Gene info: ID 7533

Gene: YWHAH

GENE ID: 7533

Synonyms: YWHA1

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

Gene type: protein-coding

Location: 22q12.3

dbXrefs: Ensembl:ENSG00000128245 MIM:113508 Vega:OTTHUMG00000030833 UniprotKB:Q04917

RefSeq: NC_000022.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.861e-1 (AD) 9.128e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YWHAG	0.98
RTN1	0.978
VSNL1	0.976
SNAP25	0.976
GOT2	0.975
ATP6V1G2	0.975
BASP1	0.974
RTN3	0.974
UCHL1	0.972
LMO4	0.971

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.645
OR4F29	-0.613
REST	-0.398
CSAG1	-0.396
TFPI2	-0.388
MAGEA12	-0.387
HEY2	-0.386
ASB4	-0.385
KCNJ15	-0.38
CXCR2	-0.379

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of YWHAH protein"	21673325
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of YWHAH mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of YWHAH mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of YWHAH mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of YWHAH mRNA	12419474
D000082	Acetaminophen	Acetaminophen affects the expression of YWHAH mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of YWHAH mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of YWHAH gene	27153756
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of YWHAH mRNA	17023530
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of YWHAH mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of YWHAH mRNA	23911876
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of YWHAH mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of YWHAH mRNA	19770486
C095105	bexarotene	bexarotene results in decreased expression of YWHAH mRNA	16648578
C006780	bisphenol A	bisphenol A results in decreased expression of YWHAH mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of YWHAH mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of YWHAH protein	20219716
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YWHAH mRNA	28628672
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of YWHAH mRNA	17553608
C515564	bromovanin	bromovanin results in increased expression of YWHAH protein	21419150
D002065	Buspirone	Buspirone results in decreased expression of YWHAH mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of YWHAH mRNA	12419474
D002330	Carmustine	Carmustine results in decreased expression of YWHAH mRNA	15980968
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of YWHAH mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of YWHAH mRNA	23650126
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of YWHAH mRNA	19320972
D003042	Cocaine	Cocaine results in decreased expression of YWHAH mRNA	12629581
D003042	Cocaine	Cocaine affects the expression of YWHAH mRNA	20187946
D003300	Copper	Copper results in increased expression of YWHAH mRNA	22465980
D016578	Crack Cocaine	Crack Cocaine results in increased expression of YWHAH mRNA	12629581
C030973	cupric oxide	cupric oxide results in decreased expression of YWHAH mRNA	22077320
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of YWHAH mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in increased expression of YWHAH mRNA	25562108
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YWHAH mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of YWHAH mRNA	16054899
D003907	Dexamethasone	Dexamethasone inhibits the reaction [YWHAH protein binds to FOXO1 protein]	20181797
D003907	Dexamethasone	INS1 protein inhibits the reaction [Dexamethasone inhibits the reaction [YWHAH protein binds to FOXO1 protein]]	20181797
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of YWHAH mRNA	21266533
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of YWHAH mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of YWHAH mRNA	20463971
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of YWHAH mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of YWHAH mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YWHAH mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of YWHAH mRNA	17108234
D018120	Finasteride	Finasteride results in increased expression of YWHAH mRNA	24136188
D005473	Fluoxetine	Fluoxetine affects the expression of YWHAH mRNA	21852994
C056933	fumonisin B1	fumonisin B1 results in increased expression of YWHAH mRNA	16221962
C492448	ICG 001	ICG 001 results in increased expression of YWHAH mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YWHAH mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of YWHAH mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YWHAH mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of YWHAH mRNA	16054899
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of YWHAH mRNA"	24972896
D009532	Nickel	Nickel results in increased expression of YWHAH mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of YWHAH mRNA	22546817
C029938	nickel sulfate	nickel sulfate results in increased expression of YWHAH mRNA	16780908
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of YWHAH mRNA	17616710
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of YWHAH mRNA	18636392
D010269	Paraquat	Paraquat results in decreased expression of YWHAH mRNA	16797015
C058305	phenethyl isothiocyanate	YWHAH protein binds to phenethyl isothiocyanate	21838287
D010634	Phenobarbital	Phenobarbital results in increased expression of YWHAH mRNA	19363144
C006253	pirinixic acid	pirinixic acid results in increased expression of YWHAH mRNA	16221962
C045950	propiconazole	propiconazole results in increased expression of YWHAH mRNA	19363144\|2127805
C059514	resveratrol	resveratrol results in decreased expression of YWHAH protein	25505154
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of YWHAH mRNA	16054899
D012402	Rotenone	Rotenone results in decreased expression of YWHAH mRNA	24002177
D012715	Sesame Oil	Sesame Oil results in decreased expression of YWHAH mRNA	29191790
C080703	SK&F 83959	SK&F 83959 results in decreased expression of YWHAH protein	25852303
C017947	sodium arsenite	sodium arsenite results in decreased expression of YWHAH mRNA	12760830
C016104	sodium bichromate	sodium bichromate results in decreased expression of YWHAH mRNA	12760830
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of YWHAH protein	27548804
D013629	Tamoxifen	Tamoxifen affects the expression of YWHAH mRNA	17555576
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of YWHAH mRNA	27914987
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of YWHAH mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YWHAH mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of YWHAH mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of YWHAH mRNA	25613284
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of YWHAH protein"	25852303
D019284	Thapsigargin	Thapsigargin results in decreased expression of YWHAH mRNA	22378314
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in increased expression of YWHAH mRNA"	17951470
D014212	Tretinoin	Tretinoin results in decreased expression of YWHAH mRNA	21934132
C012589	trichostatin A	trichostatin A affects the expression of YWHAH mRNA	28542535
C001899	triptolide	triptolide results in increased expression of YWHAH mRNA	23639586
D014415	Tunicamycin	Tunicamycin results in decreased expression of YWHAH mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of YWHAH mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of YWHAH mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of YWHAH mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in decreased expression of YWHAH mRNA	20546886
C025643	vinclozolin	vinclozolin results in decreased expression of YWHAH mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of YWHAH mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003779	actin binding	-	IEA	-
GO:0005159	insulin-like growth factor receptor binding	-	ISS	-
GO:0005515	protein binding	-	IPI	10713667 11697890 12383250 12438239 12524439 12595070 12871946 14676191 15543142 16545136 16672277 16775625 16959763 17979178 18045992 18242179 18397886 18458160 19172738 19553522 19615732 19640509 19860830 20642453 23075850 23572552 23622247 23752268 24895406 25852190 26496610
GO:0017080	sodium channel regulator activity	-	IDA	16728661
GO:0019899	enzyme binding	-	IPI	17255105
GO:0019904	protein domain specific binding	-	ISS	-
GO:0035259	glucocorticoid receptor binding	-	IPI	9079630
GO:0042802	identical protein binding	-	IPI	17085597 17979178
GO:0044325	ion channel binding	-	IPI	11953308 16728661
GO:0046982	protein heterodimerization activity	-	IPI	11953308

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002028	regulation of sodium ion transport	-	IDA	16728661
GO:0006713	glucocorticoid catabolic process	-	IDA	15790729
GO:0006886	intracellular protein transport	-	ISS	-
GO:0021762	substantia nigra development	-	HEP	22926577
GO:0042921	glucocorticoid receptor signaling pathway	-	IDA	15790729
GO:0045664	regulation of neuron differentiation	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	15790729
GO:0048167	regulation of synaptic plasticity	-	ISS	-
GO:0050774	negative regulation of dendrite morphogenesis	-	ISS	-
GO:0061024	membrane organization	-	TAS	-
GO:0086010	membrane depolarization during action potential	-	IDA	16728661
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	-
GO:2000649	regulation of sodium ion transmembrane transporter activity	-	IDA	16728661

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	ISS	-
GO:0005739	mitochondrion	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	16728661
GO:0014704	intercalated disc	-	IC	16728661
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 20458337

KEGG ID	KEGG Term
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04722	Neurotrophin signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111447	Activation of BAD and translocation to mitochondria	TAS
R-HSA-114452	Activation of BH3-only proteins	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5625740	RHO GTPases activate PKNs	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-69473	G2/M DNA damage checkpoint	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
10776673	Association study between genetic polymorphisms in the 14-3-3 eta chain and dopamine D4 receptor genes and alcoholism. (2000 Mar)	Ishiguro H	Alcohol Clin Exp Res