Gene: CACNA1A

773
APCA|BI|CACNL1A4|CAV2.1|EA2|EIEE42|FHM|HPCA|MHP|MHP1|SCA6
calcium voltage-gated channel subunit alpha1 A
protein-coding
19p13.13
Ensembl:ENSG00000141837 MIM:601011 Vega:OTTHUMG00000044590 UniprotKB:O00555
NG_011569.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.400e-1 (AD)  7.945e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRRM30.917
RAPGEFL10.917
SLC9A10.909
SYT70.908
AP3B20.907
TMEM1450.902
NAGPA0.901
CIT0.9
CELSR30.9
SLC7A80.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
ANXA13-0.474
OR4F29-0.471
SNHG18-0.471
HEY2-0.456
YES1-0.453
MBNL3-0.447
RAI14-0.445
NXT2-0.444
COPZ2-0.441

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
DB00230PregabalinSmall Molecule148553-50-8Approved|Illicit|InvestigationalTarget
DB00661VerapamilSmall Molecule52-53-9ApprovedTarget
DB00836LoperamideSmall Molecule53179-11-6ApprovedTarget
DB01244BepridilSmall Molecule64706-54-3Approved|WithdrawnTarget
DB06446DotarizineSmall Molecule84625-59-2InvestigationalTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
ID Drug Name Action PubMed
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of CACNA1A mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CACNA1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA1A mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of CACNA1A mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CACNA1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA1A mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of CACNA1A mRNA28959563
D000487AllethrinAllethrin inhibits the reaction [CACNA1A protein results in increased transport of Calcium]14634047
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CACNA1A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CACNA1A mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of CACNA1A mRNA24831965
D001464BariumCACNA1A protein results in increased transport of Barium11313431
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CACNA1A gene25435355
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CACNA1A mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CACNA1A mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of CACNA1A mRNA25047013
C006780bisphenol Abisphenol A affects the expression of CACNA1A mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1A mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1A mRNA25607892
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1A mRNA20360939
D002118CalciumAllethrin inhibits the reaction [CACNA1A protein results in increased transport of Calcium]14634047
D002118CalciumCACNA1A protein results in increased transport of Calcium14634047
D002220CarbamazepineCarbamazepine affects the expression of CACNA1A mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CACNA1A mRNA16644059
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of CACNA1A mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CACNA1A gene20938992
D002994ClofibrateClofibrate results in increased expression of CACNA1A mRNA17585979
D003024ClozapineClozapine results in decreased expression of CACNA1A mRNA14647396
D003024ClozapineClozapine results in decreased expression of CACNA1A mRNA16715494
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CACNA1A mRNA20971185
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CACNA1A mRNA21266533
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
D002945CisplatinCisplatin results in increased expression of CACNA1A mRNA21151649
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1A mRNA20360939
C118739entinostatentinostat results in increased expression of CACNA1A mRNA27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1A mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CACNA1A exon17376154
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CACNA1A gene16724327
D005492Folic AcidFolic Acid results in increased expression of CACNA1A mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CACNA1A gene20938992
C040029gabapentingabapentin promotes the reaction [[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride]12817894
C040029gabapentingabapentin results in decreased activity of CACNA1A protein12770949
D006220HaloperidolHaloperidol results in decreased expression of CACNA1A mRNA14647396
D006220HaloperidolHaloperidol results in decreased expression of CACNA1A mRNA16715494
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CACNA1A mRNA"24972896
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CACNA1A mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CACNA1A gene20938992
D008727MethotrexateMethotrexate results in increased expression of CACNA1A mRNA24449571
D008731MethoxychlorMethoxychlor results in increased methylation of CACNA1A gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CACNA1A mRNA23103053
D009569Nitric OxideCACNA1A protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide]12770949
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CACNA1A mRNA20971185
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1A mRNA25607892
D020867omega-Agatoxin IVAgabapentin promotes the reaction [[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride]12817894
D020867omega-Agatoxin IVAomega-Agatoxin IVA results in decreased activity of CACNA1A protein12817894
D020867omega-Agatoxin IVA[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride12817894
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of CACNA1A mRNA18636392
D052638Particulate MatterParticulate Matter results in decreased expression of CACNA1A mRNA17987463
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CACNA1A mRNA26300304
D010575PesticidesPesticides results in increased methylation of CACNA1A gene28396702
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CACNA1A mRNA"27188386
D010862PilocarpinePilocarpine results in decreased expression of CACNA1A protein17265461
D010862PilocarpinePilocarpine results in increased expression of CACNA1A protein17265461
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CACNA1A mRNA19710929
D011189Potassium Chloridegabapentin promotes the reaction [[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride]12817894
D011189Potassium Chloride[omega-Agatoxin IVA results in decreased activity of CACNA1A protein] which results in decreased susceptibility to Potassium Chloride12817894
D011189Potassium ChlorideCACNA1A protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide]12770949
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
D011441PropylthiouracilPropylthiouracil results in decreased expression of CACNA1A mRNA24780913
D012834SilverSilver analog results in decreased expression of CACNA1A mRNA26068065
D012834SilverSilver analog results in decreased expression of CACNA1A protein26068065
C017947sodium arsenitesodium arsenite results in decreased expression of CACNA1A mRNA21297353
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CACNA1A mRNA26378955
D043343Testosterone PropionateTestosterone Propionate results in increased expression of CACNA1A mRNA15601916
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CACNA1A mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CACNA1A mRNA21570461
D019284ThapsigarginThapsigargin results in increased expression of CACNA1A mRNA19442820
D014212TretinoinTretinoin results in decreased expression of CACNA1A mRNA21934132
D014212TretinoinTretinoin results in decreased expression of CACNA1A mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of CACNA1A mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of CACNA1A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CACNA1A mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CACNA1A mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CACNA1A gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA25607892
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA1A mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005245voltage-gated calcium channel activity-IBA21873635  
GO:0005245voltage-gated calcium channel activity-IDA10753886  12451115  
GO:0005245voltage-gated calcium channel activity-IGI21883149  
GO:0005245voltage-gated calcium channel activity-ISS-  
GO:0005245voltage-gated calcium channel activity-TAS-  
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI8692999  11865310  21078624  
GO:0008331high voltage-gated calcium channel activity-IDA21883149  24836863  26716990  
GO:0019905syntaxin binding-IDA8692999  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA10753886  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0008219cell death-IDA16595610  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0050796regulation of insulin secretion-TAS-  
GO:0051899membrane depolarization-TAS-  
GO:0070509calcium ion import-IBA21873635  
GO:0070588calcium ion transmembrane transport-IDA24836863  26716990  
GO:1904645response to amyloid-beta-IDA18216187  
GO:1904646cellular response to amyloid-beta-IDA21883149  
GO:1904646cellular response to amyloid-beta-IGI21883149  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16595610  
GO:0005737cytoplasm-IDA16595610  
GO:0005886plasma membrane-IDA16595610  26716990  
GO:0005886plasma membrane-TAS-  
GO:0005891voltage-gated calcium channel complex-IEA-  
GO:0016021integral component of membrane-NAS10753886  
GO:0016021integral component of membrane-TAS16595610  
GO:0042995cell projection-IDA16595610  
GO:0043025neuronal cell body-ISS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04730Long-term depression
hsa04742Taste transduction
hsa04930Type II diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-112308Presynaptic depolarization and calcium channel openingTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-422356Regulation of insulin secretionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12811615Pharmacogenomics: state of the research and perspectives in clinical application. (2003 May)Severino GNeurol Sci