Gene: ZAP70

7535
ADMIO2|IMD48|SRK|STCD|STD|TZK|ZAP-70
zeta chain of T cell receptor associated protein kinase 70
protein-coding
2q11.2
Ensembl:ENSG00000115085 MIM:176947 Vega:OTTHUMG00000153060 UniprotKB:P43403
NG_007727.1
PubMed
0   ANCO-SNPs
ND
1   
2.241e-1 (AD)  4.136e-1 (ND)   (Frontal_Cortex)
7.442e-1 (AD)  6.545e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12332902chr2:98330020ZAP703.500e-11Smoking27651444
cg09006159chr2:98329811ZAP703.100e-10Smoking27651444
cg07682434chr2:98350363ZAP705.610e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTSW0.683
SLAMF70.646
IL2RB0.641
PYHIN10.639
IL7R0.638
FCRL30.63
PRF10.627
FASLG0.625
MBOAT10.624
LY90.616

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALT1-0.4
ABCD2-0.371
GLRA3-0.365
GPR19-0.353
KCNG1-0.353
TMEM56-0.35
C1orf53-0.347
CYP46A1-0.341
CALB1-0.34
WNT3-0.34

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02010StaurosporineSmall Molecule62996-74-1ExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ZAP70 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of ZAP70 mRNA"19114083
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of ZAP70 mRNA"21724226
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ZAP70 mRNA"21724226
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of ZAP70 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ZAP70 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in increased expression of ZAP70 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ZAP70 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ZAP70 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ZAP70 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ZAP70 mRNA21641981
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ZAP70 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of ZAP70 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZAP70 mRNA20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZAP70 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ZAP70 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ZAP70 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZAP70 mRNA21839799
C472777bisperoxovanadiumZAP70 protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]12493747
C006780bisphenol Abisphenol A results in increased expression of ZAP70 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZAP70 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ZAP70 mRNA22659508
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ZAP70 promoter22457795
D002166CamptothecinZAP70 mRNA results in decreased susceptibility to Camptothecin25269479
D000068579CelecoxibCelecoxib results in decreased expression of ZAP70 mRNA28201806
C026690cerous chloridecerous chloride affects the expression of ZAP70 mRNA23139204
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ZAP70 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ZAP70 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ZAP70 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ZAP70 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of ZAP70 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of ZAP70 mRNA21041162
D000069439DasatinibZAP70 protein results in increased susceptibility to Dasatinib18550857
D003907DexamethasoneDexamethasone results in decreased expression of ZAP70 mRNA21041162
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZAP70 mRNA21266533
D002945CisplatinCisplatin results in increased expression of ZAP70 mRNA26546572
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ZAP70 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of ZAP70 mRNA22609946
D004041Dietary FatsDietary Fats results in increased expression of ZAP70 mRNA19467301
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ZAP70 mRNA21041162
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ZAP70 mRNA"19480007
C118739entinostatentinostat results in increased expression of ZAP70 mRNA27188386
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ZAP70 gene17767948
C056933fumonisin B1fumonisin B1 results in decreased expression of ZAP70 mRNA16221962
C039281furanfuran results in increased expression of ZAP70 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of ZAP70 mRNA22061828
D006418HemeHeme results in increased expression of ZAP70 protein11768235
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZAP70 mRNA22802445|2308692
C008261lead acetatelead acetate results in decreased expression of ZAP70 mRNA20542052
C568507N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of ZAP70 protein"21888390
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ZAP70 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ZAP70 mRNA"25554681|2562005
D019829NevirapineNevirapine results in increased expression of ZAP70 mRNA23947594
D009532NickelNickel results in increased expression of ZAP70 mRNA24768652|2558310
C507134ON 01910ON 01910 results in decreased phosphorylation of ZAP70 protein25472472
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ZAP70 mRNA25729387
C029341oxophenylarsineoxophenylarsine results in increased expression of ZAP70 protein11768235
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ZAP70 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ZAP70 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ZAP70 mRNA19482888
D010672PhenytoinPhenytoin results in decreased expression of ZAP70 mRNA15136057
C006253pirinixic acidpirinixic acid results in decreased expression of ZAP70 mRNA11798191|1622196
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ZAP70 mRNA]20059764
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased activity of ZAP70 protein10706243
C045362prochlorazprochloraz results in decreased expression of ZAP70 mRNA21470553
D011441PropylthiouracilPropylthiouracil results in increased expression of ZAP70 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in increased expression of ZAP70 mRNA18175754
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ZAP70 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZAP70 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZAP70 mRNA21724226
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ZAP70 mRNA25729387
D014635Valproic AcidValproic Acid results in increased methylation of ZAP70 gene29154799
D014639VanadiumVanadium results in decreased expression of ZAP70 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ZAP70 gene25560391
D002762CholecalciferolCholecalciferol results in decreased expression of ZAP70 mRNA16508948
D019287Zinc SulfateZinc Sulfate results in increased expression of ZAP70 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IMP12051764  
GO:0001784phosphotyrosine residue binding-IPI12051764  
GO:0004713protein tyrosine kinase activity-IDA12447358  
GO:0004713protein tyrosine kinase activity-NAS1423621  8613493  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS20135127  
GO:0005515protein binding-IPI7509083  7528772  7761456  8648092  8901551  9185620  
10318843  10556826  10704231  10752619  11855827  11891219  
12359715  12646565  15832366  16273093  16461343  19843936  
21957439  22266821  23460737  24256567  24658140  24728074  
26783323  
GO:0005524ATP binding-NAS1423621  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-TAS20135127  
GO:0006468protein phosphorylation-IDA12447358  
GO:0006468protein phosphorylation-NAS1423621  
GO:0006955immune response-IDA1423621  
GO:0018108peptidyl-tyrosine phosphorylation-IDA22732588  
GO:0018108peptidyl-tyrosine phosphorylation-IMP23620790  
GO:0030217T cell differentiation-NAS8613493  
GO:0035556intracellular signal transduction-NAS1423621  
GO:0042110T cell activation-TAS20135127  
GO:0042113B cell activation-TAS20135127  
GO:0043366beta selection-IEA-  
GO:0045059positive thymic T cell selection-IDA7630421  
GO:0045060negative thymic T cell selection-IEA-  
GO:0045582positive regulation of T cell differentiation-IDA7630421  
GO:0046638positive regulation of alpha-beta T cell differentiation-IEA-  
GO:0046641positive regulation of alpha-beta T cell proliferation-IEA-  
GO:0050850positive regulation of calcium-mediated signaling-IEA-  
GO:0050852T cell receptor signaling pathway-TAS20135127  
GO:0070489T cell aggregation-TAS20135127  
GO:0072678T cell migration-TAS20135127  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IEA-  
GO:0005737cytoplasm-TAS12359715  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA12150984  
GO:0005886plasma membrane-TAS20135127  
GO:0005911cell-cell junction-IEA-  
GO:0042101T cell receptor complex-IDA8176201  
GO:0045121membrane raftcolocalizes_withIDA12150984  
KEGG ID KEGG Term
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics