcohol. (2014 Oct 21)Songserm NBMJ Open
17493640Biomarkers of air pollution exposure--a study of policemen in Prague. (2007 Nov 1)Topinka JMutat Res
15491645Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (2004 Nov 22)Aka PMutat Res
12379880DNA adduct burden and tobacco carcinogenesis. (2002 Oct 21)Wiencke JKOncogene
22541966Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)Tucker SLInt J Radiat Oncol Biol Phys
16311243Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. (2006 May)Andrew ASCarcinogenesis
16844323Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. (2006)Jiao LCancer Detect Prev
22081374Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India. (2012 Feb)Kumar ATumour Biol
19414392Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). (2009 Apr)Narter KFAnticancer Res
16796765Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. (2006 Jun 26)Cao YBMC Cancer
23246108Study on bladder cancer susceptibility and genetic polymorphisms of XPC, XPG, and CYP in smokers and non-smokers. (2013 May)Wen HActas Urol Esp
23317230Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study. (2012)Pan XFAsian Pac J Cancer Prev
20439344Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients. (2010 Oct)Sun ZAnn Oncol
16492913Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (2006 Feb)Smedby KECancer Epidemiol Biomarkers Prev
26271249Genetic polymorphisms in XRCC1 genes and colorectal cancer susceptibility. (2015 Aug 15)Huang YWorld J Surg Oncol
24933103Associations of polymorphisms in DNA repair genes and MDR1 gene with chemotherapy response and survival of non-small cell lung cancer. (2014)Du YPLoS One
12552590Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors. (2003)Hou SMEnviron Mol Mutagen
11714530Genetic polymorphism of XRCC1 and lung cancer risk among African-Americans and Caucasians. (2001 Dec)David-Beabes GLLung Cancer
18765423A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. (2008 Nov)Lao TMutagenesis
28639054A Strong Relationship Between Oral Squamous Cell Carcinoma and DNA Repair Genes. (2017 Dec)Avci HBiochem Genet
16835078How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer? (2006 Mar)Tempfer CBGynecol Endocrinol
16255782CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. (2005 Oct 29)Mullins DNBMC Cancer
15680408Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes. (2005 Feb 15)Angelini SMutat Res
16425350Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. (2005 Nov 14)Duarte MCWorld J Gastroenterol
27565807Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[ a ]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns. (2016 Nov 1)Iyer SCarcinogenesis
17928012Molecular biomonitoring of a population of nurses handling antineoplastic drugs. (2008 Feb 1)Cornetta TMutat Res
15878910Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. (2005 Sep)Casson AGCarcinogenesis
28464886A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. (2017 May 2)Yeo JBMC Cancer
26045834Association between XRCC1 and XRCC3 gene polymorphisms and risk of thyroid cancer. (2015)Wang XInt J Clin Exp Pathol
17355790[Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer]. (2007 Mar)Jin MJAi Zheng
26767006Polymorphisms in DNA repair genes of XRCC1, XPA, XPC, XPD and associations with lung cancer risk in Chinese people. (2014 May)Mei CThorac Cancer
17417947Contrasting impact of DNA repair gene XRCC1 polymorphisms Arg399Gln and Arg194Trp on the risk of lung cancer in the north-Indian population. (2007 Mar)Pachouri SSDNA Cell Biol
29775861Screening methylation of DNA repair genes in the oral mucosa of chronic smokers. (2018 May 1)Carta CFLArch Oral Biol
18272472DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population. (2008 Mar)Arizono KJpn J Clin Oncol
12692111Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk. (2003 Apr)Zhou WCancer Epidemiol Biomarkers Prev
26590607The relationship between five non-synonymous polymorphisms within three XRCC genes and gastric cancer risk in a Han Chinese population. (2016 May)Gong HTumour Biol
22850545Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. (2012)Nakao MJ Epidemiol
19230024Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. (2009 Jun 1)Applebaum KMInt J Cancer
21942242Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status. (2012 Apr)Kim HNLeuk Lymphoma
21195504Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. (2011 Aug)Qian BLung Cancer
16824555Influence of DNA repair polymorphisms on biomarkers of genotoxic damage in peripheral lymphocytes of healthy subjects. (2006 Aug 30)Zijno AMutat Res
19959686Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. (2009 Dec)Curtin KCancer Epidemiol Biomarkers Prev
28560653Association of Single Nucleotide Polymorphisms in XRCC1 (194) and XPD (751) with Age-related cataract. (2017 May 30)Khosa TInt Ophthalmol
16172101Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma. (2005 Dec)Chen CCInt J Epidemiol
25089939Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus. (2014 Sep)Ramaniuk VPBiomarkers
25592768Putative functional variants of XRCC1 identified by RegulomeDB were not associated with lung cancer risk in a Korean population. (2015 Jan-Feb)Yoo SSCancer Genet
15225899DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk. (2004)Yu HPCancer Detect Prev
15680411DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers. (2005 Feb 15)Wilding CSMutat Res
15800946Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. (2005 Sep 1)Hong YCInt J Cancer
17412371PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms. (2007 Jul 1)Binkova BMutat Res
17531525Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. (2007 Jul 28)De Ruyck KMutat Res
16542436Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. (2006 Mar 16)Skjelbred CFBMC Cancer
24722645Complex relationships between occupation, environment, DNA adducts, genetic polymorphisms and bladder cancer in a case-control study using a structural equation modeling. (2014)Porru SPLoS One
17486273Relationship between XRCC1 polymorphisms and susceptibility to prostate cancer in men from Han, Southern China. (2007 May)Xu ZAsian J Androl
25845234[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease]. (2014 Nov-Dec)Korytina GFMol Biol (Mosk)
14639127CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx. (2003 Dec)Varzim GEur J Cancer Prev
11532866XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. (2001 Sep)Matullo GCarcinogenesis
19350405Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai. (2009 Dec)Wen HInt Urol Nephrol
24175813The codon 399 Arg/Gln XRCC1 polymorphism is associated with lung cancer in Indians. (2013)Natukula KAsian Pac J Cancer Prev
25584213XRCC-1 Gene Polymorphism (Arg399Gln) and Susceptibility to Development of Lung Cancer in Cohort of North Indian Population: A Pilot Study. (2014 Nov)Uppal VJ Clin Diagn Res
15970793A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. (2005 Jul)Hu ZPharmacogenet Genomics
28893607Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: Dose-dependent association of plasma cotinine with infant birth size among Japanese women-The Hokkaido Study. (2017 Dec)Kobayashi SReprod Toxicol
29020930The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer: a hospital-based matched case-control study. (2017 Oct 11)Putthanachote NBMC Cancer
22893750Role of XPC, XPD, XRCC1, GSTP genetic polymorphisms and Barrett's esophagus in a cohort of Italian subjects. A neural network analysis. (2012)Tarlarini CClin Exp Gastroenterol
21976407Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. (2012 Oct)Buch SCMol Carcinog
26681190Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population. (2015)Xue PPLoS One
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