Gene: CACNA1B

774
BIII|CACNL1A5|CACNN|Cav2.2|DYT23
calcium voltage-gated channel subunit alpha1 B
protein-coding
9q34.3
Ensembl:ENSG00000148408 MIM:601012 Vega:OTTHUMG00000021002 UniprotKB:Q00975
NG_042271.1
PubMed
0   ANCO-SNPs
AD
1   
2.739e-2 (AD)  2.197e-1 (ND)   (Frontal_Cortex)
2.620e-1 (AD)  6.973e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07982825chr9:141014674CACNA1BGene body6.866e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRP20.965
SLC12A50.958
ADD20.954
KCNMA10.953
ATP2B30.953
L1CAM0.952
DLGAP20.951
RIMBP20.95
CLSTN30.95
DLG30.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.572
REST-0.56
HEY2-0.559
COPZ2-0.557
MYL3-0.556
RAI14-0.55
RAB13-0.542
CSAG1-0.539
RNF135-0.534
GNG11-0.528

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00381AmlodipineSmall Molecule88150-42-9ApprovedTarget
DB00661VerapamilSmall Molecule52-53-9ApprovedTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01202LevetiracetamSmall Molecule102767-28-2Approved|InvestigationalTarget
DB05885SeletracetamSmall Molecule357336-74-4InvestigationalTarget
DB05950Contulakin-GSmall Molecule229180-41-0InvestigationalTarget
DB08838AgmatineSmall Molecule306-60-5Experimental|InvestigationalTarget
DB09231BenidipineSmall Molecule105979-17-7Approved|InvestigationalTarget
DB09232CilnidipineSmall Molecule132203-70-4Approved|InvestigationalTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CACNA1B mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CACNA1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CACNA1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA1B mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CACNA1B mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CACNA1B mRNA25929836
D001280AtrazineAtrazine results in increased expression of CACNA1B mRNA22378314
D001464BariumCACNA1B gene polymorphism affects the transport of Barium11756491
D001464BariumCACNA1B protein results in increased transport of Barium11007869|1175649
D001464BariumCadmium Chloride inhibits the reaction [CACNA1B protein results in increased transport of Barium]14559144
D001464Barium[GNB1 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB1 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB1 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB2 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB2 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB2 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB3 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB3 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB3 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB4 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB4 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB4 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB5 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D004958EstradiolEstradiol results in increased expression of CACNA1B mRNA17962382
C006780bisphenol Abisphenol A affects the expression of CACNA1B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CACNA1B gene28505145
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CACNA1B protein results in increased transport of Barium]14559144
D002118CalciumCACNA1B protein alternative form results in decreased uptake of Calcium22891239
D002118CalciumCACNA1B protein results in increased transport of Calcium18383452
D002118Calciumdecamethrin inhibits the reaction [CACNA1B protein results in increased transport of Calcium]18383452
D002118Calciumdecamethrin promotes the reaction [CACNA1B gene mutant form results in increased transport of Calcium]18383452
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of CACNA1B mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CACNA1B gene20938992
D003471CuprizoneCuprizone results in decreased expression of CACNA1B mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of CACNA1B promoter27989131
C017180decamethrindecamethrin inhibits the reaction [CACNA1B protein results in increased transport of Calcium]18383452
C017180decamethrindecamethrin promotes the reaction [CACNA1B gene mutant form results in increased transport of Calcium]18383452
C017180decamethrindecamethrin results in decreased activity of CACNA1B protein18383452
C017180decamethrindecamethrin results in decreased activity of CACNA1B protein mutant form18383452
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
D004008DiclofenacDiclofenac results in decreased expression of CACNA1B mRNA26934552
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CACNA1B mRNA24535843
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of CACNA1B mRNA"27840820
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
D005492Folic AcidFolic Acid results in increased expression of CACNA1B mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CACNA1B gene20938992
C040029gabapentingabapentin results in decreased activity of CACNA1B protein12770949
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CACNA1B mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CACNA1B gene20938992
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CACNA1B promoter]20348232
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CACNA1B mRNA"20188158
D009569Nitric OxideCACNA1B protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide]12770949
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CACNA1B mRNA17616710
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of CACNA1B mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of CACNA1B mRNA]"21673326
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of CACNA1B mRNA18636392
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CACNA1B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CACNA1B mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of CACNA1B mRNA19811616
D010862PilocarpinePilocarpine results in decreased expression of CACNA1B protein19811616
D010862PilocarpinePilocarpine results in increased expression of CACNA1B protein19811616
D011189Potassium ChlorideCACNA1B protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide]12770949
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892
C005556propionaldehydepropionaldehyde results in decreased expression of CACNA1B mRNA26079696
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CACNA1B mRNA21427059
D012834SilverSilver results in increased expression of CACNA1B mRNA27131904
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CACNA1B mRNA26378955
C012589trichostatin Atrichostatin A results in increased expression of CACNA1B mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA1B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CACNA1B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CACNA1B mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of CACNA1B mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CACNA1B gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA25607892

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005245voltage-gated calcium channel activity-IBA21873635  
GO:0005245voltage-gated calcium channel activity-TAS1321501  
GO:0005262calcium channel activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI10455105  11438518  15728831  20195357  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IPI15728831  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-IBA21873635  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS9030575  
GO:0007269neurotransmitter secretion-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0008016regulation of heart contraction-IEA-  
GO:0008217regulation of blood pressure-IEA-  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0048265response to pain-IEA-  
GO:0051899membrane depolarization-TAS-  
GO:0051924regulation of calcium ion transport-IEA-  
GO:0070509calcium ion import-IBA21873635  
GO:0070588calcium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005891voltage-gated calcium channel complex-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04742Taste transduction
hsa04930Type II diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-112308Presynaptic depolarization and calcium channel openingTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene