Gene: XRCC2

7516
FANCU
X-ray repair cross complementing 2
protein-coding
7q36.1
Ensembl:ENSG00000196584 MIM:600375 Vega:OTTHUMG00000151470 UniprotKB:O43543
NG_027988.1
PubMed
0   ANCO-SNPs
ND
10   
7.215e-1 (AD)  7.340e-1 (ND)   (Frontal_Cortex)
8.356e-1 (AD)  5.551e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEU30.775
UBE4A0.751
ZNF2530.749
VPS13B0.747
LNPEP0.746
RALGAPA10.746
ZNF910.745
MBD50.74
SLC12A60.738
ZNF7930.737

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.37
BCL7C-0.352
TCF15-0.352
FAM89A-0.352
HIST1H1C-0.35
PPP1R14B-0.344
S100A14-0.338
CSAG1-0.338
EMP3-0.336
SERTAD1-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of XRCC2 mRNA21983209
C0067574-biphenylamine4-biphenylamine results in decreased expression of XRCC2 mRNA24857880
D000082AcetaminophenAcetaminophen results in increased expression of XRCC2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of XRCC2 mRNA22100608
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of XRCC2 protein"20855422
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XRCC2 mRNA20504355
D004958EstradiolEstradiol results in decreased expression of XRCC2 mRNA24349563
C006780bisphenol Abisphenol A results in decreased expression of XRCC2 mRNA29275510
C546611brevetoxin 2brevetoxin 2 results in increased expression of XRCC2 mRNA20498034
C016274bromoacetatebromoacetate results in decreased expression of XRCC2 mRNA19753638
C584509C646 compoundC646 compound results in decreased expression of XRCC2 mRNA23698071
C584509C646 compoundC646 compound results in increased expression of XRCC2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of XRCC2 promoter22457795
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of XRCC2 mRNA21878529
C089595cylindrospermopsincylindrospermopsin results in increased expression of XRCC2 mRNA23726867
D000069439DasatinibDasatinib results in decreased expression of XRCC2 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of XRCC2 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of XRCC2 mRNA17361019|2126653
D004041Dietary FatsDietary Fats results in decreased expression of XRCC2 mRNA21852083
D002117CalcitriolCalcitriol results in decreased expression of XRCC2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of XRCC2 mRNA21592394
D004126DimethylformamideDimethylformamide affects the expression of XRCC2 mRNA26387567
D004126DimethylformamideDimethylformamide results in increased expression of XRCC2 protein26387567
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of XRCC2 mRNA26159488
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]16417649
D005047EtoposideEtoposide results in increased expression of XRCC2 protein16417649
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased expression of XRCC2 mRNA18852132
C039281furanfuran results in increased expression of XRCC2 mRNA22079235
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of XRCC2 mRNA25613284
C544151jinfukangjinfukang results in increased expression of XRCC2 mRNA27392435
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased expression of XRCC2 mRNA18852132
D001556LindaneLindane results in increased expression of XRCC2 mRNA24349563
D008154LucanthoneLucanthone results in decreased expression of XRCC2 mRNA21148553
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of XRCC2 mRNA24810058
C005246myristicinmyristicin results in decreased expression of XRCC2 mRNA24792648
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of XRCC2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of XRCC2 mRNA26516004
C030090phosphoramide mustardphosphoramide mustard results in increased expression of XRCC2 mRNA26708502
D010795Phthalic AcidsPhthalic Acids results in increased expression of XRCC2 mRNA21061450
C043680ptaquilosideptaquiloside results in increased expression of XRCC2 mRNA23274088
C059514resveratrolresveratrol results in decreased expression of XRCC2 mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of XRCC2 mRNA21427059
C009277sodium arsenatesodium arsenate results in increased expression of XRCC2 mRNA24349563
C017947sodium arsenitesodium arsenite results in increased expression of XRCC2 mRNA16014739
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of XRCC2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of XRCC2 mRNA21592394
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of XRCC2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XRCC2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of XRCC2 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of XRCC2 mRNA25613284
D013883ThiostreptonThiostrepton results in decreased expression of XRCC2 mRNA22321511
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of XRCC2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of XRCC2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of XRCC2 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of XRCC2 mRNA19631733
C057693troglitazonetroglitazone results in increased expression of XRCC2 mRNA19631733
D014520UrethaneUrethane results in decreased expression of XRCC2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of XRCC2 mRNA21427059
D014752Vinyl ChlorideXRCC2 gene polymorphism affects the susceptibility to Vinyl Chloride16217922
D014810Vitamin EVitamin E results in decreased expression of XRCC2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA bindingcontributes_toIDA20207730  
GO:0005515protein binding-IPI10749867  10871607  11751635  11842113  12975363  16710300  
24141787  25416956  25910212  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IMP21276791  
GO:0000724double-strand break repair via homologous recombination-IMP23149936  
GO:0001701in utero embryonic development-IEA-  
GO:0001756somitogenesis-IEA-  
GO:0006281DNA repair-IGI10422536  
GO:0007098centrosome cycle-IMP21276791  
GO:0010165response to X-ray-IEA-  
GO:0010332response to gamma radiation-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0042148strand invasion-IDA11834724  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0050769positive regulation of neurogenesis-IEA-  
GO:0051321meiotic cell cycle-TAS9628903  
GO:2000269regulation of fibroblast apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IDA20207730  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-IDA21276791  
GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex-IDA11751635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23319983Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population. (2012 Dec 20)Romanowicz-Makowska HArch Med Sci
17986315XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. (2008 Feb)Jiao LAm J Gastroenterol
14578164Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study. (2004 Feb)Han JCarcinogenesis
16835078How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer? (2006 Mar)Tempfer CBGynecol Endocrinol
16284380Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study. (2005 Nov)Matullo GCancer Epidemiol Biomarkers Prev
18046624An investigation on the polymorphisms of two DNA repair genes and susceptibility to ESCC and GCA of high-incidence region in northern China. (2009 Feb)Wang NMol Biol Rep
21188533An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer. (2011 Nov)Butkiewicz DMol Biol Rep
27356695Polymorphisms of XRCC1 and XRCC2 DNA Repair genes and Interaction with Environmental Factors Influence the Risk of Nasopharyngeal Carcinoma in Northeast India. (2016)Singh SAAsian Pac J Cancer Prev
29748531XRCC2 Polymorphisms and Environmental Factors Predict High Risk of Colorectal Cancer. (2018 May 7)Wang LMed Sci Monit
15386379DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. (2004 Dec 10)Benhamou SInt J Cancer