Gene: CACNA1C

775
CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS
calcium voltage-gated channel subunit alpha1 C
protein-coding
12p13.33
Ensembl:ENSG00000151067 MIM:114205 Vega:OTTHUMG00000150243 UniprotKB:Q13936
NG_008801.2
PubMed|SNP Mapped
2   ANCO-SNPs
CD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.320e-1 (AD)  1.732e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2238043chr12:2166497 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4141130chr12:1988550 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02959759chr12:2801584CACNA1C3.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIO0.898
CELSR30.888
ANKRD520.883
MAPK130.88
ACTN10.873
MNT0.872
HRH20.871
SPATS20.868
SEMA4F0.867
SYN30.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.514
NXT2-0.489
HEY2-0.483
APOM-0.477
YES1-0.468
ASB4-0.463
MBNL3-0.461
IL20RA-0.458
AAMDC-0.456
LRRCC1-0.453

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
DB00270IsradipineSmall Molecule75695-93-1Approved|InvestigationalTarget
DB00308IbutilideSmall Molecule122647-31-8ApprovedTarget
DB00381AmlodipineSmall Molecule88150-42-9ApprovedTarget
DB00393NimodipineSmall Molecule66085-59-4Approved|InvestigationalTarget
DB00401NisoldipineSmall Molecule63675-72-9ApprovedTarget
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalTarget
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalTarget
DB00653Magnesium sulfateSmall Molecule7487-88-9Approved|InvestigationalTarget
DB00661VerapamilSmall Molecule52-53-9ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01023FelodipineSmall Molecule72509-76-3Approved|InvestigationalTarget
DB01054NitrendipineSmall Molecule39562-70-4Approved|InvestigationalTarget
DB01115NifedipineSmall Molecule21829-25-4ApprovedTarget
DB01373CalciumSmall Molecule7440-70-2Approved|NutraceuticalTarget
DB01388MibefradilSmall Molecule116644-53-2Investigational|WithdrawnTarget
DB04855DronedaroneSmall Molecule141626-36-0ApprovedTarget
DB04920ClevidipineSmall Molecule167221-71-8Approved|InvestigationalTarget
DB06712NilvadipineSmall Molecule75530-68-6Approved|InvestigationalTarget
DB06751DrotaverineSmall Molecule14009-24-6Approved|InvestigationalTarget
DB09227BarnidipineSmall Molecule104713-75-9ApprovedTarget
DB09229AranidipineSmall Molecule86780-90-7Approved|InvestigationalTarget
DB09235EfonidipineSmall Molecule111011-63-3Approved|InvestigationalTarget
DB09237LevamlodipineSmall Molecule103129-82-4Approved|InvestigationalTarget
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
DB09089TrimebutineSmall Molecule39133-31-8ApprovedTarget
DB09231BenidipineSmall Molecule105979-17-7Approved|InvestigationalTarget
DB09232CilnidipineSmall Molecule132203-70-4Approved|InvestigationalTarget
DB09236LacidipineSmall Molecule103890-78-4Approved|InvestigationalTarget
DB09238ManidipineSmall Molecule89226-50-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CACNA1C mRNA"28973690
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA25607892
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CACNA1C gene27153756
D000487AllethrinAllethrin inhibits the reaction [CACNA1C protein results in increased transport of Calcium]14634047
D000638AmiodaroneAmiodarone results in decreased expression of CACNA1C mRNA15520326
D000661AmphetamineAmphetamine results in increased expression of CACNA1C mRNA15329393
D000661AmphetamineAmphetamine results in increased expression of CACNA1C protein15329393
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA25607892
D001151ArsenicArsenic affects the methylation of CACNA1C gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of CACNA1C mRNA24831965
D001262AtenololCACNA1C gene polymorphism results in increased susceptibility to Atenolol20031608
D001464BariumCACNA1C protein affects the transport of Barium11724757
D001464BariumZeneca ZD 6169 inhibits the reaction [CACNA1C protein affects the transport of Barium]11724757
D001464BariumCACNA1C protein results in increased transport of Barium17569661
C044946benazeprilbenazepril inhibits the reaction [Thyroxine results in decreased expression of CACNA1C mRNA]21545815
C044946benazeprilbenazepril inhibits the reaction [Thyroxine results in decreased expression of CACNA1C protein]21545815
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CACNA1C mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CACNA1C promoter]19654925
C006780bisphenol Abisphenol A results in increased expression of CACNA1C mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of CACNA1C mRNA17989879
C006780bisphenol Abisphenol A results in increased methylation of CACNA1C promoter27312807
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of CACNA1C mRNA25181051
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA25607892
C018475butyraldehydebutyraldehyde results in increased expression of CACNA1C mRNA26079696
D002118Calcium[CACNA1C protein co-treated with CACNB3 protein] results in increased transport of Calcium12181424
D002118CalciumCACNA1C protein results in increased transport of Calcium15299022
D002118Calcium[CACNA2D4 protein binds to CACNA1C protein binds to CACNB3 protein] which results in increased transport of Calcium12181424
D002118CalciumCACNA2D4 protein promotes the reaction [[CACNA1C protein co-treated with CACNB3 protein] results in increased transport of Calcium]12181424
D002118CalciumAllethrin inhibits the reaction [CACNA1C protein results in increased transport of Calcium]14634047
D002118CalciumCACNA1C protein results in increased transport of Calcium14634047
D002737ChloropreneChloroprene results in decreased expression of CACNA1C mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CACNA1C mRNA18668222
C551994crizotinibcrizotinib results in decreased activity of CACNA1C protein23707608
D000069439DasatinibDasatinib results in increased expression of CACNA1C mRNA20579391
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
D002945CisplatinCisplatin results in decreased expression of CACNA1C mRNA21151649
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CACNA1C mRNA20920545
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CACNA1C mRNA24535843
D004110DiltiazemDiltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]27095094
D004317DoxorubicinDoxorubicin affects the methylation of CACNA1C gene28962528
C070189(endo-N-8-methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide"(endo-N-8-methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide results in decreased activity of CACNA1C protein"28552773
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
C101866ezogabineezogabine affects the activity of CACNA1C protein28641963
D005485FlutamideFlutamide results in increased expression of CACNA1C mRNA21126777
C039281furanfuran results in increased expression of CACNA1C mRNA27387713
C081309irbesartanirbesartan inhibits the reaction [Thyroxine results in decreased expression of CACNA1C mRNA]21545815
C081309irbesartanirbesartan inhibits the reaction [Thyroxine results in decreased expression of CACNA1C protein]21545815
D007505Iron-Dextran ComplexDiltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]27095094
D007505Iron-Dextran ComplexIron-Dextran Complex affects the expression of CACNA1C protein27095094
D007505Iron-Dextran ComplexNimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]27095094
D007505Iron-Dextran ComplexVerapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]27095094
D007545IsoproterenolIsoproterenol results in increased expression of CACNA1C mRNA17526999
C057531jasplakinolidejasplakinolide results in decreased activity of CACNA1C protein23261645
D007854LeadLead affects the expression of CACNA1C mRNA28903495
C008261lead acetatelead acetate affects the expression of CACNA1C mRNA21147602
C002385linsidomine[linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein17551092
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
D008694MethamphetamineMethamphetamine results in decreased methylation of CACNA1C promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of CACNA1C mRNA26307267
D008694MethamphetamineMethamphetamine results in increased expression of CACNA1C protein26307267
D008727MethotrexateMethotrexate results in decreased expression of CACNA1C mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of CACNA1C mRNA21678067
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of CACNA1C protein"28790194
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CACNA1C mRNA26011545
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]19791473
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]19791473
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]19791473
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein]19791473
C051752nefazodonenefazodone affects the activity of CACNA1C protein26821276
D009538NicotineNicotine results in increased expression of CACNA1C protein11756415
D009543NifedipineNifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]20128810
D009543NifedipineCACNA1C protein affects the susceptibility to Nifedipine18441296
D009543NifedipineNifedipine binds to and results in decreased activity of CACNA1C protein18441296
D009543NifedipineNifedipine results in decreased activity of CACNA1C protein23261645
D009553NimodipineNimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]27095094
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CACNA1C mRNA27935865
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA25607892
D010269ParaquatParaquat results in increased expression of CACNA1C mRNA18198484
D030421Peroxynitrous Acid[linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein17551092
D030421Peroxynitrous AcidPeroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]20128810
D030421Peroxynitrous AcidPeroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form20128810
D030421Peroxynitrous Acid[Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein20128810
D010862PilocarpinePilocarpine results in decreased expression of CACNA1C protein17265461
D010862PilocarpinePilocarpine results in increased expression of CACNA1C protein17265461
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CACNA1C mRNA27935865
D011189Potassium ChlorideNifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]20128810
D011189Potassium ChloridePeroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]20128810
D011189Potassium Chloride[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein20128810
D000069583PregabalinPregabalin affects the localization of CACNA1C protein22949532
C045362prochlorazprochloraz results in increased expression of CACNA1C mRNA21470553
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
D011374ProgesteroneProgesterone results in increased expression of CACNA1C mRNA20726854
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of CACNA1C mRNA23274088
C059514resveratrolresveratrol results in decreased expression of CACNA1C mRNA22610192
D012834SilverSilver results in decreased expression of CACNA1C mRNA27131904
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]19791473
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]19791473
D019821SimvastatinSimvastatin results in decreased expression of CACNA1C mRNA19791473
D019821SimvastatinSimvastatin results in decreased expression of CACNA1C protein19791473
C009277sodium arsenatesodium arsenate results in increased expression of CACNA1C mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of CACNA1C gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of CACNA1C mRNA21776218
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of CACNA1C mRNA23274088
C473478sunitinibsunitinib results in decreased activity of CACNA1C protein23707608
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CACNA1C promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CACNA1C mRNA19465110
D013792ThalidomideThalidomide results in decreased expression of CACNA1C mRNA26006729|2621778
D013974Thyroxinebenazepril inhibits the reaction [Thyroxine results in decreased expression of CACNA1C mRNA]21545815
D013974Thyroxinebenazepril inhibits the reaction [Thyroxine results in decreased expression of CACNA1C protein]21545815
D013974Thyroxineirbesartan inhibits the reaction [Thyroxine results in decreased expression of CACNA1C mRNA]21545815
D013974Thyroxineirbesartan inhibits the reaction [Thyroxine results in decreased expression of CACNA1C protein]21545815
D013974ThyroxineThyroxine results in decreased expression of CACNA1C mRNA21545815
D013974ThyroxineThyroxine results in decreased expression of CACNA1C protein21545815
C483909torcetrapibtorcetrapib results in increased expression of CACNA1C mRNA20498617
D014212TretinoinTretinoin results in increased expression of CACNA1C mRNA23056435
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CACNA1C mRNA25847060
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CACNA1C mRNA23537331
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CACNA1C protein23537331
D014415TunicamycinTunicamycin results in increased expression of CACNA1C mRNA17127020
D014635Valproic AcidValproic Acid results in decreased methylation of CACNA1C gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CACNA1C gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CACNA1C mRNA23415681
D014700VerapamilCACNA1C gene polymorphism results in increased susceptibility to Verapamil20031608
D014700VerapamilVerapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]27095094
D014700VerapamilMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]19791473
D014700VerapamilMevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein]19791473
D014700VerapamilVerapamil results in decreased expression of CACNA1C mRNA19791473
D014700VerapamilVerapamil results in decreased expression of CACNA1C protein19791473
C025643vinclozolinvinclozolin results in increased expression of CACNA1C mRNA21126777
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA25607892
C025643vinclozolinvinclozolin results in decreased expression of CACNA1C mRNA23034163
C095007Zeneca ZD 6169Zeneca ZD 6169 inhibits the reaction [CACNA1C protein affects the transport of Barium]11724757
D015032ZincZinc results in increased expression of CACNA1C mRNA15159208|1707474
D019287Zinc SulfateZinc Sulfate results in increased expression of CACNA1C mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005245voltage-gated calcium channel activity-IBA21873635  
GO:0005245voltage-gated calcium channel activity-IDA8392192  12130699  
GO:0005245voltage-gated calcium channel activity-IMP24728418  
GO:0005245voltage-gated calcium channel activity-TAS-  
GO:0005515protein binding-IPI11438518  15140941  18535142  
GO:0005516calmodulin binding-IPI15140941  
GO:0008331high voltage-gated calcium channel activity-IBA21873635  
GO:0008331high voltage-gated calcium channel activity-IDA15454078  
GO:0008331high voltage-gated calcium channel activitycontributes_toTAS11576544  
GO:0046872metal ion binding-IEA-  
GO:0051393alpha-actinin binding-IPI17110593  
GO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potential-IMP15454078  
GO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialcontributes_toIMP17224476  
GO:0086056voltage-gated calcium channel activity involved in AV node cell action potential-IMP26253506  
GO ID GO Term Qualifier Evidence PubMed
GO:0002520immune system development-IMP15454078  
GO:0006816calcium ion transport-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA12130699  
GO:0007507heart development-IMP15454078  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-TAS11576544  
GO:0035115embryonic forelimb morphogenesis-IMP15454078  
GO:0035585calcium-mediated signaling using extracellular calcium source-TAS11576544  
GO:0043010camera-type eye development-IMP15454078  
GO:0050796regulation of insulin secretion-TAS-  
GO:0060402calcium ion transport into cytosol-TAS19095005  
GO:0061337cardiac conduction-IMP24728418  
GO:0061577calcium ion transmembrane transport via high voltage-gated calcium channel-IDA15454078  
GO:0070509calcium ion import-IBA21873635  
GO:0070588calcium ion transmembrane transport-IDA15454078  
GO:0070588calcium ion transmembrane transport-IMP24728418  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP15454078  
GO:0086012membrane depolarization during cardiac muscle cell action potential-IMP15454078  
GO:0086045membrane depolarization during AV node cell action potential-IMP26253506  
GO:0086064cell communication by electrical coupling involved in cardiac conduction-TAS11576544  
GO:0086091regulation of heart rate by cardiac conduction-IMP15454078  15863612  17224476  26253506  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP15454078  26253506  
GO:0098912membrane depolarization during atrial cardiac muscle cell action potential-IMP17224476  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA11206130  
GO:0005886plasma membrane-IDA11206130  
GO:0005886plasma membrane-TAS-  
GO:0005891voltage-gated calcium channel complex-IDA12130699  17224476  
GO:0014069postsynaptic density-IDA14140941  
GO:0016021integral component of membrane-IDA8392192  
GO:0030018Z disc-ISS-  
GO:1990454L-type voltage-gated calcium channel complex-IDA15454078  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04260Cardiac muscle contraction
hsa04270Vascular smooth muscle contraction
hsa04720Long-term potentiation
hsa04912GnRH signaling pathway
hsa04930Type II diabetes mellitus
hsa05010Alzheimer's disease
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-397014Muscle contractionTAS
R-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS
R-HSA-5576893Phase 2 - plateau phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28497380From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms. (2017 Jul)Kabir ZDNeurotherapeutics
27905406Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. (2017 Apr)Uhrig SNeuropsychopharmacology