Gene info: ID 762

Gene: CA4

GENE ID: 762

Synonyms: CAIV|Car4|RP17

Description: carbonic anhydrase 4

Gene type: protein-coding

Location: 17q23.1

dbXrefs: Ensembl:ENSG00000167434 MIM:114760 Vega:OTTHUMG00000179987 UniprotKB:P22748

RefSeq: NG_012050.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.509e-2 (AD) 2.378e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRHR1	0.753
GRM2	0.728
C2CD4C	0.728
OLFM1	0.714
TCERG1L	0.711
CHRD	0.709
FNDC5	0.709
CACNA1G	0.705
COL26A1	0.704
CHD5	0.703

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MARCH3	-0.482
REST	-0.451
STK3	-0.448
TMEM176A	-0.437
SERPINA3	-0.437
DTHD1	-0.436
SFT2D2	-0.435
BAZ1A	-0.433
CBFB	-0.433
SOWAHC	-0.43

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00232	Methyclothiazide	Small Molecule	135-07-9	Approved	Target
DB00273	Topiramate	Small Molecule	97240-79-4	Approved	Target
DB00311	Ethoxzolamide	Small Molecule	452-35-7	Withdrawn	Target
DB00436	Bendroflumethiazide	Small Molecule	73-48-3	Approved	Target
DB00562	Benzthiazide	Small Molecule	91-33-8	Approved	Target
DB00606	Cyclothiazide	Small Molecule	2259-96-3	Approved	Target
DB00703	Methazolamide	Small Molecule	554-57-4	Approved	Target
DB00774	Hydroflumethiazide	Small Molecule	135-09-1	Approved\|Investigational	Target
DB00819	Acetazolamide	Small Molecule	59-66-5	Approved	Target
DB00869	Dorzolamide	Small Molecule	120279-96-1	Approved	Target
DB00880	Chlorothiazide	Small Molecule	58-94-6	Approved	Target
DB00909	Zonisamide	Small Molecule	68291-97-4	Approved\|Investigational	Target
DB00999	Hydrochlorothiazide	Small Molecule	58-93-5	Approved	Target
DB01021	Trichlormethiazide	Small Molecule	133-67-5	Approved	Target
DB01144	Diclofenamide	Small Molecule	120-97-8	Approved\|Investigational	Target
DB01194	Brinzolamide	Small Molecule	138890-62-7	Approved	Target
DB08846	Ellagic Acid	Small Molecule	476-66-4	Investigational	Target
DB09460	Sodium carbonate	Small Molecule	497-19-8	Approved	Target

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of CA4 mRNA	26690555
D000086	Acetazolamide	Acetazolamide binds to and results in decreased activity of CA4 protein	28251759
D000447	Aldehydes	Aldehydes results in increased expression of CA4 mRNA	25014914
D001280	Atrazine	Atrazine results in increased expression of CA4 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of CA4 mRNA	22378314
C487081	belinostat	belinostat results in decreased expression of CA4 mRNA	27188386
C006780	bisphenol A	bisphenol A affects the expression of CA4 mRNA	25181051
D001959	Bromates	Bromates results in decreased activity of CA4 protein	15664814
C018475	butyraldehyde	butyraldehyde results in increased expression of CA4 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of CA4 mRNA	24376830
D002118	Calcium	Calcium affects the expression of CA4 mRNA	15913539
D002254	Carbonates	Carbonates results in decreased activity of CA4 protein	15664814
C022842	chloric acid	chloric acid results in decreased activity of CA4 protein	15664814
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of CA4 mRNA	26272509
D003300	Copper	Copper results in increased expression of CA4 mRNA	22465980
C014347	decitabine	decitabine affects the expression of CA4 mRNA	23300844
D003907	Dexamethasone	Dexamethasone results in decreased expression of CA4 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CA4 mRNA]	20032058
D002945	Cisplatin	Cisplatin affects the expression of CA4 mRNA	23300844
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of CA4 mRNA	17490981
C118739	entinostat	entinostat results in increased expression of CA4 mRNA	27188386
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of CA4 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CA4 mRNA	17557909
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of CA4 mRNA	17347304
D017313	Fenretinide	Fenretinide results in decreased expression of CA4 mRNA	28973697
D007452	Iodates	Iodates results in decreased activity of CA4 protein	15664814
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CA4 mRNA	25613284
C042720	mercuric bromide	mercuric bromide results in decreased expression of CA4 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CA4 mRNA	28001369
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of CA4 mRNA	24810058
C044659	molybdate	molybdate results in decreased activity of CA4 protein	15664814
D017942	Nitric Acid	Nitric Acid results in decreased activity of CA4 protein	15664814
C012465	oryzalin	oryzalin binds to and results in decreased activity of CA4 protein	28251759
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of CA4 mRNA	26272509
C046012	pentanal	pentanal results in increased expression of CA4 mRNA	26079696
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of CA4 mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CA4 mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of CA4 protein	17124262
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of CA4 mRNA	26272509
C037192	potassium periodate	potassium periodate results in decreased activity of CA4 protein	15664814
D011374	Progesterone	Progesterone results in increased expression of CA4 mRNA	20631399
C005556	propionaldehyde	propionaldehyde results in increased expression of CA4 mRNA	26079696
C502851	quinocetone	quinocetone results in increased expression of CA4 mRNA	27046791
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of CA4 mRNA	16079270
C059514	resveratrol	resveratrol results in increased expression of CA4 mRNA	19228061
C025349	sodium metasilicate	sodium metasilicate results in decreased activity of CA4 protein	15664814
C005741	sulfamic acid	sulfamic acid results in decreased activity of CA4 protein	15664814
D013431	Sulfates	Sulfates results in decreased activity of CA4 protein	15664814
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CA4 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CA4 mRNA	21998131
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CA4 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of CA4 gene	26756918
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of CA4 mRNA	24935251\|2627250
C045951	tungstate	tungstate results in decreased activity of CA4 protein	15664814
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CA4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CA4 mRNA	24383497\|2627250
D014635	Valproic Acid	Valproic Acid results in increased expression of CA4 mRNA	23179753\|2519280
D014638	Vanadates	Vanadates results in decreased activity of CA4 protein	15664814
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CA4 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of CA4 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004089	carbonate dehydratase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	15563508
GO:0008270	zinc ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0015701	bicarbonate transport	-	IMP	15563508
GO:0015701	bicarbonate transport	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005791	rough endoplasmic reticulum	-	IDA	17409381
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	-	IDA	17409381
GO:0005794	Golgi apparatus	-	IDA	17409381
GO:0005802	trans-Golgi network	-	IDA	17409381
GO:0005886	plasma membrane	-	IDA	15563508
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	IDA	15563508
GO:0016020	membrane	-	TAS	6811592
GO:0016323	basolateral plasma membrane	NOT	IDA	17409381
GO:0016324	apical plasma membrane	-	IDA	17409381
GO:0030658	transport vesicle membrane	-	IDA	17409381
GO:0030667	secretory granule membrane	-	IDA	17409381
GO:0031362	anchored component of external side of plasma membrane	-	IDA	17409381
GO:0031526	brush border membrane	-	IDA	17409381
GO:0048471	perinuclear region of cytoplasm	-	IDA	17409381
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145
GO:0070062	extracellular exosome	-	IDA	15326289

KEGG ID	KEGG Term
hsa00910	Nitrogen metabolism
hsa04964	Proximal tubule bicarbonate reclamation

Reactome ID	Reactome Term	Evidence
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	TAS
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1475029	Reversible hydration of carbon dioxide	TAS
R-HSA-1480926	O2/CO2 exchange in erythrocytes	TAS
R-HSA-382551	Transport of small molecules	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26108098	Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence. (2015 Aug)	Xu R	Braz J Med Biol Res
2134390	Effect of chronic alcoholism on the human hippocampus. (1990 Jul)	Bengochea O	Histol Histopathol
23395714	Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. (2013 Aug)	Sinkus ML	Brain Behav Immun
24850422	Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence. (2014 Jul 1)	Kuhn S	JAMA Psychiatry
15802186	Effects of postnatal nicotine exposure on apoptotic markers in the developing piglet brain. (2005)	Machaalani R	Neuroscience