Gene: TRIM26

7726
AFP|RNF95|ZNF173
tripartite motif containing 26
protein-coding
6p22.1
Ensembl:ENSG00000234127 MIM:600830 Vega:OTTHUMG00000031041 UniprotKB:Q12899
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRRT0.824
NOP560.814
MAX0.811
FKBP40.808
CRTC20.806
SRSF40.806
HSP90AA10.801
TCP10.797
DAXX0.795
PTGES30.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.589
OR4F5-0.573
TRDN-0.246
OR4F16-0.238
KRT73-0.232
UGT2B7-0.222
PHEX-0.218
MEI4-0.216
SPRR2B-0.216
ARHGEF35-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TRIM26 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRIM26 mRNA22100608|2715375
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TRIM26 mRNA24449571
D001151ArsenicArsenic affects the methylation of TRIM26 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of TRIM26 mRNA20458559
C044887beta-methylcholinebeta-methylcholine affects the expression of TRIM26 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of TRIM26 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TRIM26 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM26 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride affects the expression of TRIM26 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TRIM26 promoter22457795
D003078ColchicineColchicine results in decreased expression of TRIM26 mRNA24211769
D016572CyclosporineCyclosporine results in increased expression of TRIM26 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM26 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of TRIM26 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TRIM26 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TRIM26 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TRIM26 mRNA24211769
D002945CisplatinCisplatin results in increased expression of TRIM26 mRNA27392435|2759478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TRIM26 mRNA24211769
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TRIM26 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of TRIM26 mRNA23649840
C039281furanfuran results in increased expression of TRIM26 mRNA26194646
D005897GlafenineGlafenine results in decreased expression of TRIM26 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM26 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM26 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TRIM26 mRNA27392435
D007854LeadLead results in decreased expression of TRIM26 mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRIM26 mRNA24211769
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TRIM26 mRNA23649840
D016685MitomycinMitomycin results in decreased expression of TRIM26 mRNA24211769
C051752nefazodonenefazodone results in decreased expression of TRIM26 mRNA24136188
C029938nickel sulfatenickel sulfate results in increased expression of TRIM26 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TRIM26 mRNA25729387
C016030pantogabpantogab results in decreased expression of TRIM26 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TRIM26 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of TRIM26 mRNA23892564
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TRIM26 mRNA21061450
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRIM26 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRIM26 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TRIM26 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TRIM26 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of TRIM26 mRNA28973697
D014520UrethaneUrethane results in increased expression of TRIM26 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of TRIM26 mRNA23179753
D000225AdenineAdenine results in decreased expression of TRIM26 mRNA24211769
D024483Vitamin K 3Vitamin K 3 affects the expression of TRIM26 mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TRIM26 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-NAS8530076  
GO:0005515protein binding-IPI21516116  25416956  
GO:0008270zinc ion binding-IEA-  
GO:0016740transferase activity-IEA-  
GO:0046872metal ion binding-NAS8530076  
GO ID GO Term Qualifier Evidence PubMed
GO:0045087innate immune response-IDA18248090  
GO:0046597negative regulation of viral entry into host cell-IDA18248090  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA23077300  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:1902187negative regulation of viral release from host cell-IDA18248090  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19409198Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells. (2009 Jul 10)Linschooten JOMutat Res