Gene: CA3

761
CAIII|Car3
carbonic anhydrase 3
protein-coding
8q21.2
Ensembl:ENSG00000164879 MIM:114750 Vega:OTTHUMG00000164942 UniprotKB:P07451
NC_000008.11
PubMed
CD|OD|ND|AD
38   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.709e-1 (AD)  9.715e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEB0.646
KLHL410.611
ENO30.576
TUBD10.572
ATP2A10.567
XIRP20.561
MYL10.557
ACTA10.555
TNNT30.553
TEFM0.553

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.28
ACTL7A-0.249
OR4F29-0.241
CFC1B-0.206
SPRR3-0.2
RNASE8-0.192
CHP2-0.189
KCNG2-0.189
TSPY2-0.189
REN-0.189

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB00311EthoxzolamideSmall Molecule452-35-7WithdrawnTarget
DB00391SulpirideSmall Molecule15676-16-1Approved|InvestigationalTarget
DB00482CelecoxibSmall Molecule169590-42-5Approved|InvestigationalTarget
DB00580ValdecoxibSmall Molecule181695-72-7Approved|Investigational|WithdrawnTarget
DB00703MethazolamideSmall Molecule554-57-4ApprovedTarget
DB00819AcetazolamideSmall Molecule59-66-5ApprovedTarget
DB00869DorzolamideSmall Molecule120279-96-1ApprovedTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB01144DiclofenamideSmall Molecule120-97-8Approved|InvestigationalTarget
DB01194BrinzolamideSmall Molecule138890-62-7ApprovedTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB12418SaccharinSmall Molecule81-07-2InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CA3 mRNA"17690111
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of CA3 mRNA]"19414516
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CA3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CA3 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CA3 mRNA"20959002
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in decreased expression of CA3 mRNA14610520
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CA3 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CA3 protein]26598702
C5444715-hydroxythalidomide5-hydroxythalidomide binds to CA3 protein27464947
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CA3 mRNA17202762
D000086AcetazolamideAcetazolamide binds to and results in decreased activity of CA3 protein17826101
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CA3 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of CA3 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CA3 protein26597043
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA16940010|1778594
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CA3 protein]26598702
C547126AZM551248AZM551248 results in decreased expression of CA3 mRNA22323515
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CA3 mRNA17690111
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNA18164116
D001574BenzolamideBenzolamide binds to and results in decreased activity of CA3 protein17826101
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CA3 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CA3 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CA3 mRNA"17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CA3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CA3 mRNA23892563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CA3 protein23892563
D001639BicarbonatesCA3 protein results in increased chemical synthesis of Bicarbonates17826101
C006780bisphenol Abisphenol A results in decreased expression of CA3 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of CA3 mRNA25181051
C111827brinzolamidebrinzolamide binds to and results in decreased activity of CA3 protein17826101
C032036bromobenzenebromobenzene metabolite binds to CA3 protein17305373
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CA3 protein26220685
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CA3 mRNA16239168
D000068579CelecoxibCelecoxib binds to and results in decreased activity of CA3 protein17826101
D002713ChlorineChlorine results in decreased expression of CA3 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CA3 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CA3 mRNA18178546
D003300CopperCopper results in decreased expression of CA3 mRNA24403277
D003300CopperCopper results in decreased expression of CA3 mRNA22465980
C030123coumarincoumarin results in decreased expression of CA3 mRNA18480146
D016572CyclosporineCyclosporine results in decreased expression of CA3 mRNA27989131
C017180decamethrindecamethrin results in increased expression of CA3 mRNA23892563
C017180decamethrindecamethrin results in increased expression of CA3 protein23892563
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CA3 mRNA"17690111
D004005DichlorphenamideDichlorphenamide binds to and results in decreased activity of CA3 protein17826101
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CA3 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CA3 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CA3 mRNA17072980
C062765dorzolamidedorzolamide binds to and results in decreased activity of CA3 protein17826101
D000431EthanolEthanol results in increased expression of CA3 mRNA15353170|1609850
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CA3 mRNA15953391|1710823
D005016EthoxzolamideEthoxzolamide binds to and results in decreased activity of CA3 protein17826101
D005419FlavonoidsFlavonoids results in decreased expression of CA3 mRNA18035473
D004397FonofosFonofos results in increased methylation of CA3 promoter22847954
D008628MercuryMercury results in increased expression of CA3 mRNA16823088
D008704MethazolamideMethazolamide binds to and results in decreased activity of CA3 protein17826101
C439829N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide"N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide binds to and results in decreased activity of CA3 protein"17826101
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of CA3 protein19716841
C016340o,p'-DDT"o,p'-DDT affects the expression of CA3 mRNA"17984292
D009966OrphenadrineOrphenadrine affects the expression of CA3 mRNA23665939
D010098OxycodoneOxycodone results in decreased expression of CA3 mRNA23439660
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CA3 mRNA18636392
D010278ParathionParathion results in increased methylation of CA3 promoter22847954
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CA3 mRNA16221955
D010634PhenobarbitalPhenobarbital results in decreased expression of CA3 protein19952500
D059808PolyphenolsPolyphenols results in decreased expression of CA3 mRNA16293270
C019536potassium bromatepotassium bromate results in decreased expression of CA3 mRNA23588252
D012439SaccharinSaccharin binds to and results in decreased activity of CA3 protein17826101
D012643Selenium[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNA11444866
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CA3 mRNA23806026
D012969Sodium FluorideSodium Fluoride results in increased expression of CA3 protein28918527
C003359sulfamidochrysoidinesulfamidochrysoidine binds to and results in decreased activity of CA3 protein17826101
D013469SulpirideSulpiride binds to and results in decreased activity of CA3 protein17826101
C012568terbufosterbufos results in increased methylation of CA3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CA3 mRNA16054898|2095900
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CA3 mRNA28943392
C052342topiramatetopiramate binds to and results in decreased activity of CA3 protein17826101
D014212TretinoinTretinoin results in increased expression of CA3 mRNA21934132
C011559tributyltintributyltin results in decreased expression of CA3 mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CA3 mRNA24935251|2627250
C406224valdecoxibvaldecoxib binds to and results in decreased activity of CA3 protein17826101
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CA3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CA3 mRNA23179753|2438349
C025643vinclozolinvinclozolin affects the expression of CA3 mRNA19015723
D014810Vitamin E[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNA11444866
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA3 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CA3 mRNA26272509
C022189zonisamidezonisamide binds to and results in decreased activity of CA3 protein17826101

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004089carbonate dehydratase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO:0016151nickel cation binding-IEA-  
GO:0016791phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006979response to oxidative stress-IEA-  
GO:0015701bicarbonate transport-TAS-  
GO:0016311dephosphorylation-IEA-  
GO:0045471response to ethanol-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00910Nitrogen metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1475029Reversible hydration of carbon dioxideTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26108098Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence. (2015 Aug)Xu RBraz J Med Biol Res
21240373Participation of L-type voltage-gated calcium channels in facilitation of long-term potentiation during the formation of morphine dependence in rats. (2010 Dec)Beregovoy NABull Exp Biol Med
10492392Comparative effects of developmental thiamine deficiencies and ethanol exposure on the morphometry of the CA3 pyramidal cells. (1999 Sep-Oct)Ba ANeurotoxicol Teratol
28096497BDNF regains function in hippocampal long-term potentiation deficits caused by diencephalic damage. (2017 Feb)Vedder LCLearn Mem
24850422Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence. (2014 Jul 1)Kuhn SJAMA Psychiatry
12657708The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. (2003 Mar 15)Bachtell RKJ Neurosci
8672172Thiamine administration during chronic alcohol intake in pregnant and lactating rats: effects on the offspring neurobehavioural development. (1996 Jan)Ba AAlcohol Alcohol
19084907Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. (2009 Mar)Edwards SSynapse
19801271Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice. (2009 Sep)Chen GAlcohol
18358520Alpha2-containing GABA(A) receptors are involved in mediating stimulant effects of cocaine. (2008 Jul)Morris HVPharmacol Biochem Behav
9120553Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology. (1997 Jan)Baraban SCJ Neurophysiol
25769285Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. (2015 Mar)Staples MCMol Cell Neurosci
22960015The region-specific activation of Ca2+/calmodulin dependent protein kinase II and extracellular signal-regulated kinases in hippocampus following chronic alcohol exposure. (2012 Dec 1)Wang YBrain Res Bull
22911690Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials. (2012)Featherstone REPLoS One
24658151Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. (2014)Wang YPLoS One
19341783Protein receptor for activated C kinase 1 is involved in morphine reward in mice. (2009 Jul 7)Wan LNeuroscience
20423831[Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]. (2010 Apr)Huang PNan Fang Yi Ke Da Xue Xue Bao
25046735Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus. (2014 Aug 28)Nakauchi SLife Sci
22860061Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. (2012)Garcia-Fuster MJPLoS One
18289710Cigarette smoking decreases neurotrophin-3 expression in rat hippocampus after transient forebrain ischemia. (2008 Apr)Yang JTNeurosci Res
15099681(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity. (2004)Mulholland PJNeuroscience
10665983Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats. (2000)Kim HCLife Sci
27623427Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure. (2016 Nov)Holliday EDEur J Neurosci
12435490Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. (2002 Dec 13)Li SPNeurosci Lett
17439498Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. (2007 Apr)Edwards SEur J Neurosci
17676486The neuroprotective effects of caffeic acid phenethyl ester (CAPE) in the hippocampal formation of cigarette smoke exposed rabbits. (2007 Aug)Eser OPathology
22606286Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. (2012)Ho YSPLoS One
23832598Fos expression induced by cocaine-conditioned cues in male and female rats. (2014 Sep)Zhou LBrain Struct Funct
16340465Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid (25-35)-induced cytotoxicity: NMDA receptor involvement. (2005 Nov)Self RLAlcohol Clin Exp Res
8814911Chronic exposure to morphine attenuates expression of interleukin-1 beta in the rat hippocampus. (1996 Mar 18)Patel NABrain Res
9347073Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT reuptake sites. (1997 Oct)Druse MJAlcohol Clin Exp Res
11198717Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurt. (2001 Jan)Bonthius DJAlcohol Clin Exp Res
17098214Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. (2007 Apr 15)Dayas CVBiol Psychiatry
9166743Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence. (1997 Jun)Mahmoudi MJ Neurochem
11961084Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal. (2002 May)Roy AJ Pharmacol Exp Ther
27919294Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. (2016 Dec 5)Cain SMMol Brain
21861331[Functional homology between alcohol dependence and mood disorder]. (2011 Jun)Shibasaki MNihon Arukoru Yakubutsu Igakkai Zasshi
15208160Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar rats. (2004 Jul-Aug)Ortiz SAlcohol Alcohol