Gene: ZFP36

7538
G0S24|GOS24|NUP475|RNF162A|TIS11|TTP|zfp-36
ZFP36 ring finger protein
protein-coding
19q13.2
Ensembl:ENSG00000128016 MIM:190700 Vega:OTTHUMG00000182970 UniprotKB:P26651
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.272e-1 (AD)  1.463e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GADD45B0.865
CDKN1A0.853
YBX30.84
SOCS30.838
EMP10.836
SRGN0.823
MCL10.82
BTG20.813
CEBPD0.813
CXCL20.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.477
NEUROD6-0.472
CALHM1-0.461
SLC7A4-0.449
VWC2-0.447
PPEF1-0.446
MARCH4-0.445
KIT-0.444
LHX6-0.44
CNTN6-0.437

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ZFP36 mRNA"19162173
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ZFP36 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ZFP36 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ZFP36 mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ZFP36 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of ZFP36 mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of ZFP36 mRNA15606129|1756273
D000082AcetaminophenAcetaminophen results in increased expression of ZFP36 mRNA11752693
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ZFP36 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of ZFP36 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ZFP36 mRNA16483693
D000936Antigen-Antibody ComplexAntigen-Antibody Complex results in increased expression of ZFP36 mRNA25451590
D000936Antigen-Antibody Complexshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36 mRNA]25451590
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ZFP36 mRNA24449571
C102351apicidinapicidin inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
D016718Arachidonic AcidArachidonic Acid results in increased expression of ZFP36 mRNA8764118
C006632arsenic trioxidearsenic trioxide affects the expression of ZFP36 mRNA12749819
C006632arsenic trioxidearsenic trioxide results in decreased expression of ZFP36 mRNA20458559
C015001arsenitearsenite results in increased phosphorylation of ZFP36 protein15014438
C015001arsenite[arsenite results in increased phosphorylation of ZFP36 protein] promotes the reaction [ZFP36 protein binds to YWHAQ protein]15014438
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ZFP36 mRNA"18687144
C487081belinostatbelinostat results in decreased expression of ZFP36 mRNA27188386
D001554BenzeneBenzene results in decreased expression of ZFP36 mRNA19162166
D001554BenzeneBenzene results in increased expression of ZFP36 protein15468289
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZFP36 mRNA22316170|2623829
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of ZFP36 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZFP36 mRNA15034205|2156981
D004958EstradiolEstradiol affects the expression of ZFP36 mRNA14699072
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of ZFP36 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of ZFP36 mRNA19153601
D004958EstradiolEstradiol affects the expression of ZFP36 mRNA15598610
D004958EstradiolEstradiol results in increased expression of ZFP36 mRNA25210133
C006780bisphenol Abisphenol A results in decreased expression of ZFP36 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of ZFP36 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFP36 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ZFP36 mRNA17553608
D002038BungarotoxinsBungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]21606497
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ZFP36 mRNA20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ZFP36 mRNA20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ZFP36 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ZFP36 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ZFP36 mRNA]20847119
C018475butyraldehydebutyraldehyde results in decreased expression of ZFP36 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of ZFP36 mRNA26191083
D002104CadmiumCadmium results in decreased expression of ZFP36 mRNA16439709
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ZFP36 mRNA26260164
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ZFP36 promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ZFP36 mRNA19010381
D000001CalcimycinCalcimycin results in increased expression of ZFP36 mRNA25451590
D000001Calcimycinshikonin inhibits the reaction [Calcimycin results in increased expression of ZFP36 mRNA]25451590
D002220CarbamazepineCarbamazepine affects the expression of ZFP36 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ZFP36 mRNA12734012
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of ZFP36 mRNA19395590
C466997CGP 57380CGP 57380 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 protein]18032482
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
C100187chloropicrinchloropicrin results in increased expression of ZFP36 mRNA26352163
C418118CI 1044CI 1044 results in increased expression of ZFP36 mRNA17569694
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in increased expression of ZFP36 mRNA24095726
C007095cobaltiprotoporphyrinSTAT3 protein promotes the reaction [cobaltiprotoporphyrin results in increased expression of ZFP36 mRNA]24095726
C007095cobaltiprotoporphyrinzinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of ZFP36 mRNA]24095726
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of ZFP36 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ZFP36 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of ZFP36 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of ZFP36 mRNA15755911
C402665CP 31398CP 31398 results in increased expression of ZFP36 mRNA15155752
D016572CyclosporineCyclosporine results in increased expression of ZFP36 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of ZFP36 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ZFP36 mRNA24317228
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of ZFP36 mRNA24834073
D003907DexamethasoneDexamethasone results in increased expression of ZFP36 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFP36 mRNA28628672
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]15710351
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 protein]15710351
D003907DexamethasoneDexamethasone results in increased expression of ZFP36 mRNA22733784|2394649
D003907DexamethasoneDexamethasone results in increased expression of ZFP36 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of ZFP36 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZFP36 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZFP36 mRNA21266533|2174549
D002945CisplatinCisplatin results in increased expression of ZFP36 mRNA26260164
D002945CisplatinCisplatin results in increased expression of ZFP36 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of ZFP36 mRNA28302478
D004026DieldrinDieldrin results in increased expression of ZFP36 mRNA20438755
D004041Dietary FatsDietary Fats results in increased expression of ZFP36 mRNA25016146
C014476diethyl maleatediethyl maleate results in increased expression of ZFP36 protein21969073
D002117CalcitriolCalcitriol results in increased expression of ZFP36 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ZFP36 mRNA21592394
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ZFP36 mRNA"27840820
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of ZFP36 mRNA24834073
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of ZFP36 mRNA24690739
D0151175,8,11,14-Eicosatetraynoic Acid"5,8,11,14-Eicosatetraynoic Acid results in increased expression of ZFP36 mRNA"8764118
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ZFP36 mRNA20064776
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ZFP36 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ZFP36 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZFP36 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ZFP36 mRNA17351261
D005290Ferric CompoundsFerric Compounds binds to ZFP36 protein17087518
C000499ferric oxideferric oxide analog results in increased expression of ZFP36 mRNA24525745
D005296Ferrous CompoundsFerrous Compounds binds to ZFP36 protein17087518
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ZFP36 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of ZFP36 mRNA28937961
C069837fullerene C60fullerene C60 results in decreased expression of ZFP36 mRNA19167457
C069837fullerene C60fullerene C60 results in increased expression of ZFP36 mRNA19167457
C039281furanfuran results in decreased expression of ZFP36 mRNA26194646
D005839GentamicinsGentamicins results in increased expression of ZFP36 mRNA26260164
D005839GentamicinsGentamicins results in increased expression of ZFP36 mRNA22061828
D006427HeminHemin results in increased expression of ZFP36 mRNA24095726
D006427Heminzinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA]24095726
D017313FenretinideFenretinide results in increased expression of ZFP36 mRNA28973697
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in increased expression of ZFP36 mRNA"18077114
D006854HydrocortisoneHydrocortisone results in increased expression of ZFP36 mRNA21980503
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ZFP36 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZFP36 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ZFP3618687144
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of ZFP36 mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of ZFP36 mRNA19153601
C492448ICG 001ICG 001 results in increased expression of ZFP36 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFP36 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ZFP36 mRNA25613284
D007501IronIron binds to ZFP36 protein17087518
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFP36 mRNA28628672
C036643isoeugenolisoeugenol results in increased expression of ZFP36 protein21969073
C036643isoeugenolKT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]21969073
C036643isoeugenolSB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]21969073
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of ZFP36 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZFP36 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ZFP36 mRNA21889194|2479639
D007649KetamineKetamine results in increased expression of ZFP36 mRNA20080153
C057416KT 5720KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]21969073
C008261lead acetatelead acetate results in increased expression of ZFP36 mRNA20542052
C045463leflunomideleflunomide results in increased expression of ZFP36 mRNA28988120
D008070LipopolysaccharidesBungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]21606497
D008070Lipopolysaccharidesmethyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]21606497
D008070Lipopolysaccharides[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA21606497
D008070Lipopolysaccharides[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein21606497
D008070LipopolysaccharidesZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]21606497
D008070Lipopolysaccharidesapicidin inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
D008070LipopolysaccharidesCGP 57380 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 protein]18032482
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]15710351
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 protein]15710351
D008070LipopolysaccharidesHMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]24095726
D008070LipopolysaccharidesHMOX1 protein promotes the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]24095726
D008070LipopolysaccharidesHMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]24095726
D008070LipopolysaccharidesIRAK2 protein promotes the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein results in decreased degradation of ZFP36 protein]]21291324
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA24095726
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [TLR4 protein results in decreased degradation of ZFP36 protein]21291324
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [ZFP36 protein binds to YWHAQ protein]15014438
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [[ZFP36 protein binds to YWHAQ protein] which results in decreased degradation of TNF mRNA]15014438
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased phosphorylation of ZFP36 protein15014438
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ZFP36 mRNA10975854|1571035
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ZFP36 protein18032482
D008070LipopolysaccharidesMifepristone inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
D008070LipopolysaccharidesRU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]15710351
D008070LipopolysaccharidesRU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 protein]15710351
D008070LipopolysaccharidesSTAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]24095726
D008070LipopolysaccharidesSTAT3 protein promotes the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]24095726
D008070Lipopolysaccharidestrichostatin A inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
D008070LipopolysaccharidesZFP36 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]22093924
D008070LipopolysaccharidesZFP36 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]22093924
D008070LipopolysaccharidesZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]24095726
D008070LipopolysaccharidesZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]24095726
D008070Lipopolysaccharideszinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]24095726
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of ZFP36 mRNA24525745
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ZFP36 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ZFP36 mRNA26378955
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of ZFP36 mRNA15866426
C042720mercuric bromidemercuric bromide results in increased expression of ZFP36 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ZFP36 mRNA16507785
D008694MethamphetamineMethamphetamine results in increased expression of ZFP36 mRNA26307267
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of ZFP36 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of ZFP36 mRNA19564919
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]21606497
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ZFP36 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ZFP36 mRNA24810058
D015735MifepristoneMifepristone inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of ZFP36 mRNA16809437
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ZFP36 mRNA"25554681
D009281NaphthalenesNaphthalenes results in increased expression of ZFP36 protein17337753
D009532NickelNickel results in increased expression of ZFP36 mRNA24768652|2558310
D009532NickelNickel results in increased expression of ZFP36 mRNA12540486
C028007nickel monoxidenickel monoxide results in decreased expression of ZFP36 mRNA19167457
D009538NicotineBungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]21606497
D009538Nicotinemethyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]21606497
D009538Nicotine[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA21606497
D009538Nicotine[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein21606497
D009538NicotineNicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]21606497
D009538NicotineNicotine results in increased activity of ZFP36 promoter21606497
D009538NicotineZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]21606497
D009538NicotineZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]21606497
D009538NicotineHMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]24095726
D009538NicotineHMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]24095726
D009538NicotineHMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]24095726
D009538Nicotine[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA24095726
D009538NicotineNicotine results in increased expression of ZFP36 mRNA22093924|2409572
D009538NicotineNicotine results in increased expression of ZFP36 protein22093924
D009538NicotineSTAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]24095726
D009538NicotineSTAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]24095726
D009538Nicotinetin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]24095726
D009538NicotineZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]22093924
D009538NicotineZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]22093924
D009538NicotineZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]24095726
D009538NicotineZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]24095726
D009538NicotineZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]24095726
D009538NicotineZFP36 protein results in increased susceptibility to Nicotine22093924|2409572
D009538Nicotinezinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]24095726
D009538Nicotinezinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]24095726
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ZFP36 mRNA"12756304
C570897NSC668394NSC668394 results in increased expression of ZFP36 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ZFP36 mRNA20971185
D009966OrphenadrineOrphenadrine affects the expression of ZFP36 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ZFP36 mRNA25729387
D010261ParaoxonParaoxon results in increased expression of ZFP36 mRNA22093924
D010269ParaquatParaquat results in increased expression of ZFP36 mRNA12595580
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ZFP36 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of ZFP36 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ZFP36 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFP36 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ZFP36 mRNA26272509
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ZFP36 mRNA20847119
C006253pirinixic acidpirinixic acid results in increased expression of ZFP36 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of ZFP36 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of ZFP36 mRNA23370395
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ZFP36 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of ZFP36 mRNA21795739
C005556propionaldehydepropionaldehyde results in decreased expression of ZFP36 mRNA26079696
C010313pseudocumenepseudocumene results in increased expression of ZFP36 protein17337753
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ZFP36 mRNA27029645
D011794QuercetinQuercetin results in increased expression of ZFP36 mRNA21632981
D020849Raloxifene HydrochlorideESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of ZFP36 mRNA]14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ZFP36 mRNA14699072
C059514resveratrolresveratrol results in increased expression of ZFP36 mRNA26537190
C059514resveratrolresveratrol results in increased expression of ZFP36 protein26537190
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ZFP36 mRNA20847119
C000589029RU24858apicidin inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
C000589029RU24858Mifepristone inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
C000589029RU24858RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]15710351
C000589029RU24858RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 protein]15710351
C000589029RU24858trichostatin A inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
C093642SB 203580SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]21969073
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of ZFP36 mRNA19564919
C016101shikoninshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36 mRNA]25451590
C016101shikoninshikonin inhibits the reaction [Calcimycin results in increased expression of ZFP36 mRNA]25451590
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ZFP36 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZFP36 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZFP36 protein23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of ZFP36 mRNA19073995
D012834SilverSilver results in increased expression of ZFP36 mRNA27131904
C017947sodium arsenitesodium arsenite affects the localization of ZFP36 protein15944294
C017947sodium arsenitesodium arsenite results in increased expression of ZFP36 mRNA12016162
C017947sodium arsenitesodium arsenite affects the localization of ZFP36 protein15944294
C016104sodium bichromatesodium bichromate results in increased expression of ZFP36 mRNA27859739
D018038Sodium SeleniteSodium Selenite results in increased expression of ZFP36 mRNA18175754
D012999SomanSoman results in increased expression of ZFP36 mRNA19281266
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of ZFP36 mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ZFP36 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ZFP36 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of ZFP36 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of ZFP36 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ZFP36 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ZFP36 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of ZFP36 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZFP36 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZFP36 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZFP36 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZFP36 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZFP36 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZFP36 mRNA21215274
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ZFP36 mRNA19945525
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ZFP36 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of ZFP36 mRNA8764118
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]24095726
C009495titanium dioxidetitanium dioxide analog results in increased expression of ZFP36 mRNA25111187
C009495titanium dioxidetitanium dioxide results in increased expression of ZFP36 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ZFP36 mRNA28111298
D014031TobramycinTobramycin results in increased expression of ZFP36 mRNA26260164
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ZFP36 mRNA25729387
D014112ToxapheneToxaphene results in decreased expression of ZFP36 mRNA23153324
C011559tributyltintributyltin results in increased expression of ZFP36 mRNA21683754
D014241TrichloroethyleneTrichloroethylene results in decreased expression of ZFP36 mRNA19448997
C012589trichostatin Atrichostatin A inhibits the reaction [RU24858 inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]15710351
C012589trichostatin Atrichostatin A results in increased expression of ZFP36 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZFP36 mRNA"26179874
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ZFP36 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ZFP36 mRNA]20847119
C022884undecaneundecane results in increased expression of ZFP36 protein17337753
D014520UrethaneUrethane results in increased expression of ZFP36 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ZFP36 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZFP36 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ZFP36 mRNA15901671
C025643vinclozolinvinclozolin affects the expression of ZFP36 mRNA19015723|2303416
D014810Vitamin EVitamin E results in decreased expression of ZFP36 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of ZFP36 mRNA"24525044
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ZFP36 mRNA18593933
D015032ZincZinc results in increased expression of ZFP36 mRNA7860645
D015032ZincZinc results in increased stability of ZFP36 mRNA7860645
D015032ZincZinc deficiency results in increased expression of ZFP36 mRNA19111725
D015032ZincZinc binds to and results in increased activity of ZFP36 protein17087518
D015034Zinc OxideZinc Oxide results in increased expression of ZFP36 protein21769377
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of ZFP36 mRNA]24095726
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA]24095726
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]24095726
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]24095726
D019287Zinc SulfateZinc Sulfate results in increased expression of ZFP36 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  
GO:0003727single-stranded RNA binding-TAS9703499  
GO:0003729mRNA binding-IDA11782475  15687258  
GO:0003730mRNA 3'-UTR binding-IBA21873635  
GO:0005515protein binding-IPI14679154  14766228  15687258  15766526  16126846  16364915  
20221403  21784977  21964062  23644599  25106868  
GO:0017091AU-rich element binding-IDA10330172  15014438  20221403  
GO:0017091AU-rich element binding-IMP21784977  
GO:0019899enzyme binding-IPI25038453  
GO:0019901protein kinase binding-IPI15014438  
GO:0019957C-C chemokine binding-IPI21784977  
GO:0031072heat shock protein binding-IDA20221403  
GO:0035925mRNA 3'-UTR AU-rich region binding-IDA9703499  12748283  15187101  15634918  15766526  20702587  
25038453  
GO:0046872metal ion binding-IEA-  
GO:0070063RNA polymerase binding-ISS-  
GO:007188914-3-3 protein binding-IDA15014438  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP21784977  
GO:0000165MAPK cascade-IMP15187101  
GO:0000165MAPK cascade-ISS-  
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-IDA23644599  
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening-IMP23644599  
GO:0006402mRNA catabolic process-IDA10330172  10751406  11782475  20221403  
GO:0009611response to wounding-IDA27182009  
GO:0009611response to wounding-ISS-  
GO:0010837regulation of keratinocyte proliferation-IMP27182009  
GO:0031086nuclear-transcribed mRNA catabolic process, deadenylation-independent decay-IDA11279239  
GO:0032680regulation of tumor necrosis factor production-IDA15014438  
GO:0032897negative regulation of viral transcription-IMP14679154  
GO:0035278miRNA mediated inhibition of translation-ISS-  
GO:0038066p38MAPK cascade-ISS-  
GO:0042594response to starvation-IDA15014438  
GO:0043488regulation of mRNA stability-IDA9703499  11719186  15687258  20702587  
GO:0043488regulation of mRNA stability-IMP15187101  15634918  
GO:0043488regulation of mRNA stability-TAS-  
GO:0044344cellular response to fibroblast growth factor stimulus-IDA20166898  
GO:0045085negative regulation of interleukin-2 biosynthetic process-ISS-  
GO:0045600positive regulation of fat cell differentiation-ISS-  
GO:0045616regulation of keratinocyte differentiation-IMP27182009  
GO:0045647negative regulation of erythrocyte differentiation-IDA20702587  
GO:0051028mRNA transport-IMP17369404  
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening-IDA10330172  
GO:00611583'-UTR-mediated mRNA destabilization-IBA21873635  
GO:00611583'-UTR-mediated mRNA destabilization-IDA9703499  11719186  15687258  20221403  27193233  
GO:00611583'-UTR-mediated mRNA destabilization-IMP14679154  15187101  15634918  15766526  
GO:00709353'-UTR-mediated mRNA stabilization-IDA15014438  
GO:0071222cellular response to lipopolysaccharide-IDA14766228  
GO:0071222cellular response to lipopolysaccharide-IMP14679154  15187101  
GO:0071356cellular response to tumor necrosis factor-IDA20166898  
GO:0071364cellular response to epidermal growth factor stimulus-IDA20166898  
GO:0071385cellular response to glucocorticoid stimulus-IDA20166898  
GO:0097011cellular response to granulocyte macrophage colony-stimulating factor stimulus-IDA20166898  
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-IDA12748283  
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-ISS-  
GO:1901835positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA-IDA16364915  
GO:1902172regulation of keratinocyte apoptotic process-IMP27182009  
GO:1904246negative regulation of polynucleotide adenylyltransferase activity-ISS-  
GO:1904582positive regulation of intracellular mRNA localization-IMP17369404  
GO:2000637positive regulation of gene silencing by miRNA-IMP15766526  
GO ID GO Term Qualifier Evidence PubMed
GO:0000178exosome (RNase complex)NOT colocalizes_withIDA11719186  
GO:0000932P-body-IDA17369404  21964062  
GO:0005634nucleus-IDA10330172  12198173  14679154  
GO:0005737cytoplasm-IDA10330172  12198173  14679154  14766228  15634918  20221403  21784977  25038453  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA10751406  
GO:0005829cytosol-TAS-  
GO:0010494cytoplasmic stress granule-IDA15014438  21964062  
GO:0030014CCR4-NOT complexcolocalizes_withISS-  
GO:0070578RISC-loading complexcolocalizes_withIDA15766526  
GO:0098745Dcp1-Dcp2 complexcolocalizes_withIDA16364915  
GO:1990904ribonucleoprotein complex-IDA10330172  15687258  20702587  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-450513Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23744329[Association of MK2 and ZFP36 gene polymorphisms with high density lipoprotein cholesterol in Uygur population from Hetian area of Xinjiang]. (2013 Jun)Li NZhonghua Yi Xue Yi Chuan Xue Za Zhi
24780075Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy. (2014 Jul)Planck TThyroid