Gene: XRCC3

7517
CMM6
X-ray repair cross complementing 3
protein-coding
14q32.33
Ensembl:ENSG00000126215 MIM:600675 Vega:OTTHUMG00000169228 UniprotKB:O43542
NG_011516.1
PubMed
ND
71   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.870e-1 (AD)  6.032e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC27A10.821
ROBO30.796
AKT20.796
TPCN10.792
PLXNB20.789
MICALL20.789
TMEM1040.788
USP400.781
CLCN20.779
RNPEPL10.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.486
OR4F29-0.443
PAGE4-0.306
CALCR-0.292
PPP1R17-0.276
EGFL6-0.272
NTS-0.268
SIM1-0.266
FOXB1-0.265
C22orf42-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of XRCC3 mRNA"18948301
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XRCC3 mRNA"18948301
C5112952,2',4,4'-tetrabromodiphenyl ether"Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XRCC3 mRNA]"18948301
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of XRCC3 mRNA"18948301
C0067574-biphenylamine4-biphenylamine results in decreased expression of XRCC3 mRNA24857880
D000082AcetaminophenAcetaminophen affects the expression of XRCC3 mRNA17562736
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XRCC3 mRNA]"18948301
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of XRCC3 mRNA19770486
C004984apocarotenalapocarotenal results in increased expression of XRCC3 mRNA17034753
D001151ArsenicXRCC3 gene SNP affects the susceptibility to Arsenic19429237|2103547
C006632arsenic trioxidearsenic trioxide results in increased expression of XRCC3 mRNA17530438
D001194AsbestosXRCC3 gene polymorphism results in increased susceptibility to Asbestos16564556
D001241AspirinAspirin results in increased expression of XRCC3 mRNA20514442
D001241AspirinAspirin results in increased expression of XRCC3 protein20514442
D001280AtrazineAtrazine results in increased expression of XRCC3 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of XRCC3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XRCC3 mRNA20106945
D019207beta Carotenebeta Carotene results in increased expression of XRCC3 mRNA17034753
C006780bisphenol Abisphenol A affects the expression of XRCC3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of XRCC3 promoter27312807
D000069286BortezomibBortezomib results in decreased expression of XRCC3 mRNA20977926
C546611brevetoxin 2brevetoxin 2 results in increased expression of XRCC3 mRNA20498034
C016274bromoacetatebromoacetate results in decreased expression of XRCC3 mRNA19753638
C584509C646 compoundC646 compound results in decreased expression of XRCC3 mRNA26191083
D002166CamptothecinCamptothecin results in decreased expression of XRCC3 mRNA24792648
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of XRCC3 mRNA20971185
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of XRCC3 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of XRCC3 mRNA21632981
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of XRCC3 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of XRCC3 mRNA27594783
D002945CisplatinXRCC3 gene polymorphism affects the susceptibility to [Cisplatin co-treated with Fluorouracil]21347786
D002117CalcitriolCalcitriol results in decreased expression of XRCC3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of XRCC3 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"epigallocatechin gallate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
D004126DimethylformamideDimethylformamide results in increased expression of XRCC3 mRNA26387567
D004126DimethylformamideDimethylformamide results in increased expression of XRCC3 protein26387567
D004317DoxorubicinXRCC3 protein results in decreased susceptibility to Doxorubicin24675091
D004317DoxorubicinDoxorubicin results in increased expression of XRCC3 mRNA22712078
C045651epigallocatechin gallate"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
C045651epigallocatechin gallate"epigallocatechin gallate inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XRCC3 mRNA17942748
D005027Ethylene OxideXRCC3 protein affects the susceptibility to Ethylene Oxide16386346
D005038EthylnitrosoureaXRCC3 gene polymorphism affects the susceptibility to Ethylnitrosourea17158087
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein]16417649
D005047EtoposideEtoposide results in increased expression of XRCC3 protein16417649
D005472FluorouracilXRCC3 gene polymorphism affects the susceptibility to [Cisplatin co-treated with Fluorouracil]21347786
D017313FenretinideFenretinide results in increased expression of XRCC3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of XRCC3 mRNA22539617
C492448ICG 001ICG 001 affects the expression of XRCC3 mRNA26191083
C005246myristicinmyristicin results in decreased expression of XRCC3 mRNA24792648
C005246myristicinmyristicin results in increased expression of XRCC3 mRNA24792648
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of XRCC3 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of XRCC3 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of XRCC3 mRNA26516004
D010862PilocarpinePilocarpine results in increased expression of XRCC3 mRNA17971868
C006253pirinixic acidpirinixic acid results in increased expression of XRCC3 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of XRCC3 mRNA23557933
C043435polylactic acid-polyglycolic acid copolymer"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
C043435polylactic acid-polyglycolic acid copolymer"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
C019536potassium bromatepotassium bromate results in decreased expression of XRCC3 mRNA22539617
D011794QuercetinQuercetin results in increased expression of XRCC3 mRNA21632981
C547185riccardin Driccardin D results in decreased expression of XRCC3 mRNA24069304
C017947sodium arsenitesodium arsenite results in increased expression of XRCC3 mRNA16014739
D020058StyreneXRCC3 protein polymorphism affects the susceptibility to Styrene15468052
D013629TamoxifenTamoxifen results in increased expression of XRCC3 mRNA15590111
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of XRCC3 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of XRCC3 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XRCC3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XRCC3 mRNA17942748
C056068theaflavin"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
C056068theaflavin"theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]"23717041
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of XRCC3 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of XRCC3 mRNA19140230
C057693troglitazonetroglitazone results in increased expression of XRCC3 mRNA28973697
D001335Vehicle EmissionsVehicle Emissions affects the methylation of XRCC3 gene25560391
D014752Vinyl ChlorideVinyl Chloride results in increased expression of XRCC3 protein15256147

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA bindingcontributes_toIDA20207730  
GO:0005515protein binding-IPI9469824  9660962  11751635  11842113  21965664  24005329  
24141787  26496610  
GO:0005524ATP binding-IEA-  
GO:0008821crossover junction endodeoxyribonuclease activitycontributes_toIMP14716019  23108668  
GO ID GO Term Qualifier Evidence PubMed
GO:0000707meiotic DNA recombinase assembly-IBA21873635  
GO:0000722telomere maintenance via recombination-IMP15507207  
GO:0000724double-strand break repair via homologous recombination-IMP23149936  
GO:0006281DNA repair-IGI10422536  
GO:0006310DNA recombination-TAS9660962  
GO:0006974cellular response to DNA damage stimulus-TAS7603995  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0010033response to organic substance-IEA-  
GO:0010824regulation of centrosome duplication-IMP23108668  
GO:0036297interstrand cross-link repair-IMP26323318  
GO:0071140resolution of mitotic recombination intermediates-IMP23108668  
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint-IMP23108668  
GO:0090656t-circle formation-IC15507207  
GO:0090656t-circle formation-IMP21903669  
GO:0090657telomeric loop disassembly-TAS27918544  
GO:0090737telomere maintenance via telomere trimming-IGI27918544  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IC15507207  
GO:0005634nucleus-IDA16215984  26323318  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IBA21873635  
GO:0005657replication fork-IDA20207730  
GO:0005737cytoplasm-IDA16215984  
GO:0005739mitochondrion-IDA20413593  
GO:0005829cytosol-IDA-  
GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex-IBA21873635  
GO:0033065Rad51C-XRCC3 complex-IDA11751635  
GO:0048471perinuclear region of cytoplasm-IDA16215984  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14698416DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns. (2004 Jan 12)Relton CLMutat Res
28397463Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population. (2017 Apr 1)Procopciuc LMClin Lab
15199549Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer. (2004)Harms CEnviron Mol Mutagen
15468052Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers. (2004)Godderis LEnviron Mol Mutagen
25400036DNA repair gene polymorphisms in B cell non-Hodgkin's lymphoma. (2015 Mar)Bahceci ATumour Biol
23289442XRCC3 Thr241Met gene polymorphisms and lung cancer risk: a meta-analysis. (2013 Jan 4)Zhan PJ Exp Clin Cancer Res
16284380Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study. (2005 Nov)Matullo GCancer Epidemiol Biomarkers Prev
20935063Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis. (2010 Dec)Hodgson MECancer Epidemiol Biomarkers Prev
26124335Contribution of Genotype of DNA Double-strand Break Repair Gene XRCC3, Gender, and Smoking Behavior to Lung Cancer Risk in Taiwan. (2015 Jul)Chen HJAnticancer Res
28415781Relevance of DNA repair gene polymorphisms to gastric cancer risk and phenotype. (2017 May 30)Carrera-Lasfuentes POncotarget
18768166Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption. (2008 Oct 30)Werbrouck JMutat Res
20804747Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population. (2010 Dec)Sliwinski TExp Mol Pathol
16542436Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. (2006 Mar 16)Skjelbred CFBMC Cancer
15333465Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. (2004 Dec)Popanda OCarcinogenesis
17158087Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes. (2007 Mar 5)Jiao LMutat Res
16308313DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. (2006 May)Matullo GCarcinogenesis
18336773[Relationship between polymorphisms of DNA repair gene XRCC3 and susceptibility to lung cancer]. (2007 Dec)Zhang ZLZhonghua Jie He He Hu Xi Za Zhi
12223443DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. (2002 Sep)Stern MCCancer Epidemiol Biomarkers Prev
17971348hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo. (2008 Jan)Mateuca RAMutagenesis
26782595Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility. (2016 Jan 4)Xie YQGenet Mol Res
21560306[Relationship between XRCC3 gene polymorphisms and lung cancer]. (2011 Mar)Huang MWei Sheng Yan Jiu
21198260APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese. (2010)Osawa KAsian Pac J Cancer Prev
23663450Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. (2013 May 10)Zhao PBMC Cancer
21617942Gene variants of XRCC4 and XRCC3 and their association with risk for urothelial bladder cancer. (2012 Feb)Mittal RDMol Biol Rep
26159902DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival. (2015)Su YCell Physiol Biochem
27754415Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer. (2016 Oct 14)Verde ZInt J Mol Sci
29139108A 3' untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma. (2018 Mar)Ahmed TAnn Hum Genet
18037339Genetic polymorphisms and micronucleus formation: a review of the literature. (2008 Mar-Apr)Iarmarcovai GMutat Res
11532866XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. (2001 Sep)Matullo GCarcinogenesis
25252713Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy. (2014 Sep 25)De Langhe SBMC Cancer
17701750The XRCC3 Thr241Met polymorphism and breast cancer risk: a case-control study in a Thai population. (2007 Sep-Oct)Sangrajrang SBiomarkers
17953974Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. (2008 Feb 1)Angelini SMutat Res
14534887XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. (2003 Oct 15)Wang YCancer
21188533An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer. (2011 Nov)Butkiewicz DMol Biol Rep
15386379DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. (2004 Dec 10)Benhamou SInt J Cancer
17986315XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. (2008 Feb)Jiao LAm J Gastroenterol
17164360XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. (2006 Dec)Stern MCCancer Epidemiol Biomarkers Prev
20976253Smoking, DNA adducts and number of risk DNA repair alleles in lung cancer cases, in subjects with benign lung diseases and in controls. (2010 Oct 4)Peluso MJ Nucleic Acids
19733688Micronucleus-centromere assay and DNA repair gene polymorphism in lymphocytes of industrial radiographers. (2009 Nov-Dec)Cho YHMutat Res
18046624An investigation on the polymorphisms of two DNA repair genes and susceptibility to ESCC and GCA of high-incidence region in northern China. (2009 Feb)Wang NMol Biol Rep
11285194Genetic polymorphisms in DNA repair genes and risk of lung cancer. (2001 Apr)Butkiewicz DCarcinogenesis
22541966Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)Tucker SLInt J Radiat Oncol Biol Phys
19414392Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). (2009 Apr)Narter KFAnticancer Res
12917199Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations. (2003 Aug)Medina PPCancer Epidemiol Biomarkers Prev
15491645Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (2004 Nov 22)Aka PMutat Res
16357593Xenobiotic-metabolizing genes and small-for-gestational-age births: interaction with maternal smoking. (2006 Jan)Infante-Rivard CEpidemiology
16425350Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. (2005 Nov 14)Duarte MCWorld J Gastroenterol
16271954The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. (2005 Nov)Jin MJCancer Genet Cytogenet
24933103Associations of polymorphisms in DNA repair genes and MDR1 gene with chemotherapy response and survival of non-small cell lung cancer. (2014)Du YPLoS One
28639054A Strong Relationship Between Oral Squamous Cell Carcinoma and DNA Repair Genes. (2017 Dec)Avci HBiochem Genet
16824555Influence of DNA repair polymorphisms on biomarkers of genotoxic damage in peripheral lymphocytes of healthy subjects. (2006 Aug 30)Zijno AMutat Res
16492913Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (2006 Feb)Smedby KECancer Epidemiol Biomarkers Prev
15680408Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes. (2005 Feb 15)Angelini SMutat Res
17928012Molecular biomonitoring of a population of nurses handling antineoplastic drugs. (2008 Feb 1)Cornetta TMutat Res
15878910Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. (2005 Sep)Casson AGCarcinogenesis
15312685XRCC3 polymorphisms and risk of lung cancer. (2004 Sep 15)Jacobsen NRCancer Lett
26045834Association between XRCC1 and XRCC3 gene polymorphisms and risk of thyroid cancer. (2015)Wang XInt J Clin Exp Pathol
17034901Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. (2006 Dec)Ryk CLung Cancer
21195504Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. (2011 Aug)Qian BLung Cancer
29267235Relationship between Telomere Length, Genetic Traits and Environmental/Occupational Exposures in Bladder Cancer Risk by Structural Equation Modelling. (2017 Dec 21)Pavanello SInt J Environ Res Public Health
23824570DNA repair gene XRCC3 Thr241Met polymorphism and hepatocellular carcinoma risk. (2013 Oct)Duan CTumour Biol
15680411DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers. (2005 Feb 15)Wilding CSMutat Res
25687493Contribution of double strand break repair gene XRCC3 genotypes to nasopharyngeal carcinoma risk in Taiwan. (2015 Feb 28)Liu JCChin J Physiol
19815090Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population? (2009 Nov-Dec)Gangwar RMutat Res
25845234[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease]. (2014 Nov-Dec)Korytina GFMol Biol (Mosk)
19393248Genetic polymorphisms in XRCC1, OGG1, APE1 and XRCC3 DNA repair genes, ionizing radiation exposure and chromosomal DNA damage in interventional cardiologists. (2009 Jun 18)Andreassi MGMutat Res
15737490Influence of hOGG1, XRCC1 and XRCC3 genotypes on biomarkers of genotoxicity in workers exposed to cobalt or hard metal dusts. (2005 Apr 10)Mateuca RToxicol Lett
18300452[Association between genetic polymorphism in DNA repair genes XRCC3 and risks of laryngeal and hypopharyngeal carcinomas]. (2007 Nov)Wen SXZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
14578164Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study. (2004 Feb)Han JCarcinogenesis
15746160Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (2005 Jul)Broberg KCarcinogenesis
22427030Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults. (2013 Jan)Kostrzewska-Poczekaj MEur Arch Otorhinolaryngol