Gene info: ID 760

Gene: CA2

GENE ID: 760

Synonyms: CA-II|CAC|CAII|Car2|HEL-76|HEL-S-282

Description: carbonic anhydrase 2

Gene type: protein-coding

Location: 8q21.2

dbXrefs: Ensembl:ENSG00000104267 MIM:611492 Vega:OTTHUMG00000164944 UniprotKB:P00918

RefSeq: NG_007287.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 51

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.731e-1 (AD) 9.853e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PREX1	0.821
VEZF1	0.817
GLTP	0.814
CERS2	0.805
LAMP2	0.796
RAB9A	0.793
PMP22	0.786
SYPL1	0.786
GPRC5B	0.781
NPC1	0.779

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.571
OR4F29	-0.56
CNGB1	-0.255
TRIM72	-0.251
FFAR4	-0.236
FREM3	-0.233
KNCN	-0.219
FBLN7	-0.217
HTR6	-0.217
TTC6	-0.216

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00232	Methyclothiazide	Small Molecule	135-07-9	Approved	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00311	Ethoxzolamide	Small Molecule	452-35-7	Withdrawn	Target
DB00391	Sulpiride	Small Molecule	15676-16-1	Approved\|Investigational	Target
DB00436	Bendroflumethiazide	Small Molecule	73-48-3	Approved	Target
DB00482	Celecoxib	Small Molecule	169590-42-5	Approved\|Investigational	Target
DB00562	Benzthiazide	Small Molecule	91-33-8	Approved	Target
DB00580	Valdecoxib	Small Molecule	181695-72-7	Approved\|Investigational\|Withdrawn	Target
DB00606	Cyclothiazide	Small Molecule	2259-96-3	Approved	Target
DB00695	Furosemide	Small Molecule	54-31-9	Approved	Target
DB00703	Methazolamide	Small Molecule	554-57-4	Approved	Target
DB00774	Hydroflumethiazide	Small Molecule	135-09-1	Approved\|Investigational	Target
DB00819	Acetazolamide	Small Molecule	59-66-5	Approved	Target
DB00869	Dorzolamide	Small Molecule	120279-96-1	Approved	Target
DB00880	Chlorothiazide	Small Molecule	58-94-6	Approved	Target
DB00909	Zonisamide	Small Molecule	68291-97-4	Approved\|Investigational	Target
DB00999	Hydrochlorothiazide	Small Molecule	58-93-5	Approved	Target
DB01021	Trichlormethiazide	Small Molecule	133-67-5	Approved	Target
DB01031	Ethinamate	Small Molecule	126-52-3	Approved\|Illicit\|Withdrawn	Target
DB01119	Diazoxide	Small Molecule	364-98-7	Approved	Target
DB01144	Diclofenamide	Small Molecule	120-97-8	Approved\|Investigational	Target
DB01194	Brinzolamide	Small Molecule	138890-62-7	Approved	Target
DB01325	Quinethazone	Small Molecule	73-49-4	Approved	Target
DB01671	4-(Hydroxymercury)Benzoic Acid	Small Molecule		Experimental	Target
DB01748	N-Benzyl-4-Sulfamoyl-Benzamide	Small Molecule		Experimental	Target
DB01784	4-Flourobenzenesulfonamide	Small Molecule		Experimental	Target
DB01942	Formic Acid	Small Molecule	64-18-6	Approved\|Experimental\|Investigational	Target
DB01964	AL5424	Small Molecule		Experimental	Target
DB02069	N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide	Small Molecule	-	Experimental	Target
DB02087	3,5-Difluorobenzenesulfonamide	Small Molecule		Experimental	Target
DB02220	AL7089A	Small Molecule	220402-83-5	Experimental	Target
DB02221	4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide	Small Molecule		Experimental	Target
DB02292	Irosustat	Small Molecule	288628-05-7	Investigational	Target
DB02429	4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide	Small Molecule		Experimental	Target
DB02479	(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide	Small Molecule		Experimental	Target
DB02535	Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide	Small Molecule		Experimental	Target
DB02602	AL7182	Small Molecule		Experimental	Target
DB02610	N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide	Small Molecule		Experimental	Target
DB02679	Cyanamide	Small Molecule	420-04-2	Experimental	Target
DB02861	4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide	Small Molecule		Experimental	Target
DB02866	Dansylamide	Small Molecule		Experimental	Target
DB02894	Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester	Small Molecule		Experimental	Target
DB02986	N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide	Small Molecule		Experimental	Target
DB03039	4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide	Small Molecule		Experimental	Target
DB03221	AL7099A	Small Molecule		Experimental	Target
DB03262	Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]	Small Molecule	-	Experimental	Target
DB03270	2,6-Difluorobenzenesulfonamide	Small Molecule		Experimental	Target
DB03294	1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide	Small Molecule		Experimental	Target
DB03333	(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester	Small Molecule	-	Experimental	Target
DB03385	4-Methylimidazole	Small Molecule		Experimental	Target
DB03526	AL5927	Small Molecule		Experimental	Target
DB03594	1,2,4-Triazole	Small Molecule	63598-71-0	Experimental	Target
DB03596	N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide	Small Molecule		Experimental	Target
DB03598	Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]	Small Molecule		Experimental	Target
DB03697	4-Sulfonamide-[1-(4-Aminobutane)]Benzamide	Small Molecule		Experimental	Target
DB03844	N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide	Small Molecule		Experimental	Target
DB03877	AL4623	Small Molecule		Experimental	Target
DB03904	Urea	Small Molecule	57-13-6	Approved\|Investigational	Target
DB03950	(S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide	Small Molecule		Experimental	Target
DB03975	Mercuribenzoic Acid	Small Molecule		Experimental	Target
DB04002	4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide	Small Molecule		Experimental	Target
DB04081	(4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide	Small Molecule		Experimental	Target
DB04089	AL5300	Small Molecule		Experimental	Target
DB04180	4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide	Small Molecule		Experimental	Target
DB04203	3-Mercuri-4-Aminobenzenesulfonamide	Small Molecule		Experimental	Target
DB04371	AL6528	Small Molecule		Experimental	Target
DB04394	3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide	Small Molecule		Experimental	Target
DB04549	4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide	Small Molecule		Experimental	Target
DB04600	4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE	Small Molecule		Experimental	Target
DB04601	4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE	Small Molecule		Experimental	Target
DB04763	1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM	Small Molecule		Experimental	Target
DB06891	5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE	Small Molecule		Experimental	Target
DB06954	2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate	Small Molecule		Experimental	Target
DB07048	N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide	Small Molecule		Experimental	Target
DB07050	5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide	Small Molecule	-	Experimental	Target
DB07363	THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)	Small Molecule		Experimental	Target
DB07467	4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide	Small Molecule		Experimental	Target
DB07476	N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE	Small Molecule		Experimental	Target
DB07596	(17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate	Small Molecule		Experimental	Target
DB07632	5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide	Small Molecule		Experimental	Target
DB07710	PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB07742	N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE	Small Molecule		Experimental	Target
DB08046	2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide	Small Molecule		Experimental	Target
DB08083	2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide	Small Molecule		Experimental	Target
DB08155	N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE	Small Molecule		Experimental	Target
DB08156	3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID	Small Molecule		Experimental	Target
DB08157	ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE	Small Molecule		Experimental	Target
DB08165	indane-5-sulfonamide	Small Molecule		Experimental	Target
DB08202	4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB08301	N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB08329	Sulthiame	Small Molecule	61-56-3	Experimental	Target
DB08416	(9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE	Small Molecule		Experimental	Target
DB08418	(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate	Small Molecule		Experimental	Target
DB08645	6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE	Small Molecule		Experimental	Target
DB08659	2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide	Small Molecule		Experimental	Target
DB08765	6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	Small Molecule		Experimental	Target
DB08782	4-(2-AMINOETHYL)BENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB08846	Ellagic Acid	Small Molecule	476-66-4	Investigational	Target
DB09460	Sodium carbonate	Small Molecule	497-19-8	Approved	Target
DB09472	Sodium sulfate	Small Molecule	7757-82-6	Approved	Target

ID	Drug Name	Action	PubMed
C041868	1,1-ethanediol	"CA2 protein affects the metabolism of 1,1-ethanediol"	6430146
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of CA2 mRNA"	19162173
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CA2 mRNA"	25614096
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CA2 mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CA2 mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CA2 mRNA"	16984957
C035407	2,6-di-tert-butylphenol	"2,6-di-tert-butylphenol analog results in decreased activity of CA2 protein"	19231207
C035407	2,6-di-tert-butylphenol	"2,6-di-tert-butylphenol results in decreased activity of CA2 protein"	19231207
C036531	2,6-xylenol	"2,6-xylenol analog results in decreased activity of CA2 protein"	19231207
C036531	2,6-xylenol	"2,6-xylenol results in decreased activity of CA2 protein"	19231207
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CA2 mRNA"	15215175
C526438	2-methoxyestradiol-3,17-O,O-bis(sulfamate)	"2-methoxyestradiol-3,17-O,O-bis(sulfamate) results in decreased activity of CA2 protein"	18630502
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CA2 mRNA"	16984957
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CA2 mRNA"	20959002
C568517	4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide	"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased activity of CA2 protein"	21851094
C568518	4-(4-((glucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide	"4-(4-((glucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased activity of CA2 protein"	21851094
C027576	4-hydroxy-2-nonenal	CA2 protein binds to 4-hydroxy-2-nonenal	20043646
C008642	4-nitrophenyl acetate	CA2 protein results in increased metabolism of 4-nitrophenyl acetate	16858005
D000082	Acetaminophen	Acetaminophen results in decreased expression of CA2 protein	16538041
D000082	Acetaminophen	Acetaminophen results in increased expression of CA2 mRNA	17202762
D000082	Acetaminophen	Acetaminophen results in increased expression of CA2 protein	16687475
D000086	Acetazolamide	Acetazolamide binds to and results in decreased activity of CA2 protein	17826101\|2825175
D000086	Acetazolamide	Acetazolamide results in decreased activity of CA2 protein	11430635\|1685800
D000086	Acetazolamide	Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein]	11430635
D000086	Acetazolamide	Acetazolamide results in decreased activity of CA2 protein	29149534
C016601	afimoxifene	afimoxifene results in increased expression of CA2 mRNA	19698761
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CA2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CA2 gene	27153756
C000188	alachlor	alachlor results in increased expression of CA2 mRNA	12419858
C103303	alitretinoin	[alitretinoin co-treated with seocalcitol] results in increased expression of CA2 protein	16340750
C103303	alitretinoin	alitretinoin results in increased expression of CA2 protein	16340750
C035010	alizarin 1-methyl ether	alizarin 1-methyl ether results in decreased expression of CA2 mRNA	21945525
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of CA2 mRNA	17785943
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of CA2 mRNA	21298039
D000577	Amides	Amides results in decreased activity of CA2 protein	28544359
D000638	Amiodarone	Amiodarone affects the expression of CA2 mRNA	19483382
D000641	Ammonia	[Ammonia co-treated with Hydrocortisone] results in decreased expression of CA2 mRNA	19252005
D000641	Ammonia	Ammonia results in decreased expression of CA2 mRNA	19252005
D000643	Ammonium Chloride	[Ammonium Chloride co-treated with Hydrocortisone] results in decreased expression of CA2 mRNA	19252005
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of CA2 mRNA	19252005
D000872	Anthocyanins	Anthocyanins results in decreased activity of CA2 protein	28445001
D001379	Azathioprine	Azathioprine results in increased expression of CA2 mRNA	28138970
D001542	Benomyl	Benomyl results in increased expression of CA2 mRNA	15885261
D001553	Benzbromarone	Benzbromarone affects the expression of CA2 mRNA	19483382
D001562	Benzimidazoles	Benzimidazoles analog results in decreased activity of CA2 protein	29149534
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CA2 mRNA	18164116
D001574	Benzolamide	Benzolamide binds to and results in decreased activity of CA2 protein	17826101
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CA2 mRNA	20106945
D004958	Estradiol	Estradiol affects the expression of CA2 mRNA	14699072
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of CA2 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA2 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of CA2 mRNA	19619570\|2301914
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of CA2 mRNA	17404688
D001639	Bicarbonates	CA2 protein results in increased chemical synthesis of Bicarbonates	17826101
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CA2 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased methylation of CA2 gene	22576693
C006780	bisphenol A	bisphenol A results in increased expression of CA2 mRNA	19371625\|2257669
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of CA2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CA2 mRNA	18180321
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CA2 mRNA	28628672
D001761	Bleomycin	Bleomycin results in decreased expression of CA2 protein	25933445
C111827	brinzolamide	brinzolamide binds to and results in decreased activity of CA2 protein	17826101
D001959	Bromates	Bromates results in decreased activity of CA2 protein	15664814
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in decreased activity of CA2 protein	19231207
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in decreased activity of CA2 protein	19231207
C018475	butyraldehyde	butyraldehyde results in increased expression of CA2 mRNA	26079696
D002254	Carbonates	Carbonates results in decreased activity of CA2 protein	15664814
D000068579	Celecoxib	Celecoxib binds to and results in decreased activity of CA2 protein	17826101
D000068579	Celecoxib	Celecoxib results in decreased activity of CA2 protein	16858005
C022842	chloric acid	chloric acid results in decreased activity of CA2 protein	15664814
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of CA2 protein	22561108
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of CA2 protein	22561108
D002994	Clofibrate	Clofibrate affects the expression of CA2 mRNA	19483382
D003035	Cobalt	Cobalt results in decreased activity of CA2 protein	18237030
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CA2 mRNA	24386269
D003300	Copper	Copper results in decreased expression of CA2 mRNA	26293553
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of CA2 mRNA	24690739
D003300	Copper	Copper deficiency results in decreased expression of CA2 protein	18993053
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CA2 mRNA	19549813
C030123	coumarin	coumarin results in decreased activity of CA2 protein	22077347
C030123	coumarin	coumarin results in increased expression of CA2 mRNA	18480146
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of CA2 mRNA	19167446
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of CA2 mRNA	17403535
D016572	Cyclosporine	Cyclosporine results in decreased expression of CA2 mRNA	20106945
C037304	cyhalothrin	cyhalothrin results in decreased activity of CA2 protein	22561108
C037304	cyhalothrin	cyhalothrin results in decreased activity of CA2 protein	22561108
C017160	cypermethrin	cypermethrin results in decreased activity of CA2 protein	22561108
C017160	cypermethrin	cypermethrin results in decreased activity of CA2 protein	22561108
D003907	Dexamethasone	Dexamethasone results in increased expression of CA2 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CA2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CA2 mRNA	28628672
D002945	Cisplatin	CA2 protein affects the susceptibility to Cisplatin	16217747
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of CA2 mRNA	15885261
D004005	Dichlorphenamide	Dichlorphenamide binds to and results in decreased activity of CA2 protein	17826101
D004006	Dichlorvos	Dichlorvos results in decreased activity of CA2 protein	22561108
D004006	Dichlorvos	Dichlorvos results in decreased activity of CA2 protein	22561108
D004041	Dietary Fats	Dietary Fats results in increased expression of CA2 mRNA	21852083
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CA2 mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CA2 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CA2 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CA2 mRNA	19371625
D002117	Calcitriol	Calcitriol results in increased expression of CA2 mRNA	16002434\|2648566
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of CA2 mRNA	27638505
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of CA2 mRNA	17374397
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of CA2 mRNA	24690739
C062765	dorzolamide	dorzolamide binds to and results in decreased activity of CA2 protein	17826101
D004656	Enalapril	Enalapril results in decreased activity of CA2 protein	28126276
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CA2 protein	23301498
D004837	Epinephrine	Epinephrine results in increased expression of CA2 mRNA	12729923
D000431	Ethanol	Ethanol results in decreased expression of CA2 mRNA	15513904
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CA2 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CA2 mRNA	17557909
D005001	Ethionine	Ethionine affects the expression of CA2 mRNA	19483382
D005016	Ethoxzolamide	Ethoxzolamide binds to and results in decreased activity of CA2 protein	17826101
D015025	Zearalenone	Zearalenone results in increased expression of CA2 mRNA	19371625
D005419	Flavonoids	Flavonoids results in decreased activity of CA2 protein	28445001
D005485	Flutamide	Flutamide results in increased expression of CA2 mRNA	15885261
D005485	Flutamide	Flutamide results in increased expression of CA2 protein	17311803
C039281	furan	furan results in increased expression of CA2 mRNA	25539665
D005665	Furosemide	Furosemide results in decreased activity of CA2 protein	16858005
D005665	Furosemide	Furosemide results in increased expression of CA2 mRNA	28138970
D019833	Genistein	Genistein results in increased expression of CA2 mRNA	19371625\|2301914
D006139	Guaiacol	Guaiacol results in decreased activity of CA2 protein	19231207
C053526	halazone	halazone results in decreased activity of CA2 protein	16858005
D017313	Fenretinide	Fenretinide results in increased expression of CA2 mRNA	28973697
D006854	Hydrocortisone	[Ammonia co-treated with Hydrocortisone] results in decreased expression of CA2 mRNA	19252005
D006854	Hydrocortisone	[Ammonium Chloride co-treated with Hydrocortisone] results in decreased expression of CA2 mRNA	19252005
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of CA2 mRNA	19252005
D007213	Indomethacin	Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein]	11430635
D007213	Indomethacin	Indomethacin results in increased activity of CA2 protein	11430635
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CA2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CA2 mRNA	28628672
D007452	Iodates	Iodates results in decreased activity of CA2 protein	15664814
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CA2 mRNA	25613284
D007477	Ions	[Water co-treated with Ions deficiency] results in increased expression of CA2 mRNA	17299134
C520511	irosustat	irosustat binds to and results in decreased activity of CA2 protein	14623540
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CA2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CA2 mRNA	28628672
D007854	Lead	Lead affects the expression of CA2 mRNA	28903495
D007854	Lead	Lead results in decreased activity of CA2 protein	18237030
D008094	Lithium	Lithium results in increased expression of CA2 protein	18296634
C458419	malvidin-3-glucoside	malvidin-3-glucoside results in decreased activity of CA2 protein	28445001
C502603	malvin	malvin results in decreased activity of CA2 protein	28445001
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of CA2 mRNA	18497975
D008622	Merbromin	Merbromin results in decreased activity of CA2 protein	16858005
D008628	Mercury	Mercury results in decreased activity of CA2 protein	18237030
C014655	methamidophos	methamidophos results in decreased activity of CA2 protein	22561108
C014655	methamidophos	methamidophos results in decreased activity of CA2 protein	22561108
D008704	Methazolamide	Methazolamide binds to and results in decreased activity of CA2 protein	17826101
D008704	Methazolamide	Methazolamide results in decreased activity of CA2 protein	16858005
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of CA2 protein	22561108
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of CA2 protein	22561108
C044659	molybdate	molybdate results in decreased activity of CA2 protein	15664814
D009151	Mustard Gas	Mustard Gas results in increased expression of CA2 mRNA	25102026
C439829	N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide	"N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide binds to and results in decreased activity of CA2 protein"	17826101
D009532	Nickel	Nickel results in increased expression of CA2 mRNA	25583101
C029938	nickel sulfate	nickel sulfate results in decreased expression of CA2 mRNA	16780908\|1737439
D017942	Nitric Acid	Nitric Acid results in decreased activity of CA2 protein	15664814
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of CA2 mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of CA2 mRNA	19716841
D009853	Omeprazole	Omeprazole affects the expression of CA2 mRNA	19483382
D009966	Orphenadrine	Orphenadrine affects the expression of CA2 mRNA	23665939
C012465	oryzalin	oryzalin binds to and results in decreased activity of CA2 protein	28251759
D010081	Oxazolone	Oxazolone results in decreased expression of CA2 mRNA	17374397
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of CA2 mRNA	18593933
C078485	pelargonidin-3-glucoside	pelargonidin-3-glucoside results in decreased activity of CA2 protein	28445001
C494474	perchlorate	perchlorate results in decreased activity of CA2 protein	15664814
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CA2 mRNA	17560707\|1916217
D010656	Phenylephrine	Phenylephrine results in decreased activity of CA2 protein	28800181
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CA2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of CA2 mRNA	19483382
D010938	Plant Oils	Plant Oils results in increased expression of CA2 mRNA	23370395
C037192	potassium periodate	potassium periodate results in decreased activity of CA2 protein	15664814
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of CA2 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of CA2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of CA2 mRNA	17404688\|1803715
D011374	Progesterone	Progesterone results in increased expression of CA2 mRNA	18497975
D011372	Progestins	Progestins results in increased expression of CA2 mRNA	19609016
D015742	Propofol	Propofol analog results in decreased activity of CA2 protein	19231207
D015742	Propofol	Propofol results in decreased activity of CA2 protein	19231207
D011441	Propylthiouracil	Propylthiouracil affects the expression of CA2 mRNA	19483382
D011743	Pyrimidines	Pyrimidines analog results in decreased activity of CA2 protein	29283199
D011794	Quercetin	Quercetin results in increased expression of CA2 mRNA	21632981
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of CA2 mRNA	19167446
C089730	rosiglitazone	rosiglitazone affects the expression of CA2 protein	19556978
C072500	rubiadin	rubiadin results in decreased expression of CA2 mRNA	21945525
C078903	seocalcitol	[alitretinoin co-treated with seocalcitol] results in increased expression of CA2 protein	16340750
C078903	seocalcitol	seocalcitol results in increased expression of CA2 mRNA	12040012
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of CA2 mRNA"	21148743
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CA2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CA2 mRNA	23806026
C015504	silychristin	silychristin results in decreased activity of CA2 protein	28445001
C009277	sodium arsenate	sodium arsenate results in decreased expression of CA2 mRNA	23922661
C017947	sodium arsenite	sodium arsenite affects the expression of CA2 mRNA	19590694
C017947	sodium arsenite	sodium arsenite results in decreased expression of CA2 mRNA	19072884
D012969	Sodium Fluoride	Sodium Fluoride affects the localization of CA2 protein	21708216
D012969	Sodium Fluoride	Sodium Fluoride inhibits the reaction [CA2 protein binds to BAD protein]	21708216
D012969	Sodium Fluoride	[Sodium Fluoride inhibits the reaction [CA2 protein binds to BAD protein]] promotes the reaction [BAD protein binds to BCL2 protein]	21708216
C025349	sodium metasilicate	sodium metasilicate results in decreased activity of CA2 protein	15664814
C005741	sulfamic acid	sulfamic acid results in decreased activity of CA2 protein	15664814
C003359	sulfamidochrysoidine	sulfamidochrysoidine binds to and results in decreased activity of CA2 protein	17826101
D013424	Sulfanilamides	Sulfanilamides analog results in decreased activity of CA2 protein	21361354
D013431	Sulfates	Sulfates results in decreased activity of CA2 protein	15664814
D013438	Sulfhydryl Compounds	Sulfhydryl Compounds analog binds to CA2 protein	17059166
D013469	Sulpiride	Sulpiride binds to and results in decreased activity of CA2 protein	17826101
D013578	Synephrine	Synephrine results in decreased activity of CA2 protein	28800181
D013739	Testosterone	[FSHB protein co-treated with Testosterone] results in increased expression of CA2 mRNA	18535249
D013739	Testosterone	[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of CA2 mRNA	18535249
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CA2 mRNA	16443690\|2761813
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CA2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CA2 mRNA	16984957\|2095900
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CA2 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CA2 mRNA	25613284
D053778	Thiazolidines	Thiazolidines results in decreased activity of CA2 protein	28544359
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CA2 mRNA	28943392
D013853	Thioacetamide	Thioacetamide affects the expression of CA2 mRNA	19483382
D013871	Thiones	Thiones analog results in decreased activity of CA2 protein	29283199
C005151	thiosemicarbazide	thiosemicarbazide analog results in decreased activity of CA2 protein	29131470
D013890	Thiourea	Thiourea analog results in decreased activity of CA2 protein	28117934
C009474	thioxolone	thioxolone results in decreased activity of CA2 protein	16858005
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CA2 mRNA	28065790
C052342	topiramate	topiramate binds to and results in decreased activity of CA2 protein	17826101
C052342	topiramate	topiramate results in decreased activity of CA2 protein	21314129
C052342	topiramate	topiramate results in decreased activity of CA2 protein	17504132
D014212	Tretinoin	Tretinoin results in decreased expression of CA2 mRNA	18230668
D014212	Tretinoin	Tretinoin results in increased activity of CA2 protein	15970678
D014212	Tretinoin	Tretinoin results in increased expression of CA2 mRNA	16249480
D014230	Triazoles	Triazoles analog results in decreased activity of CA2 protein	29131470
C012589	trichostatin A	trichostatin A results in decreased expression of CA2 mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CA2 mRNA"	26179874
C045951	tungstate	tungstate results in decreased activity of CA2 protein	15664814
C406224	valdecoxib	valdecoxib binds to and results in decreased activity of CA2 protein	17826101
D014635	Valproic Acid	Valproic Acid results in decreased expression of CA2 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of CA2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CA2 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased methylation of CA2 gene	29154799
D014638	Vanadates	Vanadates results in decreased activity of CA2 protein	15664814
C100058	vanillin	vanillin results in decreased activity of CA2 protein	19231207
D014867	Water	[Water co-treated with Ions deficiency] results in increased expression of CA2 mRNA	17299134
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of CA2 mRNA	18593933
D015032	Zinc	Zinc deficiency results in increased expression of CA2 mRNA	19111725
C022189	zonisamide	zonisamide binds to and results in decreased activity of CA2 protein	17826101
C022189	zonisamide	zonisamide results in decreased activity of CA2 protein	17504132

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004064	arylesterase activity	-	IMP	3126084
GO:0004089	carbonate dehydratase activity	-	IMP	7758465
GO:0004089	carbonate dehydratase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	15990874
GO:0008270	zinc ion binding	-	IDA	3151020

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001822	kidney development	-	IEA	-
GO:0002009	morphogenesis of an epithelium	-	IEA	-
GO:0009268	response to pH	-	IEA	-
GO:0010043	response to zinc ion	-	IEA	-
GO:0015670	carbon dioxide transport	-	IEA	-
GO:0015701	bicarbonate transport	-	TAS	-
GO:0032230	positive regulation of synaptic transmission, GABAergic	-	IEA	-
GO:0032849	positive regulation of cellular pH reduction	-	IEA	-
GO:0038166	angiotensin-activated signaling pathway	-	IDA	15990874
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0044070	regulation of anion transport	-	IDA	15990874
GO:0045672	positive regulation of osteoclast differentiation	-	IEA	-
GO:0045780	positive regulation of bone resorption	-	IEA	-
GO:0046903	secretion	-	IEA	-
GO:0048545	response to steroid hormone	-	IEA	-
GO:0051453	regulation of intracellular pH	-	ISS	-
GO:0071498	cellular response to fluid shear stress	-	IEA	-
GO:2001150	positive regulation of dipeptide transmembrane transport	-	ISS	-
GO:2001225	regulation of chloride transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	114507 15990874
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	15990874
GO:0005902	microvillus	-	IEA	-
GO:0016323	basolateral plasma membrane	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0043209	myelin sheath	-	IEA	-
GO:0045177	apical part of cell	-	IDA	14675051
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa00910	Nitrogen metabolism
hsa04964	Proximal tubule bicarbonate reclamation
hsa04966	Collecting duct acid secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa04976	Bile secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	TAS
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1475029	Reversible hydration of carbon dioxide	TAS
R-HSA-1480926	O2/CO2 exchange in erythrocytes	TAS
R-HSA-382551	Transport of small molecules	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28260499	Regulatory role of G protein-coupled receptors in pancreatic cancer development and progression. (2017 Mar 3)	Schuller HM	Curr Med Chem
10329510	Magnesium modulates contractile responses of rat aorta to thiocyanate: A possible relationship to smoking-induced atherosclerosis. (1999 May 15)	Li W	Toxicol Appl Pharmacol
7847587	Magnesium deficiency in alcoholism: possible contribution to osteoporosis and cardiovascular disease in alcoholics. (1994 Oct)	Abbott L	Alcohol Clin Exp Res
24850422	Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence. (2014 Jul 1)	Kuhn S	JAMA Psychiatry
17507236	Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting. (2007 Jul)	Novella S	Eur J Cardiothorac Surg
12378824	Potassium channels and erectile dysfunction. (2002 Jan)	Archer SL	Vascul Pharmacol
12628473	Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line. (2003 Mar 28)	Kimura R	Life Sci
10442089	Endothelium-derived nitric oxide and vascular physiology and pathology. (1999 Jul)	Arnal JF	Cell Mol Life Sci
26276084	Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy. (2015 Oct)	Hu N	Pharmacol Res
23244430	Opioid withdrawal syndrome: emerging concepts and novel therapeutic targets. (2013 Feb 1)	Rehni AK	CNS Neurol Disord Drug Targets
9300320	Negative inotropic effect of methylecgonidine, a major product of cocaine base pyrolysis, on ferret and human myocardium. (1997 Sep)	Woolf JH	J Cardiovasc Pharmacol
10708265	Agonist-stimulated Ca2+ response in neutrophils from patients with primary alcoholism and alcoholized healthy subjects. (1999 Dec 27)	Gann H	Psychiatry Res
25016090	Bupropion-induced inhibition of alpha7 nicotinic acetylcholine receptors expressed in heterologous cells and neurons from dorsal raphe nucleus and hippocampus. (2014 Oct 5)	Vazquez-Gomez E	Eur J Pharmacol
18189313	The effect of nicotine on spiking activity and Ca2+ dynamics of dendritic spines in rat CA1 pyramidal neurons. (2008)	Szabo SI	Hippocampus
26418512	Nicotine-Mediated Ca(2+)-Influx Induces IL-8 Secretion in Oral Squamous Cell Carcinoma Cell. (2016 Apr)	Tsunoda K	J Cell Biochem
22960015	The region-specific activation of Ca2+/calmodulin dependent protein kinase II and extracellular signal-regulated kinases in hippocampus following chronic alcohol exposure. (2012 Dec 1)	Wang Y	Brain Res Bull
12435490	Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. (2002 Dec 13)	Li SP	Neurosci Lett
17867559	A novel effect of lobeline on vascular smooth muscle cell: inhibition of proliferation induced by endothelin-1. (2007 Aug)	Wang JJ	Pharmazie
26217968	Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1). (2015)	Christophersen P	Channels (Austin)
16166743	Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats. (2005 Dec)	Chiba Y	Am J Respir Cell Mol Biol
17676486	The neuroprotective effects of caffeic acid phenethyl ester (CAPE) in the hippocampal formation of cigarette smoke exposed rabbits. (2007 Aug)	Eser O	Pathology
28025040	Acetylcholine released from T cells regulates intracellular Ca(2+), IL-2 secretion and T cell proliferation through nicotinic acetylcholine receptor. (2017 Mar 1)	Mashimo M	Life Sci
9438526	Alcoholism and carcinoma change the intracellular pH and activate platelet Na+/H+-exchange in men. (1997 Dec)	Spies CD	Alcohol Clin Exp Res
11961084	Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal. (2002 May)	Roy A	J Pharmacol Exp Ther
21960509	Long-term maternal hypoxia: the role of extracellular Ca2+ entry during serotonin-mediated contractility in fetal ovine pulmonary arteries. (2011 Oct)	Goyal R	Reprod Sci
9178701	Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment. (1997 Jun)	Saso K	Gastroenterology
25662840	KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. (2015 Jul)	Padula AE	Neuropsychopharmacology
28194001	Enhancing VTA Cav1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. (2017 Dec)	Martinez-Rivera A	Mol Psychiatry
15208160	Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar rats. (2004 Jul-Aug)	Ortiz S	Alcohol Alcohol
24705155	alpha,beta-Unsaturated aldehyde crotonaldehyde triggers cardiomyocyte contractile dysfunction: role of TRPV1 and mitochondrial function. (2014 Apr)	Pei Z	Pharmacol Res
3945618	Alterations in canine coronary arteries produced by chronic cigarette smoking. (1986 Jan)	Cox RH	Proc Soc Exp Biol Med
15785003	Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population. (2004 Oct)	Kokubo Y	Hypertens Res
12711919	Short-term acetaldehyde exposure depresses ventricular myocyte contraction: role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation. (2003 Apr)	Aberle NS 2nd	Alcohol Clin Exp Res
15948156	Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain. (2005 Jul 15)	Depaz IM	J Neurosci Res
29266170	Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal alpha7 nACh receptors in mice. (2017 Dec 20)	Keyworth H	Br J Pharmacol
27588478	Essential role of Na+/Ca2+ exchanger 1 in smoking-induced growth and migration of esophageal squamous cell carcinoma. (2016 Sep 27)	Wen J	Oncotarget
9153634	Regulation of immunolabelled mu-opioid receptors and protein kinase C-alpha and zeta isoforms in the frontal cortex of human opiate addicts. (1997 Apr 18)	Garcia-Sevilla JA	Neurosci Lett
12711604	Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. (2003 Jul 11)	Le Poul E	J Biol Chem
12349904	Protective role of magnesium in cardiovascular diseases: a review. (2002 Sep)	Chakraborti S	Mol Cell Biochem
19936715	Tobacco smoke exposure induces nicotine dependence in rats. (2010 Jan)	Small E	Psychopharmacology (Berl)
10509892	Serotonin stimulation of calcium mobilisation in human platelets: choice of units of measurement, effects of age and tobacco use, and correlation with serotonin2A receptor density. (1999 Sep)	Fowler CJ	Clin Chim Acta
25484085	Autophagy and ethanol neurotoxicity. (2014)	Luo J	Autophagy
17220028	[The effect of calcium channel blocker lercanidipine on lowgrade inflammation parameters in essential hypertension patients]. (2006 Dec)	Shurtz-Swirski R	Harefuah
12614343	In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice. (2003 Mar)	Brunzell DH	J Neurochem
18075463	Protein tyrosine kinase 2beta as a candidate gene for hypertension. (2007 Nov)	Kamide K	Pharmacogenet Genomics
19001277	Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. (2008 Nov 11)	Bilbao A	Proc Natl Acad Sci U S A
16959216	Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction. (2006 Oct 20)	Jiang DJ	Biochem Biophys Res Commun
18522770	Coronary artery spasm--clinical features, diagnosis, pathogenesis, and treatment. (2008 Feb)	Yasue H	J Cardiol
25911614	Crucial role of nicotinic alpha5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. (2015 Aug)	Sciaccaluga M	FASEB J
1346466	Ethanol inhibits mitogen-induced calcium mobilization in mouse splenocytes. (1992)	Sei Y	Life Sci
8889405	Effects of cocaine on human and goat isolated cerebral arteries. (1996 Sep)	Salom JB	Drug Alcohol Depend