Gene: PTTG1IP

754
C21orf1|C21orf3|PBF
PTTG1 interacting protein
protein-coding
21q22.3
Ensembl:ENSG00000183255 MIM:603784 Vega:OTTHUMG00000090254 UniprotKB:P53801
NG_033966.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.555e-2 (AD)  8.186e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NECAP20.927
ATP6V0E10.924
ABHD40.923
WASF20.921
STOM0.918
LRP100.915
NFE2L20.914
CALCOCO20.913
HDAC10.906
TMBIM10.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.517
OR4F29-0.509
OR4F5-0.497
CALHM1-0.495
PPEF1-0.49
ADRA1D-0.489
FBLN7-0.483
SLC7A4-0.475
NXPH2-0.471
MYOZ3-0.466

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in increased expression of PTTG1IP mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTTG1IP mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of PTTG1IP mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PTTG1IP mRNA24449571
D001280AtrazineAtrazine results in decreased expression of PTTG1IP mRNA25929836
D001553BenzbromaroneBenzbromarone affects the expression of PTTG1IP mRNA19483382
C006780bisphenol Abisphenol A results in increased expression of PTTG1IP mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of PTTG1IP mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PTTG1IP promoter22457795
D002922CiguatoxinsCiguatoxins affects the expression of PTTG1IP mRNA18353800
D002994ClofibrateClofibrate affects the expression of PTTG1IP mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of PTTG1IP mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of PTTG1IP mRNA19376846
D003907DexamethasoneDexamethasone results in increased expression of PTTG1IP mRNA22733784
D005001EthionineEthionine affects the expression of PTTG1IP mRNA19483382
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PTTG1IP mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTTG1IP mRNA19465457
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTTG1IP mRNA"25554681
D009853OmeprazoleOmeprazole affects the expression of PTTG1IP mRNA19483382
D010634PhenobarbitalPhenobarbital results in decreased expression of PTTG1IP mRNA23091169|2527062
C006253pirinixic acidpirinixic acid affects the expression of PTTG1IP mRNA19483382
D010936Plant ExtractsPlant Extracts results in increased expression of PTTG1IP mRNA23557933
D011441PropylthiouracilPropylthiouracil affects the expression of PTTG1IP mRNA19483382
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of PTTG1IP mRNA25626140
D012715Sesame OilSesame Oil results in decreased expression of PTTG1IP mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PTTG1IP mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of PTTG1IP mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of PTTG1IP mRNA21795629
D018038Sodium SeleniteSodium Selenite results in increased expression of PTTG1IP mRNA18175754
D012999SomanSoman results in increased expression of PTTG1IP mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of PTTG1IP mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTTG1IP mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PTTG1IP mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTTG1IP mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PTTG1IP mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of PTTG1IP mRNA19483382
D014212TretinoinTretinoin results in decreased expression of PTTG1IP mRNA20488242
C012589trichostatin Atrichostatin A affects the expression of PTTG1IP mRNA28542535

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IPI24506068  
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006606protein import into nucleus-IBA21873635  
GO:0006606protein import into nucleus-IDA10781616  
GO:0031398positive regulation of protein ubiquitination-IDA24506068  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IMP24506068  
GO:1902254negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator-IMP24506068  
GO:1903364positive regulation of cellular protein catabolic process-IDA24506068  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10781616  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10781616  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27709636PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma. (2017 May)Nieuwenhuis MAAllergy