Gene: CA9

768
CAIX|MN
carbonic anhydrase 9
protein-coding
9p13.3
Ensembl:ENSG00000107159 MIM:603179 Vega:OTTHUMG00000021029 UniprotKB:Q16790
NC_000009.12
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.381e-1 (AD)  9.205e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53I110.567
NPAS10.506
PRTN30.493
RGS120.485
COL5A10.479
CXCL140.462
PDE4C0.461
CHRNA20.46
SCN5A0.457
CACNA1G0.456

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTUD7B-0.284
DTHD1-0.282
ZFP57-0.273
VRK2-0.269
SHISA3-0.267
CTNNA3-0.264
BVES-0.259
CNTF-0.255
C5orf64-0.252
LAYN-0.248

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00562BenzthiazideSmall Molecule91-33-8ApprovedTarget
DB00774HydroflumethiazideSmall Molecule135-09-1Approved|InvestigationalTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB00999HydrochlorothiazideSmall Molecule58-93-5ApprovedTarget
DB05304WX-G250Small Molecule-InvestigationalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB09460Sodium carbonateSmall Molecule497-19-8ApprovedTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of CA9 mRNA"19502547
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]"24403227
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]"24403227
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased expression of CA9 mRNA"24403227
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"EGLN1 mRNA promotes the reaction [1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased expression of CA9 mRNA]"24403227
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased expression of CA9 protein"21994956
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]19808899
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]19808899
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-onePTEN protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]19808899
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-onePTEN protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]19808899
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]19808899
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]19808899
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-onePTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]19808899
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-onePTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]19808899
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"[4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] which results in increased expression of CA12 protein"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased activity of CA9 protein"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased expression of CA9 mRNA"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased expression of CA9 protein"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"[4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased expression of CA9 protein] which results in increased expression of CA12 protein"21851094
C5685184-(4-((glucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((glucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased activity of CA9 protein"21851094
C0268454-methylumbelliferyl-galactopyranoside4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein22077347
C0314777-hydroxycoumarin7-hydroxycoumarin results in decreased activity of CA9 protein22077347
D000082AcetaminophenAcetaminophen results in decreased expression of CA9 mRNA29067470
D000086AcetazolamideAcetazolamide binds to and results in decreased activity of CA9 protein28251759
D000086AcetazolamideAcetazolamide results in decreased activity of CA9 protein21851094
D000667AmpicillinAmpicillin results in increased expression of CA9 mRNA21632981
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CA9 mRNA24449571
C519728archazolid Barchazolid B results in increased expression of CA9 mRNA25218289
C006632arsenic trioxidearsenic trioxide promotes the reaction [silybin results in decreased expression of CA9 mRNA]21969006
C006632arsenic trioxidearsenic trioxide results in decreased expression of CA9 mRNA21969006
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nickel sulfate results in increased expression of CA9 protein]16288478
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]20228066
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]20228066
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CA9 mRNA20228066
D004958EstradiolEstradiol results in decreased expression of CA9 mRNA20106945|2163298
C002503betulinbetulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26540049
C002070betulinic acidbetulinic acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26540049
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of CA9 mRNA27685785
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of CA9 mRNA"20162321
C006780bisphenol Abisphenol A results in decreased expression of CA9 mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of CA9 mRNA21040473
C025703bleomycetinbleomycetin results in increased expression of CA9 protein21040473
C025703bleomycetinCA9 protein inhibits the reaction [bleomycetin results in increased activity of CASP3 protein]21040473
C025703bleomycetinCA9 protein results in decreased susceptibility to bleomycetin21040473
D000069286BortezomibBortezomib results in decreased expression of CA9 protein16061869
D001959BromatesBromates results in decreased activity of CA9 protein15664814
C018475butyraldehydebutyraldehyde results in decreased expression of CA9 mRNA25014914|2607969
D020148Butyric AcidButyric Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26305601
C459604candoxincandoxin results in decreased expression of CA9 mRNA16309724
C031639caprylic aldehydecaprylic aldehyde results in decreased expression of CA9 mRNA25014914
D002254CarbonatesCarbonates results in decreased activity of CA9 protein15664814
C022842chloric acidchloric acid results in decreased activity of CA9 protein15664814
D003035Cobalt[tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNA20105288
C018021cobaltous chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]19808899
C018021cobaltous chloride2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]19808899
C018021cobaltous chlorideARNT gene mutant form inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]24299737
C018021cobaltous chlorideBenzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]20228066
C018021cobaltous chlorideBenzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]20228066
C018021cobaltous chloridecobaltous chloride results in increased expression of CA9 mRNA19376846|1950254
C018021cobaltous chloridecobaltous chloride results in increased expression of CA9 protein19808899|2022806
C018021cobaltous chloridePTEN protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]19808899
C018021cobaltous chloridePTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]19808899
C018021cobaltous chloridetriptolide inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]24842335
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]22202117
C026305cobalt sulfatecobalt sulfate results in increased expression of CA9 mRNA19502547
D016572CyclosporineCyclosporine results in decreased expression of CA9 mRNA20106945|2163298
D003676DeferoxamineDeferoxamine results in increased expression of CA9 mRNA25351418
C107676deguelindeguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]22745725
D002945CisplatinCisplatin results in decreased expression of CA9 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CA9 mRNA27614199
D002117CalcitriolCalcitriol results in increased expression of CA9 mRNA26485663
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of CA9 mRNA23876855
D004317DoxorubicinDoxorubicin results in decreased expression of CA9 mRNA22908232
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of CA9 mRNA25398874
C568713GSK1210151AGSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]27292261
C568713GSK1210151AGSK1210151A results in decreased expression of CA9 mRNA27292261
C554645GSK525762AGSK525762A inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]27292261
C554645GSK525762AGSK525762A results in decreased expression of CA9 mRNA27292261
C046204heptanalheptanal results in decreased expression of CA9 mRNA25014914
D007452IodatesIodates results in decreased activity of CA9 protein15664814
C544151jinfukangjinfukang results in increased expression of CA9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Oxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]]27292261
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]27292261
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26305601|2729226
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CA9 mRNA26752646|2729226
D007854LeadLead affects the expression of CA9 mRNA28903495
C008512methylumbelliferyl-alpha-D-mannopyranosidemethylumbelliferyl-alpha-D-mannopyranoside analog results in decreased activity of CA9 protein22077347
C044659molybdatemolybdate results in decreased activity of CA9 protein15664814
C010463n-hexanaln-hexanal results in decreased expression of CA9 mRNA25014914
C022838nickel chlorideHIF1A protein promotes the reaction [nickel chloride results in increased expression of CA9 protein]28552779
C022838nickel chloridenickel chloride results in increased expression of CA9 mRNA21455298|2855277
C029938nickel sulfateAscorbic Acid inhibits the reaction [nickel sulfate results in increased expression of CA9 protein]16288478
C029938nickel sulfatenickel sulfate results in decreased expression of CA9 mRNA22714537
C029938nickel sulfatenickel sulfate results in increased expression of CA9 protein16288478
D017942Nitric AcidNitric Acid results in decreased activity of CA9 protein15664814
C010615Nonidet P-40Nonidet P-40 results in decreased expression of CA9 mRNA26552463
C558013NSC 689534NSC 689534 results in increased expression of CA9 mRNA20971185
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of CA9 mRNA24888373
C012465oryzalinoryzalin binds to and results in decreased activity of CA9 protein28251759
C030110oxaliplatinoxaliplatin results in decreased expression of CA9 mRNA17762391
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]"24403227
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]"24403227
D010100Oxygen2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]19808899
D010100Oxygen2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]19808899
D010100Oxygen"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]"21851094
D010100Oxygen"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]"21851094
D010100Oxygen"[4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] which results in increased expression of CA12 protein"21851094
D010100Oxygenbetulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26540049
D010100Oxygenbetulinic acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26540049
D010100OxygenButyric Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26305601
D010100OxygenCA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ABCC2 mRNA]26305601|2630560
D010100OxygenCA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ALDH1 mRNA]26305601|2630560
D010100OxygenCA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of LIN28A mRNA]26305601|2630560
D010100OxygenCA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA]26305601|2630560
D010100OxygenCA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of WNT2 mRNA]26305601|2630560
D010100Oxygendeguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]22745725
D010100OxygenGSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]27292261
D010100OxygenGSK525762A inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]27292261
D010100OxygenHIF1A mRNA promotes the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]25351418
D010100OxygenHIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]20042640
D010100Oxygen(+)-JQ1 compound inhibits the reaction [Oxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]]27292261
D010100Oxygen(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]27292261
D010100Oxygen(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26305601|2729226
D010100OxygenOxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]27292261
D010100OxygenOxygen deficiency promotes the reaction [BRD4 protein binds to CA9 promoter]27292261
D010100OxygenOxygen deficiency results in increased expression of CA921361354
D010100OxygenOxygen deficiency results in increased expression of CA9 mRNA18924134|1915418
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ABCC2 mRNA26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ALDH1 mRNA26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ALDH1 protein26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of IGF1 mRNA26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of LIN28A mRNA26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of SOX2 mRNA26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA26305601
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of WNT2 mRNA26305601
D010100OxygenOxygen deficiency results in increased expression of CA9 protein19154183|1980889
D010100OxygenPTEN protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]19808899
D010100OxygenPTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]19808899
D010100OxygenTetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]19154183
D010100OxygenTetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]19154183
D010100Oxygenvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26305601
D010100OxygenARNT protein affects the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]19154183
D010100OxygenOxygen deficiency results in increased expression of CA921361354
D010100OxygenOxygen deficiency results in increased expression of CA9 mRNA19154183
D010100OxygenTetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]19154183
C046012pentanalpentanal results in decreased expression of CA9 mRNA25014914|2607969
C494474perchlorateperchlorate results in decreased activity of CA9 protein15664814
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CA9 mRNA23978341
D010634PhenobarbitalPhenobarbital affects the expression of CA9 mRNA19159669
C522973PI103PI103 results in decreased phosphorylation of CA9 protein21994956
D010936Plant ExtractsPlant Extracts results in decreased expression of CA9 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of CA9 mRNA24888373
C037192potassium periodatepotassium periodate results in decreased activity of CA9 protein15664814
C005556propionaldehydepropionaldehyde results in decreased expression of CA9 mRNA25014914|2607969
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CA9 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CA9 mRNA25351596
C440975silybinarsenic trioxide promotes the reaction [silybin results in decreased expression of CA9 mRNA]21969006
C440975silybinsilybin results in decreased expression of CA9 mRNA21969006
C017947sodium arsenitesodium arsenite affects the expression of CA9 mRNA29319823
C025349sodium metasilicatesodium metasilicate results in decreased activity of CA9 protein15664814
C005741sulfamic acidsulfamic acid results in decreased activity of CA9 protein15664814
D013424SulfanilamidesSulfanilamides analog results in decreased activity of CA9 protein21361354
D013431SulfatesSulfates results in decreased activity of CA9 protein15664814
D013438Sulfhydryl CompoundsSulfhydryl Compounds analog binds to and results in decreased activity of CA9 protein17059166
D013467SulindacSulindac analog results in decreased expression of CA9 mRNA18924134
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of CA9 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]19154183
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]19154183
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]19154183
C001899triptolidetriptolide inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]24842335
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CA9 mRNA"26179874
C045951tungstatetungstate results in decreased activity of CA9 protein15664814
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNA20105288
C002802tungsten carbidetungsten carbide results in increased expression of CA9 mRNA20105288
D014520UrethaneUrethane affects the expression of CA9 mRNA28818685
D014638VanadatesVanadates results in decreased activity of CA9 protein15664814
D014638VanadatesVanadates results in increased expression of CA9 mRNA22714537
C111237vorinostatvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]26305601
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004089carbonate dehydratase activity-TAS-  
GO:0005515protein binding-IPI26871637  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002009morphogenesis of an epithelium-IEA-  
GO:0015701bicarbonate transport-TAS-  
GO:0033574response to testosterone-IEA-  
GO:0042493response to drug-IEA-  
GO:0046903secretion-IEA-  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IEA-  
GO:0005886plasma membrane-IDA22087255  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0031528microvillus membrane-IEA-  
KEGG ID KEGG Term
hsa00910Nitrogen metabolism
Reactome ID Reactome Term Evidence
R-HSA-1234158Regulation of gene expression by Hypoxia-inducible FactorTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1430728MetabolismTAS
R-HSA-1475029Reversible hydration of carbon dioxideTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26418512Nicotine-Mediated Ca(2+)-Influx Induces IL-8 Secretion in Oral Squamous Cell Carcinoma Cell. (2016 Apr)Tsunoda KJ Cell Biochem
18922923Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. (2008 Oct 15)Chiang SLCancer Res
24321995Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking. (2014 Jul)Schweiger TEur J Cardiothorac Surg
18440050Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma. (2008 Sep)Choi SWHum Pathol
26667496Role of mitogen-activated protein kinase pathways in migration of gingival epithelial cells in response to stimulation by cigarette smoke condensate and infection by Porphyromonas gingivalis. (2016 Oct)Imamura KJ Periodontal Res
23852087Disulfiram deregulates HIF-alpha subunits and blunts tumor adaptation to hypoxia in hepatoma cells. (2013 Sep)Park HJActa Pharmacol Sin
23226559Impacts of CA9 gene polymorphisms and environmental factors on oral-cancer susceptibility and clinicopathologic characteristics in Taiwan. (2012)Chien MHPLoS One