Gene: CA1

759
CA-I|CAB|Car1|HEL-S-11
carbonic anhydrase 1
protein-coding
8q21.2
Ensembl:ENSG00000133742 MIM:114800 Vega:OTTHUMG00000164941 UniprotKB:P00915
NG_016221.1
PubMed
CD|OD|ND|AD
81   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.135e-1 (AD)  9.426e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A10.919
AHSP0.841
SPTA10.827
ALAS20.809
HBM0.72
TRIM100.689
IL18RAP0.669
LILRA50.653
CD300E0.636
BPI0.63

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.504
SVOP-0.466
PRKCZ-0.466
KCNC2-0.461
SYT3-0.455
NEUROD6-0.452
BCL11A-0.452
HAS1-0.448
HCN1-0.446
CDK5R2-0.443

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00232MethyclothiazideSmall Molecule135-07-9ApprovedTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00311EthoxzolamideSmall Molecule452-35-7WithdrawnTarget
DB00381AmlodipineSmall Molecule88150-42-9ApprovedTarget
DB00423MethocarbamolSmall Molecule532-03-6ApprovedTarget
DB00436BendroflumethiazideSmall Molecule73-48-3ApprovedTarget
DB00562BenzthiazideSmall Molecule91-33-8ApprovedTarget
DB00606CyclothiazideSmall Molecule2259-96-3ApprovedTarget
DB00703MethazolamideSmall Molecule554-57-4ApprovedTarget
DB00774HydroflumethiazideSmall Molecule135-09-1Approved|InvestigationalTarget
DB00819AcetazolamideSmall Molecule59-66-5ApprovedTarget
DB00869DorzolamideSmall Molecule120279-96-1ApprovedTarget
DB00880ChlorothiazideSmall Molecule58-94-6ApprovedTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB00999HydrochlorothiazideSmall Molecule58-93-5ApprovedTarget
DB01021TrichlormethiazideSmall Molecule133-67-5ApprovedTarget
DB01031EthinamateSmall Molecule126-52-3Approved|Illicit|WithdrawnTarget
DB01119DiazoxideSmall Molecule364-98-7ApprovedTarget
DB01144DiclofenamideSmall Molecule120-97-8Approved|InvestigationalTarget
DB01194BrinzolamideSmall Molecule138890-62-7ApprovedTarget
DB01325QuinethazoneSmall Molecule73-49-4ApprovedTarget
DB08155N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDESmall MoleculeExperimentalTarget
DB081563-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDSmall MoleculeExperimentalTarget
DB08157ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATESmall MoleculeExperimentalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB09460Sodium carbonateSmall Molecule497-19-8ApprovedTarget
DB09472Sodium sulfateSmall Molecule7757-82-6ApprovedTarget
ID Drug Name Action PubMed
C0354072,6-di-tert-butylphenol"2,6-di-tert-butylphenol analog results in decreased activity of CA1 protein"19231207
C0365312,6-xylenol"2,6-xylenol analog results in decreased activity of CA1 protein"19231207
D000082AcetaminophenAcetaminophen results in decreased expression of CA1 mRNA26690555
D000086AcetazolamideAcetazolamide binds to and results in decreased activity of CA1 protein17826101|2825175
D000086AcetazolamideAcetazolamide results in decreased activity of CA1 protein11430635|1923120
D000086AcetazolamideIndomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein]11430635
D000086AcetazolamideAcetazolamide results in decreased activity of CA1 protein29149534
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CA1 gene27153756
D000577AmidesAmides results in decreased activity of CA1 protein28544359
D000872AnthocyaninsAnthocyanins results in decreased activity of CA1 protein28445001
D001562BenzimidazolesBenzimidazoles analog results in decreased activity of CA1 protein29149534
D001574BenzolamideBenzolamide binds to and results in decreased activity of CA1 protein17826101
D001639BicarbonatesCA1 protein results in increased chemical synthesis of Bicarbonates17826101
C006780bisphenol Abisphenol A results in decreased expression of CA1 protein16603574
D001761BleomycinBleomycin results in decreased expression of CA1 protein25933445
D001959BromatesBromates results in decreased activity of CA1 protein15664814
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in decreased activity of CA1 protein19231207
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CA1 mRNA17582521
C081643candesartancandesartan results in decreased activity of CA1 protein11196069
D002254CarbonatesCarbonates results in decreased activity of CA1 protein15664814
C022842chloric acidchloric acid results in decreased activity of CA1 protein15664814
D003035CobaltCobalt results in decreased activity of CA1 protein18237030
C018021cobaltous chloridecobaltous chloride results in decreased expression of CA1 mRNA22941251
C030123coumarincoumarin results in decreased activity of CA1 protein22077347
C049098diallyl phthalatediallyl phthalate results in decreased expression of CA1 protein16603574
D000431EthanolEthanol results in increased expression of CA1 protein23200777
D005016EthoxzolamideEthoxzolamide binds to and results in decreased activity of CA1 protein17826101
D005419FlavonoidsFlavonoids results in decreased activity of CA1 protein28445001
D006139GuaiacolGuaiacol results in decreased activity of CA1 protein19231207
D017313FenretinideFenretinide results in decreased expression of CA1 mRNA28973697
D007213IndomethacinIndomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein]11430635
D007213IndomethacinIndomethacin results in increased activity of CA1 protein11430635
D007452IodatesIodates results in decreased activity of CA1 protein15664814
C081309irbesartanirbesartan results in decreased activity of CA1 protein11196069
D007854LeadLead results in decreased activity of CA1 protein18237030
C458419malvidin-3-glucosidemalvidin-3-glucoside results in decreased activity of CA1 protein28445001
C502603malvinmalvin results in decreased activity of CA1 protein28445001
D008628MercuryMercury results in decreased activity of CA1 protein18237030
D008704MethazolamideMethazolamide binds to and results in decreased activity of CA1 protein17826101
C439829N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide"N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide binds to and results in decreased activity of CA1 protein"17826101
D017942Nitric AcidNitric Acid results in decreased activity of CA1 protein15664814
D009966OrphenadrineOrphenadrine affects the expression of CA1 mRNA23665939
C012465oryzalinoryzalin binds to and results in decreased activity of CA1 protein28251759
C078485pelargonidin-3-glucosidepelargonidin-3-glucoside results in decreased activity of CA1 protein28445001
C494474perchlorateperchlorate results in decreased activity of CA1 protein15664814
D010656PhenylephrinePhenylephrine results in decreased activity of CA1 protein28800181
C037192potassium periodatepotassium periodate results in decreased activity of CA1 protein15664814
D011374ProgesteroneProgesterone results in decreased expression of CA1 mRNA19690047
D015742PropofolPropofol analog results in decreased activity of CA1 protein19231207
D015742PropofolPropofol results in decreased activity of CA1 protein19231207
D011743PyrimidinesPyrimidines analog results in decreased activity of CA1 protein29283199
D012293RifampinRifampin results in decreased expression of CA1 mRNA24552687
C089730rosiglitazonerosiglitazone affects the expression of CA1 protein19556978
C015504silychristinsilychristin results in decreased activity of CA1 protein28445001
D012969Sodium FluorideSodium Fluoride results in decreased expression of CA1 protein28918527
C025349sodium metasilicatesodium metasilicate results in decreased activity of CA1 protein15664814
C005741sulfamic acidsulfamic acid results in decreased activity of CA1 protein15664814
D013431SulfatesSulfates results in decreased activity of CA1 protein15664814
D013438Sulfhydryl CompoundsSulfhydryl Compounds analog binds to CA1 protein17059166
D013578SynephrineSynephrine results in decreased activity of CA1 protein28800181
D053778ThiazolidinesThiazolidines results in decreased activity of CA1 protein28544359
D013871ThionesThiones analog results in decreased activity of CA1 protein29283199
C005151thiosemicarbazidethiosemicarbazide analog results in decreased activity of CA1 protein29131470
D013890ThioureaThiourea analog results in decreased activity of CA1 protein28117934
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CA1 protein27189315
C052342topiramatetopiramate binds to and results in decreased activity of CA1 protein17826101
D014230TriazolesTriazoles analog results in decreased activity of CA1 protein29131470
C045951tungstatetungstate results in decreased activity of CA1 protein15664814
D014638VanadatesVanadates results in decreased activity of CA1 protein15664814
C100058vanillinvanillin results in decreased activity of CA1 protein19231207
D015032ZincCA1 gene SNP affects the abundance of Zinc23720494
C022189zonisamidezonisamide binds to and results in decreased activity of CA1 protein17826101

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004064arylesterase activity-IMP7758465  
GO:0004089carbonate dehydratase activity-IMP7758465  
GO:0004089carbonate dehydratase activity-TAS-  
GO:0005515protein binding-IPI25416956  25910212  
GO:0008270zinc ion binding-IEA-  
GO:0016836hydro-lyase activity-IDA2114290  
GO ID GO Term Qualifier Evidence PubMed
GO:0006730one-carbon metabolic process-IEA-  
GO:0015701bicarbonate transport-TAS-  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00910Nitrogen metabolism
Reactome ID Reactome Term Evidence
R-HSA-1237044Erythrocytes take up carbon dioxide and release oxygenTAS
R-HSA-1247673Erythrocytes take up oxygen and release carbon dioxideTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1475029Reversible hydration of carbon dioxideTAS
R-HSA-1480926O2/CO2 exchange in erythrocytesTAS
R-HSA-168256Immune SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26108098Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence. (2015 Aug)Xu RBraz J Med Biol Res
23352971Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons. (2013 Mar 14)DuBois DWLife Sci
15795061Maternal exposure of rats to nicotine via infusion during gestation produces neurobehavioral deficits and elevated expression of glial fibrillary acidic protein in the cerebellum and CA1 subfield in the offspring at puberty. (2005 May 5)Abdel-Rahman AToxicology
28096497BDNF regains function in hippocampal long-term potentiation deficits caused by diencephalic damage. (2017 Feb)Vedder LCLearn Mem
17989301Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication. (2007 Nov 7)Liang JJ Neurosci
25139850Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats. (2014 Nov)Zhang JJNeuropharmacology
24850983Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats. (2014 May)Hakimizadeh EIran J Med Sci
19376201Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2. (2009 Jul 7)Guan XNeuroscience
23395714Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. (2013 Aug)Sinkus MLBrain Behav Immun
25016090Bupropion-induced inhibition of alpha7 nicotinic acetylcholine receptors expressed in heterologous cells and neurons from dorsal raphe nucleus and hippocampus. (2014 Oct 5)Vazquez-Gomez EEur J Pharmacol
15152029gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors. (2004 Oct)Schweitzer PJ Pharmacol Exp Ther
19084907Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. (2009 Mar)Edwards SSynapse
9166743Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence. (1997 Jun)Mahmoudi MJ Neurochem
22119395Chronic neonatal nicotine exposure increases excitation in the young adult rat hippocampus in a sex-dependent manner. (2012 Jan 9)Damborsky JCBrain Res
28924491SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics. (2017)Berent DTransl Neurosci
23889203Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner. (2013 Dec)Butler TRAlcohol Clin Exp Res
9120553Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology. (1997 Jan)Baraban SCJ Neurophysiol
18358520Alpha2-containing GABA(A) receptors are involved in mediating stimulant effects of cocaine. (2008 Jul)Morris HVPharmacol Biochem Behav
25769285Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. (2015 Mar)Staples MCMol Cell Neurosci
2134390Effect of chronic alcoholism on the human hippocampus. (1990 Jul)Bengochea OHistol Histopathol
22960015The region-specific activation of Ca2+/calmodulin dependent protein kinase II and extracellular signal-regulated kinases in hippocampus following chronic alcohol exposure. (2012 Dec 1)Wang YBrain Res Bull
17156213Nicotine withdrawal suppresses nicotinic modulation of long-term potentiation induction in the hippocampal CA1 region. (2006 Nov)Yamazaki YEur J Neurosci
27784625Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. (2017 Feb)Yamazaki YNeuropharmacology
9789829Contribution of nicotinic receptors to the function of synapses in the central nervous system: the action of choline as a selective agonist of alpha 7 receptors. (1998 Jun-Aug)Albuquerque EXJ Physiol Paris
19341783Protein receptor for activated C kinase 1 is involved in morphine reward in mice. (2009 Jul 7)Wan LNeuroscience
12435490Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. (2002 Dec 13)Li SPNeurosci Lett
22860061Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. (2012)Garcia-Fuster MJPLoS One
20423831[Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]. (2010 Apr)Huang PNan Fang Yi Ke Da Xue Xue Bao
9884165Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. (1998 Dec)Kang MHAlcohol Clin Exp Res
11056193Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression. (2000 Nov 3)Lilly SMBrain Res
25046735Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus. (2014 Aug 28)Nakauchi SLife Sci
28263897Lewis and Fischer 344 rats as a model for genetic differences in spatial learning and memory: Cocaine effects. (2017 Jun 2)Fole AProg Neuropsychopharmacol Biol Psychiatry
20018661Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. (2010 Jan 5)Thorsen TSProc Natl Acad Sci U S A
17259867Chronic nicotine exposure affects the normal operation of hippocampal circuits. (2007 Jan 8)Nakauchi SNeuroreport
25545599Early postnatal nicotine exposure causes hippocampus-dependent memory impairments in adolescent mice: Association with altered nicotinic cholinergic modulation of LTP, but not impaired LTP. (2015 Feb)Nakauchi SNeurobiol Learn Mem
14555401Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. (2003 Nov 14)Abdel-Rahman AJ Toxicol Environ Health A
22548195Kalirin, a key player in synapse formation, is implicated in human diseases. (2012)Mandela PNeural Plast
8208336Hirano bodies and chronic alcoholism. (1994 Feb)Laas RNeuropathol Appl Neurobiol
18289710Cigarette smoking decreases neurotrophin-3 expression in rat hippocampus after transient forebrain ischemia. (2008 Apr)Yang JTNeurosci Res
18634806Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration. (2008 Oct)Miguens MNeuropharmacology
11044743Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. (2000 Oct)Alkondon MNeuropharmacology
15099681(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity. (2004)Mulholland PJNeuroscience
26692207Cocaine self-administration induces changes in synaptic transmission and plasticity in ventral hippocampus. (2017 Mar)Keralapurath MMAddict Biol
11388409Tetrodotoxin-sensitive enhancement of inhibition in CA1 pyramidal neurones by nicotine. (2001 May 25)Hulo SNeuroreport
10665983Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats. (2000)Kim HCLife Sci
18189313The effect of nicotine on spiking activity and Ca2+ dynamics of dendritic spines in rat CA1 pyramidal neurons. (2008)Szabo SIHippocampus
27623427Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure. (2016 Nov)Holliday EDEur J Neurosci
11026484Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists--in vitro characterisation. (2000)Parsons CGAmino Acids
19692619Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. (2009 Aug 19)Tu BJ Neurosci
9138671Chronic alcohol consumption does not cause hippocampal neuron loss in humans. (1997)Harding AJHippocampus
20192946NMDA receptors in frontal cortex and hippocampus of alcohol consumers. (2011 Jan)Villegas EAddict Biol
26386153Early postnatal nicotine exposure disrupts the alpha2* nicotinic acetylcholine receptor-mediated control of oriens-lacunosum moleculare cells during adolescence in rats. (2016 Feb)Chen KNeuropharmacology
17439498Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. (2007 Apr)Edwards SEur J Neurosci
16725127Chronic but not acute nicotine treatment reverses stress-induced impairment of LTP in anesthetized rats. (2006 Jun 30)Aleisa AMBrain Res
27751532Blockade of dorsal hippocampal orexin-1 receptors impaired morphine-induced state-dependent learning. (2016 Dec)Farahmandfar MNeuropeptides
17676486The neuroprotective effects of caffeic acid phenethyl ester (CAPE) in the hippocampal formation of cigarette smoke exposed rabbits. (2007 Aug)Eser OPathology
27905406Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. (2017 Apr)Uhrig SNeuropsychopharmacology
27660076Impaired function of alpha2-containing nicotinic acetylcholine receptors on oriens-lacunosum moleculare cells causes hippocampus-dependent memory impairments. (2016 Dec)Kleeman ENeurobiol Learn Mem
16340465Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid (25-35)-induced cytotoxicity: NMDA receptor involvement. (2005 Nov)Self RLAlcohol Clin Exp Res
23832598Fos expression induced by cocaine-conditioned cues in male and female rats. (2014 Sep)Zhou LBrain Struct Funct
11410716Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. (2001 Jun)Petrie JAlcohol Clin Exp Res
15219680Modulation of long-term potentiation in the rat hippocampus following cocaine self-administration. (2004)Thompson AMNeuroscience
8814911Chronic exposure to morphine attenuates expression of interleukin-1 beta in the rat hippocampus. (1996 Mar 18)Patel NABrain Res
12488536Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. (2003 Jan)Cagetti EMol Pharmacol
21334425Nicotine and estrogen synergistically exacerbate cerebral ischemic injury. (2011 May 5)Raval APNeuroscience
26707655Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function. (2016 Apr)Hernandez RVNeuropharmacology
15950760Conditioned place preference associates with the mRNA expression of diazepam binding inhibitor in brain regions of the addicted rat during withdrawal. (2005 Jun 13)Liu XBrain Res Mol Brain Res
11198717Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurt. (2001 Jan)Bonthius DJAlcohol Clin Exp Res
11880521Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. (2002 Mar 1)Pu LJ Neurosci
19376142Strain differences between Lewis and Fischer 344 rats in the modulation of dopaminergic receptors after morphine self-administration and during extinction. (2009 Jul)Sanchez-Cardoso PNeuropharmacology
15126642Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence. (2004 Sep)Liang JJ Pharmacol Exp Ther
24950455Neonatal nicotine exposure increases excitatory synaptic transmission and attenuates nicotine-stimulated GABA release in the adult rat hippocampus. (2015 Jan)Damborsky JCNeuropharmacology
23192463Differential responses of hippocampal neurons and astrocytes to nicotine and hypoxia in the fetal guinea pig. (2013 Jul)Blutstein TNeurotox Res
16631170A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. (2006 Aug)Evrard SGExp Neurol
11961084Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal. (2002 May)Roy AJ Pharmacol Exp Ther
26332690Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration. (2017 Jan)Selvas AAddict Biol
25388276Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. (2016 Mar)Dominguez GBrain Struct Funct
23723052The effect of chronic thienorphine administration on long-term potentiation and synaptic structure in rat hippocampus. (2013 Nov)Yong ZSynapse
15014116Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction. (2004 Mar 10)Yang YJ Neurosci
21861331[Functional homology between alcohol dependence and mood disorder]. (2011 Jun)Shibasaki MNihon Arukoru Yakubutsu Igakkai Zasshi
15208160Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar rats. (2004 Jul-Aug)Ortiz SAlcohol Alcohol