Gene info: ID 7520

Gene: XRCC5

GENE ID: 7520

Synonyms: KARP-1|KARP1|KU80|KUB2|Ku86|NFIV

Description: X-ray repair cross complementing 5

Gene type: protein-coding

Location: 2q35

dbXrefs: Ensembl:ENSG00000079246 MIM:194364 Vega:OTTHUMG00000133059 UniprotKB:P13010

RefSeq: NG_029780.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.782e-1 (AD) 7.256e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KPNB1	0.956
GDI2	0.954
HNRNPK	0.948
CAP1	0.946
ARCN1	0.946
PPP6C	0.945
CCDC47	0.943
TSN	0.943
DCTN4	0.941
ILF2	0.94

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.809
OR4F29	-0.779
MTRNR2L6	-0.193
MTRNR2L9	-0.174
HMHB1	-0.17
MTRNR2L10	-0.168
TTLL10	-0.158
OR4F16	-0.15
PTGDR2	-0.145
C8orf74	-0.14

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of XRCC5 mRNA"	21346803
C031319	2-hydroxyethyl disulfide	[2-hydroxyethyl disulfide co-treated with Glucose deficiency] results in decreased activity of [XRCC5 protein binds to XRCC6 protein]	22926048
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of XRCC5 mRNA"	12734338
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of XRCC5 mRNA"	18648102
C086538	4-amino-1,8-naphthalimide	"XRCC5 protein affects the susceptibility to 4-amino-1,8-naphthalimide"	16556909
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of XRCC5 mRNA"	21346803
C013813	4-anisidine	4-anisidine results in decreased expression of XRCC5 mRNA	12929121
D000082	Acetaminophen	Acetaminophen results in decreased expression of XRCC5 mRNA	21420995\|2649742
D000082	Acetaminophen	Acetaminophen affects the expression of XRCC5 mRNA	17562736
C016601	afimoxifene	afimoxifene results in decreased expression of XRCC5 mRNA	16514628
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of XRCC5 gene	27153756
D000393	Air Pollutants	Air Pollutants results in increased expression of XRCC5 protein	28389379
D000638	Amiodarone	Amiodarone results in increased expression of XRCC5 mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of XRCC5 mRNA	16483693
D001151	Arsenic	Arsenic results in increased expression of XRCC5 protein	19818359
C006632	arsenic trioxide	arsenic trioxide results in increased expression of XRCC5 mRNA	22521957
D001280	Atrazine	Atrazine results in decreased expression of XRCC5 mRNA	22378314
D001554	Benzene	Benzene results in increased expression of XRCC5 mRNA	15342939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of XRCC5 mRNA	28461126
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of XRCC5 mRNA	20504355
D004958	Estradiol	Estradiol results in increased expression of XRCC5 mRNA	16514628
C006780	bisphenol A	bisphenol A affects the expression of XRCC5 mRNA	21786754
C006780	bisphenol A	bisphenol A inhibits the reaction [PRKDC protein binds to XRCC5 protein]	23227178
C006780	bisphenol A	bisphenol A affects the methylation of XRCC5 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of XRCC5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of XRCC5 gene	28505145
D001761	Bleomycin	XRCC5 protein affects the susceptibility to Bleomycin	12384553
C584509	C646 compound	C646 compound results in decreased expression of XRCC5 mRNA	26191083
C037123	cadmium sulfate	cadmium sulfate affects the expression of XRCC5 mRNA	23770381
C028337	cadmium telluride	cadmium telluride analog affects the expression of XRCC5 mRNA	23770381
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of XRCC5 mRNA	20360939
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of XRCC5 mRNA	16039398
C524865	carfilzomib	[carfilzomib co-treated with vorinostat] results in increased acetylation of XRCC5 protein	20233973
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of XRCC5 mRNA	23650126
D002994	Clofibrate	Clofibrate results in increased expression of XRCC5 mRNA	16081524
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of XRCC5 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of XRCC5 mRNA	19320972\|1937684
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of XRCC5 mRNA	21878529
D003474	Curcumin	Curcumin results in decreased expression of XRCC5 mRNA	17596214
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of XRCC5 mRNA	29038839
C014347	decitabine	decitabine affects the expression of XRCC5 mRNA	23300844
D013759	Dronabinol	Dronabinol results in decreased expression of XRCC5 mRNA	16039398
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of XRCC5 mRNA	17361019
D002945	Cisplatin	Cisplatin affects the expression of XRCC5 mRNA	23300844
D002945	Cisplatin	XRCC5 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]	18546291
C000944	dicrotophos	dicrotophos results in decreased expression of XRCC5 mRNA	28302478
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of XRCC5 mRNA	19690152
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of XRCC5 mRNA	20360939
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of XRCC5 mRNA	17602206
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of XRCC5 mRNA	18253720\|1877588
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of XRCC5 mRNA	22467019
D002117	Calcitriol	Calcitriol results in decreased expression of XRCC5 mRNA	15951637
C067311	docetaxel	[wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein	20878124
D004317	Doxorubicin	Doxorubicin results in increased expression of XRCC5 protein	24812279
D004317	Doxorubicin	STAT3 gene mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC5 protein]	24812279
D004317	Doxorubicin	[STAT3 gene mutant form results in increased susceptibility to Doxorubicin] which results in increased expression of XRCC5 protein	24812279
D004317	Doxorubicin	TRP53 protein mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC5 protein]	24812279
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of XRCC5 protein"	18422750
D004391	Dust	Dust results in decreased expression of XRCC5 mRNA	17805423
D004726	Endosulfan	Endosulfan results in decreased expression of XRCC5 mRNA	26722802
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of XRCC5 protein	23301498
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of XRCC5 mRNA	29038839
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of XRCC5 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of XRCC5 mRNA	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of XRCC5 mRNA	17555576
D005047	Etoposide	XRCC5 protein affects the susceptibility to Etoposide	12384553
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of XRCC5 mRNA	18253720\|1877588
D011345	Fenofibrate	Fenofibrate results in increased expression of XRCC5 mRNA	17264098\|1877588
D018120	Finasteride	Finasteride results in increased expression of XRCC5 mRNA	24136188
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of XRCC5 mRNA	17347304
C024352	fludarabine	[LAQ824 co-treated with fludarabine] results in decreased expression of XRCC5 protein	18852132
D005472	Fluorouracil	XRCC5 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]	18546291
D005485	Flutamide	Flutamide results in decreased expression of XRCC5 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of XRCC5 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of XRCC5 mRNA	20655997
C070081	fulvestrant	fulvestrant results in decreased expression of XRCC5 mRNA	16514628
C039281	furan	furan results in increased expression of XRCC5 mRNA	25539665
D005947	Glucose	[2-hydroxyethyl disulfide co-treated with Glucose deficiency] results in decreased activity of [XRCC5 protein binds to XRCC6 protein]	22926048
D017313	Fenretinide	Fenretinide results in increased expression of XRCC5 mRNA	28973697
D006918	Hydroxyurea	Hydroxyurea results in decreased expression of XRCC5 mRNA	12929121
D006918	Hydroxyurea	Hydroxyurea results in increased mutagenesis of XRCC5 gene	16868089
C051890	irinotecan	irinotecan analog results in decreased expression of XRCC5 mRNA	18927307
C544151	jinfukang	jinfukang results in decreased expression of XRCC5 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of XRCC5 mRNA	25961927
C477361	LAQ824	[LAQ824 co-treated with fludarabine] results in decreased expression of XRCC5 protein	18852132
C477361	LAQ824	LAQ824 results in decreased expression of and results in decreased activity of XRCC5 protein	18852132
C031895	lead chromate	XRCC5 protein affects the susceptibility to lead chromate	17361020
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of XRCC5 mRNA"	24972896
D008727	Methotrexate	Methotrexate affects the expression of XRCC5 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of XRCC5 protein	25809596
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of XRCC5 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of XRCC5 mRNA	23649840
D008770	Methylnitrosourea	Methylnitrosourea results in increased mutagenesis of XRCC5 gene	16868089
D015741	Metribolone	Metribolone results in decreased expression of XRCC5 protein	17152098
C028007	nickel monoxide	nickel monoxide results in increased expression of XRCC5 mRNA	19167457
D009588	Nitrogen Mustard Compounds	XRCC5 protein affects the susceptibility to Nitrogen Mustard Compounds	10717383
D017239	Paclitaxel	Paclitaxel results in decreased expression of XRCC5 mRNA	12929121
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of XRCC5 protein	26178269
C011272	perfosfamide	perfosfamide results in decreased expression of XRCC5 mRNA	11754170
D010882	Piperonyl Butoxide	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of XRCC5 mRNA	19690152
D010882	Piperonyl Butoxide	Piperonyl Butoxide affects the expression of XRCC5 mRNA	17014948
C006253	pirinixic acid	pirinixic acid results in increased expression of XRCC5 mRNA	19162173\|2012707
D010936	Plant Extracts	Plant Extracts results in increased expression of XRCC5 mRNA	23557933
C045362	prochloraz	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of XRCC5 mRNA	29038839
D011794	Quercetin	Quercetin results in decreased expression of XRCC5 protein	19207037
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of XRCC5 mRNA	16514628
C547185	riccardin D	riccardin D results in decreased expression of and results in decreased activity of XRCC5 protein	24069304
C547185	riccardin D	riccardin D results in decreased expression of XRCC5 mRNA	24069304
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of XRCC5 protein	28918527
D018038	Sodium Selenite	Sodium Selenite results in increased expression of XRCC5 mRNA	18175754
D013467	Sulindac	Sulindac results in decreased expression of XRCC5 mRNA	24136188
D014212	Tretinoin	Tretinoin results in increased expression of XRCC5 protein	20888851
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of XRCC5 gene	27618143
C012589	trichostatin A	trichostatin A results in increased acetylation of XRCC5 protein	27064363
C012589	trichostatin A	trichostatin A results in increased expression of XRCC5 mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of XRCC5 mRNA	19042947
D014315	Triterpenes	Triterpenes results in decreased expression of XRCC5 protein	18422750
D014635	Valproic Acid	Valproic Acid results in decreased expression of XRCC5 mRNA	23179753\|2718838
D014800	Vitallium	Vitallium analog results in decreased expression of XRCC5 mRNA	23825117
C111237	vorinostat	vorinostat results in decreased expression of XRCC5 protein	16928817\|2064684
C111237	vorinostat	[carfilzomib co-treated with vorinostat] results in increased acetylation of XRCC5 protein	20233973
C009687	wortmannin	[wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein	20878124

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	NAS	1537839
GO:0003684	damaged DNA binding	-	IEA	-
GO:0003690	double-stranded DNA binding	CONTRIBUTES_TO	IBA	21873635
GO:0003690	double-stranded DNA binding	-	TAS	7957065
GO:0003691	double-stranded telomeric DNA binding	contributes_to	IDA	10409678
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0003723	RNA binding	-	IDA	14704337
GO:0004003	ATP-dependent DNA helicase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	8621488 10783163 11493912 12145306 12377759 14704337 15075319 17159921 17283121 17308091 17396150 19142223 19303849 20023628 20085707 20098424 20711232 21070772 21679440 22451927 22504299 23178593 23685356 24485452 24610814 25277244 25574025 25749521 25852083 26359349 26496610 26502055 28330616 28959974
GO:0005524	ATP binding	-	IEA	-
GO:0008022	protein C-terminus binding	-	IPI	10783163
GO:0008047	enzyme activator activity	-	TAS	19188702
GO:0031625	ubiquitin protein ligase binding	-	IPI	22266820
GO:0042162	telomeric DNA binding	-	IBA	21873635
GO:0042162	telomeric DNA binding	-	IDA	10535943
GO:0042162	telomeric DNA binding	-	TAS	12377759
GO:0044212	transcription regulatory region DNA binding	-	IDA	18809223
GO:0044877	protein-containing complex binding	-	IPI	12377759
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	contributes_to	IMP	20383123

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000723	telomere maintenance	-	IBA	21873635
GO:0000723	telomere maintenance	-	IEA	-
GO:0002218	activation of innate immune response	-	IDA	28712728
GO:0006302	double-strand break repair	-	IMP	19581589
GO:0006303	double-strand break repair via nonhomologous end joining	-	IBA	21873635
GO:0006303	double-strand break repair via nonhomologous end joining	-	IDA	26359349
GO:0006303	double-strand break repair via nonhomologous end joining	-	IMP	20383123
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	15824061
GO:0006310	DNA recombination	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007420	brain development	-	IEA	-
GO:0008283	cell proliferation	-	IEA	-
GO:0032204	regulation of telomere maintenance	-	TAS	15824061 18710952 24095731
GO:0032212	positive regulation of telomere maintenance via telomerase	-	IMP	19188702
GO:0032481	positive regulation of type I interferon production	-	TAS	-
GO:0032508	DNA duplex unwinding	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0043085	positive regulation of catalytic activity	-	TAS	19188702
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	IEA	-
GO:0045860	positive regulation of protein kinase activity	-	IDA	22504299
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	8621488
GO:0048660	regulation of smooth muscle cell proliferation	-	IMP	25852083
GO:0050769	positive regulation of neurogenesis	-	IEA	-
GO:0051973	positive regulation of telomerase activity	-	TAS	19188702
GO:0060218	hematopoietic stem cell differentiation	-	IEA	-
GO:0070198	protein localization to chromosome, telomeric region	-	TAS	19188702
GO:0071398	cellular response to fatty acid	-	IEA	-
GO:0071475	cellular hyperosmotic salinity response	-	IEA	-
GO:0071480	cellular response to gamma radiation	-	IBA	21873635
GO:0071480	cellular response to gamma radiation	-	IDA	26359349
GO:0071481	cellular response to X-ray	-	IBA	21873635
GO:0071481	cellular response to X-ray	-	IEA	-
GO:0075713	establishment of integrated proviral latency	-	TAS	-
GO:1904430	negative regulation of t-circle formation	-	IMP	19581589
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000783	nuclear telomere cap complex	-	TAS	15100233
GO:0000784	nuclear chromosome, telomeric region	-	HDA	19135898
GO:0000784	nuclear chromosome, telomeric region	-	IBA	21873635
GO:0000784	nuclear chromosome, telomeric region	-	IDA	10535943
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	-
GO:0016020	membrane	-	HDA	19946888
GO:0032991	protein-containing complex	-	IDA	22504299
GO:0032993	protein-DNA complex	-	IDA	22504299
GO:0034774	secretory granule lumen	-	TAS	-
GO:0043564	Ku70:Ku80 complex	-	IBA	21873635
GO:0043564	Ku70:Ku80 complex	-	IDA	20383123 24095731 26359349
GO:0043564	Ku70:Ku80 complex	-	TAS	19188702
GO:0070419	nonhomologous end joining complex	-	IDA	20383123 25941166
GO:1990904	ribonucleoprotein complex	-	IDA	14704337

KEGG ID	KEGG Term
hsa03450	Non-homologous end-joining

Reactome ID	Reactome Term	Evidence
R-HSA-162587	HIV Life Cycle	TAS
R-HSA-162592	Integration of provirus	TAS
R-HSA-162594	Early Phase of HIV Life Cycle	TAS
R-HSA-162906	HIV Infection	TAS
R-HSA-1643685	Disease	TAS
R-HSA-164843	2-LTR circle formation	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1834941	STING mediated induction of host immune responses	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-3270619	IRF3-mediated induction of type I IFN	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-73894	DNA Repair	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17355791	[Correlations of XRCC5 polymorphisms to genetic susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a high incidence region]. (2007 Mar)	Dong XJ	Ai Zheng
23663450	Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. (2013 May 10)	Zhao P	BMC Cancer
17289874	Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. (2007 Feb 1)	Lee MN	Clin Cancer Res
25702660	Association of the genetic polymorphisms in XRCC6 and XRCC5 with the risk of ESCC in a high-incidence region of North China. (2015 Jan-Feb)	Li K	Tumori
15680411	DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers. (2005 Feb 15)	Wilding CS	Mutat Res
25035082	XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. (2015 Jan)	Juraeva D	Neuropsychopharmacology