Gene: SF1

7536
BBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162
splicing factor 1
protein-coding
11q13.1
Ensembl:ENSG00000168066 MIM:601516 Vega:OTTHUMG00000066833 UniprotKB:Q15637
NG_021399.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.091e-1 (AD)  8.058e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF400.935
RBM100.932
EWSR10.929
KHSRP0.928
TRIM280.928
SUPT5H0.921
MARK30.92
U2AF20.92
SSRP10.919
EIF3B0.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.835
OR4F29-0.808
OR6C74-0.176
KLRB1-0.173
VNN2-0.172
CXCR2-0.168
ODAM-0.167
HMHB1-0.164
CEACAM3-0.164
CLEC6A-0.164

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of SF1 mRNA"22101062
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SF1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SF1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SF1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SF1 mRNA"28973690
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of SF1 mRNA25716159
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SF1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SF1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SF1 mRNA16483693
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of SF1 mRNA25566086
D004958EstradiolEstradiol promotes the reaction [SF1 protein binds to ESR1 protein]27156127
C044887beta-methylcholinebeta-methylcholine affects the expression of SF1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SF1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SF1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SF1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SF1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SF1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SF1 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SF1 mRNA12419474
D002330CarmustineSF1 mRNA affects the susceptibility to Carmustine16365179
D002392CatechinCatechin results in decreased expression of SF1 mRNA15465739
C026690cerous chloridecerous chloride results in increased expression of SF1 mRNA23573234
D019327Copper SulfateCopper Sulfate results in decreased expression of SF1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SF1 mRNA"19167446
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of SF1 protein23811945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SF1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SF1 mRNA28628672
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of SF1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of SF1 mRNA27594783
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of SF1 mRNA]27392435
C000944dicrotophosdicrotophos results in increased expression of SF1 mRNA28302478
D004026DieldrinDieldrin affects the expression of SF1 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of SF1 mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of SF1 mRNA21852083
C039060dihydroartemisinindihydroartemisinin analog binds to SF1 protein26340163
C012301domoic aciddomoic acid results in decreased expression of SF1 mRNA18936300
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SF1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SF1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SF1 mRNA24096037
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SF1 mRNA24096037
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SF1 mRNA23550701
D005485FlutamideFlutamide results in increased expression of SF1 mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SF1 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SF1 mRNA12419474
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SF1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SF1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SF1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SF1 mRNA28628672
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of SF1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of SF1 mRNA]27392435
C028577monobutyl phthalatemonobutyl phthalate affects the expression of SF1 mRNA20864626
D009151Mustard GasMustard Gas results in increased phosphorylation of SF1 protein19845377
C016340o,p'-DDT"o,p'-DDT results in increased expression of SF1 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of SF1 mRNA"24096037
D000073878Palm OilPalm Oil results in decreased expression of SF1 mRNA18042831
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SF1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SF1 mRNA22079256
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of SF1 mRNA21852083
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SF1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of SF1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SF1 mRNA25895662
D012999SomanSoman results in increased expression of SF1 mRNA19281266
D013501Surface-Active AgentsSurface-Active Agents results in decreased expression of SF1 mRNA22467014
C047246temozolomideSF1 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SF1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SF1 mRNA18087596
C032910triadimefontriadimefon results in increased expression of SF1 mRNA26705709
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of SF1 mRNA]15363585
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of SF1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SF1 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SF1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of SF1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SF1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SF1 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SF1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of SF1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-TAS9660765  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-TAS8752089  
GO:0005515protein binding-IPI16189514  17332742  17589525  22365833  23273425  25416956  
26420826  
GO:0008270zinc ion binding-IEA-  
GO:0042802identical protein binding-IPI22365833  26420826  
GO:0045131pre-mRNA branch point binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000245spliceosomal complex assembly-NAS8752089  
GO:0000389mRNA 3'-splice site recognition-TAS15647371  
GO:0000398mRNA splicing, via spliceosome-IC9731529  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0030238male sex determination-IEA-  
GO:0030575nuclear body organization-IEA-  
GO:0033327Leydig cell differentiation-IEA-  
GO:0048662negative regulation of smooth muscle cell proliferation-IEA-  
GO:0050810regulation of steroid biosynthetic process-IEA-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS7912130  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-IDA9731529  
GO:0005840ribosome-NAS8752089  
GO:0016604nuclear body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29427673Improvements in health-related quality of life among smokers who quit after hospitalization. (2018 May)Levy DEPrev Med
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget