Gene info: ID 7704

Gene: ZBTB16

GENE ID: 7704

Synonyms: PLZF|ZNF145

Description: zinc finger and BTB domain containing 16

Gene type: protein-coding

Location: 11q23.2

dbXrefs: Ensembl:ENSG00000109906 MIM:176797 Vega:OTTHUMG00000168243 UniprotKB:Q05516

RefSeq: NG_012140.2

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.969e-1 (AD) 8.496e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs549427	chr11:114214137 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg01439566	chr11:113932189	ZBTB16		1.700e-20	Smoking	27651444
cg17518710	chr11:113954170	ZBTB16		7.000e-9	Smoking	27651444
cg20268992	chr11:113953621	ZBTB16		7.800e-9	Smoking	27651444
cg04420138	chr11:113932235	ZBTB16		3.200e-8	Smoking	27651444
cg10827488	chr11:113953838	ZBTB16		7.700e-8	Smoking	27651444
cg22768358	chr11:113947148	ZBTB16		6.050e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MROH1	0.852
SOCS7	0.85
SMCR8	0.841
PLEKHM3	0.832
HECTD4	0.829
GPATCH8	0.828
AP5B1	0.828
INCENP	0.824
SMAP1	0.822
FTO	0.819

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KLRK1	-0.401
BCL7C	-0.385
COPZ2	-0.376
KLRC3	-0.374
OR4F5	-0.366
ZNF114	-0.362
APOM	-0.359
TNFRSF13B	-0.355
PINLYP	-0.354
OR4F29	-0.353

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of ZBTB16 mRNA"	26377693
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of ZBTB16 mRNA"	20206263
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of ZBTB16 mRNA"	27567155
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of ZBTB16 mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of ZBTB16 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of ZBTB16 mRNA	17562736
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZBTB16 mRNA	22129741
D020106	Acrylamide	Acrylamide results in increased expression of ZBTB16 mRNA	28959563
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of ZBTB16 mRNA	19920212
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of ZBTB16 mRNA	28522335
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of ZBTB16 mRNA	21298039
D001151	Arsenic	Arsenic results in decreased expression of ZBTB16 mRNA	19654921
C547126	AZM551248	AZM551248 results in decreased expression of ZBTB16 mRNA	22323515
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of ZBTB16 mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ZBTB16 mRNA	18164116
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of ZBTB16 mRNA	17404688
C095105	bexarotene	bexarotene results in increased expression of ZBTB16 mRNA	23292798
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZBTB16 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of ZBTB16 mRNA	28159858
C006780	bisphenol A	bisphenol A affects the expression of ZBTB16 mRNA	27010169
C006780	bisphenol A	bisphenol A results in decreased expression of ZBTB16 mRNA	27685785
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] affects the expression of ZBTB16 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of ZBTB16 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of ZBTB16 mRNA	25594700
C006780	bisphenol A	bisphenol A results in decreased expression of ZBTB16 mRNA	25181051\|2717856
C006780	bisphenol A	bisphenol A results in increased methylation of ZBTB16 gene	28505145
D002066	Busulfan	Busulfan results in increased expression of ZBTB16 mRNA	26524245
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ZBTB16 mRNA	24982889
D002220	Carbamazepine	Carbamazepine affects the expression of ZBTB16 mRNA	22634333
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of ZBTB16 mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of ZBTB16 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of ZBTB16 mRNA	20350560
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZBTB16 gene	20938992
D003042	Cocaine	Cocaine affects the expression of ZBTB16 mRNA	20187946
D003471	Cuprizone	Cuprizone results in decreased expression of ZBTB16 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of ZBTB16 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of ZBTB16 mRNA	19770486
C093628	cyproconazole	cyproconazole results in increased expression of ZBTB16 mRNA	22045034
D003907	Dexamethasone	Dexamethasone results in increased expression of ZBTB16 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZBTB16 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] affects the expression of ZBTB16 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ZBTB16 mRNA	28628672
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of ZBTB16 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of ZBTB16 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of ZBTB16 mRNA	27594783
D004026	Dieldrin	Dieldrin affects the expression of ZBTB16 mRNA	22546817
D004041	Dietary Fats	Dietary Fats results in decreased expression of ZBTB16 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ZBTB16 mRNA	25975992
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ZBTB16 mRNA	18164116
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZBTB16 mRNA	22129741
D004317	Doxorubicin	Doxorubicin results in increased expression of ZBTB16 mRNA	21040762\|2589636
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of ZBTB16 mRNA	21040762
D004610	Ellagic Acid	Ellagic Acid results in decreased expression of ZBTB16 mRNA	12002526
C118739	entinostat	entinostat results in decreased expression of ZBTB16 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
D000431	Ethanol	Ethanol affects the expression of ZBTB16 mRNA	27010169
C061365	flusilazole	flusilazole affects the expression of ZBTB16 mRNA	22634333
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZBTB16 gene	20938992
C069837	fullerene C60	fullerene C60 affects the expression of ZBTB16 mRNA	19167457
C039281	furan	furan results in increased expression of ZBTB16 mRNA	25539665\|2619464
C004312	glycidol	glycidol results in increased expression of ZBTB16 mRNA	24915197
C412815	GW 4064	GW 4064 results in decreased expression of ZBTB16 mRNA	26655953
C409722	hexaconazole	hexaconazole results in increased expression of ZBTB16 mRNA	22045034
D017313	Fenretinide	Fenretinide results in decreased expression of ZBTB16 mRNA	28973697
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZBTB16 mRNA	22129741
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZBTB16 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] affects the expression of ZBTB16 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ZBTB16 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZBTB16 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] affects the expression of ZBTB16 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ZBTB16 mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in increased expression of ZBTB16 mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of ZBTB16 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ZBTB16 mRNA	23086925
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of ZBTB16 mRNA	20843944
D015122	Mercaptopurine	Mercaptopurine results in increased expression of ZBTB16 mRNA	23358152
C042720	mercuric bromide	mercuric bromide results in decreased expression of ZBTB16 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of ZBTB16 mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of ZBTB16 mRNA	16507785
D008628	Mercury	Mercury results in increased expression of ZBTB16 mRNA	19937285
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZBTB16 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ZBTB16 mRNA	28001369
D008777	Methyltestosterone	Methyltestosterone results in increased expression of ZBTB16 mRNA	29191790
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of ZBTB16 mRNA	16809437
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of ZBTB16 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of ZBTB16 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ZBTB16 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ZBTB16 mRNA"	25620056
D009532	Nickel	Nickel results in decreased expression of ZBTB16 mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of ZBTB16 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of ZBTB16 mRNA	16166746
D010100	Oxygen	Oxygen affects the reaction [AHR protein results in increased expression of ZBTB16 mRNA]	27103661
D010126	Ozone	Ozone results in increased expression of ZBTB16 mRNA	17460151
D000073878	Palm Oil	Palm Oil results in decreased expression of ZBTB16 mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of ZBTB16 mRNA	26272509
C016030	pantogab	pantogab results in increased expression of ZBTB16 mRNA	17379144
D010634	Phenobarbital	Phenobarbital results in decreased expression of ZBTB16 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of ZBTB16 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of ZBTB16 mRNA	18445702
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ZBTB16 mRNA	27413110\|2890350
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of ZBTB16 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of ZBTB16 mRNA	17404688\|2086464
D011374	Progesterone	Progesterone affects the expression of ZBTB16 mRNA	17251523
D011374	Progesterone	Progesterone results in increased expression of ZBTB16 mRNA	22238285
C045950	propiconazole	propiconazole results in decreased expression of ZBTB16 mRNA	21278054
C059514	resveratrol	resveratrol results in decreased expression of ZBTB16 mRNA	12002526
D015474	Isotretinoin	Isotretinoin results in decreased expression of ZBTB16 mRNA	20436886
D012715	Sesame Oil	Sesame Oil results in decreased expression of ZBTB16 mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ZBTB16 mRNA	22431001
C017947	sodium arsenite	sodium arsenite affects the methylation of ZBTB16 gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of ZBTB16 mRNA	17682005
D053260	Soot	Soot affects the expression of ZBTB16 mRNA	26551751
C061133	tamibarotene	tamibarotene results in decreased expression of ZBTB16 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of ZBTB16 mRNA	20937368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ZBTB16 mRNA	20055451
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ZBTB16 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ZBTB16 mRNA	22298810
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ZBTB16 mRNA	28973375
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ZBTB16 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of ZBTB16 mRNA	20133372
D014212	Tretinoin	Tretinoin results in decreased expression of ZBTB16 mRNA	15498508\|2193413
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of ZBTB16 mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in decreased expression of ZBTB16 mRNA	28973697
C112106	UAB 30	UAB 30 results in increased expression of ZBTB16 mRNA	23292798
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB16 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of ZBTB16 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of ZBTB16 mRNA	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ZBTB16 mRNA	22045034
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ZBTB16 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	IDA	12802276
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IDA	12802276
GO:0003677	DNA binding	-	IDA	12802276
GO:0003677	DNA binding	-	NAS	9294197
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	9294197 10980608 16169070 16189514 16676348 16828757 17118363 19648967 21988832 23088713 24359566 25241761 25416956 26871637 27107012
GO:0008022	protein C-terminus binding	-	IEA	-
GO:0019904	protein domain specific binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	9294197 25416956 27107012
GO:0042803	protein homodimerization activity	-	IDA	8622986
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	12802276
GO:0001823	mesonephros development	-	ISS	8541544
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006915	apoptotic process	-	NAS	9294197
GO:0007417	central nervous system development	-	ISS	8541544
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009880	embryonic pattern specification	-	IEA	-
GO:0009952	anterior/posterior pattern specification	-	IEA	-
GO:0016567	protein ubiquitination	-	IEA	-
GO:0030097	hemopoiesis	-	IDA	8541544
GO:0030097	hemopoiesis	-	TAS	9294197
GO:0030099	myeloid cell differentiation	-	TAS	9294197
GO:0032332	positive regulation of chondrocyte differentiation	-	IMP	21547890
GO:0034504	protein localization to nucleus	-	IEA	-
GO:0035116	embryonic hindlimb morphogenesis	-	IEA	-
GO:0035136	forelimb morphogenesis	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0045600	positive regulation of fat cell differentiation	-	IMP	21547890
GO:0045638	negative regulation of myeloid cell differentiation	-	ISS	8541544
GO:0045778	positive regulation of ossification	-	IDA	21547890
GO:0045892	negative regulation of transcription, DNA-templated	-	IBA	21873635
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	12802276 24359566
GO:0045892	negative regulation of transcription, DNA-templated	-	NAS	9294197
GO:0045893	positive regulation of transcription, DNA-templated	-	IBA	21873635
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	21547890
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0048133	male germ-line stem cell asymmetric division	-	IEA	-
GO:0048856	anatomical structure development	-	IBA	21873635
GO:0051138	positive regulation of NK T cell differentiation	-	IEA	-
GO:0051216	cartilage development	-	IDA	21547890
GO:0061036	positive regulation of cartilage development	-	IDA	21547890

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	COLOCALIZES_WITH	IBA	21873635
GO:0005634	nucleus	-	IDA	9294197 11929873 21547890 24359566
GO:0005654	nucleoplasm	COLOCALIZES_WITH	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-
GO:0016604	nuclear body	-	IDA	19648967 24359566
GO:0016605	PML body	-	IDA	9294197
GO:0016607	nuclear speck	-	IDA	8541544
GO:0017053	transcriptional repressor complex	-	IDA	12802276
GO:0032991	protein-containing complex	-	IMP	10980608

KEGG ID	KEGG Term
hsa05200	Pathways in cancer
hsa05221	Acute myeloid leukemia

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal