Gene: ZFX

7543
ZNF926
zinc finger protein X-linked
protein-coding
Xp22.11
Ensembl:ENSG00000005889 MIM:314980 Vega:OTTHUMG00000021264 UniprotKB:P17010
NG_021253.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDM6A0.759
QSER10.708
NIPBL0.707
ZNF240.702
SIRT10.694
SOCS40.692
SMC30.682
CDC730.678
ARID20.678
ADAM100.677

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPS4Y1-0.621
EIF1AY-0.585
KDM5D-0.585
TMSB4Y-0.583
USP9Y-0.582
DDX3Y-0.582
NLGN4Y-0.569
UTY-0.532
ZFY-0.516
PCDH11Y-0.486

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ZFX mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZFX mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZFX mRNA26238291
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of ZFX mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZFX mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZFX mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ZFX mRNA"26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZFX mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of ZFX mRNA25181051
D000069286BortezomibBortezomib results in increased expression of ZFX mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of ZFX mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ZFX mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ZFX mRNA24982889
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of ZFX mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of ZFX mRNA25596134
D002994ClofibrateClofibrate results in increased expression of ZFX mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ZFX mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ZFX mRNA22147139|2556210
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ZFX mRNA"23811387
D005485FlutamideFlutamide results in increased expression of ZFX mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of ZFX mRNA20655997
C070081fulvestrantfulvestrant results in increased expression of ZFX mRNA12154049
C039281furanfuran results in increased methylation of ZFX gene22079235
C001277geldanamycingeldanamycin results in increased expression of ZFX mRNA26705709
C401858GW 7604GW 7604 results in increased expression of ZFX mRNA12154049
D017313FenretinideFenretinide results in decreased expression of ZFX mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ZFX mRNA18951874
C051890irinotecanirinotecan metabolite results in decreased expression of ZFX mRNA15956246
C051890irinotecanirinotecan results in decreased expression of ZFX mRNA15956246
C544151jinfukangjinfukang results in decreased expression of ZFX mRNA27392435
C045463leflunomideleflunomide results in decreased expression of ZFX mRNA28988120
C002950methylformamidemethylformamide analog results in increased expression of ZFX mRNA17040096
C002950methylformamidemethylformamide results in increased expression of ZFX mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZFX mRNA28001369
D009285NaphthoquinonesNaphthoquinones results in increased expression of ZFX mRNA23811387
D010936Plant ExtractsPlant Extracts results in increased expression of ZFX mRNA23557933
D011794QuercetinQuercetin results in decreased expression of ZFX mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of ZFX mRNA12154049
C049705S-1,2-dichlorovinyl-N-acetylcysteine"S-1,2-dichlorovinyl-N-acetylcysteine results in increased expression of ZFX mRNA"16844155
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ZFX mRNA21427059
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ZFX mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZFX mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZFX mRNA16962184|2157046
C012589trichostatin Atrichostatin A affects the expression of ZFX mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ZFX mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZFX mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ZFX mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of ZFX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZFX mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of ZFX mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ZFX gene25560391
C025643vinclozolinvinclozolin results in increased expression of ZFX mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003713transcription coactivator activity-TAS2105457  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26540164ZFX is a Strong Predictor of Poor Prognosis in Renal Cell Carcinoma. (2015 Nov 5)Li CMed Sci Monit