Gene info: ID 761

Gene: CA3

GENE ID: 761

Synonyms: CAIII|Car3

Description: carbonic anhydrase 3

Gene type: protein-coding

Location: 8q21.2

dbXrefs: Ensembl:ENSG00000164879 MIM:114750 Vega:OTTHUMG00000164942 UniprotKB:P07451

RefSeq: NC_000008.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 38

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.709e-1 (AD) 9.715e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEB	0.646
KLHL41	0.611
ENO3	0.576
TUBD1	0.572
ATP2A1	0.567
XIRP2	0.561
MYL1	0.557
ACTA1	0.555
TNNT3	0.553
TEFM	0.553

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.28
ACTL7A	-0.249
OR4F29	-0.241
CFC1B	-0.206
SPRR3	-0.2
RNASE8	-0.192
CHP2	-0.189
KCNG2	-0.189
TSPY2	-0.189
REN	-0.189

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00311	Ethoxzolamide	Small Molecule	452-35-7	Withdrawn	Target
DB00391	Sulpiride	Small Molecule	15676-16-1	Approved\|Investigational	Target
DB00482	Celecoxib	Small Molecule	169590-42-5	Approved\|Investigational	Target
DB00580	Valdecoxib	Small Molecule	181695-72-7	Approved\|Investigational\|Withdrawn	Target
DB00703	Methazolamide	Small Molecule	554-57-4	Approved	Target
DB00819	Acetazolamide	Small Molecule	59-66-5	Approved	Target
DB00869	Dorzolamide	Small Molecule	120279-96-1	Approved	Target
DB00909	Zonisamide	Small Molecule	68291-97-4	Approved\|Investigational	Target
DB01144	Diclofenamide	Small Molecule	120-97-8	Approved\|Investigational	Target
DB01194	Brinzolamide	Small Molecule	138890-62-7	Approved	Target
DB08846	Ellagic Acid	Small Molecule	476-66-4	Investigational	Target
DB12418	Saccharin	Small Molecule	81-07-2	Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CA3 mRNA"	17690111
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of CA3 mRNA]"	19414516
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CA3 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CA3 mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CA3 mRNA"	20959002
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in decreased expression of CA3 mRNA	14610520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to CA3 protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CA3 protein]	26598702
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to CA3 protein	27464947
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of CA3 mRNA	17202762
D000086	Acetazolamide	Acetazolamide binds to and results in decreased activity of CA3 protein	17826101
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CA3 gene	27153756
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of CA3 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of CA3 protein	26597043
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA	16940010\|1778594
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CA3 protein]	26598702
C547126	AZM551248	AZM551248 results in decreased expression of CA3 mRNA	22323515
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CA3 mRNA	17690111
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNA	18164116
D001574	Benzolamide	Benzolamide binds to and results in decreased activity of CA3 protein	17826101
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CA3 mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CA3 mRNA	17690111
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CA3 mRNA"	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CA3 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CA3 mRNA	23892563
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CA3 protein	23892563
D001639	Bicarbonates	CA3 protein results in increased chemical synthesis of Bicarbonates	17826101
C006780	bisphenol A	bisphenol A results in decreased expression of CA3 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of CA3 mRNA	25181051
C111827	brinzolamide	brinzolamide binds to and results in decreased activity of CA3 protein	17826101
C032036	bromobenzene	bromobenzene metabolite binds to CA3 protein	17305373
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CA3 protein	26220685
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CA3 mRNA	16239168
D000068579	Celecoxib	Celecoxib binds to and results in decreased activity of CA3 protein	17826101
D002713	Chlorine	Chlorine results in decreased expression of CA3 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of CA3 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CA3 mRNA	18178546
D003300	Copper	Copper results in decreased expression of CA3 mRNA	24403277
D003300	Copper	Copper results in decreased expression of CA3 mRNA	22465980
C030123	coumarin	coumarin results in decreased expression of CA3 mRNA	18480146
D016572	Cyclosporine	Cyclosporine results in decreased expression of CA3 mRNA	27989131
C017180	decamethrin	decamethrin results in increased expression of CA3 mRNA	23892563
C017180	decamethrin	decamethrin results in increased expression of CA3 protein	23892563
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CA3 mRNA"	17690111
D004005	Dichlorphenamide	Dichlorphenamide binds to and results in decreased activity of CA3 protein	17826101
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CA3 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CA3 mRNA	19638242
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of CA3 mRNA	17072980
C062765	dorzolamide	dorzolamide binds to and results in decreased activity of CA3 protein	17826101
D000431	Ethanol	Ethanol results in increased expression of CA3 mRNA	15353170\|1609850
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CA3 mRNA	15953391\|1710823
D005016	Ethoxzolamide	Ethoxzolamide binds to and results in decreased activity of CA3 protein	17826101
D005419	Flavonoids	Flavonoids results in decreased expression of CA3 mRNA	18035473
D004397	Fonofos	Fonofos results in increased methylation of CA3 promoter	22847954
D008628	Mercury	Mercury results in increased expression of CA3 mRNA	16823088
D008704	Methazolamide	Methazolamide binds to and results in decreased activity of CA3 protein	17826101
C439829	N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide	"N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide binds to and results in decreased activity of CA3 protein"	17826101
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of CA3 protein	19716841
C016340	o,p'-DDT	"o,p'-DDT affects the expression of CA3 mRNA"	17984292
D009966	Orphenadrine	Orphenadrine affects the expression of CA3 mRNA	23665939
D010098	Oxycodone	Oxycodone results in decreased expression of CA3 mRNA	23439660
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of CA3 mRNA	18636392
D010278	Parathion	Parathion results in increased methylation of CA3 promoter	22847954
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CA3 mRNA	16221955
D010634	Phenobarbital	Phenobarbital results in decreased expression of CA3 protein	19952500
D059808	Polyphenols	Polyphenols results in decreased expression of CA3 mRNA	16293270
C019536	potassium bromate	potassium bromate results in decreased expression of CA3 mRNA	23588252
D012439	Saccharin	Saccharin binds to and results in decreased activity of CA3 protein	17826101
D012643	Selenium	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNA	11444866
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CA3 mRNA	23806026
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CA3 protein	28918527
C003359	sulfamidochrysoidine	sulfamidochrysoidine binds to and results in decreased activity of CA3 protein	17826101
D013469	Sulpiride	Sulpiride binds to and results in decreased activity of CA3 protein	17826101
C012568	terbufos	terbufos results in increased methylation of CA3 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CA3 mRNA	16054898\|2095900
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CA3 mRNA	28943392
C052342	topiramate	topiramate binds to and results in decreased activity of CA3 protein	17826101
D014212	Tretinoin	Tretinoin results in increased expression of CA3 mRNA	21934132
C011559	tributyltin	tributyltin results in decreased expression of CA3 mRNA	27614199
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of CA3 mRNA	24935251\|2627250
C406224	valdecoxib	valdecoxib binds to and results in decreased activity of CA3 protein	17826101
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CA3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CA3 mRNA	23179753\|2438349
C025643	vinclozolin	vinclozolin affects the expression of CA3 mRNA	19015723
D014810	Vitamin E	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNA	11444866
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of CA3 mRNA	26272509
C022189	zonisamide	zonisamide binds to and results in decreased activity of CA3 protein	17826101

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004089	carbonate dehydratase activity	-	TAS	-
GO:0008270	zinc ion binding	-	IEA	-
GO:0016151	nickel cation binding	-	IEA	-
GO:0016791	phosphatase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006979	response to oxidative stress	-	IEA	-
GO:0015701	bicarbonate transport	-	TAS	-
GO:0016311	dephosphorylation	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00910	Nitrogen metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1475029	Reversible hydration of carbon dioxide	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26108098	Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence. (2015 Aug)	Xu R	Braz J Med Biol Res
21240373	Participation of L-type voltage-gated calcium channels in facilitation of long-term potentiation during the formation of morphine dependence in rats. (2010 Dec)	Beregovoy NA	Bull Exp Biol Med
10492392	Comparative effects of developmental thiamine deficiencies and ethanol exposure on the morphometry of the CA3 pyramidal cells. (1999 Sep-Oct)	Ba A	Neurotoxicol Teratol
28096497	BDNF regains function in hippocampal long-term potentiation deficits caused by diencephalic damage. (2017 Feb)	Vedder LC	Learn Mem
24850422	Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence. (2014 Jul 1)	Kuhn S	JAMA Psychiatry
12657708	The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. (2003 Mar 15)	Bachtell RK	J Neurosci
8672172	Thiamine administration during chronic alcohol intake in pregnant and lactating rats: effects on the offspring neurobehavioural development. (1996 Jan)	Ba A	Alcohol Alcohol
19084907	Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. (2009 Mar)	Edwards S	Synapse
19801271	Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice. (2009 Sep)	Chen G	Alcohol
18358520	Alpha2-containing GABA(A) receptors are involved in mediating stimulant effects of cocaine. (2008 Jul)	Morris HV	Pharmacol Biochem Behav
9120553	Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology. (1997 Jan)	Baraban SC	J Neurophysiol
25769285	Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. (2015 Mar)	Staples MC	Mol Cell Neurosci
22960015	The region-specific activation of Ca2+/calmodulin dependent protein kinase II and extracellular signal-regulated kinases in hippocampus following chronic alcohol exposure. (2012 Dec 1)	Wang Y	Brain Res Bull
22911690	Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials. (2012)	Featherstone RE	PLoS One
24658151	Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. (2014)	Wang Y	PLoS One
19341783	Protein receptor for activated C kinase 1 is involved in morphine reward in mice. (2009 Jul 7)	Wan L	Neuroscience
20423831	[Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]. (2010 Apr)	Huang P	Nan Fang Yi Ke Da Xue Xue Bao
25046735	Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus. (2014 Aug 28)	Nakauchi S	Life Sci
22860061	Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. (2012)	Garcia-Fuster MJ	PLoS One
18289710	Cigarette smoking decreases neurotrophin-3 expression in rat hippocampus after transient forebrain ischemia. (2008 Apr)	Yang JT	Neurosci Res
15099681	(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity. (2004)	Mulholland PJ	Neuroscience
10665983	Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats. (2000)	Kim HC	Life Sci
27623427	Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure. (2016 Nov)	Holliday ED	Eur J Neurosci
12435490	Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. (2002 Dec 13)	Li SP	Neurosci Lett
17439498	Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. (2007 Apr)	Edwards S	Eur J Neurosci
17676486	The neuroprotective effects of caffeic acid phenethyl ester (CAPE) in the hippocampal formation of cigarette smoke exposed rabbits. (2007 Aug)	Eser O	Pathology
22606286	Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. (2012)	Ho YS	PLoS One
23832598	Fos expression induced by cocaine-conditioned cues in male and female rats. (2014 Sep)	Zhou L	Brain Struct Funct
16340465	Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid (25-35)-induced cytotoxicity: NMDA receptor involvement. (2005 Nov)	Self RL	Alcohol Clin Exp Res
8814911	Chronic exposure to morphine attenuates expression of interleukin-1 beta in the rat hippocampus. (1996 Mar 18)	Patel NA	Brain Res
9347073	Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT reuptake sites. (1997 Oct)	Druse MJ	Alcohol Clin Exp Res
11198717	Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurt. (2001 Jan)	Bonthius DJ	Alcohol Clin Exp Res
17098214	Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. (2007 Apr 15)	Dayas CV	Biol Psychiatry
9166743	Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence. (1997 Jun)	Mahmoudi M	J Neurochem
11961084	Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal. (2002 May)	Roy A	J Pharmacol Exp Ther
27919294	Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. (2016 Dec 5)	Cain SM	Mol Brain
21861331	[Functional homology between alcohol dependence and mood disorder]. (2011 Jun)	Shibasaki M	Nihon Arukoru Yakubutsu Igakkai Zasshi
15208160	Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar rats. (2004 Jul-Aug)	Ortiz S	Alcohol Alcohol