Gene: CA12

771
CA-XII|CAXII|HsT18816|T18816
carbonic anhydrase 12
protein-coding
15q22.2
Ensembl:ENSG00000074410 MIM:603263 Vega:OTTHUMG00000132881 UniprotKB:O43570
NG_028022.2
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.881e-1 (AD)  7.722e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFCP2L10.67
PHKA10.631
ZNF5160.622
ZNF8440.622
MDK0.616
EYA10.614
SLC35F50.611
FERMT20.608
MEIS20.606
ZNF4420.606

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.39
LRRC38-0.358
PHOSPHO1-0.355
KCNS3-0.354
SAMD5-0.352
ARHGAP22-0.346
PVALB-0.345
PLXDC1-0.34
GALNTL5-0.338
PIP5KL1-0.337

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00562BenzthiazideSmall Molecule91-33-8ApprovedTarget
DB00774HydroflumethiazideSmall Molecule135-09-1Approved|InvestigationalTarget
DB00819AcetazolamideSmall Molecule59-66-5ApprovedTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB00999HydrochlorothiazideSmall Molecule58-93-5ApprovedTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of CA12 mRNA"22101062
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CA12 mRNA"19167446
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"[4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] which results in increased expression of CA12 protein"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased activity of CA12 protein"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"[4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased expression of CA9 protein] which results in increased expression of CA12 protein"21851094
C5685174-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in increased expression of CA12 protein"21851094
C5685184-(4-((glucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide"4-(4-((glucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide results in decreased activity of CA12 protein"21851094
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C0165954-methylumbelliferyl beta-D-ribopyranoside4-methylumbelliferyl beta-D-ribopyranoside analog results in decreased activity of CA12 protein22077347
C0268454-methylumbelliferyl-galactopyranoside4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein22077347
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C0314777-hydroxycoumarin7-hydroxycoumarin results in decreased activity of CA12 protein22077347
D000086AcetazolamideAcetazolamide binds to and results in decreased activity of CA12 protein28251759
D000086AcetazolamideAcetazolamide results in decreased activity of CA12 protein21851094
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of CA12 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CA12 mRNA22100608
D000393Air PollutantsAir Pollutants analog results in decreased expression of CA12 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CA12 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of CA12 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CA12 mRNA25690898
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CA12 mRNA21802500
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CA12 mRNA"20382639
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of CA12 mRNA]24758408
D004958EstradiolEstradiol affects the expression of CA12 mRNA14699072
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CA12 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA12 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of CA12 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of CA12 mRNA15223131|1591388
C006780bisphenol Abisphenol A affects the expression of CA12 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of CA12 mRNA16474171|2301914
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA12 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CA12 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CA12 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of CA12 mRNA17720352
D002104CadmiumCadmium results in increased expression of CA12 mRNA21120746
D002996ClomipheneClomiphene results in decreased expression of CA12 mRNA26865669
C018021cobaltous chloridecobaltous chloride results in increased expression of CA12 mRNA23052192
D019327Copper SulfateCopper Sulfate results in increased expression of CA12 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CA12 mRNA"19167446
D003520CyclophosphamideCA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D016572CyclosporineCyclosporine results in increased expression of CA12 mRNA20106945|2798913
D003561CytarabineCytarabine results in decreased expression of CA12 mRNA21198554
C014347decitabinedecitabine results in increased expression of CA12 mRNA21856257
D003671DEET[fipronil co-treated with DEET] results in increased expression of CA12 mRNA27091632
D003907DexamethasoneDexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]25136773
D003907DexamethasoneDexamethasone results in increased expression of CA12 mRNA25136773
D003907Dexamethasonefulvestrant promotes the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA12 mRNA28628672
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
D003907DexamethasoneNR3C1 mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CA12 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CA12 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CA12 mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CA12 mRNA26865669
D002117CalcitriolCalcitriol results in increased expression of CA12 mRNA14996990
D004317DoxorubicinCA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CA12 mRNA26159488
C118739entinostatentinostat results in increased expression of CA12 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of CA12 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of CA12 mRNA21233418
D004970EstroneEstrone results in increased expression of CA12 mRNA26865669
D008656MestranolMestranol results in increased expression of CA12 mRNA26865669
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CA12 mRNA27091632
C082360fipronilfipronil results in increased expression of CA12 mRNA27091632
D005472FluorouracilCA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in increased expression of CA12 mRNA]25136773
C070081fulvestrantfulvestrant promotes the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
C070081fulvestrantfulvestrant results in decreased expression of CA12 mRNA26865669
D019833GenisteinDexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]25136773
D019833GenisteinESR1 mutant form inhibits the reaction [Genistein results in increased expression of CA12 mRNA]25136773
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in increased expression of CA12 mRNA]25136773
D019833Genisteinfulvestrant promotes the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
D019833GenisteinGenistein results in increased expression of CA12 mRNA16474171|2301914
D019833GenisteinMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
D019833GenisteinNR3C1 mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
C071834glycidamideglycidamide results in decreased expression of CA12 mRNA17822822
D006589HexestrolHexestrol results in increased expression of CA12 mRNA26865669
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CA12 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA12 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CA12 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CA12 mRNA27392435
C544151jinfukangjinfukang results in increased expression of CA12 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CA12 mRNA24796395|2675264
D007854LeadLead results in decreased expression of CA12 mRNA19921347
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CA12 promoter]20348232
C008512methylumbelliferyl-alpha-D-mannopyranosidemethylumbelliferyl-alpha-D-mannopyranoside analog results in decreased activity of CA12 protein22077347
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]25136773
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CA12 mRNA26924002
C012465oryzalinoryzalin binds to and results in decreased activity of CA12 protein28251759
D010100Oxygen"[4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] which results in increased expression of CA12 protein"21851094
D010100OxygenOxygen deficiency results in increased expression of CA12 mRNA19695866|2004264
D010100OxygenOxygen deficiency results in increased expression of CA12 protein21851094
D017239PaclitaxelCA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CA12 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CA12 mRNA26705709
D010634PhenobarbitalPhenobarbital results in increased expression of CA12 mRNA19084549
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CA12 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of CA12 mRNA16474171
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CA12 mRNA20660070
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CA12 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CA12 mRNA19059307
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CA12 mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of CA12 mRNA26865669
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CA12 mRNA25895662
D012906SmokeSmoke results in increased expression of CA12 mRNA21095227
D013424SulfanilamidesSulfanilamides analog results in decreased activity of CA12 protein21361354
D013629TamoxifenTamoxifen affects the expression of CA12 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of CA12 mRNA19059307
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CA12 mRNA19059307
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CA12 mRNA26159488
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA12 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CA12 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CA12 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CA12 mRNA19619570|2010694
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CA12 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CA12 mRNA27404394
C052342topiramatetopiramate results in decreased activity of CA12 protein21314129
C012589trichostatin Atrichostatin A results in increased expression of CA12 mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of CA12 mRNA15901671
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CA12 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of CA12 mRNA25572481
D014520UrethaneUrethane results in increased expression of CA12 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CA12 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CA12 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of CA12 mRNA15901671
D014638VanadatesVanadates results in increased expression of CA12 mRNA22714537
D024483Vitamin K 3Vitamin K 3 affects the expression of CA12 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004089carbonate dehydratase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015701bicarbonate transport-TAS-  
GO:0055064chloride ion homeostasis-IMP21035102  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00910Nitrogen metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1475029Reversible hydration of carbon dioxideTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147396Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009 Aug)Cheong SCOral Oncol