Gene info: ID 7532

Gene: YWHAG

GENE ID: 7532

Synonyms: 14-3-3GAMMA|EIEE56|PPP1R170

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

Gene type: protein-coding

Location: 7q11.23

dbXrefs: Ensembl:ENSG00000170027 MIM:605356 Vega:OTTHUMG00000022862 UniprotKB:P61981

RefSeq: NC_000007.14

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.691e-1 (AD) 4.279e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YWHAH	0.98
MOAP1	0.978
RTN1	0.978
ATXN7L3B	0.976
PCMT1	0.976
TSPYL4	0.976
YWHAB	0.976
ATP6V1B2	0.975
NECAP1	0.975
MAP2K4	0.974

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.62
OR4F29	-0.597
CSAG1	-0.43
ASB4	-0.407
RNF135	-0.404
CXCR2	-0.404
IL18RAP	-0.403
MYL3	-0.397
MAGEA12	-0.396
HEY2	-0.393

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of YWHAG protein"	21673325
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of YWHAG mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of YWHAG mRNA"	21346803
C438868	3,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide	"[3,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein"	14534293
C438868	3,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide	"3,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide results in decreased metabolism of YWHAG protein"	14534293
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of YWHAG mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of YWHAG mRNA"	25380136
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of YWHAG mRNA"	21346803
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of YWHAG mRNA	20829426
D000082	Acetaminophen	Acetaminophen results in increased expression of YWHAG mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of YWHAG mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of YWHAG mRNA	19770486
D000638	Amiodarone	Amiodarone affects the expression of YWHAG mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of YWHAG mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of YWHAG gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of YWHAG protein	19364129
C547126	AZM551248	AZM551248 results in increased expression of YWHAG mRNA	22323515
D001553	Benzbromarone	Benzbromarone affects the expression of YWHAG mRNA	19483382
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of YWHAG mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of YWHAG mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of YWHAG mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of YWHAG mRNA	21839799
D004958	Estradiol	Estradiol affects the expression of YWHAG mRNA	22574217
C006780	bisphenol A	bisphenol A results in decreased methylation of YWHAG promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of YWHAG mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of YWHAG gene	28505145
C515564	bromovanin	bromovanin results in increased expression of YWHAG protein	21419150
C584509	C646 compound	C646 compound results in decreased expression of YWHAG mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of YWHAG protein	24527689
C054133	casticin	casticin results in decreased expression of YWHAG mRNA	28444820
D002713	Chlorine	Chlorine results in increased expression of YWHAG mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of YWHAG mRNA	18636392
C007020	chlorophyllin	"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of YWHAG mRNA"	22485181
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of YWHAG mRNA	28472532
D002994	Clofibrate	Clofibrate affects the expression of YWHAG mRNA	19483382
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of YWHAG mRNA	17602206
D003300	Copper	Copper results in decreased expression of YWHAG protein	23882024
D019327	Copper Sulfate	Copper Sulfate results in increased expression of YWHAG mRNA	19549813
C030973	cupric oxide	cupric oxide analog results in decreased expression of YWHAG protein	23882024
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of YWHAG mRNA	17654400
D013759	Dronabinol	Dronabinol results in increased expression of YWHAG mRNA	11015613
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of YWHAG mRNA	17602206
D015127	9,10-Dimethyl-1,2-benzanthracene	"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of YWHAG mRNA"	22485181
C100264	enniatins	enniatins results in decreased expression of YWHAG mRNA	27163883
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of YWHAG mRNA	22079256
D000431	Ethanol	Ethanol results in increased expression of YWHAG mRNA	15353170
D005001	Ethionine	Ethionine affects the expression of YWHAG mRNA	19483382
D005485	Flutamide	Flutamide results in increased expression of YWHAG mRNA	24136188
C026211	fumagillin	[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein	14534293
C056933	fumonisin B1	fumonisin B1 results in increased expression of YWHAG mRNA	16221962
D005839	Gentamicins	Gentamicins results in increased expression of YWHAG mRNA	22061828
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of YWHAG mRNA	22634610
D005978	Glutathione	Glutathione deficiency results in increased expression of YWHAG mRNA	15345336
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA	19695318
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of YWHAG mRNA	15469884
D007854	Lead	Lead affects the expression of YWHAG mRNA	28903495
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of YWHAG mRNA	16507785
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of YWHAG protein	26558463
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of YWHAG mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of YWHAG protein	26558463
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of YWHAG mRNA"	15329391
C063855	microcystin RR	microcystin RR results in decreased expression of YWHAG protein	19111056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of YWHAG protein"	22001959
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of YWHAG mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of YWHAG mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of YWHAG mRNA	25380136
C051752	nefazodone	nefazodone results in increased expression of YWHAG mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of YWHAG mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of YWHAG protein	19716841
D009853	Omeprazole	Omeprazole affects the expression of YWHAG mRNA	19483382
D010100	Oxygen	Oxygen deficiency results in increased expression of YWHAG mRNA	24205000
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of YWHAG mRNA	18636392
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of YWHAG protein	19954255
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of YWHAG mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of YWHAG mRNA	19162173
C006253	pirinixic acid	pirinixic acid results in increased expression of YWHAG mRNA	16221962\|1830175
C006253	pirinixic acid	pirinixic acid affects the expression of YWHAG mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in increased expression of YWHAG mRNA	19162173
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA	19695318
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of YWHAG mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of YWHAG mRNA	22079256
D011374	Progesterone	Progesterone affects the expression of YWHAG mRNA	23012394
D011374	Progesterone	Progesterone results in decreased expression of YWHAG mRNA	23012394
C045950	propiconazole	propiconazole results in increased expression of YWHAG mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil affects the expression of YWHAG mRNA	19483382
D015237	Dinoprost	Dinoprost results in increased expression of YWHAG mRNA	11517196
C059514	resveratrol	resveratrol results in decreased expression of YWHAG protein	25505154
D012402	Rotenone	YWHAG protein results in decreased susceptibility to Rotenone	22490660
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of YWHAG protein	25895662
C080703	SK&F 83959	SK&F 83959 results in decreased expression of YWHAG protein	25852303
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of YWHAG protein	27548804
D013605	T-2 Toxin	T-2 Toxin affects the expression of YWHAG protein	26141394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of YWHAG mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of YWHAG mRNA	26232522
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of YWHAG protein"	25852303
D019284	Thapsigargin	Thapsigargin results in decreased expression of YWHAG mRNA	22378314
D013853	Thioacetamide	Thioacetamide affects the expression of YWHAG mRNA	19483382
D013853	Thioacetamide	Thioacetamide results in increased expression of YWHAG mRNA	23411599
C001899	triptolide	triptolide results in increased expression of YWHAG mRNA	23639586
D014415	Tunicamycin	Tunicamycin results in decreased expression of YWHAG mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of YWHAG mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of YWHAG gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0005080	protein kinase C binding	-	IPI	10433554
GO:0005159	insulin-like growth factor receptor binding	-	IPI	12482592
GO:0005515	protein binding	-	IPI	11237865 11504882 11697890 12364343 12383250 12438239 15324660 15598710 16511560 16511572 16516142 16959763 17085597 17159145 17353931 17979178 18045992 18458160 18771726 18812399 19172738 19640509 19860830 19933256 20451386 20639859 20642453 20936779 21044950 21988832 22653443 23075850 23572552 23622247 23752268 24255178 24366813 24947832 25416956 25852190 26496610 26638075 28330616
GO:0008426	protein kinase C inhibitor activity	-	NAS	10433554
GO:0019904	protein domain specific binding	-	IEA	-
GO:0030971	receptor tyrosine kinase binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	17085597 20639859

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	-
GO:0006469	negative regulation of protein kinase activity	-	NAS	10433554
GO:0006605	protein targeting	-	IEA	-
GO:0009966	regulation of signal transduction	-	NAS	10433554 10486217
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	-
GO:0032869	cellular response to insulin stimulus	-	IEA	-
GO:0045664	regulation of neuron differentiation	-	IMP	11824616
GO:0048167	regulation of synaptic plasticity	-	IMP	11824616
GO:0061024	membrane organization	-	TAS	-
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	-
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	-
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0016020	membrane	-	HDA	19946888
GO:0043209	myelin sheath	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 20458337

KEGG ID	KEGG Term
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04722	Neurotrophin signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111447	Activation of BAD and translocation to mitochondria	TAS
R-HSA-114452	Activation of BH3-only proteins	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-380259	Loss of Nlp from mitotic centrosomes	TAS
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	TAS
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	TAS
R-HSA-380287	Centrosome maturation	TAS
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	TAS
R-HSA-5625740	RHO GTPases activate PKNs	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69473	G2/M DNA damage checkpoint	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	TAS
R-HSA-8854518	AURKA Activation by TPX2	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17284169	RhoA, encoding a Rho GTPase, is associated with smoking initiation. (2007 Nov)	Chen X	Genes Brain Behav